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The map label for this gene is apbA [C]

Identifier: 18309768

GI number: 18309768

Start: 970747

End: 971673

Strand: Direct

Name: apbA [C]

Synonym: CPE0786

Alternate gene names: 18309768

Gene position: 970747-971673 (Clockwise)

Preceding gene: 18309767

Following gene: 18309769

Centisome position: 32.02

GC content: 31.5

Gene sequence:

>927_bases
ATGAAAATCGCAATTGTTGGAGCAGGAGCAATGGGCTCACGTTATGGATATATGTTACATGAAGCTGGAAATGAAGTTAT
GCTAATAGATGGGTGGAAGGATCATGTAGATACTATAAACAAAGAGGGATTAACTGTTGAGGAAAATGGAGAAATTAAAA
AAGTAAAGATACCAGCAATGCTACCTCAAGATGCTAAAGAAATTCCAGAGTTAATAATATTATTTACTAAATCTATGGGA
TTAGAATCAATGTTAGAATCTATAAAAGGTATATTAGGAAAAAATACAAAGGTATTATGCCTATTAAATGGATTAGGACA
TAATGAAACTGTAGCAAAATATGTTGATAGCAAAAACATACTTATGGGAGTAACTTTATGGACAGCTGGGTTAAAAGGTC
CAGGACATGTTGTATTAACAGGAAGCGGAAGCCTAGAAGTTCAAAATATTGATCCAAGTATGGAAAAAGAGGCAAAAGAA
ATTTGTGATATATTAAGTAATGCTGGATTAAAAGCTCACTATAGTGAAAATGTATTATTTTCAATATGGCGTAAAGCTTG
CGTAAATGGAACTTTAAATAGTGGATGTACAATTTTAGATTGTAATATTAAAGAATTTGGTGAATTAAAAGAAGCTCCAG
AGCTTATACGTAATATCATAAAAGAATTTGCTGATGTTGCATCTAAATATGGAGTAAAGTTAGATGTTGAAGAGGTTGCA
AGGGGAATAGAGGCAATATATGATCCAAGCCAAGCTGGCGCTCACTATCCATCAATGCATCAAGATTTAATACAAAATCA
TCGTCTTACAGAAATAGATTATATAAATGGTTATGTATCAAGAAAAGGTAAAGAGTTTAATATAAATACACCATATAATG
ACTTACTTACTACTCTTGTCATGCAAAAGAGCATACTTATTAAATAA

Upstream 100 bases:

>100_bases
TTATTGAATGGTTCTGTAGAAAAGTTATACATTTATATGATGAAAATATTTTTAAATATATTTAATTTACAAAAAAGATA
ATAGAGGAGAGTTGATTTAA

Downstream 100 bases:

>100_bases
GAATATACAATAAATATAGTTTTTTTAAAGTTGATTTTTATGTTTTATAGAAATCAACTTTTTATATTTTATAATTTAAC
TTGGTATAAATACTTATTTT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKIAIVGAGAMGSRYGYMLHEAGNEVMLIDGWKDHVDTINKEGLTVEENGEIKKVKIPAMLPQDAKEIPELIILFTKSMG
LESMLESIKGILGKNTKVLCLLNGLGHNETVAKYVDSKNILMGVTLWTAGLKGPGHVVLTGSGSLEVQNIDPSMEKEAKE
ICDILSNAGLKAHYSENVLFSIWRKACVNGTLNSGCTILDCNIKEFGELKEAPELIRNIIKEFADVASKYGVKLDVEEVA
RGIEAIYDPSQAGAHYPSMHQDLIQNHRLTEIDYINGYVSRKGKEFNINTPYNDLLTTLVMQKSILIK

Sequences:

>Translated_308_residues
MKIAIVGAGAMGSRYGYMLHEAGNEVMLIDGWKDHVDTINKEGLTVEENGEIKKVKIPAMLPQDAKEIPELIILFTKSMG
LESMLESIKGILGKNTKVLCLLNGLGHNETVAKYVDSKNILMGVTLWTAGLKGPGHVVLTGSGSLEVQNIDPSMEKEAKE
ICDILSNAGLKAHYSENVLFSIWRKACVNGTLNSGCTILDCNIKEFGELKEAPELIRNIIKEFADVASKYGVKLDVEEVA
RGIEAIYDPSQAGAHYPSMHQDLIQNHRLTEIDYINGYVSRKGKEFNINTPYNDLLTTLVMQKSILIK
>Mature_308_residues
MKIAIVGAGAMGSRYGYMLHEAGNEVMLIDGWKDHVDTINKEGLTVEENGEIKKVKIPAMLPQDAKEIPELIILFTKSMG
LESMLESIKGILGKNTKVLCLLNGLGHNETVAKYVDSKNILMGVTLWTAGLKGPGHVVLTGSGSLEVQNIDPSMEKEAKE
ICDILSNAGLKAHYSENVLFSIWRKACVNGTLNSGCTILDCNIKEFGELKEAPELIRNIIKEFADVASKYGVKLDVEEVA
RGIEAIYDPSQAGAHYPSMHQDLIQNHRLTEIDYINGYVSRKGKEFNINTPYNDLLTTLVMQKSILIK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=305, Percent_Identity=27.8688524590164, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33907; Mature: 33907

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVGAGAMGSRYGYMLHEAGNEVMLIDGWKDHVDTINKEGLTVEENGEIKKVKIPAM
CEEEEEECCCCCCCCCEEEEECCCEEEEEECCHHHHHHHCCCCCEEECCCCEEEEEECCC
LPQDAKEIPELIILFTKSMGLESMLESIKGILGKNTKVLCLLNGLGHNETVAKYVDSKNI
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCE
LMGVTLWTAGLKGPGHVVLTGSGSLEVQNIDPSMEKEAKEICDILSNAGLKAHYSENVLF
EEEEEEEECCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCHHHH
SIWRKACVNGTLNSGCTILDCNIKEFGELKEAPELIRNIIKEFADVASKYGVKLDVEEVA
HHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
RGIEAIYDPSQAGAHYPSMHQDLIQNHRLTEIDYINGYVSRKGKEFNINTPYNDLLTTLV
HHHHHHCCCHHCCCCCCHHHHHHHHCCCCCEEHHHHHHHHCCCCEEECCCCHHHHHHHHH
MQKSILIK
HHHHHHCC
>Mature Secondary Structure
MKIAIVGAGAMGSRYGYMLHEAGNEVMLIDGWKDHVDTINKEGLTVEENGEIKKVKIPAM
CEEEEEECCCCCCCCCEEEEECCCEEEEEECCHHHHHHHCCCCCEEECCCCEEEEEECCC
LPQDAKEIPELIILFTKSMGLESMLESIKGILGKNTKVLCLLNGLGHNETVAKYVDSKNI
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCE
LMGVTLWTAGLKGPGHVVLTGSGSLEVQNIDPSMEKEAKEICDILSNAGLKAHYSENVLF
EEEEEEEECCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCHHHH
SIWRKACVNGTLNSGCTILDCNIKEFGELKEAPELIRNIIKEFADVASKYGVKLDVEEVA
HHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
RGIEAIYDPSQAGAHYPSMHQDLIQNHRLTEIDYINGYVSRKGKEFNINTPYNDLLTTLV
HHHHHHCCCHHCCCCCCHHHHHHHHCCCCCEEHHHHHHHHCCCCEEECCCCHHHHHHHHH
MQKSILIK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]