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The map label for this gene is hisB [H]

Identifier: 17547669

GI number: 17547669

Start: 3178738

End: 3179328

Strand: Reverse

Name: hisB [H]

Synonym: RSc2950

Alternate gene names: 17547669

Gene position: 3179328-3178738 (Counterclockwise)

Preceding gene: 17547670

Following gene: 17547668

Centisome position: 85.55

GC content: 65.99

Gene sequence:

>591_bases
ATGAGCCGCCGCGCCGAGGTCACTCGCAACACCTCCGAAACGCAGATCCGCGTCGCCCTTGATCTGGACGGCACGGGCAA
GCAGACGCTGAATACCGGCGTTCCCTTCCTCGACCACATGCTCGACCAGATCGCCCGTCATGGCATGGTCGACCTGGACG
TCACGGCCACCGGCGACACCCACATCGACGATCACCACACCGTGGAAGACGTCGGCATCACGCTCGGCCAGGCGGTCGCC
AAGGCTATCGGCGACAAGAAGGGCATCGTGCGCTACGGCCATAGCTACGTGCCGCTGGACGAAGCCCTGTCGCGCGTGGT
GATCGACTTCTCCGGCCGTCCGGGCCTGGAGTTCCACGTGCCGTTCACGCGGGCGCGCGTGGGCAGCTTCGACGTGGACC
TGTCCATCGAATTCTTCCGCGGGTTCGTCAACCATGCCGGCGTGACGCTGCATATCGACAACCTGCGCGGCGTCAACGCG
CATCACCAGATCGAAACCGTGTTCAAGGCCTTCGGCCGCGCGCTGCGCATGGCGGTGGAGATCGATCCGCGTGCCGCCGG
CACGATCCCGTCGACCAAGGGCGCGCTCTGA

Upstream 100 bases:

>100_bases
TGCACCCGTTGCTGGCCAACTGTCTGCGCGTGACGGTCAGCAACCCCGAAGAAAACGCGCAATTTCTTGATGCCTTTGCC
GCATCGCTGCAGGACACCCC

Downstream 100 bases:

>100_bases
TTCCACGCATCGGCACGGCCGCGCCCGCCCGATACCTGACCGGCCACCCGATCCCATGGATCTGACCAAGAGCTTCTTTT
CGCTGCTGGCACTGATCAAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVTATGDTHIDDHHTVEDVGITLGQAVA
KAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARVGSFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNA
HHQIETVFKAFGRALRMAVEIDPRAAGTIPSTKGAL

Sequences:

>Translated_196_residues
MSRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVTATGDTHIDDHHTVEDVGITLGQAVA
KAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARVGSFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNA
HHQIETVFKAFGRALRMAVEIDPRAAGTIPSTKGAL
>Mature_195_residues
SRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVTATGDTHIDDHHTVEDVGITLGQAVAK
AIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARVGSFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAH
HQIETVFKAFGRALRMAVEIDPRAAGTIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50, Blast_Score=192, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=40.3669724770642, Blast_Score=161, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21390; Mature: 21258

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVTATGDT
CCCCCCCCCCCCCEEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCC
HIDDHHTVEDVGITLGQAVAKAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHEEEEEECCCCCCEEEC
PFTRARVGSFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQIETVFKAFGRALRMAVE
CHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEE
IDPRAAGTIPSTKGAL
ECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRRAEVTRNTSETQIRVALDLDGTGKQTLNTGVPFLDHMLDQIARHGMVDLDVTATGDT
CCCCCCCCCCCCEEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCC
HIDDHHTVEDVGITLGQAVAKAIGDKKGIVRYGHSYVPLDEALSRVVIDFSGRPGLEFHV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHEEEEEECCCCCCEEEC
PFTRARVGSFDVDLSIEFFRGFVNHAGVTLHIDNLRGVNAHHQIETVFKAFGRALRMAVE
CHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEE
IDPRAAGTIPSTKGAL
ECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA