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The map label for this gene is fhuB [H]

Identifier: 18309793

GI number: 18309793

Start: 995087

End: 996100

Strand: Direct

Name: fhuB [H]

Synonym: CPE0811

Alternate gene names: 18309793

Gene position: 995087-996100 (Clockwise)

Preceding gene: 18309792

Following gene: 18309794

Centisome position: 32.83

GC content: 32.54

Gene sequence:

>1014_bases
ATGAAAATAGGAAGGAAAAGGACCTTGGCTTATGGATTAATGTTTATAGGTTTATTACTTTTGCTTAGTGGAATCATTCT
ATCTATATCTATAGGGGCAAAAGAAATTGATTTTTCTATGATAATAAATGCTATTTTTACAAATGATGCAGATATAAATA
CTAATATAATTAGGGATGTAAGAATACCTAGAGCACTTGCAGCGGCTTTAGTAGGAGGATTTTTAGCCGTAGCTGGTGCC
ATCATGCAAGGAATAACTAGAAATCCAATTGCAGAACCTTCTGTAATGGGTATAACTCAAGGAGCTACATTTATGATAGC
TGTAGCATTTGTTTTACAAAGAATATATCCTAATTTAGTTATAAATAGCTTTGCTCTTATGATTTTTGCATTTTTAGGAG
CAAGTATAAGTGGTCTTTTAGTATATTTTATAAGCTCTAGAGCATCTAGAAAAGTTGATCCTGTTAAGTTAGCTCTTGCA
GGAACAGCCTTAGGAACTTTACTTATATCCTTAGCAATGGGAATATCAATGTATTTTAATTTATCTCAACAGTTAAGTTT
CTGGGTATCAGGTGGACTGGTAAGTGCTAAATGGGAAGGGGTAATTTTATTAGCTTTAATTGGAGGAATAGCATTTATTG
GGGCCATGATTATGTCACCTAGAATAACAATTTTGAGTTTAGGAGAAGAAGTAGCCATAGGACTTGGACAAAAAACTAAT
CTTGTAAGGTTTATATCCATAATGATAGTTATATGTCTAACAGGTGCTTCTGTTTCAGTAGCTGGTAATATTGTCTTTGT
AGGATTAATAATTCCTCAAATATGCAAAGGAATAGTAGGATCTGATTATAGATATATAATACCTAGCTCAATGATATTAG
GTGCTGTTTTATTAGTGTATAGTGATATATTAGCAAGGATTATAAACCCTCCTTATGAAACACCAATAGGATCTTTAACT
GCCTTATTAGGAGTGCCAGTGTTTATATACTTAGTTAGAAAGGGAGGTAAGTAA

Upstream 100 bases:

>100_bases
AATTAAAATTTTTAGTAGGGGCTGTATCAAAATATAAGGATACAGCCCCACTATTTAAGTTAAAATAGAAATTTTGGTGA
TACTTTAAGGAGGACAACTT

Downstream 100 bases:

>100_bases
TTTATGAATATAAAAAAGAATCATAAATTTATATGGGTAACGGGAATTTTAATAGGTTTAATTTTTATTACCTTTTTAAT
AAGTTTAAACATGGGTTCAC

Product: ferrichrome ABC transporter

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKIGRKRTLAYGLMFIGLLLLLSGIILSISIGAKEIDFSMIINAIFTNDADINTNIIRDVRIPRALAAALVGGFLAVAGA
IMQGITRNPIAEPSVMGITQGATFMIAVAFVLQRIYPNLVINSFALMIFAFLGASISGLLVYFISSRASRKVDPVKLALA
GTALGTLLISLAMGISMYFNLSQQLSFWVSGGLVSAKWEGVILLALIGGIAFIGAMIMSPRITILSLGEEVAIGLGQKTN
LVRFISIMIVICLTGASVSVAGNIVFVGLIIPQICKGIVGSDYRYIIPSSMILGAVLLVYSDILARIINPPYETPIGSLT
ALLGVPVFIYLVRKGGK

Sequences:

>Translated_337_residues
MKIGRKRTLAYGLMFIGLLLLLSGIILSISIGAKEIDFSMIINAIFTNDADINTNIIRDVRIPRALAAALVGGFLAVAGA
IMQGITRNPIAEPSVMGITQGATFMIAVAFVLQRIYPNLVINSFALMIFAFLGASISGLLVYFISSRASRKVDPVKLALA
GTALGTLLISLAMGISMYFNLSQQLSFWVSGGLVSAKWEGVILLALIGGIAFIGAMIMSPRITILSLGEEVAIGLGQKTN
LVRFISIMIVICLTGASVSVAGNIVFVGLIIPQICKGIVGSDYRYIIPSSMILGAVLLVYSDILARIINPPYETPIGSLT
ALLGVPVFIYLVRKGGK
>Mature_337_residues
MKIGRKRTLAYGLMFIGLLLLLSGIILSISIGAKEIDFSMIINAIFTNDADINTNIIRDVRIPRALAAALVGGFLAVAGA
IMQGITRNPIAEPSVMGITQGATFMIAVAFVLQRIYPNLVINSFALMIFAFLGASISGLLVYFISSRASRKVDPVKLALA
GTALGTLLISLAMGISMYFNLSQQLSFWVSGGLVSAKWEGVILLALIGGIAFIGAMIMSPRITILSLGEEVAIGLGQKTN
LVRFISIMIVICLTGASVSVAGNIVFVGLIIPQICKGIVGSDYRYIIPSSMILGAVLLVYSDILARIINPPYETPIGSLT
ALLGVPVFIYLVRKGGK

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=34.0425531914894, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786805, Length=310, Percent_Identity=33.5483870967742, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1790740, Length=317, Percent_Identity=31.8611987381703, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788004, Length=298, Percent_Identity=36.241610738255, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1786347, Length=343, Percent_Identity=29.7376093294461, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786804, Length=333, Percent_Identity=27.9279279279279, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35715; Mature: 35715

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGRKRTLAYGLMFIGLLLLLSGIILSISIGAKEIDFSMIINAIFTNDADINTNIIRDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
RIPRALAAALVGGFLAVAGAIMQGITRNPIAEPSVMGITQGATFMIAVAFVLQRIYPNLV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHH
INSFALMIFAFLGASISGLLVYFISSRASRKVDPVKLALAGTALGTLLISLAMGISMYFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSQQLSFWVSGGLVSAKWEGVILLALIGGIAFIGAMIMSPRITILSLGEEVAIGLGQKTN
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCHH
LVRFISIMIVICLTGASVSVAGNIVFVGLIIPQICKGIVGSDYRYIIPSSMILGAVLLVY
HHHHHHHHHHHHHCCCCEEHHCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHH
SDILARIINPPYETPIGSLTALLGVPVFIYLVRKGGK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGRKRTLAYGLMFIGLLLLLSGIILSISIGAKEIDFSMIINAIFTNDADINTNIIRDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
RIPRALAAALVGGFLAVAGAIMQGITRNPIAEPSVMGITQGATFMIAVAFVLQRIYPNLV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHH
INSFALMIFAFLGASISGLLVYFISSRASRKVDPVKLALAGTALGTLLISLAMGISMYFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSQQLSFWVSGGLVSAKWEGVILLALIGGIAFIGAMIMSPRITILSLGEEVAIGLGQKTN
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCHH
LVRFISIMIVICLTGASVSVAGNIVFVGLIIPQICKGIVGSDYRYIIPSSMILGAVLLVY
HHHHHHHHHHHHHCCCCEEHHCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHH
SDILARIINPPYETPIGSLTALLGVPVFIYLVRKGGK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]