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The map label for this gene is trpC

Identifier: 17547604

GI number: 17547604

Start: 3112570

End: 3113373

Strand: Direct

Name: trpC

Synonym: RSc2885

Alternate gene names: 17547604

Gene position: 3112570-3113373 (Clockwise)

Preceding gene: 17547603

Following gene: 17547605

Centisome position: 83.75

GC content: 69.28

Gene sequence:

>804_bases
ATGTCCGACATCCTGCAGAAAATCCTGGCCGTGAAGGCCGAAGAAGTGGCCGCGGCGCGCAAGCACCGCGATCTGCCGAG
CGTGCGCGCCGAGGCCGAGGCCAACCGCCACGACAGCACCCTGGGCCCGCGCGGCTTTGCGCAGGCCCTGCGCGACAAGA
TCGGCGCGGGCCGGGCGGCCGTGATCGCCGAGGTCAAGAAGGCCTCGCCGTCCAAGGGCGTGCTGCGCCCGGACTTCAAG
CCCGCCGAAATCGCCGGCAGCTATGCCGAACACGGCGCGGCCTGCCTGTCGGTGCTGACCGACGAACAGTTCTTCCAGGG
CCACGCCGACTACCTGCGCGAAGCCCGCGCCGCCTGCGCGCTGCCCGCGCTGCGCAAGGACTTCATGGTCGATCTGTACC
AGGTGTACGAGGCCCGCTCGTGGGGCGCGGACTGCATCCTGCTGATCGTCTCCGCCCTGGACCAGGGGCTGATGGCCGAG
CTGGAAGCCTGCGCGCACGAGCTCGGCATGGACGTGCTGGTGGAAGTGCACGATGGTCATGAGCTGGAGCGCGCGCTGCG
CCTGTCGACGCCGCTGGTGGGCGTCAACAACCGCAACCTGCGCACCTTCGAGACCACGCTCGACACCACGCTGGGCCTGC
TCAAGCACATGCCGGACGACCGCATCGTCGTGACCGAATCGGGCATCCTCAAGCCCGACGACGTGCGCAAGATGCGCGCG
GCCGACGTCAACGCCTTCCTGGTCGGCGAAGCCTTCATGCGTGCCGACGATCCGGGCACCGAGCTGGCGCGCCTGTTCGC
CTGA

Upstream 100 bases:

>100_bases
GCGATGGCATCACGCTGGCGCGCGAGGCGATCGCATCCGGCGCGGCACGCGCCAAGGTGGACGAGCTGGTGCGCGTGACC
AATCAATTCAAGAAGTGAAC

Downstream 100 bases:

>100_bases
CGCGATGGCCCGCGAGATCGAACTGAAGCTGGCGGTGCCCGCCGGCGCGCACGACGCGCTGGCCGGCTGGCTGGACGCGC
ATGCGCAGCCGGCCGGCTCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS 1

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSDILQKILAVKAEEVAAARKHRDLPSVRAEAEANRHDSTLGPRGFAQALRDKIGAGRAAVIAEVKKASPSKGVLRPDFK
PAEIAGSYAEHGAACLSVLTDEQFFQGHADYLREARAACALPALRKDFMVDLYQVYEARSWGADCILLIVSALDQGLMAE
LEACAHELGMDVLVEVHDGHELERALRLSTPLVGVNNRNLRTFETTLDTTLGLLKHMPDDRIVVTESGILKPDDVRKMRA
ADVNAFLVGEAFMRADDPGTELARLFA

Sequences:

>Translated_267_residues
MSDILQKILAVKAEEVAAARKHRDLPSVRAEAEANRHDSTLGPRGFAQALRDKIGAGRAAVIAEVKKASPSKGVLRPDFK
PAEIAGSYAEHGAACLSVLTDEQFFQGHADYLREARAACALPALRKDFMVDLYQVYEARSWGADCILLIVSALDQGLMAE
LEACAHELGMDVLVEVHDGHELERALRLSTPLVGVNNRNLRTFETTLDTTLGLLKHMPDDRIVVTESGILKPDDVRKMRA
ADVNAFLVGEAFMRADDPGTELARLFA
>Mature_266_residues
SDILQKILAVKAEEVAAARKHRDLPSVRAEAEANRHDSTLGPRGFAQALRDKIGAGRAAVIAEVKKASPSKGVLRPDFKP
AEIAGSYAEHGAACLSVLTDEQFFQGHADYLREARAACALPALRKDFMVDLYQVYEARSWGADCILLIVSALDQGLMAEL
EACAHELGMDVLVEVHDGHELERALRLSTPLVGVNNRNLRTFETTLDTTLGLLKHMPDDRIVVTESGILKPDDVRKMRAA
DVNAFLVGEAFMRADDPGTELARLFA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=258, Percent_Identity=41.0852713178295, Blast_Score=170, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=266, Percent_Identity=38.7218045112782, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC1_RALSO (Q8XVE6)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521006.1
- ProteinModelPortal:   Q8XVE6
- SMR:   Q8XVE6
- GeneID:   1221738
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2885
- NMPDR:   fig|267608.1.peg.2885
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   RSOL267608:RSC2885-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29142; Mature: 29010

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILQKILAVKAEEVAAARKHRDLPSVRAEAEANRHDSTLGPRGFAQALRDKIGAGRAA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHH
VIAEVKKASPSKGVLRPDFKPAEIAGSYAEHGAACLSVLTDEQFFQGHADYLREARAACA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPALRKDFMVDLYQVYEARSWGADCILLIVSALDQGLMAELEACAHELGMDVLVEVHDGH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
ELERALRLSTPLVGVNNRNLRTFETTLDTTLGLLKHMPDDRIVVTESGILKPDDVRKMRA
HHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHH
ADVNAFLVGEAFMRADDPGTELARLFA
HCCCHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
SDILQKILAVKAEEVAAARKHRDLPSVRAEAEANRHDSTLGPRGFAQALRDKIGAGRAA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHH
VIAEVKKASPSKGVLRPDFKPAEIAGSYAEHGAACLSVLTDEQFFQGHADYLREARAACA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPALRKDFMVDLYQVYEARSWGADCILLIVSALDQGLMAELEACAHELGMDVLVEVHDGH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
ELERALRLSTPLVGVNNRNLRTFETTLDTTLGLLKHMPDDRIVVTESGILKPDDVRKMRA
HHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHH
ADVNAFLVGEAFMRADDPGTELARLFA
HCCCHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852