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The map label for this gene is visC [H]

Identifier: 17547612

GI number: 17547612

Start: 3121700

End: 3122992

Strand: Reverse

Name: visC [H]

Synonym: RSc2893

Alternate gene names: 17547612

Gene position: 3122992-3121700 (Counterclockwise)

Preceding gene: 17547616

Following gene: 17547611

Centisome position: 84.03

GC content: 72.62

Gene sequence:

>1293_bases
ATGAATACACCCGCGTTTTCCTCCTCCGCCGGCGCACCGGCTTTCCACGTCGCGGTGGTGGGCGGCGGCATCGTCGGGCG
GGCGTGCGCGCTGCGGCTGGCCCAGGCCGGCTTGCGCGTCGCCCACGTGGCACCGGCCGCATCGCCCGCGCCGTCGTCGG
CGCCCGCCGGGCCGGATGCCTGGGACGCCCGCGTCTATGCGTTCTCGTCCAGTTCGCAGGCGCTGCTCGAGCAGTTGCGC
ATCTGGCCGGCGCTGGACATGTCGCGCGTGCAGCCGGTGCAGGACATGCGTGTCTTCGGCGACGCGGCGGCCGCGCGCGG
CGAGCATGCGCACGCCGACCTGCATTTCTCCGCCTATGCGGCCGGCGCGCCGCAGTTGGCGTGGATTGCCGAATCGTCCC
TGGTCGAGCGCGCGCTGGAAACCGCGCTGCGGTTCTCCCATACCGTCCAGACCTTCGCCCACGCCGCCACCGGCTTCGAG
ATGGAGGCCGATGCCGTGCGCCTGACGCTGTCCGACGGACAGGCGATCCGCGCCGAATGCGTGGTCGGCGCCGACGGCAA
GCAGTCGTGGGTGCGCCAGCAGGCCGGCATCCGCGCCGACGCGAAGCCGTATCGCCAGTTGGGCGTGGTCGCCAACTTCC
AGGCCGAGCACTGGCATCAGGACACCGCCTGGCAGTGGTTCCTCGGCGCCTCGGTCGATGGCGCGCGCGCGTCGGGCGAT
ACCGCCCCCGCGCGCGGCGAGATTCTCGCCATGCTGCCGCTGCCGGACCGGCGCGTGTCGATGGTGTGGTCCGCCGGCGA
GGACCATGCGCGCGACCTGCTGGCGCTGTCGCCGGATGCGCTGTGCCGCGCGGTCGAGGCGGCGGCCGGCGGCGCGGTGG
CGGCGCGCTTCGGGCGGCTGTCGTGCGTCACCCCGGCGCTGGGGTTCCCGCTGGTGCTGCAGCAGGCCGAGCGGCTGGTC
GCGCCGCGGGTCGCGCTGGTCGGCGATGCGGCGCATGTGATTCATCCGCTGGCCGGCCAGGGCATGAACCTGGGCCTGCG
CGATGTCGCTGAATTGGGTCAGGTGATGGCGGAACGCGAAACCATGCGCGATCATGGCGATCTGAGGCTGCTGCGCCGCT
ACGAGCGGGCCCGCCGCGAAGACCTGCTGTCGCTGACGGCTGCCACCGACGGGCTGCACACGTTGTTCGCCCTGCCGGGT
GCATTGCCCCGCATGGTCCGCAACGCGGGCATGCGCGTGGTGGGCCTGACGCCATTCATCAAACGCCTGCTGGTCAGGCA
CGCGCTAGGCTAG

Upstream 100 bases:

>100_bases
TCCACGCCATGCGGCACGAGCGCGCCGCCATGGTGTGACCCAAGCGCACCTTGCGTCGCCGCAAAGCCGAGCCACCCCCC
GCCGCTATAATTGGCCCACC

Downstream 100 bases:

>100_bases
CCGTCCGTCGGCAGCCGGCTTCCAGGAGTTGTCATGTCGTTTCGTATTCGGGTGGCGGCCATCGCCTCGGCGGCGCTGGT
TGTCGCCATGGGCGCGGGCT

Product: ubiquinone biosynthesis hydroxylase family protein

Products: 2-Octaprenyl-3-Methyl-5-Hydroxy-6-Methoxy-1,4- Benzoquinol [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNTPAFSSSAGAPAFHVAVVGGGIVGRACALRLAQAGLRVAHVAPAASPAPSSAPAGPDAWDARVYAFSSSSQALLEQLR
IWPALDMSRVQPVQDMRVFGDAAAARGEHAHADLHFSAYAAGAPQLAWIAESSLVERALETALRFSHTVQTFAHAATGFE
MEADAVRLTLSDGQAIRAECVVGADGKQSWVRQQAGIRADAKPYRQLGVVANFQAEHWHQDTAWQWFLGASVDGARASGD
TAPARGEILAMLPLPDRRVSMVWSAGEDHARDLLALSPDALCRAVEAAAGGAVAARFGRLSCVTPALGFPLVLQQAERLV
APRVALVGDAAHVIHPLAGQGMNLGLRDVAELGQVMAERETMRDHGDLRLLRRYERARREDLLSLTAATDGLHTLFALPG
ALPRMVRNAGMRVVGLTPFIKRLLVRHALG

Sequences:

>Translated_430_residues
MNTPAFSSSAGAPAFHVAVVGGGIVGRACALRLAQAGLRVAHVAPAASPAPSSAPAGPDAWDARVYAFSSSSQALLEQLR
IWPALDMSRVQPVQDMRVFGDAAAARGEHAHADLHFSAYAAGAPQLAWIAESSLVERALETALRFSHTVQTFAHAATGFE
MEADAVRLTLSDGQAIRAECVVGADGKQSWVRQQAGIRADAKPYRQLGVVANFQAEHWHQDTAWQWFLGASVDGARASGD
TAPARGEILAMLPLPDRRVSMVWSAGEDHARDLLALSPDALCRAVEAAAGGAVAARFGRLSCVTPALGFPLVLQQAERLV
APRVALVGDAAHVIHPLAGQGMNLGLRDVAELGQVMAERETMRDHGDLRLLRRYERARREDLLSLTAATDGLHTLFALPG
ALPRMVRNAGMRVVGLTPFIKRLLVRHALG
>Mature_430_residues
MNTPAFSSSAGAPAFHVAVVGGGIVGRACALRLAQAGLRVAHVAPAASPAPSSAPAGPDAWDARVYAFSSSSQALLEQLR
IWPALDMSRVQPVQDMRVFGDAAAARGEHAHADLHFSAYAAGAPQLAWIAESSLVERALETALRFSHTVQTFAHAATGFE
MEADAVRLTLSDGQAIRAECVVGADGKQSWVRQQAGIRADAKPYRQLGVVANFQAEHWHQDTAWQWFLGASVDGARASGD
TAPARGEILAMLPLPDRRVSMVWSAGEDHARDLLALSPDALCRAVEAAAGGAVAARFGRLSCVTPALGFPLVLQQAERLV
APRVALVGDAAHVIHPLAGQGMNLGLRDVAELGQVMAERETMRDHGDLRLLRRYERARREDLLSLTAATDGLHTLFALPG
ALPRMVRNAGMRVVGLTPFIKRLLVRHALG

Specific function: Not yet known [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=409, Percent_Identity=27.3838630806846, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI32967307, Length=292, Percent_Identity=31.8493150684932, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789273, Length=424, Percent_Identity=32.7830188679245, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786883, Length=425, Percent_Identity=34.5882352941176, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789274, Length=423, Percent_Identity=29.0780141843972, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI25146631, Length=430, Percent_Identity=26.9767441860465, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19920760, Length=411, Percent_Identity=29.1970802919708, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 45690; Mature: 45690

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPAFSSSAGAPAFHVAVVGGGIVGRACALRLAQAGLRVAHVAPAASPAPSSAPAGPDA
CCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCC
WDARVYAFSSSSQALLEQLRIWPALDMSRVQPVQDMRVFGDAAAARGEHAHADLHFSAYA
CCCEEEEECCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEC
AGAPQLAWIAESSLVERALETALRFSHTVQTFAHAATGFEMEADAVRLTLSDGQAIRAEC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCEEEEEE
VVGADGKQSWVRQQAGIRADAKPYRQLGVVANFQAEHWHQDTAWQWFLGASVDGARASGD
EECCCCHHHHHHHHCCCCCCCCHHHHHCCEECCCHHHCCCCCCEEEEECCCCCCCCCCCC
TAPARGEILAMLPLPDRRVSMVWSAGEDHARDLLALSPDALCRAVEAAAGGAVAARFGRL
CCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCC
SCVTPALGFPLVLQQAERLVAPRVALVGDAAHVIHPLAGQGMNLGLRDVAELGQVMAERE
EECCCCCCHHHHHHHHHHHHCCHHHEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TMRDHGDLRLLRRYERARREDLLSLTAATDGLHTLFALPGALPRMVRNAGMRVVGLTPFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHCCCEEEEHHHHH
KRLLVRHALG
HHHHHHHCCC
>Mature Secondary Structure
MNTPAFSSSAGAPAFHVAVVGGGIVGRACALRLAQAGLRVAHVAPAASPAPSSAPAGPDA
CCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCC
WDARVYAFSSSSQALLEQLRIWPALDMSRVQPVQDMRVFGDAAAARGEHAHADLHFSAYA
CCCEEEEECCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEC
AGAPQLAWIAESSLVERALETALRFSHTVQTFAHAATGFEMEADAVRLTLSDGQAIRAEC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCEEEEEE
VVGADGKQSWVRQQAGIRADAKPYRQLGVVANFQAEHWHQDTAWQWFLGASVDGARASGD
EECCCCHHHHHHHHCCCCCCCCHHHHHCCEECCCHHHCCCCCCEEEEECCCCCCCCCCCC
TAPARGEILAMLPLPDRRVSMVWSAGEDHARDLLALSPDALCRAVEAAAGGAVAARFGRL
CCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHCCC
SCVTPALGFPLVLQQAERLVAPRVALVGDAAHVIHPLAGQGMNLGLRDVAELGQVMAERE
EECCCCCCHHHHHHHHHHHHCCHHHEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
TMRDHGDLRLLRRYERARREDLLSLTAATDGLHTLFALPGALPRMVRNAGMRVVGLTPFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHCCCEEEEHHHHH
KRLLVRHALG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: @OCTA02.txt*2-Octaprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol! [C]

Specific reaction: @OCTA02.txt*2-Octaprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol! = 2-Octaprenyl-3-Methyl-5-Hydroxy-6-Methoxy-1,4- Benzoquinol [C]

General reaction: Hydroxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]