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The map label for this gene is rfbC [H]

Identifier: 18309599

GI number: 18309599

Start: 773532

End: 774014

Strand: Direct

Name: rfbC [H]

Synonym: CPE0617

Alternate gene names: 18309599

Gene position: 773532-774014 (Clockwise)

Preceding gene: 18309598

Following gene: 18309600

Centisome position: 25.52

GC content: 30.23

Gene sequence:

>483_bases
ATGGAAACATATAGTCAAAAAGCTTTTGAAGAAGCTGGACTTACTATGAAATTTGTTCAAGATAATGAATCAAAATCTAA
AAAAGGTGTTTTAAGAGGATTACATTTCCAAACTAAACATACTCAAGGAAAGCTTGTTAGAGTAACTCAAGGAGAGGTTT
GGGATGTAGCTGTAGATTTAAGAAAAGGATCACCTACATTTGGACAATGGGAAGGTGTTCATTTAAGTGCAGAAAATAAA
AGACAATTCTACGTTCCAGAAGGATTTGCTCATGGATTTGTAGTTTTATCTGATGAAGCTGTATTTAACTATAAATGTAC
AGATTTTTATGCTCCAGAATATGACAGTGGACTTCTTTGGAATGATAAATATGTTAATGTAGAATGGCCTTTAGAAGGAA
TAGAAGAAATAATCTTATCAGAAAAAGATAAGAAACAAAAAACTTTAAAAGAATTAGATATTCCTTTTATATATGAAGGT
TAA

Upstream 100 bases:

>100_bases
AAGTGGTGAAAAGATGAGTAACTTTAAATTTATAGAAACAAAAATAAAAGATTTATATATTATAGAACCAAAAGTTTTTG
GAGATGAAAGAGGATATTTC

Downstream 100 bases:

>100_bases
TAGGAGGAAGTCTATGAAAATATTAATAACAGGTTCAAATGGACAATTAGGAAATGAACTTCAATCAATAATAAAAAGTG
GAAAAGCAGAAATAGGTTCA

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
METYSQKAFEEAGLTMKFVQDNESKSKKGVLRGLHFQTKHTQGKLVRVTQGEVWDVAVDLRKGSPTFGQWEGVHLSAENK
RQFYVPEGFAHGFVVLSDEAVFNYKCTDFYAPEYDSGLLWNDKYVNVEWPLEGIEEIILSEKDKKQKTLKELDIPFIYEG

Sequences:

>Translated_160_residues
METYSQKAFEEAGLTMKFVQDNESKSKKGVLRGLHFQTKHTQGKLVRVTQGEVWDVAVDLRKGSPTFGQWEGVHLSAENK
RQFYVPEGFAHGFVVLSDEAVFNYKCTDFYAPEYDSGLLWNDKYVNVEWPLEGIEEIILSEKDKKQKTLKELDIPFIYEG
>Mature_160_residues
METYSQKAFEEAGLTMKFVQDNESKSKKGVLRGLHFQTKHTQGKLVRVTQGEVWDVAVDLRKGSPTFGQWEGVHLSAENK
RQFYVPEGFAHGFVVLSDEAVFNYKCTDFYAPEYDSGLLWNDKYVNVEWPLEGIEEIILSEKDKKQKTLKELDIPFIYEG

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=153, Percent_Identity=54.2483660130719, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17550412, Length=153, Percent_Identity=46.4052287581699, Blast_Score=132, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 18448; Mature: 18448

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METYSQKAFEEAGLTMKFVQDNESKSKKGVLRGLHFQTKHTQGKLVRVTQGEVWDVAVDL
CCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCEEEECCCCCCEEEEECCCEEEEEEEE
RKGSPTFGQWEGVHLSAENKRQFYVPEGFAHGFVVLSDEAVFNYKCTDFYAPEYDSGLLW
ECCCCCCCCCCCEEEECCCCEEEECCCCCCCCEEEEECCEEEEEEECCEECCCCCCCCEE
NDKYVNVEWPLEGIEEIILSEKDKKQKTLKELDIPFIYEG
CCEEEEEECCHHHHHHHHHCCCCHHHHHHHHCCCCEEECC
>Mature Secondary Structure
METYSQKAFEEAGLTMKFVQDNESKSKKGVLRGLHFQTKHTQGKLVRVTQGEVWDVAVDL
CCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCEEEECCCCCCEEEEECCCEEEEEEEE
RKGSPTFGQWEGVHLSAENKRQFYVPEGFAHGFVVLSDEAVFNYKCTDFYAPEYDSGLLW
ECCCCCCCCCCCEEEECCCCEEEECCCCCCCCEEEEECCEEEEEEECCEECCCCCCCCEE
NDKYVNVEWPLEGIEEIILSEKDKKQKTLKELDIPFIYEG
CCEEEEEECCHHHHHHHHHCCCCHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463; 10827167 [H]