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The map label for this gene is pyrC [H]

Identifier: 18310163

GI number: 18310163

Start: 1376997

End: 1378196

Strand: Reverse

Name: pyrC [H]

Synonym: CPE1181

Alternate gene names: 18310163

Gene position: 1378196-1376997 (Counterclockwise)

Preceding gene: 18310164

Following gene: 18310162

Centisome position: 45.46

GC content: 31.17

Gene sequence:

>1200_bases
ATGAATTTGCTAATTAAAAATGTAAATTTAATAGATGAAAGCAACAACTTTTTTGGTGATATATATATAGAAAAAGGGGT
AATAAAAGAACTTGGAACTGAACTAAATAAAGAATGTGAAACTCTAGATGGAAAAGGCTTAGTACTTATGCCTGCATTTA
TAGATACTCATGCACACTTTAGAGATCCAGGCTTTGAATATAAAGAAGATATTGAAAGTGGATCTAAGGCTGCAGTGAGA
GGTGGATACACAACAGTAACCTTAATGCCAAACACAAAACCAGTTTGTAGTTCAAAAGAAATTTTAGATTACGTGGTTAA
TAAGGGTAAAGAGGTAGGCTTAGTAGATCTATACCAAACAGTTTCCATAACAAAGAATTTATCAGGTGAAGAAATAAATC
ATCTTAGAGAATTTGAGGGCAATCCTAATGTTAAGGCAATAACAGATGACGGTAAAGGTGTGTCAGATTCTAAGATTATG
ATGGAAGCTATGAAAATAGCTAAGGAAAATAACTGGATAGTAATGTCCCATGCTGAAAGCCCAGAGTTTTCAAGGGTTGA
TATGAGATTAGCTGAAAATATGATGACATGGAGAGATATTACATTAGCAAAGTTTGTAGATTGTAGACTTCACATGTCTC
ATGTAAGTACTAAGGAAGCTATGAAATATATAATAGAAGGAAAAAATGATGGAGTTAAAGTAACTTGTGAAATAACTCCT
CACCACTTAGCTTTAAATAATAAGATTAGTAATTATAGAGTTAATCCTCCTATAAGAGAAGAAGAGGATGTAAATTTCTT
AATAAAGGCAATAAAAATGAACTATGTTGATTGTATAGGAACAGATCATGCTCCTCATTCAAAGGAAGATAAGGAAAAAG
GAGCACCTGGCATGATTGGAATTGAACAAGCTTTCTCAATATGTTATACGAAGCTAGTTAAAGAAAATCACATAAGCTTA
AATAAGCTAAGTCAATTAATGAGTGGAAATGCCGCTAAGTTATTAAACATAAATAAAGGAAAACTTCAACCAGGTTTTCT
TGGAGATTTAGTTCTTATAGATTTAAACAAGAAAAGAATATTCAAAGAAGAAGATATAGTATCTAGAAGTAAAAACACAC
CATTTAATGGAATGGAGTTTTATGGAGATGTAGTAGTAACAATAAAGAATGGAAAAATAGTTTATAATGGTGAATTTTAG

Upstream 100 bases:

>100_bases
CTTTACTTTAGTAGATAAAAAGAATAATACATACAATTGTGATTATTGTAACGCAGAAAACACTTTTCAAAAGCATTAAA
TTTAGGAGGACATAATTAAG

Downstream 100 bases:

>100_bases
GAGGTATATATGATAGCTGATAAATTATTTGAAAAAGTAGAAAAAAACGGAGTAGTTTGTGTTGGACTAGATACAAGCTT
AGATTATATACCAGAGGAGT

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNLLIKNVNLIDESNNFFGDIYIEKGVIKELGTELNKECETLDGKGLVLMPAFIDTHAHFRDPGFEYKEDIESGSKAAVR
GGYTTVTLMPNTKPVCSSKEILDYVVNKGKEVGLVDLYQTVSITKNLSGEEINHLREFEGNPNVKAITDDGKGVSDSKIM
MEAMKIAKENNWIVMSHAESPEFSRVDMRLAENMMTWRDITLAKFVDCRLHMSHVSTKEAMKYIIEGKNDGVKVTCEITP
HHLALNNKISNYRVNPPIREEEDVNFLIKAIKMNYVDCIGTDHAPHSKEDKEKGAPGMIGIEQAFSICYTKLVKENHISL
NKLSQLMSGNAAKLLNINKGKLQPGFLGDLVLIDLNKKRIFKEEDIVSRSKNTPFNGMEFYGDVVVTIKNGKIVYNGEF

Sequences:

>Translated_399_residues
MNLLIKNVNLIDESNNFFGDIYIEKGVIKELGTELNKECETLDGKGLVLMPAFIDTHAHFRDPGFEYKEDIESGSKAAVR
GGYTTVTLMPNTKPVCSSKEILDYVVNKGKEVGLVDLYQTVSITKNLSGEEINHLREFEGNPNVKAITDDGKGVSDSKIM
MEAMKIAKENNWIVMSHAESPEFSRVDMRLAENMMTWRDITLAKFVDCRLHMSHVSTKEAMKYIIEGKNDGVKVTCEITP
HHLALNNKISNYRVNPPIREEEDVNFLIKAIKMNYVDCIGTDHAPHSKEDKEKGAPGMIGIEQAFSICYTKLVKENHISL
NKLSQLMSGNAAKLLNINKGKLQPGFLGDLVLIDLNKKRIFKEEDIVSRSKNTPFNGMEFYGDVVVTIKNGKIVYNGEF
>Mature_399_residues
MNLLIKNVNLIDESNNFFGDIYIEKGVIKELGTELNKECETLDGKGLVLMPAFIDTHAHFRDPGFEYKEDIESGSKAAVR
GGYTTVTLMPNTKPVCSSKEILDYVVNKGKEVGLVDLYQTVSITKNLSGEEINHLREFEGNPNVKAITDDGKGVSDSKIM
MEAMKIAKENNWIVMSHAESPEFSRVDMRLAENMMTWRDITLAKFVDCRLHMSHVSTKEAMKYIIEGKNDGVKVTCEITP
HHLALNNKISNYRVNPPIREEEDVNFLIKAIKMNYVDCIGTDHAPHSKEDKEKGAPGMIGIEQAFSICYTKLVKENHISL
NKLSQLMSGNAAKLLNINKGKLQPGFLGDLVLIDLNKKRIFKEEDIVSRSKNTPFNGMEFYGDVVVTIKNGKIVYNGEF

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=390, Percent_Identity=26.4102564102564, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4503051, Length=439, Percent_Identity=24.373576309795, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI62422571, Length=441, Percent_Identity=24.9433106575964, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=25.1111111111111, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503375, Length=446, Percent_Identity=25.7847533632287, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI190194363, Length=441, Percent_Identity=24.7165532879819, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786722, Length=445, Percent_Identity=26.9662921348315, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=22.5950782997763, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=414, Percent_Identity=27.2946859903382, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI86575075, Length=445, Percent_Identity=22.9213483146067, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=422, Percent_Identity=23.696682464455, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24642586, Length=365, Percent_Identity=28.7671232876712, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221377917, Length=458, Percent_Identity=24.235807860262, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137462, Length=449, Percent_Identity=24.4988864142539, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44816; Mature: 44816

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIKNVNLIDESNNFFGDIYIEKGVIKELGTELNKECETLDGKGLVLMPAFIDTHAHF
CCEEEECCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCC
RDPGFEYKEDIESGSKAAVRGGYTTVTLMPNTKPVCSSKEILDYVVNKGKEVGLVDLYQT
CCCCCCHHHHHCCCCCEEEECCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHH
VSITKNLSGEEINHLREFEGNPNVKAITDDGKGVSDSKIMMEAMKIAKENNWIVMSHAES
HHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCC
PEFSRVDMRLAENMMTWRDITLAKFVDCRLHMSHVSTKEAMKYIIEGKNDGVKVTCEITP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEECC
HHLALNNKISNYRVNPPIREEEDVNFLIKAIKMNYVDCIGTDHAPHSKEDKEKGAPGMIG
CEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHCCCCCEEE
IEQAFSICYTKLVKENHISLNKLSQLMSGNAAKLLNINKGKLQPGFLGDLVLIDLNKKRI
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHH
FKEEDIVSRSKNTPFNGMEFYGDVVVTIKNGKIVYNGEF
CCHHHHHHCCCCCCCCCCEEECEEEEEEECCEEEECCCC
>Mature Secondary Structure
MNLLIKNVNLIDESNNFFGDIYIEKGVIKELGTELNKECETLDGKGLVLMPAFIDTHAHF
CCEEEECCEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCC
RDPGFEYKEDIESGSKAAVRGGYTTVTLMPNTKPVCSSKEILDYVVNKGKEVGLVDLYQT
CCCCCCHHHHHCCCCCEEEECCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHH
VSITKNLSGEEINHLREFEGNPNVKAITDDGKGVSDSKIMMEAMKIAKENNWIVMSHAES
HHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCC
PEFSRVDMRLAENMMTWRDITLAKFVDCRLHMSHVSTKEAMKYIIEGKNDGVKVTCEITP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEECC
HHLALNNKISNYRVNPPIREEEDVNFLIKAIKMNYVDCIGTDHAPHSKEDKEKGAPGMIG
CEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHCCCCCEEE
IEQAFSICYTKLVKENHISLNKLSQLMSGNAAKLLNINKGKLQPGFLGDLVLIDLNKKRI
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHH
FKEEDIVSRSKNTPFNGMEFYGDVVVTIKNGKIVYNGEF
CCHHHHHHCCCCCCCCCCEEECEEEEEEECCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA