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The map label for this gene is mutT [C]

Identifier: 18309870

GI number: 18309870

Start: 1091766

End: 1092416

Strand: Direct

Name: mutT [C]

Synonym: CPE0888

Alternate gene names: 18309870

Gene position: 1091766-1092416 (Clockwise)

Preceding gene: 18309867

Following gene: 18309871

Centisome position: 36.01

GC content: 25.04

Gene sequence:

>651_bases
ATGAATAATATTGAGAATATAAAAGATATCTTTAGAGATTATAGAATAGGAATAAATGGGGAAGAGGACATGAAAAGATG
TTCTGTTTTAATCCAAGTTGTAAATATAGATGGAGAAGATAATATTATTTTTGAAATAAGAAACAATAAATTAAATAGTA
ATCCAGGAGAAATATGTTTCCCAGGTGGTGCCATAGAAGAAGGAGAGACTCCTAAAGAAGCTGCCTTAAGAGAATGCTTT
GAGGAAATTGGTTTAGGAGAAGAAAATCTAGAAATCATAAGCCAATTAGATTTTTATGTTTCACCTAACAATATATTAAT
TTATCCTTTTTTAGGAGTTCAAAAAAATCAAAAAGAAAATATAAAAAATCTCATTTCAATTAACAAAGAAGAAGTATCTC
ATATATTATTAGTTCCTTTAAAATATTTATTAAATTATGAACCTGAAATTACCTACAGCAAAATTATAAATATGCCAAAG
GAGGATTTTCCTTTTCATAATATAATAGGTGGTAAAGATTATAAATTTAGAGATGGAAGATACAAAGTTATGTTCTACAA
ATATAATAATTTTGTGATTTGGGGAATGACAGCTAGAATATTAGAAAATTTCTTAAATGTATATAAGGAACATTATAATA
AAAATATTTAA

Upstream 100 bases:

>100_bases
TAAAATAACAAAACTCAATGTAATAAAAATAAATTTAATTTTATAATATTGATAATAAGTATTGAAAATACATTAGTGGT
ATTAAGAGGTGAATTATATT

Downstream 100 bases:

>100_bases
TATAGTAATTTAAAAATAAACTAAAACTTGTATTAAAACAGGTTTTTGTTAAATTTTATAAATATATAGACATTTTAAAG
GAGCGATTAAGTGGACCAAA

Product: pyrophosphatase, MutT/nudix family

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: Phosphohydrolase; Nudix-Family Protein; MutT/NUDIX Family Protein; NUDIX Family Hydrolase; MutT/NUDIX NTP Pyrophosphatase; Pyrophosphatase MutT/Nudix Family; Nucleoside Diphosphate Hydrolase; MutT/Nudix Family Protein; NTP Pyrophosphohydrolase Including Oxidative Damage Repair; Hydrolase; MutT/NUDIX Hydrolase Family Protein; Hydrolase NUDIX Family; NUDIX Family Protein

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNNIENIKDIFRDYRIGINGEEDMKRCSVLIQVVNIDGEDNIIFEIRNNKLNSNPGEICFPGGAIEEGETPKEAALRECF
EEIGLGEENLEIISQLDFYVSPNNILIYPFLGVQKNQKENIKNLISINKEEVSHILLVPLKYLLNYEPEITYSKIINMPK
EDFPFHNIIGGKDYKFRDGRYKVMFYKYNNFVIWGMTARILENFLNVYKEHYNKNI

Sequences:

>Translated_216_residues
MNNIENIKDIFRDYRIGINGEEDMKRCSVLIQVVNIDGEDNIIFEIRNNKLNSNPGEICFPGGAIEEGETPKEAALRECF
EEIGLGEENLEIISQLDFYVSPNNILIYPFLGVQKNQKENIKNLISINKEEVSHILLVPLKYLLNYEPEITYSKIINMPK
EDFPFHNIIGGKDYKFRDGRYKVMFYKYNNFVIWGMTARILENFLNVYKEHYNKNI
>Mature_216_residues
MNNIENIKDIFRDYRIGINGEEDMKRCSVLIQVVNIDGEDNIIFEIRNNKLNSNPGEICFPGGAIEEGETPKEAALRECF
EEIGLGEENLEIISQLDFYVSPNNILIYPFLGVQKNQKENIKNLISINKEEVSHILLVPLKYLLNYEPEITYSKIINMPK
EDFPFHNIIGGKDYKFRDGRYKVMFYKYNNFVIWGMTARILENFLNVYKEHYNKNI

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI157785656, Length=144, Percent_Identity=32.6388888888889, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17536993, Length=118, Percent_Identity=37.2881355932203, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 25301; Mature: 25301

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIENIKDIFRDYRIGINGEEDMKRCSVLIQVVNIDGEDNIIFEIRNNKLNSNPGEICF
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCCEEE
PGGAIEEGETPKEAALRECFEEIGLGEENLEIISQLDFYVSPNNILIYPFLGVQKNQKEN
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCEEEEEECCCCCCCHHH
IKNLISINKEEVSHILLVPLKYLLNYEPEITYSKIINMPKEDFPFHNIIGGKDYKFRDGR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCEEECCE
YKVMFYKYNNFVIWGMTARILENFLNVYKEHYNKNI
EEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNNIENIKDIFRDYRIGINGEEDMKRCSVLIQVVNIDGEDNIIFEIRNNKLNSNPGEICF
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCCEEE
PGGAIEEGETPKEAALRECFEEIGLGEENLEIISQLDFYVSPNNILIYPFLGVQKNQKEN
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCEEEEEECCCCCCCHHH
IKNLISINKEEVSHILLVPLKYLLNYEPEITYSKIINMPKEDFPFHNIIGGKDYKFRDGR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHCCCCCCCEEECCE
YKVMFYKYNNFVIWGMTARILENFLNVYKEHYNKNI
EEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA