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The map label for this gene is purE [H]

Identifier: 18309663

GI number: 18309663

Start: 849450

End: 849929

Strand: Direct

Name: purE [H]

Synonym: CPE0681

Alternate gene names: 18309663

Gene position: 849450-849929 (Clockwise)

Preceding gene: 18309662

Following gene: 18309664

Centisome position: 28.02

GC content: 33.54

Gene sequence:

>480_bases
ATGAAGGTAGCAATATTTTTTGGAAGTAAATCAGATATAGATGTTATGAAGGGAGCAGGAAATGCTCTTAAAGAGTTTGG
AATTCCTTATAATGCTTATATTTTATCAGCTCATAGGGTTCCAGAAAAACTTATTGAAACTTTAGAAAAAATTGAGAAAG
AAGGCTGTGAAGTAATAATAGCTGGAGCAGGATTAGCTGCTCATCTTCCTGGAGTTATAGCTTCTCATACTATACTTCCT
GTAATAGGAGTTCCAGTGAGAGCAGCAGTAGAGGGAATGGATGCATTACTATCAATAGTTCAGATGCCAAAATCAATTCC
TGTAGCCACTGTTGGAATAAATAATAGTTATAATGCAGGAATGTTAGCAGTCCAAATGCTTTCATTAAAATATCCAGAAC
TAAGAGAAAAATTAATTCAATTTAGAATCGACATGAAACATAAATTCATAGCAGAAAATGGAGAAGGAGTGGAATTATAA

Upstream 100 bases:

>100_bases
GATGATATAGCTGTATAGCTTTAAAAAATTAAGTTAGGTCTTTAGGGTTATCTAGAAAATAAGTATTATTAAAACTTTAA
AATATAGGGAGGAAATTTTA

Downstream 100 bases:

>100_bases
TGGTAAATCAACTAGAAATGTTATATGAGGGAAAAGCTAAAAAAATATATGCAACAGATAAGGAAGATATGGTAATTGTT
CATTATAAGGATGATGCTAC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKVAIFFGSKSDIDVMKGAGNALKEFGIPYNAYILSAHRVPEKLIETLEKIEKEGCEVIIAGAGLAAHLPGVIASHTILP
VIGVPVRAAVEGMDALLSIVQMPKSIPVATVGINNSYNAGMLAVQMLSLKYPELREKLIQFRIDMKHKFIAENGEGVEL

Sequences:

>Translated_159_residues
MKVAIFFGSKSDIDVMKGAGNALKEFGIPYNAYILSAHRVPEKLIETLEKIEKEGCEVIIAGAGLAAHLPGVIASHTILP
VIGVPVRAAVEGMDALLSIVQMPKSIPVATVGINNSYNAGMLAVQMLSLKYPELREKLIQFRIDMKHKFIAENGEGVEL
>Mature_159_residues
MKVAIFFGSKSDIDVMKGAGNALKEFGIPYNAYILSAHRVPEKLIETLEKIEKEGCEVIIAGAGLAAHLPGVIASHTILP
VIGVPVRAAVEGMDALLSIVQMPKSIPVATVGINNSYNAGMLAVQMLSLKYPELREKLIQFRIDMKHKFIAENGEGVEL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=52.2522522522522, Blast_Score=114, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=140, Percent_Identity=50.7142857142857, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17141; Mature: 17141

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAIFFGSKSDIDVMKGAGNALKEFGIPYNAYILSAHRVPEKLIETLEKIEKEGCEVII
CEEEEEECCCCCCHHHHCCCHHHHHHCCCHHHEEEEHHHCHHHHHHHHHHHHHCCCEEEE
AGAGLAAHLPGVIASHTILPVIGVPVRAAVEGMDALLSIVQMPKSIPVATVGINNSYNAG
ECCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
MLAVQMLSLKYPELREKLIQFRIDMKHKFIAENGEGVEL
HHHHHHHHCCCHHHHHHHHHHHHCCHHHEECCCCCCCCC
>Mature Secondary Structure
MKVAIFFGSKSDIDVMKGAGNALKEFGIPYNAYILSAHRVPEKLIETLEKIEKEGCEVII
CEEEEEECCCCCCHHHHCCCHHHHHHCCCHHHEEEEHHHCHHHHHHHHHHHHHCCCEEEE
AGAGLAAHLPGVIASHTILPVIGVPVRAAVEGMDALLSIVQMPKSIPVATVGINNSYNAG
ECCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
MLAVQMLSLKYPELREKLIQFRIDMKHKFIAENGEGVEL
HHHHHHHHCCCHHHHHHHHHHHHCCHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]