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The map label for this gene is trpD

Identifier: 17547603

GI number: 17547603

Start: 3111530

End: 3112567

Strand: Direct

Name: trpD

Synonym: RSc2884

Alternate gene names: 17547603

Gene position: 3111530-3112567 (Clockwise)

Preceding gene: 17547602

Following gene: 17547604

Centisome position: 83.72

GC content: 66.18

Gene sequence:

>1038_bases
ATGACCATTTCTCCGCAGGACGCGCTGACCCGCTGCATCGAGCATCGCGAGATCTTCCACGACGAAATGCTGCACCTGAT
GCGGCTGATCATGCGCGGCGAGATGTCGCCGGTGATCGCCTCGGCGCTCATCATGGGGCTGCGCGTCAAGAAAGAGACGA
TCGGCGAAATCGCTGCCGCGGCCACCGTGATGCGCGAATTCGCCACCACGGTGGACGTGCCGGCGGCGATCCTGGATCAC
TTTGTCGACATCGTCGGCACCGGCGGCGACGGCGCCAACACCTTCAATATCTCCACCGCGTCGATGTTCGTGGCCGCCGC
GGCCGGCGCGCGCATCGCCAAGCACGGCGGGCGCGGCGTGAGCTCCAAGTCGGGCAGCGCCGACGTGCTGGAGGCGCTGG
GCGTCAACATCATGCTGACGCCCGAGCAGGTGGCGCAAAGCATCGAGGCGGTGGGCATCGGCTTCATGTTCGCGCCCAAT
CACCATCCGGCGATGAAGAACGTCGCGCCGATCCGCAAGGAGCTGGGCGTGCGCACCCTCTTCAACATCCTGGGGCCGCT
GACCAATCCGGCCGGCGCGCCGAACATCCTGATGGGCGTGTTCCATCCGGACCTGGTCGGCATCCAGGTGCGCGTGATGC
AGCGCCTCGGTGCCAGGCATGCGGTGGTGGTCTATGGTAAAGACGGGATGGACGAAGTGTCGCTGGGCGCCGCCACGGTG
GTCGGCGAGCTCAAGGACGGCGAAGTGCGCGAGTACGAAATCCATCCGGAAGACTACGGCCTGCAGATGGTCTCCAACCG
GGGCCTGAAGGTGGCCGACGCAGAGGAATCCAAGGCGATGTTGCTCGGCGCTCTGGAGAACGTGCCCGGCACGCCACGCG
AGATCGTGACGCTCAATGCGGGCGCGGCGCTGTATGCGGCCAACCTGGCCGGCTCGATCGGCGATGGCATCACGCTGGCG
CGCGAGGCGATCGCATCCGGCGCGGCACGCGCCAAGGTGGACGAGCTGGTGCGCGTGACCAATCAATTCAAGAAGTGA

Upstream 100 bases:

>100_bases
CGAGCGCATCGGTGCCCTGCGCGAGGCCACGTACCCGGCAACCCCGGCGCCCAACCCGGCGGCGGCACCGGCAAAACCGT
AACCGAATCCCACGACCATC

Downstream 100 bases:

>100_bases
ACATGTCCGACATCCTGCAGAAAATCCTGGCCGTGAAGGCCGAAGAAGTGGCCGCGGCGCGCAAGCACCGCGATCTGCCG
AGCGTGCGCGCCGAGGCCGA

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTISPQDALTRCIEHREIFHDEMLHLMRLIMRGEMSPVIASALIMGLRVKKETIGEIAAAATVMREFATTVDVPAAILDH
FVDIVGTGGDGANTFNISTASMFVAAAAGARIAKHGGRGVSSKSGSADVLEALGVNIMLTPEQVAQSIEAVGIGFMFAPN
HHPAMKNVAPIRKELGVRTLFNILGPLTNPAGAPNILMGVFHPDLVGIQVRVMQRLGARHAVVVYGKDGMDEVSLGAATV
VGELKDGEVREYEIHPEDYGLQMVSNRGLKVADAEESKAMLLGALENVPGTPREIVTLNAGAALYAANLAGSIGDGITLA
REAIASGAARAKVDELVRVTNQFKK

Sequences:

>Translated_345_residues
MTISPQDALTRCIEHREIFHDEMLHLMRLIMRGEMSPVIASALIMGLRVKKETIGEIAAAATVMREFATTVDVPAAILDH
FVDIVGTGGDGANTFNISTASMFVAAAAGARIAKHGGRGVSSKSGSADVLEALGVNIMLTPEQVAQSIEAVGIGFMFAPN
HHPAMKNVAPIRKELGVRTLFNILGPLTNPAGAPNILMGVFHPDLVGIQVRVMQRLGARHAVVVYGKDGMDEVSLGAATV
VGELKDGEVREYEIHPEDYGLQMVSNRGLKVADAEESKAMLLGALENVPGTPREIVTLNAGAALYAANLAGSIGDGITLA
REAIASGAARAKVDELVRVTNQFKK
>Mature_344_residues
TISPQDALTRCIEHREIFHDEMLHLMRLIMRGEMSPVIASALIMGLRVKKETIGEIAAAATVMREFATTVDVPAAILDHF
VDIVGTGGDGANTFNISTASMFVAAAAGARIAKHGGRGVSSKSGSADVLEALGVNIMLTPEQVAQSIEAVGIGFMFAPNH
HPAMKNVAPIRKELGVRTLFNILGPLTNPAGAPNILMGVFHPDLVGIQVRVMQRLGARHAVVVYGKDGMDEVSLGAATVV
GELKDGEVREYEIHPEDYGLQMVSNRGLKVADAEESKAMLLGALENVPGTPREIVTLNAGAALYAANLAGSIGDGITLAR
EAIASGAARAKVDELVRVTNQFKK

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=281, Percent_Identity=41.9928825622776, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320561, Length=366, Percent_Identity=29.5081967213115, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD1_RALSO (Q8XVE7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521005.1
- ProteinModelPortal:   Q8XVE7
- SMR:   Q8XVE7
- GeneID:   1221737
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2884
- NMPDR:   fig|267608.1.peg.2884
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- ProtClustDB:   PRK00188
- BioCyc:   RSOL267608:RSC2884-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36418; Mature: 36287

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISPQDALTRCIEHREIFHDEMLHLMRLIMRGEMSPVIASALIMGLRVKKETIGEIAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATVMREFATTVDVPAAILDHFVDIVGTGGDGANTFNISTASMFVAAAAGARIAKHGGRGV
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCC
SSKSGSADVLEALGVNIMLTPEQVAQSIEAVGIGFMFAPNHHPAMKNVAPIRKELGVRTL
CCCCCCHHHHHHHCCEEEECHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHH
FNILGPLTNPAGAPNILMGVFHPDLVGIQVRVMQRLGARHAVVVYGKDGMDEVSLGAATV
HHHHCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCHHHH
VGELKDGEVREYEIHPEDYGLQMVSNRGLKVADAEESKAMLLGALENVPGTPREIVTLNA
EECCCCCCEEEEEECCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCEEEEECC
GAALYAANLAGSIGDGITLAREAIASGAARAKVDELVRVTNQFKK
CHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TISPQDALTRCIEHREIFHDEMLHLMRLIMRGEMSPVIASALIMGLRVKKETIGEIAAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATVMREFATTVDVPAAILDHFVDIVGTGGDGANTFNISTASMFVAAAAGARIAKHGGRGV
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCC
SSKSGSADVLEALGVNIMLTPEQVAQSIEAVGIGFMFAPNHHPAMKNVAPIRKELGVRTL
CCCCCCHHHHHHHCCEEEECHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHHH
FNILGPLTNPAGAPNILMGVFHPDLVGIQVRVMQRLGARHAVVVYGKDGMDEVSLGAATV
HHHHCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCHHHH
VGELKDGEVREYEIHPEDYGLQMVSNRGLKVADAEESKAMLLGALENVPGTPREIVTLNA
EECCCCCCEEEEEECCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCEEEEECC
GAALYAANLAGSIGDGITLAREAIASGAARAKVDELVRVTNQFKK
CHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852