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The map label for this gene is purC

Identifier: 18309664

GI number: 18309664

Start: 849929

End: 850636

Strand: Direct

Name: purC

Synonym: CPE0682

Alternate gene names: 18309664

Gene position: 849929-850636 (Clockwise)

Preceding gene: 18309663

Following gene: 18309665

Centisome position: 28.04

GC content: 28.95

Gene sequence:

>708_bases
ATGGTAAATCAACTAGAAATGTTATATGAGGGAAAAGCTAAAAAAATATATGCAACAGATAAGGAAGATATGGTAATTGT
TCATTATAAGGATGATGCTACAGCTTTCAATGGAGAAAAAAAGGCTCAAATAGAAAGCAAGGGAGTATTAAACAACGAAA
TTACTAGTCTTATTTTTGAGATGTTAAATAAAGAAGGAATAAAAACTCACTTTGTAGAGAAGTTAAATGATAGAGATCAA
TTATGTAAGAAAGTTGAAATAGTTCCTTTAGAAGTAATAGTTAGAAATGTGGCAGCTGGAAGTATGGCTAAGAGATTAGG
TCTTGAAGAAGGATATGAATTAAAGACTACAGTTTTTGAATTATCATACAAGGATGATTCTTTAGGAGATCCACTTATAA
ATGACTATCATGCTGTAGGAATTGGAGCTACAACTTTTGAAGAATTAAATAAAATTTATGAAATAACTGCTAAAGTAAAT
GAAATTTTAAAAGAAGCTTTCAAAAAACAAAATATCAACTTAATAGATTTTAAATTAGAGTTTGGAAGATATAATGGAGA
GATATTATTAGCTGATGAAATTTCACCAGATACTTGTAGATTTTGGGATGCTACAACAGGAGAAAAAATGGACAAAGACA
GATTTAGAAGAGATATGGGGAATGTAATCAATGGCTATAGAGAGGTTTTAAATAGACTAAGAAATTAG

Upstream 100 bases:

>100_bases
TTTCATTAAAATATCCAGAACTAAGAGAAAAATTAATTCAATTTAGAATCGACATGAAACATAAATTCATAGCAGAAAAT
GGAGAAGGAGTGGAATTATA

Downstream 100 bases:

>100_bases
GTAGTAAGAGGAGTAGAAAATATGGTGAAGCCAAATTTTGATATTATGGATCCACAAAATGATAAATTCAAAGATGAATG
CGGAGTTTTTGGAGTTTTCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MVNQLEMLYEGKAKKIYATDKEDMVIVHYKDDATAFNGEKKAQIESKGVLNNEITSLIFEMLNKEGIKTHFVEKLNDRDQ
LCKKVEIVPLEVIVRNVAAGSMAKRLGLEEGYELKTTVFELSYKDDSLGDPLINDYHAVGIGATTFEELNKIYEITAKVN
EILKEAFKKQNINLIDFKLEFGRYNGEILLADEISPDTCRFWDATTGEKMDKDRFRRDMGNVINGYREVLNRLRN

Sequences:

>Translated_235_residues
MVNQLEMLYEGKAKKIYATDKEDMVIVHYKDDATAFNGEKKAQIESKGVLNNEITSLIFEMLNKEGIKTHFVEKLNDRDQ
LCKKVEIVPLEVIVRNVAAGSMAKRLGLEEGYELKTTVFELSYKDDSLGDPLINDYHAVGIGATTFEELNKIYEITAKVN
EILKEAFKKQNINLIDFKLEFGRYNGEILLADEISPDTCRFWDATTGEKMDKDRFRRDMGNVINGYREVLNRLRN
>Mature_235_residues
MVNQLEMLYEGKAKKIYATDKEDMVIVHYKDDATAFNGEKKAQIESKGVLNNEITSLIFEMLNKEGIKTHFVEKLNDRDQ
LCKKVEIVPLEVIVRNVAAGSMAKRLGLEEGYELKTTVFELSYKDDSLGDPLINDYHAVGIGATTFEELNKIYEITAKVN
EILKEAFKKQNINLIDFKLEFGRYNGEILLADEISPDTCRFWDATTGEKMDKDRFRRDMGNVINGYREVLNRLRN

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=223, Percent_Identity=34.9775784753363, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI5453539, Length=223, Percent_Identity=34.9775784753363, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI119220559, Length=230, Percent_Identity=33.4782608695652, Blast_Score=117, Evalue=7e-27,
Organism=Escherichia coli, GI1788820, Length=226, Percent_Identity=43.8053097345133, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17531275, Length=228, Percent_Identity=35.5263157894737, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319326, Length=272, Percent_Identity=26.8382352941176, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583917, Length=211, Percent_Identity=34.5971563981043, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18860083, Length=229, Percent_Identity=30.5676855895196, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_CLOP1 (Q0TTB4)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_695126.1
- PDB:   3NUA
- PDBsum:   3NUA
- ProteinModelPortal:   Q0TTB4
- SMR:   Q0TTB4
- STRING:   Q0TTB4
- GeneID:   4203660
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_0673
- TIGR:   CPF_0673
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   CPER195103:CPF_0673-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27003; Mature: 27003

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNQLEMLYEGKAKKIYATDKEDMVIVHYKDDATAFNGEKKAQIESKGVLNNEITSLIFE
CCCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
MLNKEGIKTHFVEKLNDRDQLCKKVEIVPLEVIVRNVAAGSMAKRLGLEEGYELKTTVFE
HHCCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
LSYKDDSLGDPLINDYHAVGIGATTFEELNKIYEITAKVNEILKEAFKKQNINLIDFKLE
EEECCCCCCCCHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FGRYNGEILLADEISPDTCRFWDATTGEKMDKDRFRRDMGNVINGYREVLNRLRN
ECCCCCEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVNQLEMLYEGKAKKIYATDKEDMVIVHYKDDATAFNGEKKAQIESKGVLNNEITSLIFE
CCCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
MLNKEGIKTHFVEKLNDRDQLCKKVEIVPLEVIVRNVAAGSMAKRLGLEEGYELKTTVFE
HHCCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
LSYKDDSLGDPLINDYHAVGIGATTFEELNKIYEITAKVNEILKEAFKKQNINLIDFKLE
EEECCCCCCCCHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FGRYNGEILLADEISPDTCRFWDATTGEKMDKDRFRRDMGNVINGYREVLNRLRN
ECCCCCEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA