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The map label for this gene is mrcA [H]

Identifier: 17547695

GI number: 17547695

Start: 3208628

End: 3211033

Strand: Direct

Name: mrcA [H]

Synonym: RSc2976

Alternate gene names: 17547695

Gene position: 3208628-3211033 (Clockwise)

Preceding gene: 17547686

Following gene: 17547697

Centisome position: 86.34

GC content: 66.83

Gene sequence:

>2406_bases
ATGGCTACTGCCCAAACCGCCCCTGCCTCGCCCAAGCCGCCCAAAGCCCGCCGCCCGCTGTGGCTGCGCCTGATCCTGTG
GATGCTTGGCCTGTTCGTCGCCATGGGGGTCGTGGGAGCGCTGCTGTTGGGCTATGCCCTGCTGGTCGCCGCGCCCAACC
TGCCGTCGCTGGATGCGATCACCGACTACCGCCCGAAGATCCCGCTGCGCGTCTACACTGCCGACAACGTCCTGATCGGC
GAATTCGGCGAAGAGCGCCGCAGCTTCGTGCCGATCACGCAGATGCCCGACGTGATGAAACGCGCCGTGCTCGCCATCGA
GGATGACCGCTTCTACGAGCACGGCGGCGTCGACTTCATCGGCGTGCTGCGCGCGGGGCTGGCCAACCTGCACGGCGGCC
TGTCGCAGGGCGCCTCGACCATCACCATGCAGGTGGCGCGCAACTTCTTCCTCTCCAGCGAGAAGACGTACACGCGCAAG
ATCTACGAGATGCTGCTGTCCTACAAGATCGAGGCCAGCCTGACGAAGGACCAGATCCTCGAGCTCTACATGAACCAGAT
CTACCTCGGCCAGCGCGCCTACGGCTTTGCCAGCGCCGAGCAGATCTACTTCGGCAAGAACATCAAGGACATCACGCTGG
CCGAGGCCGCCATGCTGGCCGGGCTGCCCAAGGCGCCGTCGGCATACAACCCGGTGGTGAACCCCAAGCGCGCCAAGATC
CGCCAGGAGTACATCCTGCAGCGCATGCGCGACCTGCACTACATCACGCCGGAGCAGTACGCGCAGGCCATCCACGAACA
GCTGCCCGTGCGCGGCGAGGGCCATGAATTCGACGTGCACGCCGAATACGTGGCGGAAATGGTGCGCCAGCTGATGTACG
CGCAGTACCGCGAAGAGACGTATACGCGCGGCCTGAACGTCTACACCACGCTGCGCAAGGGCGACCAGGAAGTCGCCTAT
GAATCGGTGCGGCGCGGCATCCTCGACTATGAGCGCCGCCACGGCTATCGCGGCCCGGAAGCTTTCATCGACCTGCCCGC
CGATGCCGACGAGCGCGAGCAGGCCATCGACGACGCGCTGGTCGAGCACCCCAACAGCGACGACCTGCAATCGGCCGTGG
TGGTCAGCGCGGCGCCCAAGCTGGTGCGGGCGACCATGCTGTCGGGCGAGACCATCGACCTCGCCGGCGACGGCCTGCGG
TTCGCGCAGGCGGCGCTGTCGGCCAACGCCCAGCCCAAGATCAAGCTGCGCCCGGGCGCGATCATCCGCGTGATCCAGGA
CCCGAAGACGGGCAAATGGTCGATCACGCAACTGCCGGAAGTGGCCTCGGGCTTCGTGTCGCTCGACCCGCAGACCGGCG
GGATCTATTCGATGGTCGGCGGCTTCGACTTCAACCGCAGCAAGTTCAACCACGTCACGCAGGCCTGGCGCCAGCCGGGT
TCGAGCTTCAAGCCGTTCATCTACTCGGCGGCGGTGGACAAGGGCTTCTCGCCGTCGACCGTCATCAACGACGCACCGCT
GTCGATCCCGACCGGCGACACCGGCGGCCAGCTGTGGGAGCCGAAGAACTACGGCGGCGGCTACGACGGCCCGATGACGA
TGCGCCGCGCGCTGCAGAAGTCGAAGAACCTCGTTTCCGTGCGCATCCTGCGGACCATCGGTACGCAGTACGCGCAGCAG
TACATCACCCGCTTCGGCTTCGAGCCCGACAAGCACCCGGCCTACCTGCCGATGGCGCTCGGCGCCGGCTCGGTGACGGT
GCTGCAGATGGCCGGCGCATACTCGGTGTTCGCCAACGGCGGCTACCGCGTCAACCCGTACATCATCGACCGCGTGACCG
ATGCGCGCGGCACCGTGATCCAGCAAACCCACCCGATGACGGCCAGCAAGGACGCGGTGCGCGTGATCGATCCGCGCAAC
GACTTCATCATGGATTCGCTGCTGCGCAGCGTGGTGTCGGGCGGCACCGGCTACCTGGCCAAGCAGAAGCTGGGCCGCAG
CGACATGGCCGGCAAGACGGGCACGACCAACGATTCGTTCGATGCCTGGTTCTGCGGCTACACGCCCAAGCTGGTGGGCG
TGGCCTGGATCGGCTACGACAACCCGCGCAGCCTCGGCGACCGCGAAACCGGCGGCGGCCTGGCCTTGCCGATCTGGATC
AATTACATGAGCTACGCGCTCAAGGGCCAGCCGGAAACCGAGCGCCAGCCGCCCGAAGGCGTGGTGCAGATGGCTGGCGA
CTGGGCCTACGAGGAATACGCCAACGGCCAGGGCGTCGCCTCGGTCGGCCTGGGCGATGCCCTGCCGGGCGGTCCGCCGG
CATCGGGCCCCGAAGCCGCGCCGAGCCTGGCGCCGACGCCTGAGCAGGAGAAACAGAAGATTCTCGACATGTTCCGCGGC
AACTGA

Upstream 100 bases:

>100_bases
AGGCCCGCGCGACACCGGTTACGCGCTGTTACGCCACACCGGCCGGACCCCGCCGACGCCGACGATATAATCGCCGCCAC
GCTGACAGACACCCCTCGTA

Downstream 100 bases:

>100_bases
CGTGCGTCACGCGCCGACAAAAAAGCCGCCCGATCGGGCGGCTTTTCTTTTGCGGTGGCGCGGCGGCGGCTCAGTCCGCC
ACCAGCGTGACATCGACCTC

Product: penicillin-binding 1 transmembrane protein

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MATAQTAPASPKPPKARRPLWLRLILWMLGLFVAMGVVGALLLGYALLVAAPNLPSLDAITDYRPKIPLRVYTADNVLIG
EFGEERRSFVPITQMPDVMKRAVLAIEDDRFYEHGGVDFIGVLRAGLANLHGGLSQGASTITMQVARNFFLSSEKTYTRK
IYEMLLSYKIEASLTKDQILELYMNQIYLGQRAYGFASAEQIYFGKNIKDITLAEAAMLAGLPKAPSAYNPVVNPKRAKI
RQEYILQRMRDLHYITPEQYAQAIHEQLPVRGEGHEFDVHAEYVAEMVRQLMYAQYREETYTRGLNVYTTLRKGDQEVAY
ESVRRGILDYERRHGYRGPEAFIDLPADADEREQAIDDALVEHPNSDDLQSAVVVSAAPKLVRATMLSGETIDLAGDGLR
FAQAALSANAQPKIKLRPGAIIRVIQDPKTGKWSITQLPEVASGFVSLDPQTGGIYSMVGGFDFNRSKFNHVTQAWRQPG
SSFKPFIYSAAVDKGFSPSTVINDAPLSIPTGDTGGQLWEPKNYGGGYDGPMTMRRALQKSKNLVSVRILRTIGTQYAQQ
YITRFGFEPDKHPAYLPMALGAGSVTVLQMAGAYSVFANGGYRVNPYIIDRVTDARGTVIQQTHPMTASKDAVRVIDPRN
DFIMDSLLRSVVSGGTGYLAKQKLGRSDMAGKTGTTNDSFDAWFCGYTPKLVGVAWIGYDNPRSLGDRETGGGLALPIWI
NYMSYALKGQPETERQPPEGVVQMAGDWAYEEYANGQGVASVGLGDALPGGPPASGPEAAPSLAPTPEQEKQKILDMFRG
N

Sequences:

>Translated_801_residues
MATAQTAPASPKPPKARRPLWLRLILWMLGLFVAMGVVGALLLGYALLVAAPNLPSLDAITDYRPKIPLRVYTADNVLIG
EFGEERRSFVPITQMPDVMKRAVLAIEDDRFYEHGGVDFIGVLRAGLANLHGGLSQGASTITMQVARNFFLSSEKTYTRK
IYEMLLSYKIEASLTKDQILELYMNQIYLGQRAYGFASAEQIYFGKNIKDITLAEAAMLAGLPKAPSAYNPVVNPKRAKI
RQEYILQRMRDLHYITPEQYAQAIHEQLPVRGEGHEFDVHAEYVAEMVRQLMYAQYREETYTRGLNVYTTLRKGDQEVAY
ESVRRGILDYERRHGYRGPEAFIDLPADADEREQAIDDALVEHPNSDDLQSAVVVSAAPKLVRATMLSGETIDLAGDGLR
FAQAALSANAQPKIKLRPGAIIRVIQDPKTGKWSITQLPEVASGFVSLDPQTGGIYSMVGGFDFNRSKFNHVTQAWRQPG
SSFKPFIYSAAVDKGFSPSTVINDAPLSIPTGDTGGQLWEPKNYGGGYDGPMTMRRALQKSKNLVSVRILRTIGTQYAQQ
YITRFGFEPDKHPAYLPMALGAGSVTVLQMAGAYSVFANGGYRVNPYIIDRVTDARGTVIQQTHPMTASKDAVRVIDPRN
DFIMDSLLRSVVSGGTGYLAKQKLGRSDMAGKTGTTNDSFDAWFCGYTPKLVGVAWIGYDNPRSLGDRETGGGLALPIWI
NYMSYALKGQPETERQPPEGVVQMAGDWAYEEYANGQGVASVGLGDALPGGPPASGPEAAPSLAPTPEQEKQKILDMFRG
N
>Mature_800_residues
ATAQTAPASPKPPKARRPLWLRLILWMLGLFVAMGVVGALLLGYALLVAAPNLPSLDAITDYRPKIPLRVYTADNVLIGE
FGEERRSFVPITQMPDVMKRAVLAIEDDRFYEHGGVDFIGVLRAGLANLHGGLSQGASTITMQVARNFFLSSEKTYTRKI
YEMLLSYKIEASLTKDQILELYMNQIYLGQRAYGFASAEQIYFGKNIKDITLAEAAMLAGLPKAPSAYNPVVNPKRAKIR
QEYILQRMRDLHYITPEQYAQAIHEQLPVRGEGHEFDVHAEYVAEMVRQLMYAQYREETYTRGLNVYTTLRKGDQEVAYE
SVRRGILDYERRHGYRGPEAFIDLPADADEREQAIDDALVEHPNSDDLQSAVVVSAAPKLVRATMLSGETIDLAGDGLRF
AQAALSANAQPKIKLRPGAIIRVIQDPKTGKWSITQLPEVASGFVSLDPQTGGIYSMVGGFDFNRSKFNHVTQAWRQPGS
SFKPFIYSAAVDKGFSPSTVINDAPLSIPTGDTGGQLWEPKNYGGGYDGPMTMRRALQKSKNLVSVRILRTIGTQYAQQY
ITRFGFEPDKHPAYLPMALGAGSVTVLQMAGAYSVFANGGYRVNPYIIDRVTDARGTVIQQTHPMTASKDAVRVIDPRND
FIMDSLLRSVVSGGTGYLAKQKLGRSDMAGKTGTTNDSFDAWFCGYTPKLVGVAWIGYDNPRSLGDRETGGGLALPIWIN
YMSYALKGQPETERQPPEGVVQMAGDWAYEEYANGQGVASVGLGDALPGGPPASGPEAAPSLAPTPEQEKQKILDMFRGN

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=622, Percent_Identity=41.9614147909968, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1786343, Length=249, Percent_Identity=36.9477911646586, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI1788867, Length=237, Percent_Identity=32.9113924050633, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1789601, Length=165, Percent_Identity=33.9393939393939, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 88059; Mature: 87928

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAQTAPASPKPPKARRPLWLRLILWMLGLFVAMGVVGALLLGYALLVAAPNLPSLDAI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TDYRPKIPLRVYTADNVLIGEFGEERRSFVPITQMPDVMKRAVLAIEDDRFYEHGGVDFI
CCCCCCCCEEEEECCCEEEECCCHHHHCCCCHHCCHHHHHHHHHEEECCCCCCCCCCHHH
GVLRAGLANLHGGLSQGASTITMQVARNFFLSSEKTYTRKIYEMLLSYKIEASLTKDQIL
HHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
ELYMNQIYLGQRAYGFASAEQIYFGKNIKDITLAEAAMLAGLPKAPSAYNPVVNPKRAKI
HHHHHHHHHCCHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
RQEYILQRMRDLHYITPEQYAQAIHEQLPVRGEGHEFDVHAEYVAEMVRQLMYAQYREET
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHH
YTRGLNVYTTLRKGDQEVAYESVRRGILDYERRHGYRGPEAFIDLPADADEREQAIDDAL
HHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCHHHHHHHHHH
VEHPNSDDLQSAVVVSAAPKLVRATMLSGETIDLAGDGLRFAQAALSANAQPKIKLRPGA
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCCCEEECCCE
IIRVIQDPKTGKWSITQLPEVASGFVSLDPQTGGIYSMVGGFDFNRSKFNHVTQAWRQPG
EEEEEECCCCCCEEHHHCHHHHCCCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
SSFKPFIYSAAVDKGFSPSTVINDAPLSIPTGDTGGQLWEPKNYGGGYDGPMTMRRALQK
CCCCCCEEHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
SKNLVSVRILRTIGTQYAQQYITRFGFEPDKHPAYLPMALGAGSVTVLQMAGAYSVFANG
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEECC
GYRVNPYIIDRVTDARGTVIQQTHPMTASKDAVRVIDPRNDFIMDSLLRSVVSGGTGYLA
CEEECCEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHH
KQKLGRSDMAGKTGTTNDSFDAWFCGYTPKLVGVAWIGYDNPRSLGDRETGGGLALPIWI
HHHCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEHHHHH
NYMSYALKGQPETERQPPEGVVQMAGDWAYEEYANGQGVASVGLGDALPGGPPASGPEAA
HHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCC
PSLAPTPEQEKQKILDMFRGN
CCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATAQTAPASPKPPKARRPLWLRLILWMLGLFVAMGVVGALLLGYALLVAAPNLPSLDAI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TDYRPKIPLRVYTADNVLIGEFGEERRSFVPITQMPDVMKRAVLAIEDDRFYEHGGVDFI
CCCCCCCCEEEEECCCEEEECCCHHHHCCCCHHCCHHHHHHHHHEEECCCCCCCCCCHHH
GVLRAGLANLHGGLSQGASTITMQVARNFFLSSEKTYTRKIYEMLLSYKIEASLTKDQIL
HHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
ELYMNQIYLGQRAYGFASAEQIYFGKNIKDITLAEAAMLAGLPKAPSAYNPVVNPKRAKI
HHHHHHHHHCCHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
RQEYILQRMRDLHYITPEQYAQAIHEQLPVRGEGHEFDVHAEYVAEMVRQLMYAQYREET
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHH
YTRGLNVYTTLRKGDQEVAYESVRRGILDYERRHGYRGPEAFIDLPADADEREQAIDDAL
HHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCHHHHHHHHHH
VEHPNSDDLQSAVVVSAAPKLVRATMLSGETIDLAGDGLRFAQAALSANAQPKIKLRPGA
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCCCEEECCCE
IIRVIQDPKTGKWSITQLPEVASGFVSLDPQTGGIYSMVGGFDFNRSKFNHVTQAWRQPG
EEEEEECCCCCCEEHHHCHHHHCCCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
SSFKPFIYSAAVDKGFSPSTVINDAPLSIPTGDTGGQLWEPKNYGGGYDGPMTMRRALQK
CCCCCCEEHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
SKNLVSVRILRTIGTQYAQQYITRFGFEPDKHPAYLPMALGAGSVTVLQMAGAYSVFANG
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEECC
GYRVNPYIIDRVTDARGTVIQQTHPMTASKDAVRVIDPRNDFIMDSLLRSVVSGGTGYLA
CEEECCEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHH
KQKLGRSDMAGKTGTTNDSFDAWFCGYTPKLVGVAWIGYDNPRSLGDRETGGGLALPIWI
HHHCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEHHHHH
NYMSYALKGQPETERQPPEGVVQMAGDWAYEEYANGQGVASVGLGDALPGGPPASGPEAA
HHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCC
PSLAPTPEQEKQKILDMFRGN
CCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA