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The map label for this gene is coaE

Identifier: 17547547

GI number: 17547547

Start: 3042454

End: 3043068

Strand: Direct

Name: coaE

Synonym: RSc2828

Alternate gene names: 17547547

Gene position: 3042454-3043068 (Clockwise)

Preceding gene: 17547546

Following gene: 17547548

Centisome position: 81.87

GC content: 71.54

Gene sequence:

>615_bases
ATGCGCGTGATCGGCCTGACCGGCGGCATCGGCAGCGGCAAGAGCTACGTTGCGGAGCGCCTTGCCGAACGGGGTGCCGC
GGTCGTCGACACCGACGCCATCGCGCACGAGATCACCGCACCGGGCGGCGCGGCCATCCCGAAGCTGGTCGAAGCCTTCG
GGCCCGGCATCCTGCGCGCCGATGGCGCCATGGACCGCGACGCCATGCGCGCCCTCGCCTTCTCCGACGCCACCGCCAAG
GCCCGCCTGGAGCGGATCACGCACCCGCTGATCCGCGAGATCAGCCTGTCACGCGGCGCGGCGGCGCAGGCTTCGGATGC
CTGCCCTTATCTGGTCTACGTGGTCCCCCTGTTGGTGGAGTCCCTGAGCGGACATCACAGCTGGCGCGCGCTGGTCGACC
GCATCCTGGTGATCGACTGCCCGGTCGAGACGCAGATCGCGCGCGTGATCGCCCGCAACGGCCTGCCGCGCGCGCTGGTC
GAATCCATCGTCGCCCGCCAGGCCACGCGCGAAGCCCGCCTGGCGGTGGCCGACGATGTCATCGACAACGGCGGCGCCCT
GGCCGACCTCCTTCCCCAGATCGACCGCCTGGACCTCGCCTACCGGGCGCATTGA

Upstream 100 bases:

>100_bases
GTTCATCGCGGGTGCCGGCGTGATCGCGCTGCTGGCCGGCCCGCAACTGGTGGCGCTGACGGGGCTCGCGCCACTGCTGG
CGCGGTAAGAGGCTGCCTGC

Downstream 100 bases:

>100_bases
AAGCGTCTGAAAGCGGCCCTCGAATCCCGCTGCATTGTGATGCGCGAGGGTCTCGCATAGAATGCGGGCAGATCGAGGCC
AAACGGGCTTCGTACGATCC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MRVIGLTGGIGSGKSYVAERLAERGAAVVDTDAIAHEITAPGGAAIPKLVEAFGPGILRADGAMDRDAMRALAFSDATAK
ARLERITHPLIREISLSRGAAAQASDACPYLVYVVPLLVESLSGHHSWRALVDRILVIDCPVETQIARVIARNGLPRALV
ESIVARQATREARLAVADDVIDNGGALADLLPQIDRLDLAYRAH

Sequences:

>Translated_204_residues
MRVIGLTGGIGSGKSYVAERLAERGAAVVDTDAIAHEITAPGGAAIPKLVEAFGPGILRADGAMDRDAMRALAFSDATAK
ARLERITHPLIREISLSRGAAAQASDACPYLVYVVPLLVESLSGHHSWRALVDRILVIDCPVETQIARVIARNGLPRALV
ESIVARQATREARLAVADDVIDNGGALADLLPQIDRLDLAYRAH
>Mature_204_residues
MRVIGLTGGIGSGKSYVAERLAERGAAVVDTDAIAHEITAPGGAAIPKLVEAFGPGILRADGAMDRDAMRALAFSDATAK
ARLERITHPLIREISLSRGAAAQASDACPYLVYVVPLLVESLSGHHSWRALVDRILVIDCPVETQIARVIARNGLPRALV
ESIVARQATREARLAVADDVIDNGGALADLLPQIDRLDLAYRAH

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=185, Percent_Identity=31.8918918918919, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI191252795, Length=185, Percent_Identity=31.8918918918919, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI110227607, Length=171, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI110227605, Length=171, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI110227603, Length=171, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI110227601, Length=171, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI205277394, Length=171, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786292, Length=199, Percent_Identity=42.2110552763819, Blast_Score=144, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17554944, Length=210, Percent_Identity=29.0476190476191, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=31.5, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644728, Length=190, Percent_Identity=28.9473684210526, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24658602, Length=166, Percent_Identity=33.1325301204819, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_RALSO (Q8XVK2)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520949.1
- ProteinModelPortal:   Q8XVK2
- GeneID:   1221676
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2828
- NMPDR:   fig|267608.1.peg.2828
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   RSOL267608:RSC2828-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21613; Mature: 21613

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVIGLTGGIGSGKSYVAERLAERGAAVVDTDAIAHEITAPGGAAIPKLVEAFGPGILRA
CEEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHCCCEEEC
DGAMDRDAMRALAFSDATAKARLERITHPLIREISLSRGAAAQASDACPYLVYVVPLLVE
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SLSGHHSWRALVDRILVIDCPVETQIARVIARNGLPRALVESIVARQATREARLAVADDV
HHCCCHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IDNGGALADLLPQIDRLDLAYRAH
HCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVIGLTGGIGSGKSYVAERLAERGAAVVDTDAIAHEITAPGGAAIPKLVEAFGPGILRA
CEEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHCCCEEEC
DGAMDRDAMRALAFSDATAKARLERITHPLIREISLSRGAAAQASDACPYLVYVVPLLVE
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SLSGHHSWRALVDRILVIDCPVETQIARVIARNGLPRALVESIVARQATREARLAVADDV
HHCCCHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IDNGGALADLLPQIDRLDLAYRAH
HCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852