Click here to switch to the map view.

The map label for this gene is lonB [H]

Identifier: 18310373

GI number: 18310373

Start: 1641151

End: 1642863

Strand: Reverse

Name: lonB [H]

Synonym: CPE1391

Alternate gene names: 18310373

Gene position: 1642863-1641151 (Counterclockwise)

Preceding gene: 18310374

Following gene: 18310372

Centisome position: 54.19

GC content: 32.69

Gene sequence:

>1713_bases
ATGAATACTTATACATTTATAATGTTTCTACAATTACTTATGTCAATTTTATTCTATATATATATGAGCAAGTCCTTTGC
GAGTAAGAAGAAAGATAATAGTGTTTTAGAAAAAGAAAATGAAAAAGAAATGGAAAAATTAAATAAATTAAGAATGATAA
AACTGACAGAACCTTTAACTGAAAAAAGTAGACCAAGTAATTTAGAAGAAATAATAGGACAGGAAAAGGGAATAAAAGCT
CTTAAAGCAGCACTTTGTGGGCCAAATCCACAGCATGTAATAATATATGGTCCGCCAGGGGTAGGAAAAACTGCAGCTGC
TAGAATAATTTTAGAAGAGGCTAAGAAAATGGCAGCATCTCCTTTTAATAAGGACTCTAAATTTGTTGAAATAGATGCCA
CAACTTTAAGATTTGATGAGAGGGGGATAGCAGATCCACTAATAGGTTCCGTTCATGATCCAATATATCAAGGAGCAGGT
TCCTTAGGGATTGCAGGGGTTCCTCAACCTAAGCCAGGAGCTGTAACAAAGGCTCATGGAGGAATACTTTTTATAGATGA
AATAGGAGAACTCCATCCTATTGAATTAAATAAACTTCTTAAAGTTTTAGAGGATAGAAAAGTTTTTTTAGATTCAGCCT
ATTATAGTTCAGAAGATCCCAATACTCCTAGATATATAAAAGAAATATTTGATAATGGATTACCAGCAGATTTTAGATTA
ATTGGTGCAACTACAAGAAGTCCAGAGGAAATAGTGCCAGCTATAAGGTCAAGGTGCGTAGAAATATTTTTTAGAGGGCT
AACTGTTGAAGAGATTAGAAAAATTGCTTTAAATGCCACAAATAAGGTTGGTTATAGAATAAGTGATGAGGGATTAGACA
TAGTATCTAGATATTGTACTAATGGAAGAGAAGTTATAAACTTAGTGCAATTATGTTCTGGCCTTGCAATAAATGAAAAT
AGAGATTACATAAAAGAGAGTGATATTTATTGGGTTATTGAAAATGGTCAATATAATCCTAGAATGGAAAGAATGATAAA
TGATAAACCTGAAATTGGGTATGTAAATGGCTTAGCTGTGTATGGAGCTAACAATGGAGCTTTAATGGAAATAGAAGCTA
CAGCAAAGCTATCAAGTAATAGTATAGGTAGTATAAAAATTACTGGAATAGTTGATGATGAGGAACTAGGCGGTGGAGAG
AAGAAAATAAAGAGAAAAAGCACAGCATATTGTTCTGTACAGAATGTATTGACAGTATTAGATAATATATTTAATTTAAA
TTCAAAGGCATATGATATACATGTTAACTTTCCAGGCGGAATACCAGTAGACGGTCCATCTGCTGGAATAAGTATAGCTA
CAGCCATATATAGTGCCATAAAAGGAGTGCCTGTAAATAATAGAGTGGCTATGACTGGTGAGATATCAATAAAGGGAAAG
GTAAAACCAATAGGGGGAGTAAATGCAAAGATATTAGCAGCAAAGAGAGCTGGAGTAGAATTGGTAATTGTTCCAAAGGA
AAATTTAAGTAGTATAACTAGAGATATTGATGGAATAAAGATAGTTGGTGTTAAGAAAATTGAAGAGGTATTAGATCTTG
CACTTTATGAAGAAGAATGTATAGAAAAAGAGAGCTTAATAATTAAAGATAATAGGGCATTTTTTGGTACTGGTGCCTTA
AATGCAGAATCTATAAAGAAAGCTAACACTTAA

Upstream 100 bases:

>100_bases
TGCATACTATTTATGCATCTTTTTTATTTTTTATGGAGTTTTTGGAATATCATCACAAAAATAGGTAAATACTAACCGTA
TAGAACGGGAGGTATTAGAG

Downstream 100 bases:

>100_bases
AGTGTTAGTTTTCTTTTATGGAATTAAATAAGCTTGAAAAAAACTTGTAATATGTGTATACTTGTTAAAGACTATATATT
TATATAATATGTAGTTATTA

Product: Lon-like ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MNTYTFIMFLQLLMSILFYIYMSKSFASKKKDNSVLEKENEKEMEKLNKLRMIKLTEPLTEKSRPSNLEEIIGQEKGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARIILEEAKKMAASPFNKDSKFVEIDATTLRFDERGIADPLIGSVHDPIYQGAG
SLGIAGVPQPKPGAVTKAHGGILFIDEIGELHPIELNKLLKVLEDRKVFLDSAYYSSEDPNTPRYIKEIFDNGLPADFRL
IGATTRSPEEIVPAIRSRCVEIFFRGLTVEEIRKIALNATNKVGYRISDEGLDIVSRYCTNGREVINLVQLCSGLAINEN
RDYIKESDIYWVIENGQYNPRMERMINDKPEIGYVNGLAVYGANNGALMEIEATAKLSSNSIGSIKITGIVDDEELGGGE
KKIKRKSTAYCSVQNVLTVLDNIFNLNSKAYDIHVNFPGGIPVDGPSAGISIATAIYSAIKGVPVNNRVAMTGEISIKGK
VKPIGGVNAKILAAKRAGVELVIVPKENLSSITRDIDGIKIVGVKKIEEVLDLALYEEECIEKESLIIKDNRAFFGTGAL
NAESIKKANT

Sequences:

>Translated_570_residues
MNTYTFIMFLQLLMSILFYIYMSKSFASKKKDNSVLEKENEKEMEKLNKLRMIKLTEPLTEKSRPSNLEEIIGQEKGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARIILEEAKKMAASPFNKDSKFVEIDATTLRFDERGIADPLIGSVHDPIYQGAG
SLGIAGVPQPKPGAVTKAHGGILFIDEIGELHPIELNKLLKVLEDRKVFLDSAYYSSEDPNTPRYIKEIFDNGLPADFRL
IGATTRSPEEIVPAIRSRCVEIFFRGLTVEEIRKIALNATNKVGYRISDEGLDIVSRYCTNGREVINLVQLCSGLAINEN
RDYIKESDIYWVIENGQYNPRMERMINDKPEIGYVNGLAVYGANNGALMEIEATAKLSSNSIGSIKITGIVDDEELGGGE
KKIKRKSTAYCSVQNVLTVLDNIFNLNSKAYDIHVNFPGGIPVDGPSAGISIATAIYSAIKGVPVNNRVAMTGEISIKGK
VKPIGGVNAKILAAKRAGVELVIVPKENLSSITRDIDGIKIVGVKKIEEVLDLALYEEECIEKESLIIKDNRAFFGTGAL
NAESIKKANT
>Mature_570_residues
MNTYTFIMFLQLLMSILFYIYMSKSFASKKKDNSVLEKENEKEMEKLNKLRMIKLTEPLTEKSRPSNLEEIIGQEKGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARIILEEAKKMAASPFNKDSKFVEIDATTLRFDERGIADPLIGSVHDPIYQGAG
SLGIAGVPQPKPGAVTKAHGGILFIDEIGELHPIELNKLLKVLEDRKVFLDSAYYSSEDPNTPRYIKEIFDNGLPADFRL
IGATTRSPEEIVPAIRSRCVEIFFRGLTVEEIRKIALNATNKVGYRISDEGLDIVSRYCTNGREVINLVQLCSGLAINEN
RDYIKESDIYWVIENGQYNPRMERMINDKPEIGYVNGLAVYGANNGALMEIEATAKLSSNSIGSIKITGIVDDEELGGGE
KKIKRKSTAYCSVQNVLTVLDNIFNLNSKAYDIHVNFPGGIPVDGPSAGISIATAIYSAIKGVPVNNRVAMTGEISIKGK
VKPIGGVNAKILAAKRAGVELVIVPKENLSSITRDIDGIKIVGVKKIEEVLDLALYEEECIEKESLIIKDNRAFFGTGAL
NAESIKKANT

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=488, Percent_Identity=26.0245901639344, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI31377667, Length=502, Percent_Identity=25.0996015936255, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1786643, Length=492, Percent_Identity=28.6585365853659, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17505831, Length=497, Percent_Identity=26.9617706237425, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17556486, Length=78, Percent_Identity=50, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319449, Length=89, Percent_Identity=43.8202247191011, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221513036, Length=492, Percent_Identity=27.2357723577236, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666867, Length=494, Percent_Identity=27.1255060728745, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 62516; Mature: 62516

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYTFIMFLQLLMSILFYIYMSKSFASKKKDNSVLEKENEKEMEKLNKLRMIKLTEPLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHEEEEEECCCHH
EKSRPSNLEEIIGQEKGIKALKAALCGPNPQHVIIYGPPGVGKTAAARIILEEAKKMAAS
CCCCCCCHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PFNKDSKFVEIDATTLRFDERGIADPLIGSVHDPIYQGAGSLGIAGVPQPKPGAVTKAHG
CCCCCCCEEEEEEEEEEECCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEEECCC
GILFIDEIGELHPIELNKLLKVLEDRKVFLDSAYYSSEDPNTPRYIKEIFDNGLPADFRL
CEEEEECCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEE
IGATTRSPEEIVPAIRSRCVEIFFRGLTVEEIRKIALNATNKVGYRISDEGLDIVSRYCT
EECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHC
NGREVINLVQLCSGLAINENRDYIKESDIYWVIENGQYNPRMERMINDKPEIGYVNGLAV
CCHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCEEECCEEE
YGANNGALMEIEATAKLSSNSIGSIKITGIVDDEELGGGEKKIKRKSTAYCSVQNVLTVL
EECCCCEEEEEEEEEEECCCCCCEEEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DNIFNLNSKAYDIHVNFPGGIPVDGPSAGISIATAIYSAIKGVPVNNRVAMTGEISIKGK
HHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEE
VKPIGGVNAKILAAKRAGVELVIVPKENLSSITRDIDGIKIVGVKKIEEVLDLALYEEEC
ECCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
IEKESLIIKDNRAFFGTGALNAESIKKANT
CCCCCEEEECCCEEEECCCCCHHHHHCCCC
>Mature Secondary Structure
MNTYTFIMFLQLLMSILFYIYMSKSFASKKKDNSVLEKENEKEMEKLNKLRMIKLTEPLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHEEEEEECCCHH
EKSRPSNLEEIIGQEKGIKALKAALCGPNPQHVIIYGPPGVGKTAAARIILEEAKKMAAS
CCCCCCCHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
PFNKDSKFVEIDATTLRFDERGIADPLIGSVHDPIYQGAGSLGIAGVPQPKPGAVTKAHG
CCCCCCCEEEEEEEEEEECCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEEECCC
GILFIDEIGELHPIELNKLLKVLEDRKVFLDSAYYSSEDPNTPRYIKEIFDNGLPADFRL
CEEEEECCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEE
IGATTRSPEEIVPAIRSRCVEIFFRGLTVEEIRKIALNATNKVGYRISDEGLDIVSRYCT
EECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHC
NGREVINLVQLCSGLAINENRDYIKESDIYWVIENGQYNPRMERMINDKPEIGYVNGLAV
CCHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCEEECCEEE
YGANNGALMEIEATAKLSSNSIGSIKITGIVDDEELGGGEKKIKRKSTAYCSVQNVLTVL
EECCCCEEEEEEEEEEECCCCCCEEEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DNIFNLNSKAYDIHVNFPGGIPVDGPSAGISIATAIYSAIKGVPVNNRVAMTGEISIKGK
HHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEE
VKPIGGVNAKILAAKRAGVELVIVPKENLSSITRDIDGIKIVGVKKIEEVLDLALYEEEC
ECCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
IEKESLIIKDNRAFFGTGALNAESIKKANT
CCCCCEEEECCCEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]