Click here to switch to the map view.

The map label for this gene is cqsS [H]

Identifier: 17547642

GI number: 17547642

Start: 3153812

End: 3155044

Strand: Reverse

Name: cqsS [H]

Synonym: RSc2923

Alternate gene names: 17547642

Gene position: 3155044-3153812 (Counterclockwise)

Preceding gene: 17547644

Following gene: 17547640

Centisome position: 84.89

GC content: 66.42

Gene sequence:

>1233_bases
ATGGCCGCCGTATCGAATGCCATCATCGCGGATGGCGAGCGAGCGACGCGGCTTCGGCGCGCCCGTCTGGCCGGCGTTAT
CGGCGTCATCGGGCATCCGCTCTATTTCGTGATCTGGTCGTATGTCTTTCCGCAGCCTTATGAGAGCGTCTGGCTGCGGG
GGCTGTGTACGCTGCTGTTCGTCCCGCTGCTGTTTGTCGATCGGGTGGCCGGGTGCAAATGGCTGCCGGCCTATGCGGCG
TTCGCCGTGACGGTGGGGCTGCCATTCGCGTTTGTCTTCCTGTATCTGCAGAATGCCGGGGCGATGGTGTGGGCGGAGTC
CCTGCTCATTGCCGTCGTGATCCTCTTTCACTTCAGCACCGCATTTGCCGTGTTCTCCCTGGTCACGGGCGCTTCGGCCG
CGATGGCGCTGTTCCTGCTGACGGGGCCGGCCGCCGGCGGATTTCCATGGCATGCCTTGCTGGAACAGGTGCCGATCCTG
GCGTTCTTCTTTGTTGTCGGGGTGCTGGTCGTCATCCGGCTGGATCGGCAGATCCTGATCGAGCAGAAGCAGCGCGGGAT
GGCGCTGGCATTGGGGACGGTGGCGCACGAGTTGCGTACGCCGCTGGCCAGTCTTGCCTTGACGGCCAGCGGCATCCAGA
GCCGGCTGCCGCGGGCGGTGTGGCCGGACCATCCCGATCTGCCGGTGCTGCGGCAGGCTGTCGAGCGGATGCGCGCGGAC
GTGATCCGCGCCACCAACAGCATCGAGCTGCTGGTGGCCAATTCGAAGGATCCGCAGGCGGTGTGCACCGCGTGGTTCGA
TCCGCATGAGGCGATCTGCGCGGCTATCGATGCCTACCCGTTCGAGCCGGGGGCGCGCCCGCATGTGCATATCGCGCCGA
GCACGGGGATGCGGGTGCTGGGCAACGCCGGGCTGTTCGAGCACGTCATCACCAACCTGACCAAGAATGCGCTCGAGGCG
ATCCAGCGGGGCGGCAAGGGCGATCTGCGCATCGGCTATGAGCGAATGCCGCAGGCGGTGGAGATCGTCGTGCGCGACAC
GGGGGCCGGCGTGTCGCCGGCGGTCCTCAGGCGGATGTTCCAGCCGTTCTTCTCGCACCCGGCCCATCGGGGGACGGGGA
TCGGCCTCACGTTCTGCAGGAAGGTTCTGCGCGGCTGGGGCGCCAGCATTTCGTGCCGATCGGTCGAGCACGAGTTCACC
GAGTTCCGGATCCGGTTCCCGAATCCGCGCTGA

Upstream 100 bases:

>100_bases
CCGGCGGCCAGCCGGAAGATTCTCCCGAGACCCCATGACCCAGGACCGCGCAGTTCGACCCAACCCAGGTCGCGGGCTAG
CCCGCGTGTGGCGGCGGCTG

Downstream 100 bases:

>100_bases
GGCACCGCGCCCGTCAGAACGTCCAGGCGATGCCGGCCCGCACCGTGCGCGGCTCGGCCGGGTGGATGTGCCGGTCGTTG
ATGCCGGTTGCCGCGCCGCT

Product: transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAAVSNAIIADGERATRLRRARLAGVIGVIGHPLYFVIWSYVFPQPYESVWLRGLCTLLFVPLLFVDRVAGCKWLPAYAA
FAVTVGLPFAFVFLYLQNAGAMVWAESLLIAVVILFHFSTAFAVFSLVTGASAAMALFLLTGPAAGGFPWHALLEQVPIL
AFFFVVGVLVVIRLDRQILIEQKQRGMALALGTVAHELRTPLASLALTASGIQSRLPRAVWPDHPDLPVLRQAVERMRAD
VIRATNSIELLVANSKDPQAVCTAWFDPHEAICAAIDAYPFEPGARPHVHIAPSTGMRVLGNAGLFEHVITNLTKNALEA
IQRGGKGDLRIGYERMPQAVEIVVRDTGAGVSPAVLRRMFQPFFSHPAHRGTGIGLTFCRKVLRGWGASISCRSVEHEFT
EFRIRFPNPR

Sequences:

>Translated_410_residues
MAAVSNAIIADGERATRLRRARLAGVIGVIGHPLYFVIWSYVFPQPYESVWLRGLCTLLFVPLLFVDRVAGCKWLPAYAA
FAVTVGLPFAFVFLYLQNAGAMVWAESLLIAVVILFHFSTAFAVFSLVTGASAAMALFLLTGPAAGGFPWHALLEQVPIL
AFFFVVGVLVVIRLDRQILIEQKQRGMALALGTVAHELRTPLASLALTASGIQSRLPRAVWPDHPDLPVLRQAVERMRAD
VIRATNSIELLVANSKDPQAVCTAWFDPHEAICAAIDAYPFEPGARPHVHIAPSTGMRVLGNAGLFEHVITNLTKNALEA
IQRGGKGDLRIGYERMPQAVEIVVRDTGAGVSPAVLRRMFQPFFSHPAHRGTGIGLTFCRKVLRGWGASISCRSVEHEFT
EFRIRFPNPR
>Mature_409_residues
AAVSNAIIADGERATRLRRARLAGVIGVIGHPLYFVIWSYVFPQPYESVWLRGLCTLLFVPLLFVDRVAGCKWLPAYAAF
AVTVGLPFAFVFLYLQNAGAMVWAESLLIAVVILFHFSTAFAVFSLVTGASAAMALFLLTGPAAGGFPWHALLEQVPILA
FFFVVGVLVVIRLDRQILIEQKQRGMALALGTVAHELRTPLASLALTASGIQSRLPRAVWPDHPDLPVLRQAVERMRADV
IRATNSIELLVANSKDPQAVCTAWFDPHEAICAAIDAYPFEPGARPHVHIAPSTGMRVLGNAGLFEHVITNLTKNALEAI
QRGGKGDLRIGYERMPQAVEIVVRDTGAGVSPAVLRRMFQPFFSHPAHRGTGIGLTFCRKVLRGWGASISCRSVEHEFTE
FRIRFPNPR

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=254, Percent_Identity=27.9527559055118, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44909; Mature: 44778

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVSNAIIADGERATRLRRARLAGVIGVIGHPLYFVIWSYVFPQPYESVWLRGLCTLLF
CCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VPLLFVDRVAGCKWLPAYAAFAVTVGLPFAFVFLYLQNAGAMVWAESLLIAVVILFHFST
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AFAVFSLVTGASAAMALFLLTGPAAGGFPWHALLEQVPILAFFFVVGVLVVIRLDRQILI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQKQRGMALALGTVAHELRTPLASLALTASGIQSRLPRAVWPDHPDLPVLRQAVERMRAD
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VIRATNSIELLVANSKDPQAVCTAWFDPHEAICAAIDAYPFEPGARPHVHIAPSTGMRVL
HHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHH
GNAGLFEHVITNLTKNALEAIQRGGKGDLRIGYERMPQAVEIVVRDTGAGVSPAVLRRMF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCHHHEEEEECCCCCCCHHHHHHHH
QPFFSHPAHRGTGIGLTFCRKVLRGWGASISCRSVEHEFTEFRIRFPNPR
HHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHEEEECCCCC
>Mature Secondary Structure 
AAVSNAIIADGERATRLRRARLAGVIGVIGHPLYFVIWSYVFPQPYESVWLRGLCTLLF
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VPLLFVDRVAGCKWLPAYAAFAVTVGLPFAFVFLYLQNAGAMVWAESLLIAVVILFHFST
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AFAVFSLVTGASAAMALFLLTGPAAGGFPWHALLEQVPILAFFFVVGVLVVIRLDRQILI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQKQRGMALALGTVAHELRTPLASLALTASGIQSRLPRAVWPDHPDLPVLRQAVERMRAD
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VIRATNSIELLVANSKDPQAVCTAWFDPHEAICAAIDAYPFEPGARPHVHIAPSTGMRVL
HHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHH
GNAGLFEHVITNLTKNALEAIQRGGKGDLRIGYERMPQAVEIVVRDTGAGVSPAVLRRMF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCHHHEEEEECCCCCCCHHHHHHHH
QPFFSHPAHRGTGIGLTFCRKVLRGWGASISCRSVEHEFTEFRIRFPNPR
HHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]