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The map label for this gene is lonA [H]

Identifier: 18310372

GI number: 18310372

Start: 1638699

End: 1641029

Strand: Reverse

Name: lonA [H]

Synonym: CPE1390

Alternate gene names: 18310372

Gene position: 1641029-1638699 (Counterclockwise)

Preceding gene: 18310373

Following gene: 18310371

Centisome position: 54.13

GC content: 30.59

Gene sequence:

>2331_bases
ATGAAAGAAGATAAATTAATTCTTCCTTTAATTCCTCTAAGAGGTCTAACTGTATTTCCTAATATGGTTATATACTTTGA
CGTTGGTAGGGAAAAGTCAATAGAAGCTGTTGAAAAGGCTATGGCAGGAGATCAAAAGATATTTTTAGCAGCTCAAAAAG
ATATAGAGATTGACAATCCGAGTGAAGATGACATCTTTAATATAGGTACAATCTGTGAAATAAAGCAAATTGTAAAAATG
CCAAAAAACACTATAAGAGTTTTAGTAGAAGGTATTGAAAGAGCAAAGATGGATGAATTCTTTGATAAAGAGGAATTACT
TGAAGCATCAATAGAGAAAATAGATATTGATAATGAAATTGACCATGAACTTGAAGCTTTATCAAGAAAGTTAAAGGATG
ATTTTTTTGAGTTTTTAGATATTACAGCAAGTAGTGGAATAAATGGTGTTGATTTATTTGATAATCTAGAAGAAGAAAAA
GATTTAAATAAGGTTACAGATTTAATTTCTTCATATGCTCTTATAAAACAAGAGGACAAGCAGGATATTCTTCAAACTTT
AGATTTAAAGAAAAGAATAGAAAAATTAATATTTTATGTGAAAGAAGAAATTGAAGTAGCTAAAATAGAAAAAAGAATTG
GAACTAAAGTTAAGAAGAAATTAGATAAAGGCCAAAGAGAATATTATTTAAGAGAGCAAATGAAGGTAATCCAAGAGGAA
CTTGGAGAAGATGATGATAATAAGAAAGCTATAATTGAGTTTGAGAAAGTTATAAATGAAAAAAAATTACCTAATCAGGT
TAAGGAAAAAGCTCAATATGAAATTTCAAAGCTTAAGGCATCATCTCCATATTCTCAAGATGGAGGAGTTACAAGAACTT
ACTTAGAAAATTTATTAGACATGCCTTGGGGAGAATTTACTGAGGATACTTTAAATATAAAAGATGCGAGAAAAGTATTA
GATAAAGATCATTATGGATTAAAGGACGTAAAGGATAGAATTCTTGAATATTTAGCTGTAAAGCAAATAAGTAATTCATT
AAGAGGCCCTATTCTTTGTCTAGTTGGACCTCCAGGGGTAGGTAAAACTTCTATAGCTAAAAGTGTTGCAACTTCACTAA
ATAGAAAGTTTGTAAGAATGTCTTTAGGTGGAGTTAGAGATGAAGCTGATATAAGAGGACATAGAAGAACTTACGTTGGA
GCAATTCCAGGAAGAATAGTTACTGGATTAAAGGAAGCTAAAAGTATGAATCCAGTATTTTTACTAGATGAAATTGATAA
GTTAGGAATGGATTTCAAAGGAAATCCAGCTGATGCCTTACTAGAGGTTTTTGATAATGAGCAAAATAAAACTTTTAGAG
ACCATTATCTAGAGGTGGATGTTGATTTATCAGAGGTTATGTTTATAACAACAGCAAACTCTTTAGATGGAATTCCAAGA
CCTCTTTTAGATAGAATGGAATTAATAGAGGTATCAGGATATACTTATGAAGAAAAATTCAGAATAGCTAAGAAATATTT
AGTACCAAAGGTATTAAAAGAACATGGTGTTGATAATAAAATAATAACTATATCTGATTCTGCTTTAAAACTTATTATAG
ATAGCTATACAAGAGAATCTGGAGTAAGAAATCTTCAAAGACAAATAGCTAATGTTATAAGAAAAGGAATAAAGGATATA
ATAGAAAAAGATAAGAAAAATTTAAATATATCTACTAAGTTAGTTGAAAAATACTTGGGGCCAAAAATCTTTAGCTATGA
AGAAATTGATAAGGAAGATAAGGTTGGAGTAGTTACAGGAATGGCTTGGACTGCTTATGGTGGAGATACTTTACCAGTAG
AAGTAATGGTTATGGATGGTAAGGGCAGATTAGAGCTTACTGGACAACTTGGAGATGTAATGAAGGAATCTGCAAGAGCT
GCATACTCTTATGTGAGAGCTCATATGAAGGAATTAGGAATAAAGGATGAGTTTTATTCTAAGAAAGATATTCATATACA
TGCTCCAGAGGGTGCAGTACCAAAGGATGGTCCTTCTGCAGGGGTTACTATGACTACTGCCTTAGTATCAGCATTAACTG
GTAAAAAAGTTAAACACAATGTTGCTATGACTGGAGAAATAACTTTAACTGGAAAAGTTTTAGCTATTGGTGGTTTAAAA
GAAAAATGCTTAGCAGCAAGAAGAGTAGGAATTGATACGGTTATAGTTCCTAAGGAAAATGAAAAAGACGTAATTAAACT
TCCTAAAATAGTTAAGGATAGTTTAAATATAATACTTGCAGATAAAATTGATGATGTATTAGAAAATGCATTGGTTGGAG
TTGAAAAATAA

Upstream 100 bases:

>100_bases
AATTAAATAAGCTTGAAAAAAACTTGTAATATGTGTATACTTGTTAAAGACTATATATTTATATAATATGTAGTTATTAA
TTTTTTTGGAGGGGATATTT

Downstream 100 bases:

>100_bases
TGAAAATAAAAAGTTCGGAATTTATAATATCAGCGGTTAAGAGAGAACAGTATCCTGATGATAACCTACCAGAAATAGCT
TTTGTTGGTAGATCAAATGT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MKEDKLILPLIPLRGLTVFPNMVIYFDVGREKSIEAVEKAMAGDQKIFLAAQKDIEIDNPSEDDIFNIGTICEIKQIVKM
PKNTIRVLVEGIERAKMDEFFDKEELLEASIEKIDIDNEIDHELEALSRKLKDDFFEFLDITASSGINGVDLFDNLEEEK
DLNKVTDLISSYALIKQEDKQDILQTLDLKKRIEKLIFYVKEEIEVAKIEKRIGTKVKKKLDKGQREYYLREQMKVIQEE
LGEDDDNKKAIIEFEKVINEKKLPNQVKEKAQYEISKLKASSPYSQDGGVTRTYLENLLDMPWGEFTEDTLNIKDARKVL
DKDHYGLKDVKDRILEYLAVKQISNSLRGPILCLVGPPGVGKTSIAKSVATSLNRKFVRMSLGGVRDEADIRGHRRTYVG
AIPGRIVTGLKEAKSMNPVFLLDEIDKLGMDFKGNPADALLEVFDNEQNKTFRDHYLEVDVDLSEVMFITTANSLDGIPR
PLLDRMELIEVSGYTYEEKFRIAKKYLVPKVLKEHGVDNKIITISDSALKLIIDSYTRESGVRNLQRQIANVIRKGIKDI
IEKDKKNLNISTKLVEKYLGPKIFSYEEIDKEDKVGVVTGMAWTAYGGDTLPVEVMVMDGKGRLELTGQLGDVMKESARA
AYSYVRAHMKELGIKDEFYSKKDIHIHAPEGAVPKDGPSAGVTMTTALVSALTGKKVKHNVAMTGEITLTGKVLAIGGLK
EKCLAARRVGIDTVIVPKENEKDVIKLPKIVKDSLNIILADKIDDVLENALVGVEK

Sequences:

>Translated_776_residues
MKEDKLILPLIPLRGLTVFPNMVIYFDVGREKSIEAVEKAMAGDQKIFLAAQKDIEIDNPSEDDIFNIGTICEIKQIVKM
PKNTIRVLVEGIERAKMDEFFDKEELLEASIEKIDIDNEIDHELEALSRKLKDDFFEFLDITASSGINGVDLFDNLEEEK
DLNKVTDLISSYALIKQEDKQDILQTLDLKKRIEKLIFYVKEEIEVAKIEKRIGTKVKKKLDKGQREYYLREQMKVIQEE
LGEDDDNKKAIIEFEKVINEKKLPNQVKEKAQYEISKLKASSPYSQDGGVTRTYLENLLDMPWGEFTEDTLNIKDARKVL
DKDHYGLKDVKDRILEYLAVKQISNSLRGPILCLVGPPGVGKTSIAKSVATSLNRKFVRMSLGGVRDEADIRGHRRTYVG
AIPGRIVTGLKEAKSMNPVFLLDEIDKLGMDFKGNPADALLEVFDNEQNKTFRDHYLEVDVDLSEVMFITTANSLDGIPR
PLLDRMELIEVSGYTYEEKFRIAKKYLVPKVLKEHGVDNKIITISDSALKLIIDSYTRESGVRNLQRQIANVIRKGIKDI
IEKDKKNLNISTKLVEKYLGPKIFSYEEIDKEDKVGVVTGMAWTAYGGDTLPVEVMVMDGKGRLELTGQLGDVMKESARA
AYSYVRAHMKELGIKDEFYSKKDIHIHAPEGAVPKDGPSAGVTMTTALVSALTGKKVKHNVAMTGEITLTGKVLAIGGLK
EKCLAARRVGIDTVIVPKENEKDVIKLPKIVKDSLNIILADKIDDVLENALVGVEK
>Mature_776_residues
MKEDKLILPLIPLRGLTVFPNMVIYFDVGREKSIEAVEKAMAGDQKIFLAAQKDIEIDNPSEDDIFNIGTICEIKQIVKM
PKNTIRVLVEGIERAKMDEFFDKEELLEASIEKIDIDNEIDHELEALSRKLKDDFFEFLDITASSGINGVDLFDNLEEEK
DLNKVTDLISSYALIKQEDKQDILQTLDLKKRIEKLIFYVKEEIEVAKIEKRIGTKVKKKLDKGQREYYLREQMKVIQEE
LGEDDDNKKAIIEFEKVINEKKLPNQVKEKAQYEISKLKASSPYSQDGGVTRTYLENLLDMPWGEFTEDTLNIKDARKVL
DKDHYGLKDVKDRILEYLAVKQISNSLRGPILCLVGPPGVGKTSIAKSVATSLNRKFVRMSLGGVRDEADIRGHRRTYVG
AIPGRIVTGLKEAKSMNPVFLLDEIDKLGMDFKGNPADALLEVFDNEQNKTFRDHYLEVDVDLSEVMFITTANSLDGIPR
PLLDRMELIEVSGYTYEEKFRIAKKYLVPKVLKEHGVDNKIITISDSALKLIIDSYTRESGVRNLQRQIANVIRKGIKDI
IEKDKKNLNISTKLVEKYLGPKIFSYEEIDKEDKVGVVTGMAWTAYGGDTLPVEVMVMDGKGRLELTGQLGDVMKESARA
AYSYVRAHMKELGIKDEFYSKKDIHIHAPEGAVPKDGPSAGVTMTTALVSALTGKKVKHNVAMTGEITLTGKVLAIGGLK
EKCLAARRVGIDTVIVPKENEKDVIKLPKIVKDSLNIILADKIDDVLENALVGVEK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=617, Percent_Identity=44.2463533225284, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI31377667, Length=769, Percent_Identity=40.1820546163849, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1786643, Length=777, Percent_Identity=47.4903474903475, Blast_Score=720, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=635, Percent_Identity=42.2047244094488, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=33.2496863237139, Blast_Score=427, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=665, Percent_Identity=42.5563909774436, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24666867, Length=622, Percent_Identity=45.3376205787781, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221513036, Length=622, Percent_Identity=45.3376205787781, Blast_Score=551, Evalue=1e-157,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87429; Mature: 87429

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEDKLILPLIPLRGLTVFPNMVIYFDVGREKSIEAVEKAMAGDQKIFLAAQKDIEIDNP
CCCCCEEEEECCCCCCEECCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCC
SEDDIFNIGTICEIKQIVKMPKNTIRVLVEGIERAKMDEFFDKEELLEASIEKIDIDNEI
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHH
DHELEALSRKLKDDFFEFLDITASSGINGVDLFDNLEEEKDLNKVTDLISSYALIKQEDK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
QDILQTLDLKKRIEKLIFYVKEEIEVAKIEKRIGTKVKKKLDKGQREYYLREQMKVIQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LGEDDDNKKAIIEFEKVINEKKLPNQVKEKAQYEISKLKASSPYSQDGGVTRTYLENLLD
HCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
MPWGEFTEDTLNIKDARKVLDKDHYGLKDVKDRILEYLAVKQISNSLRGPILCLVGPPGV
CCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSIAKSVATSLNRKFVRMSLGGVRDEADIRGHRRTYVGAIPGRIVTGLKEAKSMNPVF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCEEEECCCHHHHHHHHHHCCCCCEE
LLDEIDKLGMDFKGNPADALLEVFDNEQNKTFRDHYLEVDVDLSEVMFITTANSLDGIPR
EEECHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHCEEEEECCHHHEEEEEECCCCCCCCH
PLLDRMELIEVSGYTYEEKFRIAKKYLVPKVLKEHGVDNKIITISDSALKLIIDSYTRES
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
GVRNLQRQIANVIRKGIKDIIEKDKKNLNISTKLVEKYLGPKIFSYEEIDKEDKVGVVTG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEC
MAWTAYGGDTLPVEVMVMDGKGRLELTGQLGDVMKESARAAYSYVRAHMKELGIKDEFYS
CEEEECCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
KKDIHIHAPEGAVPKDGPSAGVTMTTALVSALTGKKVKHNVAMTGEITLTGKVLAIGGLK
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEEEEEEEEEECEEEEECCCH
EKCLAARRVGIDTVIVPKENEKDVIKLPKIVKDSLNIILADKIDDVLENALVGVEK
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCEEEHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKEDKLILPLIPLRGLTVFPNMVIYFDVGREKSIEAVEKAMAGDQKIFLAAQKDIEIDNP
CCCCCEEEEECCCCCCEECCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCC
SEDDIFNIGTICEIKQIVKMPKNTIRVLVEGIERAKMDEFFDKEELLEASIEKIDIDNEI
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHH
DHELEALSRKLKDDFFEFLDITASSGINGVDLFDNLEEEKDLNKVTDLISSYALIKQEDK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
QDILQTLDLKKRIEKLIFYVKEEIEVAKIEKRIGTKVKKKLDKGQREYYLREQMKVIQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
LGEDDDNKKAIIEFEKVINEKKLPNQVKEKAQYEISKLKASSPYSQDGGVTRTYLENLLD
HCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
MPWGEFTEDTLNIKDARKVLDKDHYGLKDVKDRILEYLAVKQISNSLRGPILCLVGPPGV
CCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSIAKSVATSLNRKFVRMSLGGVRDEADIRGHRRTYVGAIPGRIVTGLKEAKSMNPVF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCEEEECCCHHHHHHHHHHCCCCCEE
LLDEIDKLGMDFKGNPADALLEVFDNEQNKTFRDHYLEVDVDLSEVMFITTANSLDGIPR
EEECHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHCEEEEECCHHHEEEEEECCCCCCCCH
PLLDRMELIEVSGYTYEEKFRIAKKYLVPKVLKEHGVDNKIITISDSALKLIIDSYTRES
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
GVRNLQRQIANVIRKGIKDIIEKDKKNLNISTKLVEKYLGPKIFSYEEIDKEDKVGVVTG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEC
MAWTAYGGDTLPVEVMVMDGKGRLELTGQLGDVMKESARAAYSYVRAHMKELGIKDEFYS
CEEEECCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
KKDIHIHAPEGAVPKDGPSAGVTMTTALVSALTGKKVKHNVAMTGEITLTGKVLAIGGLK
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEEEEEEEEEECEEEEECCCH
EKCLAARRVGIDTVIVPKENEKDVIKLPKIVKDSLNIILADKIDDVLENALVGVEK
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCEEEHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]