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The map label for this gene is fruA [H]

Identifier: 17547582

GI number: 17547582

Start: 3085106

End: 3086827

Strand: Direct

Name: fruA [H]

Synonym: RSc2863

Alternate gene names: 17547582

Gene position: 3085106-3086827 (Clockwise)

Preceding gene: 17547581

Following gene: 17547583

Centisome position: 83.01

GC content: 72.65

Gene sequence:

>1722_bases
ATGCCCCATCTGTTGGCAATTCTCGGCGCGGACAGCCACAGCACGCGCCCCCTGCTGGCCGGCGAAGCGCTGCGGCATGC
GGCGCAGCAAGCCGGCTGCCGGCTCGACGTGGACGTGCGCACACCCGACACCCTGTCGGCGGTGGCCGCCACCGCGCTGG
CCAACGCCGACGCGGTGGTGTGGGCCGGTGTCGCGCCCGACGCCGCCGCGCGCCAGGCCAATCCGCGCATGATCGAGGTG
GCCCTCGACGATGTGCTGGCCGATGCCCGCGCCGTGCTGGCGCGCATGCTGGACAGCCACCCCGCCCCGCCCACCGCGGC
CGAACAAGGCCGGCGCATCGTCGCCATCACCTCGTGCCCGACCGGCATCGCCCATACTTTCATGGCCGCCGAGGCGCTGA
CCCAGGCAGCCAGCGCGCTCGGCCACCCCATCCATGTCGAGACGCAGGGCTCGGTGGGGGCGCAGAACACCTTGTCGGCC
GACGCGATCGCCCAGGCAGACATCGTGCTGATCGCGGCAGACACGCAGGTCGATCTGTCGCGCTTCGAGGGCAAGCGCGT
CTTCCGCAGCGGCACCAAGGCCGCCATCCACGACGGGCAGGCGCTGATCCGCCGCGCGCTGGCCGAGGCCGCCATCGCCG
CGCCCAGCGGGCAGGTCCAGGCCGATGCCGGCGCGAACGCAACCCCCGCCGAACAGCAGCGCACCGGACCTTACAAACAC
CTGATGACCGGAGTGTCGTTCATGCTGCCTTTCGTGGTAGCCGGCGGCATCCTGATCGCGCTGGCCTTTGCCGTGGGCGG
CATCTACGCCGCCGACGACGCGGCGCGCGGCACGCTCGGCTGGGCCCTGTTCCAGATTGGCGCCAAGTCCGCCTTTGCGC
TGATGGTGCCGGCGCTGGCCGGGTACATCGCCTACTCCGTCGCCAACCGGCCCGGCATCGCCCCCGGCATGGTCGGCGGC
ATGCTGGCCGCGAGCCTCGGCGCGGGCTTCCTGGGCGGCATCGTGGCCGGGTTCGTGGCCGGCTACGGCACCTCGGCGCT
CAACCGGTGGCTGCGGCTGCCGCGCAACCTCGACGGCCTCAAGCCGGTGCTGATCCTGCCGGTGCTCGGCTCGCTGCTGA
CAGGCCTGGTGATGCTCTATGTCGTGGGCGCGCCGGTGGCCACGCTGCTGGCCTCGCTGACCGCCTGGCTGCGCGGCATG
CAGGGCGCCAACGCCGTGCCGCTGGGCGCGCTGCTGGGCGGCATGATGGCATTCGACATGGGCGGACCGGTCAACAAGGC
CGCCTATGCCTTCAGCACCGGCCTCATCGGCAGCCAGGTCTACACGCCGATGGCCGCGACCATGGCCGCCGGCATGACGC
CGCCGCTGGGCATCGCGCTGGCGGCCTGGCTGTTCCCCTCGCGCTTCACCGGCGAGGAACGGCAGGCCGCGCGTGCCACC
GCCGTGCTCGGCCTGGCCTTCATCAGCGAAGGCGCGATCCCGTATGCCGCGCGCGATCCGCTGCGCGTCATTCCCGCGCT
GGTGACCGGTTCGGCCTGTGCCGGCGCGCTGTCGATGCTGTTCGGCGTCGAGCTGCGCGTGCCCCACGGCGGCGCGTTCG
TGCTGCCGATTCCCAATGCGGTCACGCACCTGGGCGGCTACGTGGTGGCGCTCGTCGCCGGCACCGTGCTGACAGCCGTG
CTGCTGGCGCTGCTCAAGCGCCGCGTAGCCGCCACCGCCTGA

Upstream 100 bases:

>100_bases
CCCACCTGCCGCCGCCGCAGCAAGTACGCGAGCGCGCCGCCGCCGTGCACATGCAGCGGGTGGCCTGACGCCCCGCTCAA
CCGATTCCAAGGAGCTAGAC

Downstream 100 bases:

>100_bases
CGCCCGCCCGCGGCGTCCATGACGCTGCTGCCCCGTATCAAAAACACCGCAGTCTTAGCAATTCCCCCCTTGCCTGTCAC
GCAAGTTTGGCTATGATGGC

Product: PTS system, fructose-specific IIBC component (EIIBC-fru) (fructose-permease IIBC component) transmembrane protein

Products: NA

Alternate protein names: EIIBC-Fru; EII-Fru; Fructose-specific phosphotransferase enzyme IIB component; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MPHLLAILGADSHSTRPLLAGEALRHAAQQAGCRLDVDVRTPDTLSAVAATALANADAVVWAGVAPDAAARQANPRMIEV
ALDDVLADARAVLARMLDSHPAPPTAAEQGRRIVAITSCPTGIAHTFMAAEALTQAASALGHPIHVETQGSVGAQNTLSA
DAIAQADIVLIAADTQVDLSRFEGKRVFRSGTKAAIHDGQALIRRALAEAAIAAPSGQVQADAGANATPAEQQRTGPYKH
LMTGVSFMLPFVVAGGILIALAFAVGGIYAADDAARGTLGWALFQIGAKSAFALMVPALAGYIAYSVANRPGIAPGMVGG
MLAASLGAGFLGGIVAGFVAGYGTSALNRWLRLPRNLDGLKPVLILPVLGSLLTGLVMLYVVGAPVATLLASLTAWLRGM
QGANAVPLGALLGGMMAFDMGGPVNKAAYAFSTGLIGSQVYTPMAATMAAGMTPPLGIALAAWLFPSRFTGEERQAARAT
AVLGLAFISEGAIPYAARDPLRVIPALVTGSACAGALSMLFGVELRVPHGGAFVLPIPNAVTHLGGYVVALVAGTVLTAV
LLALLKRRVAATA

Sequences:

>Translated_573_residues
MPHLLAILGADSHSTRPLLAGEALRHAAQQAGCRLDVDVRTPDTLSAVAATALANADAVVWAGVAPDAAARQANPRMIEV
ALDDVLADARAVLARMLDSHPAPPTAAEQGRRIVAITSCPTGIAHTFMAAEALTQAASALGHPIHVETQGSVGAQNTLSA
DAIAQADIVLIAADTQVDLSRFEGKRVFRSGTKAAIHDGQALIRRALAEAAIAAPSGQVQADAGANATPAEQQRTGPYKH
LMTGVSFMLPFVVAGGILIALAFAVGGIYAADDAARGTLGWALFQIGAKSAFALMVPALAGYIAYSVANRPGIAPGMVGG
MLAASLGAGFLGGIVAGFVAGYGTSALNRWLRLPRNLDGLKPVLILPVLGSLLTGLVMLYVVGAPVATLLASLTAWLRGM
QGANAVPLGALLGGMMAFDMGGPVNKAAYAFSTGLIGSQVYTPMAATMAAGMTPPLGIALAAWLFPSRFTGEERQAARAT
AVLGLAFISEGAIPYAARDPLRVIPALVTGSACAGALSMLFGVELRVPHGGAFVLPIPNAVTHLGGYVVALVAGTVLTAV
LLALLKRRVAATA
>Mature_572_residues
PHLLAILGADSHSTRPLLAGEALRHAAQQAGCRLDVDVRTPDTLSAVAATALANADAVVWAGVAPDAAARQANPRMIEVA
LDDVLADARAVLARMLDSHPAPPTAAEQGRRIVAITSCPTGIAHTFMAAEALTQAASALGHPIHVETQGSVGAQNTLSAD
AIAQADIVLIAADTQVDLSRFEGKRVFRSGTKAAIHDGQALIRRALAEAAIAAPSGQVQADAGANATPAEQQRTGPYKHL
MTGVSFMLPFVVAGGILIALAFAVGGIYAADDAARGTLGWALFQIGAKSAFALMVPALAGYIAYSVANRPGIAPGMVGGM
LAASLGAGFLGGIVAGFVAGYGTSALNRWLRLPRNLDGLKPVLILPVLGSLLTGLVMLYVVGAPVATLLASLTAWLRGMQ
GANAVPLGALLGGMMAFDMGGPVNKAAYAFSTGLIGSQVYTPMAATMAAGMTPPLGIALAAWLFPSRFTGEERQAARATA
VLGLAFISEGAIPYAARDPLRVIPALVTGSACAGALSMLFGVELRVPHGGAFVLPIPNAVTHLGGYVVALVAGTVLTAVL
LALLKRRVAATA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=457, Percent_Identity=53.1728665207877, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786951, Length=476, Percent_Identity=38.0252100840336, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI87082348, Length=488, Percent_Identity=35.655737704918, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1790386, Length=299, Percent_Identity=43.1438127090301, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788729, Length=379, Percent_Identity=26.1213720316623, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1790387, Length=104, Percent_Identity=42.3076923076923, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788730, Length=95, Percent_Identity=41.0526315789474, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 58137; Mature: 58006

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHLLAILGADSHSTRPLLAGEALRHAAQQAGCRLDVDVRTPDTLSAVAATALANADAVV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEE
WAGVAPDAAARQANPRMIEVALDDVLADARAVLARMLDSHPAPPTAAEQGRRIVAITSCP
EECCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCC
TGIAHTFMAAEALTQAASALGHPIHVETQGSVGAQNTLSADAIAQADIVLIAADTQVDLS
CHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCEEEEEECCCHHHH
RFEGKRVFRSGTKAAIHDGQALIRRALAEAAIAAPSGQVQADAGANATPAEQQRTGPYKH
HHCCHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHCCCHHHH
LMTGVSFMLPFVVAGGILIALAFAVGGIYAADDAARGTLGWALFQIGAKSAFALMVPALA
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
GYIAYSVANRPGIAPGMVGGMLAASLGAGFLGGIVAGFVAGYGTSALNRWLRLPRNLDGL
HHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
KPVLILPVLGSLLTGLVMLYVVGAPVATLLASLTAWLRGMQGANAVPLGALLGGMMAFDM
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
GGPVNKAAYAFSTGLIGSQVYTPMAATMAAGMTPPLGIALAAWLFPSRFTGEERQAARAT
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
AVLGLAFISEGAIPYAARDPLRVIPALVTGSACAGALSMLFGVELRVPHGGAFVLPIPNA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCEEECCCCCEEEEECCHH
VTHLGGYVVALVAGTVLTAVLLALLKRRVAATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHLLAILGADSHSTRPLLAGEALRHAAQQAGCRLDVDVRTPDTLSAVAATALANADAVV
CCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEE
WAGVAPDAAARQANPRMIEVALDDVLADARAVLARMLDSHPAPPTAAEQGRRIVAITSCP
EECCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCC
TGIAHTFMAAEALTQAASALGHPIHVETQGSVGAQNTLSADAIAQADIVLIAADTQVDLS
CHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCEEEEEECCCHHHH
RFEGKRVFRSGTKAAIHDGQALIRRALAEAAIAAPSGQVQADAGANATPAEQQRTGPYKH
HHCCHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHCCCHHHH
LMTGVSFMLPFVVAGGILIALAFAVGGIYAADDAARGTLGWALFQIGAKSAFALMVPALA
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
GYIAYSVANRPGIAPGMVGGMLAASLGAGFLGGIVAGFVAGYGTSALNRWLRLPRNLDGL
HHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
KPVLILPVLGSLLTGLVMLYVVGAPVATLLASLTAWLRGMQGANAVPLGALLGGMMAFDM
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
GGPVNKAAYAFSTGLIGSQVYTPMAATMAAGMTPPLGIALAAWLFPSRFTGEERQAARAT
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
AVLGLAFISEGAIPYAARDPLRVIPALVTGSACAGALSMLFGVELRVPHGGAFVLPIPNA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCEEECCCCCEEEEECCHH
VTHLGGYVVALVAGTVLTAVLLALLKRRVAATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1655739; 12024217; 1650911 [H]