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The map label for this gene is mro [H]

Identifier: 18310326

GI number: 18310326

Start: 1587084

End: 1588106

Strand: Reverse

Name: mro [H]

Synonym: CPE1344

Alternate gene names: 18310326

Gene position: 1588106-1587084 (Counterclockwise)

Preceding gene: 18310329

Following gene: 18310322

Centisome position: 52.39

GC content: 27.96

Gene sequence:

>1023_bases
TTGGTTATAGAAAGTAAAATTAATGATGAAATAAGTAAAATAATATTAAAAAATAATAAAGTATCTGTGGAAATATTAAA
CTTAGGTGCTATTGTAGAAAAAATAAATGTAGAGGATAGATATGGAAATAAAGAAAATATAGTGCTTGCATATAAGGATG
AGGAAAGCTATATTGAAAATCCTTCAAGTTTAGGTTCTATAGTAGGAAGAGTAGCAGGTAGAATAGGAAAGGGTTCCTTT
AAATTAAATGGTATTAATTATGAATTAGATAAAAATAATAATGGAAACTGCCTTCATGGAGGGTATAAAGGTTTTAGTAA
AAAAATCTGGGATTATTCATATAGTGAAGATGAAGAAAAATCTACAGCAATATTTACTTCTTTTAGTAAGGATGGAGAAG
GGGGATTCCCAGGAAATTTAAAGGTTCAGGTTACTTATTCTCTAGAAGGAGACAAGCTTTCCATAGAATATAGAGCTTCT
TCAGATAAAGATACAGTAGTAAATTTAACTAATCATTCATATTTTAATTTATCAGGAAATAATAAAAGAAATGTATTAGA
ACAAAAGCTTTATATAGATTCAGATAAAATATGTGAGTTAGATAAAGATTTAATTCCAACAGGAGAGTTTTTAAGTGTAG
AAAAAACACCTTTTGACTTTAGGAAGTTAAAAAAAATAGGTGAGGATATAAATAAAAACCACTTGCAATTAGAAATTGGA
TCAGGATATGATCATCCATGGGTTTTAAATAAGAAGGGTGATTTTGATGCAATCTTAGTAGATGAAGAATCAGGAAGAAT
TATGAAGGTTAAGACAGATCAAAAGGCAGTAGTATGTTATTCAATGAATTTTCCAGATGAATTACCTTTAGAAAATGGCA
AAGTAGCCAAAAAGCATGATGGAATATGTTTTGAAACACAAAACTTACCAGTAGGATATGATGATTGCTTCTTAGATGGA
ATAATACTTAAAAAGGATGAAGAGTATTATCAAAAAACAACTTTTGAATTTGAGTATATGTAA

Upstream 100 bases:

>100_bases
AATTCTTAAAAATAGCATGTTTAATAGAGTAAATATTATTGAAAAACTTATATTAAGTTGTTAAAATCAAACTATAGATA
TGAAAGGGAGAGTGAATAAT

Downstream 100 bases:

>100_bases
AAAAATGTATGGAAGAAATATTTCTTCCATACATTTTTTATTAGTTCTTTTTCATGTATTTTCTCATATCAAGAGCTACA
GCTAGAACTATAATTAAACC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MVIESKINDEISKIILKNNKVSVEILNLGAIVEKINVEDRYGNKENIVLAYKDEESYIENPSSLGSIVGRVAGRIGKGSF
KLNGINYELDKNNNGNCLHGGYKGFSKKIWDYSYSEDEEKSTAIFTSFSKDGEGGFPGNLKVQVTYSLEGDKLSIEYRAS
SDKDTVVNLTNHSYFNLSGNNKRNVLEQKLYIDSDKICELDKDLIPTGEFLSVEKTPFDFRKLKKIGEDINKNHLQLEIG
SGYDHPWVLNKKGDFDAILVDEESGRIMKVKTDQKAVVCYSMNFPDELPLENGKVAKKHDGICFETQNLPVGYDDCFLDG
IILKKDEEYYQKTTFEFEYM

Sequences:

>Translated_340_residues
MVIESKINDEISKIILKNNKVSVEILNLGAIVEKINVEDRYGNKENIVLAYKDEESYIENPSSLGSIVGRVAGRIGKGSF
KLNGINYELDKNNNGNCLHGGYKGFSKKIWDYSYSEDEEKSTAIFTSFSKDGEGGFPGNLKVQVTYSLEGDKLSIEYRAS
SDKDTVVNLTNHSYFNLSGNNKRNVLEQKLYIDSDKICELDKDLIPTGEFLSVEKTPFDFRKLKKIGEDINKNHLQLEIG
SGYDHPWVLNKKGDFDAILVDEESGRIMKVKTDQKAVVCYSMNFPDELPLENGKVAKKHDGICFETQNLPVGYDDCFLDG
IILKKDEEYYQKTTFEFEYM
>Mature_340_residues
MVIESKINDEISKIILKNNKVSVEILNLGAIVEKINVEDRYGNKENIVLAYKDEESYIENPSSLGSIVGRVAGRIGKGSF
KLNGINYELDKNNNGNCLHGGYKGFSKKIWDYSYSEDEEKSTAIFTSFSKDGEGGFPGNLKVQVTYSLEGDKLSIEYRAS
SDKDTVVNLTNHSYFNLSGNNKRNVLEQKLYIDSDKICELDKDLIPTGEFLSVEKTPFDFRKLKKIGEDINKNHLQLEIG
SGYDHPWVLNKKGDFDAILVDEESGRIMKVKTDQKAVVCYSMNFPDELPLENGKVAKKHDGICFETQNLPVGYDDCFLDG
IILKKDEEYYQKTTFEFEYM

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=330, Percent_Identity=38.4848484848485, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1786971, Length=336, Percent_Identity=32.4404761904762, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17557428, Length=332, Percent_Identity=26.8072289156627, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI115533334, Length=332, Percent_Identity=26.8072289156627, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319493, Length=216, Percent_Identity=31.0185185185185, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322004, Length=342, Percent_Identity=28.0701754385965, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324399, Length=221, Percent_Identity=28.9592760180996, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=31.858407079646, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24668278, Length=345, Percent_Identity=31.0144927536232, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24659048, Length=355, Percent_Identity=32.112676056338, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24668282, Length=350, Percent_Identity=30.8571428571429, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24641876, Length=340, Percent_Identity=27.0588235294118, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38560; Mature: 38560

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIESKINDEISKIILKNNKVSVEILNLGAIVEKINVEDRYGNKENIVLAYKDEESYIEN
CEECCHHHHHHHEEEEECCCEEEEEEECCEEEEEECCHHCCCCCCCEEEEEECCHHHHCC
PSSLGSIVGRVAGRIGKGSFKLNGINYELDKNNNGNCLHGGYKGFSKKIWDYSYSEDEEK
HHHHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCCEEECCCCCHHHHHCCCCCCCCCCC
STAIFTSFSKDGEGGFPGNLKVQVTYSLEGDKLSIEYRASSDKDTVVNLTNHSYFNLSGN
CEEEEEEECCCCCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEEEECCEEEEECCC
NKRNVLEQKLYIDSDKICELDKDLIPTGEFLSVEKTPFDFRKLKKIGEDINKNHLQLEIG
CCHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEC
SGYDHPWVLNKKGDFDAILVDEESGRIMKVKTDQKAVVCYSMNFPDELPLENGKVAKKHD
CCCCCCEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCEEECCC
GICFETQNLPVGYDDCFLDGIILKKDEEYYQKTTFEFEYM
CEEEECCCCCCCCCHHHCCCEEEECCHHHHHHEEEEEEEC
>Mature Secondary Structure
MVIESKINDEISKIILKNNKVSVEILNLGAIVEKINVEDRYGNKENIVLAYKDEESYIEN
CEECCHHHHHHHEEEEECCCEEEEEEECCEEEEEECCHHCCCCCCCEEEEEECCHHHHCC
PSSLGSIVGRVAGRIGKGSFKLNGINYELDKNNNGNCLHGGYKGFSKKIWDYSYSEDEEK
HHHHHHHHHHHHHCCCCCEEEECCEEEEECCCCCCCEEECCCCCHHHHHCCCCCCCCCCC
STAIFTSFSKDGEGGFPGNLKVQVTYSLEGDKLSIEYRASSDKDTVVNLTNHSYFNLSGN
CEEEEEEECCCCCCCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEEEECCEEEEECCC
NKRNVLEQKLYIDSDKICELDKDLIPTGEFLSVEKTPFDFRKLKKIGEDINKNHLQLEIG
CCHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEC
SGYDHPWVLNKKGDFDAILVDEESGRIMKVKTDQKAVVCYSMNFPDELPLENGKVAKKHD
CCCCCCEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCCCCEEECCC
GICFETQNLPVGYDDCFLDGIILKKDEEYYQKTTFEFEYM
CEEEECCCCCCCCCHHHCCCEEEECCHHHHHHEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]