Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 18310415

GI number: 18310415

Start: 1690491

End: 1691456

Strand: Reverse

Name: hemB [H]

Synonym: CPE1433

Alternate gene names: 18310415

Gene position: 1691456-1690491 (Counterclockwise)

Preceding gene: 18310416

Following gene: 18310414

Centisome position: 55.8

GC content: 31.78

Gene sequence:

>966_bases
ATGATAAAGAGAGGAAGAAGACTTAGAATAAATAAGGAAATGAGAGACCTTGTTAGAGAAAATATTTTAACAGCAAATGA
TTTTATATTTCCTATATTTGTAGTTGAAGGAAACAACATAAAAAAGGAGATAAGTTCTCTACCAGGAAACTATCATGTAT
CTTTAGATAGATTAAATGAAATAGTTGATGAAGTGGTAGCTTTAAATATAAAAGGTGTAATCATATTTGGTCTTCCAGAA
CATAAAGATGCTTGTGGATCAGAGGCATATTCTGATAATGGAATTGTTCAAAAGGCTATTAGAAAATTAAGAGAAGATTA
TGAGAACTTATTAGTAATAACTGATGTTTGTATGTGTGAATATACTAGTCATGGTCATTGTGGAATAATAGAAGGAAAAG
ATGTAGATAATGACAAAACTTTAAGTTTCTTAGATAAAATAGCAGTTTCACACGCTAAGGCTGGTGCTCATATGGTAGCT
CCTTCAGATATGATGGATGGAAGAATATTATCTATGAGAAATGCTTTAGATGAAGCTGGATTTGTTAATGTTGGAATAAT
GAGTTATTCTGCAAAATATTGCTCAGCTTTCTATGGACCTTTCAGAGAAGCTGCTAATTCAGCACCACAATTTGGAGATA
GAAAAACTTATCAAATGGATCCTGCAAACTCAAGAGAAGCCATAAAAGAAGTAGAGCAAGACATAGAAGAGGGTGCAGAT
ATAGTTATGGTTAAACCTGCCTTATCATATTTAGATATTGTTAAGGAAGTAAGAAATAAAGTAGATGTACCAGTTTGTGT
TTATAATGTAAGTGGTGAATTTGCTATGGTTAAGGCAGCAGCTAAACTTGGACTTATAAATGAAAAACAAGTAGCTTTAG
AAATGCTTTTATCAATGAAAAGAGCAGGGGCAGATATGATAATAACTTATTATGCTATAGAAGCTGCTAAATGGTTACAA
GAATAG

Upstream 100 bases:

>100_bases
TTTTAAGTGAAATTGAGGGGATATGGCAAGAGGTTAAAAAATAAATTTGTGGTAAAATTAATTTTATAGGCAAATTACAA
ACAAATTAGGAGGAAAGATT

Downstream 100 bases:

>100_bases
TTTAAGACTATAATATAATGAAAAAAATATTTGCTTAACAATCTTATAGTTAGGAGAATGAATATGGACAGAAATAAAGA
AATATTTGAAGAATCAAAAA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIKRGRRLRINKEMRDLVRENILTANDFIFPIFVVEGNNIKKEISSLPGNYHVSLDRLNEIVDEVVALNIKGVIIFGLPE
HKDACGSEAYSDNGIVQKAIRKLREDYENLLVITDVCMCEYTSHGHCGIIEGKDVDNDKTLSFLDKIAVSHAKAGAHMVA
PSDMMDGRILSMRNALDEAGFVNVGIMSYSAKYCSAFYGPFREAANSAPQFGDRKTYQMDPANSREAIKEVEQDIEEGAD
IVMVKPALSYLDIVKEVRNKVDVPVCVYNVSGEFAMVKAAAKLGLINEKQVALEMLLSMKRAGADMIITYYAIEAAKWLQ
E

Sequences:

>Translated_321_residues
MIKRGRRLRINKEMRDLVRENILTANDFIFPIFVVEGNNIKKEISSLPGNYHVSLDRLNEIVDEVVALNIKGVIIFGLPE
HKDACGSEAYSDNGIVQKAIRKLREDYENLLVITDVCMCEYTSHGHCGIIEGKDVDNDKTLSFLDKIAVSHAKAGAHMVA
PSDMMDGRILSMRNALDEAGFVNVGIMSYSAKYCSAFYGPFREAANSAPQFGDRKTYQMDPANSREAIKEVEQDIEEGAD
IVMVKPALSYLDIVKEVRNKVDVPVCVYNVSGEFAMVKAAAKLGLINEKQVALEMLLSMKRAGADMIITYYAIEAAKWLQ
E
>Mature_321_residues
MIKRGRRLRINKEMRDLVRENILTANDFIFPIFVVEGNNIKKEISSLPGNYHVSLDRLNEIVDEVVALNIKGVIIFGLPE
HKDACGSEAYSDNGIVQKAIRKLREDYENLLVITDVCMCEYTSHGHCGIIEGKDVDNDKTLSFLDKIAVSHAKAGAHMVA
PSDMMDGRILSMRNALDEAGFVNVGIMSYSAKYCSAFYGPFREAANSAPQFGDRKTYQMDPANSREAIKEVEQDIEEGAD
IVMVKPALSYLDIVKEVRNKVDVPVCVYNVSGEFAMVKAAAKLGLINEKQVALEMLLSMKRAGADMIITYYAIEAAKWLQ
E

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=46.078431372549, Blast_Score=281, Evalue=7e-76,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=47.0031545741325, Blast_Score=295, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6321398, Length=314, Percent_Identity=42.9936305732484, Blast_Score=259, Evalue=4e-70,
Organism=Drosophila melanogaster, GI21358291, Length=293, Percent_Identity=44.3686006825939, Blast_Score=261, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35769; Mature: 35769

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRGRRLRINKEMRDLVRENILTANDFIFPIFVVEGNNIKKEISSLPGNYHVSLDRLNE
CCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHCCCCEEEEHHHHHH
IVDEVVALNIKGVIIFGLPEHKDACGSEAYSDNGIVQKAIRKLREDYENLLVITDVCMCE
HHHHHHHEEECEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEHHHHHH
YTSHGHCGIIEGKDVDNDKTLSFLDKIAVSHAKAGAHMVAPSDMMDGRILSMRNALDEAG
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHCCHHHHHHHHHHHCC
FVNVGIMSYSAKYCSAFYGPFREAANSAPQFGDRKTYQMDPANSREAIKEVEQDIEEGAD
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCC
IVMVKPALSYLDIVKEVRNKVDVPVCVYNVSGEFAMVKAAAKLGLINEKQVALEMLLSMK
EEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
RAGADMIITYYAIEAAKWLQE
HCCCCEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MIKRGRRLRINKEMRDLVRENILTANDFIFPIFVVEGNNIKKEISSLPGNYHVSLDRLNE
CCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHCCCCEEEEHHHHHH
IVDEVVALNIKGVIIFGLPEHKDACGSEAYSDNGIVQKAIRKLREDYENLLVITDVCMCE
HHHHHHHEEECEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEHHHHHH
YTSHGHCGIIEGKDVDNDKTLSFLDKIAVSHAKAGAHMVAPSDMMDGRILSMRNALDEAG
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHCCHHHHHHHHHHHCC
FVNVGIMSYSAKYCSAFYGPFREAANSAPQFGDRKTYQMDPANSREAIKEVEQDIEEGAD
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCC
IVMVKPALSYLDIVKEVRNKVDVPVCVYNVSGEFAMVKAAAKLGLINEKQVALEMLLSMK
EEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
RAGADMIITYYAIEAAKWLQE
HCCCCEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377 [H]