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The map label for this gene is ftsI [H]

Identifier: 17547569

GI number: 17547569

Start: 3067551

End: 3069338

Strand: Reverse

Name: ftsI [H]

Synonym: RSc2850

Alternate gene names: 17547569

Gene position: 3069338-3067551 (Counterclockwise)

Preceding gene: 17547570

Following gene: 17547568

Centisome position: 82.59

GC content: 68.01

Gene sequence:

>1788_bases
ATGAGCGGCGCACACAAGCATCCGGGGACGGCGGCCCGCGCCCGCCTGGGCCAGTTCTCCGCCAGCCCGGTGCTGGGGCT
GCGCTTGCCGATGTGGCGCTCCAAGCTGGTGGTCTTCCTGATGTTTGCCGCGTTCATGGCGCTGATCGTCCGTGCGGCGT
GGATCCAGGGACCGGGCAACCGCTTCTACGAGGCCGAGGGCAAGAAGCGCTTCCAGCGCACGCTGGAACTGCCGGCCACG
CGCGGCAAGATCCTCGACCGCAACGGCCTGGTGCTGGCCACCAGCCTGCCGGTCAAGGCCATCTGGGCCGTGCCCGAGGA
CGTGCCCAACACCGTGCCCGGCGAAGACATGCAGAAGCTCGCCAAGCTGCTCGGCATGAGCAACAAGGATCTGGCGGGCA
AACTCGGCGAGGACAAGGGCTTCGTCTACCTGAAGCGCCAGGTGCTGCCGGACATTGCCGACCAGATCGCCGGCCTGAAG
ATCGACGGCATCTATCAGACGCGCGAATACAAGCGCTTCTACCCGGAAGGCGAAGCGATGGCGCACATCGTCGGCTTCAC
CAACGTCGAGGACAAGGGCCAGGAAGGCATGGAGCTGGCGCGCGAGCCGGATCTCGCGGGCGCGTCCGGCCAGCGCCAGG
TGATCAAGGATCGCCTGGGCCGCGTGGTGGAGGACGTCGGCGTGCTGAAGGCGCCGCGCGAGGGCCGCGACCTGACGCTC
TCCATCGACGCCAAGATCCAGTACCTGACCTTCAACGAGCTCAAGGCGGCCGTGGAGCGCAACCGTGCCAAGGCCGGCAG
CGCCATCGTGCTCGACGCCCAGACCGGCGAGGTGCTGGCGCTGGCCAACTATCCGACCTACAACCCGAACGACCGCTCGC
GCCTGTCGGGCGAACAGCTGCGCAACCGCGTGCTGACCGACACCTTCGAGCCCGGCTCGATGATGAAGCCGATCAGCATC
GGCCTCGCGCTGCAGTTGCACCGCGTGACGCCCAACACGCTGGTGCAGACCAACGGCAAGTTCACACTGGACGGCGCGAC
CATCTCCGACACCAGCAACTACGGCACGCTGACCGTCGGCCAGGTCATCCAGCACTCGAGCAATATCGGCACGACCAAGA
TCGCGCTGATGCTCAAGCCGCAGGAAATGTGGGACATGTTCACCAGCGTCGGCTTCGGCCAGGCGCCCAAGATCGGCTTC
CCGGGCGCGGTGGCGGGGCGGCTGCGCCCGGCCAAGAACTGGCGGCGCATCGAGCAGGCGACCATGTCGTACGGCTACGG
CCTGTCGGTGTCGCTGTTCCAGATGGCGCATGCCTACACGATCTTCGCGCACGACGGCGAACTGATCCCGGTCACGATGT
ACCGCACCAACGGCCAGCCGCCGCAGGGGGAGCGCGTGCTGTCGCCCGAGGTGGCGCGGCAGGTGCGCCAGATGCTGGAA
ACCGTGACATCGCCCGGCGGCACCGCGCCGCAGGCGCAGGTGATGGGCTACCGCGTGGGCGGCAAGACCGGCACGGCGTA
CAAGCACGTCGGCCGCGGATATGACCGCTCCAAGTACCGTGCGTCGTTCATCGGCCTGGCGCCCATGTCGAACCCGCGCA
TCATCGTCGCCGTCAGCGTCGACGAGCCTTCGGCCGGCAGCCACTACGGCGGCTCGGTGGCCGGGCCGGTGTTTGCCTCG
ATCGCCGGCGGCAGCCTGCGCGCGCTGAACGTATCGCCGGATTCGCCGGTGCGCCAGCTCGTGATGACCGAAGGCGTGGC
CGAAGAACCCGTGGGGGCGCTGCAATGA

Upstream 100 bases:

>100_bases
CCGCGCAGGCGGGCCGCACGCAGTATCTGCAGGGGTTTGCCGACTTGCCGGCGGCGGCGTCCGCCGCGGCCAGCGCGCCC
GCGGCTTCGGGAGTCCAGCC

Downstream 100 bases:

>100_bases
CGGCCGTGCCGACCTCCGAACGAGCGCCGATCGCTGCGCGCCTGGCACCGGTGCTGGACTGGCTGCGCGCGCACGTGCCG
GCCGGCGCCGATCTGACCAG

Product: penicillin-binding 3 precursor PBP-3 transmembrane protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSGAHKHPGTAARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFMALIVRAAWIQGPGNRFYEAEGKKRFQRTLELPAT
RGKILDRNGLVLATSLPVKAIWAVPEDVPNTVPGEDMQKLAKLLGMSNKDLAGKLGEDKGFVYLKRQVLPDIADQIAGLK
IDGIYQTREYKRFYPEGEAMAHIVGFTNVEDKGQEGMELAREPDLAGASGQRQVIKDRLGRVVEDVGVLKAPREGRDLTL
SIDAKIQYLTFNELKAAVERNRAKAGSAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQLRNRVLTDTFEPGSMMKPISI
GLALQLHRVTPNTLVQTNGKFTLDGATISDTSNYGTLTVGQVIQHSSNIGTTKIALMLKPQEMWDMFTSVGFGQAPKIGF
PGAVAGRLRPAKNWRRIEQATMSYGYGLSVSLFQMAHAYTIFAHDGELIPVTMYRTNGQPPQGERVLSPEVARQVRQMLE
TVTSPGGTAPQAQVMGYRVGGKTGTAYKHVGRGYDRSKYRASFIGLAPMSNPRIIVAVSVDEPSAGSHYGGSVAGPVFAS
IAGGSLRALNVSPDSPVRQLVMTEGVAEEPVGALQ

Sequences:

>Translated_595_residues
MSGAHKHPGTAARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFMALIVRAAWIQGPGNRFYEAEGKKRFQRTLELPAT
RGKILDRNGLVLATSLPVKAIWAVPEDVPNTVPGEDMQKLAKLLGMSNKDLAGKLGEDKGFVYLKRQVLPDIADQIAGLK
IDGIYQTREYKRFYPEGEAMAHIVGFTNVEDKGQEGMELAREPDLAGASGQRQVIKDRLGRVVEDVGVLKAPREGRDLTL
SIDAKIQYLTFNELKAAVERNRAKAGSAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQLRNRVLTDTFEPGSMMKPISI
GLALQLHRVTPNTLVQTNGKFTLDGATISDTSNYGTLTVGQVIQHSSNIGTTKIALMLKPQEMWDMFTSVGFGQAPKIGF
PGAVAGRLRPAKNWRRIEQATMSYGYGLSVSLFQMAHAYTIFAHDGELIPVTMYRTNGQPPQGERVLSPEVARQVRQMLE
TVTSPGGTAPQAQVMGYRVGGKTGTAYKHVGRGYDRSKYRASFIGLAPMSNPRIIVAVSVDEPSAGSHYGGSVAGPVFAS
IAGGSLRALNVSPDSPVRQLVMTEGVAEEPVGALQ
>Mature_594_residues
SGAHKHPGTAARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFMALIVRAAWIQGPGNRFYEAEGKKRFQRTLELPATR
GKILDRNGLVLATSLPVKAIWAVPEDVPNTVPGEDMQKLAKLLGMSNKDLAGKLGEDKGFVYLKRQVLPDIADQIAGLKI
DGIYQTREYKRFYPEGEAMAHIVGFTNVEDKGQEGMELAREPDLAGASGQRQVIKDRLGRVVEDVGVLKAPREGRDLTLS
IDAKIQYLTFNELKAAVERNRAKAGSAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQLRNRVLTDTFEPGSMMKPISIG
LALQLHRVTPNTLVQTNGKFTLDGATISDTSNYGTLTVGQVIQHSSNIGTTKIALMLKPQEMWDMFTSVGFGQAPKIGFP
GAVAGRLRPAKNWRRIEQATMSYGYGLSVSLFQMAHAYTIFAHDGELIPVTMYRTNGQPPQGERVLSPEVARQVRQMLET
VTSPGGTAPQAQVMGYRVGGKTGTAYKHVGRGYDRSKYRASFIGLAPMSNPRIIVAVSVDEPSAGSHYGGSVAGPVFASI
AGGSLRALNVSPDSPVRQLVMTEGVAEEPVGALQ

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=549, Percent_Identity=40.6193078324226, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1786854, Length=569, Percent_Identity=23.3743409490334, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64535; Mature: 64404

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAHKHPGTAARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFMALIVRAAWIQGPGN
CCCCCCCCCHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RFYEAEGKKRFQRTLELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNTVPGEDMQKL
CEEECHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHH
AKLLGMSNKDLAGKLGEDKGFVYLKRQVLPDIADQIAGLKIDGIYQTREYKRFYPEGEAM
HHHHCCCCCCHHCCCCCCCCEEEEHHHHHHHHHHHHCCEEEECEECCCHHHHHCCCCCCE
AHIVGFTNVEDKGQEGMELAREPDLAGASGQRQVIKDRLGRVVEDVGVLKAPREGRDLTL
EEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
SIDAKIQYLTFNELKAAVERNRAKAGSAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQL
EEECEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCHHHCCHHHH
RNRVLTDTFEPGSMMKPISIGLALQLHRVTPNTLVQTNGKFTLDGATISDTSNYGTLTVG
HHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCEEEECCCEECCCCCCCEEEHH
QVIQHSSNIGTTKIALMLKPQEMWDMFTSVGFGQAPKIGFPGAVAGRLRPAKNWRRIEQA
HHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
TMSYGYGLSVSLFQMAHAYTIFAHDGELIPVTMYRTNGQPPQGERVLSPEVARQVRQMLE
HHHCCCCCHHHHHHHHHEEEEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
TVTSPGGTAPQAQVMGYRVGGKTGTAYKHVGRGYDRSKYRASFIGLAPMSNPRIIVAVSV
HHCCCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCHHEEEEEEECCCCCCEEEEEEEE
DEPSAGSHYGGSVAGPVFASIAGGSLRALNVSPDSPVRQLVMTEGVAEEPVGALQ
CCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SGAHKHPGTAARARLGQFSASPVLGLRLPMWRSKLVVFLMFAAFMALIVRAAWIQGPGN
CCCCCCCCHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RFYEAEGKKRFQRTLELPATRGKILDRNGLVLATSLPVKAIWAVPEDVPNTVPGEDMQKL
CEEECHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHH
AKLLGMSNKDLAGKLGEDKGFVYLKRQVLPDIADQIAGLKIDGIYQTREYKRFYPEGEAM
HHHHCCCCCCHHCCCCCCCCEEEEHHHHHHHHHHHHCCEEEECEECCCHHHHHCCCCCCE
AHIVGFTNVEDKGQEGMELAREPDLAGASGQRQVIKDRLGRVVEDVGVLKAPREGRDLTL
EEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
SIDAKIQYLTFNELKAAVERNRAKAGSAIVLDAQTGEVLALANYPTYNPNDRSRLSGEQL
EEECEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCHHHCCHHHH
RNRVLTDTFEPGSMMKPISIGLALQLHRVTPNTLVQTNGKFTLDGATISDTSNYGTLTVG
HHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCEEEECCCEECCCCCCCEEEHH
QVIQHSSNIGTTKIALMLKPQEMWDMFTSVGFGQAPKIGFPGAVAGRLRPAKNWRRIEQA
HHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
TMSYGYGLSVSLFQMAHAYTIFAHDGELIPVTMYRTNGQPPQGERVLSPEVARQVRQMLE
HHHCCCCCHHHHHHHHHEEEEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
TVTSPGGTAPQAQVMGYRVGGKTGTAYKHVGRGYDRSKYRASFIGLAPMSNPRIIVAVSV
HHCCCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCHHEEEEEEECCCCCCEEEEEEEE
DEPSAGSHYGGSVAGPVFASIAGGSLRALNVSPDSPVRQLVMTEGVAEEPVGALQ
CCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]