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The map label for this gene is obgE

Identifier: 17547539

GI number: 17547539

Start: 3033574

End: 3034674

Strand: Reverse

Name: obgE

Synonym: RSc2820

Alternate gene names: 17547539

Gene position: 3034674-3033574 (Counterclockwise)

Preceding gene: 17547540

Following gene: 17547538

Centisome position: 81.66

GC content: 67.03

Gene sequence:

>1101_bases
ATGAAGTTCATCGACGAAGCCCGGATTGAAGTGATCGCTGGTGACGGCGGCAACGGCAGCGCTTCGATGCGCCGCGAGAA
ATTCGTCCCGTTCGGTGGCCCCGACGGTGGCGACGGTGGCCGCGGCGGCAGCGTGTGGGCGGTGGCCGACCGCAATATCA
ACACCCTGATCGACTACCGCTTCGCCAAGAAGCACCTGGCGCGCAACGGCGAAAACGGCCGCGGCTCCGACTGTTATGGT
GCGGCCGGCGAAGACATCACGCTGCGGCTGCCGGTCGGCACCGCCATCTATGACGCCGATACCGATGAGCAGATCGCCGA
CCTGACGCTCGATGGCCAGCGCCTGTGCCTGGCGCGCGGCGGTGAGGGCGGCTGGGGCAACATCCACTTCAAGTCGAGCA
CCAACCGCGCACCGCGCCAGAAGACCGACGGCAAGCCCGGCGAGCGCCGCAACCTGCGGCTGGAGCTGAAGGTGTTGGCC
GACGTCGGTTTGCTGGGCATGCCCAACGCCGGCAAGTCGACGCTGATCACGGCCATTTCCAACGCTCGCCCGAAGATCGC
CGACTATCCGTTCACGACGCTGCATCCCAACCTGGGCGTGGTCCGCACCGGGCCGTCGAAGTCGTTCGTGGTGGCCGATA
TCCCGGGCCTGATCGAAGGCGCTGCCGAGGGTGCGGGCCTGGGCCACCAGTTCCTGCGCCACCTGCAGCGCACGCGCGTG
CTGCTGCACGTGGTGGACCTCGCTCCGTTCGACGAGGGCATCGACCCGGTGGCCGAAGCCAAGGCGATCGTCGGCGAACT
GAAGAAATACGACGCCGAACTGTACGACAAGCCGCGCTGGCTGGTGCTCAACAAGCTCGACATGGTGCCCGAGGACGAAC
GCGAGGCGCGCGTGAAGGACTTCATCAAGCGCTTCAAGTGGAAAGGGCCGGTGCACCGCATTTCCGCGCTGACGCACGAC
GGCTGTCCGGGCCTGATCCACGCGATCCAGGACTACCTCGATACGCTGCGTGCCGAAGAGGAGGCCGCCGCTGCCGCGCC
GGACGCGCGCCTCGACCCGACGCTGCACAACGTCGACCACGACGGCAGCGCCAACGCATAA

Upstream 100 bases:

>100_bases
TCCTGGGCGATACGATGTCGCAGGCGCGTTCTGTTAGCGATGGCGCAGCAGCGCCGATTCTTTGACCTGCCGTGCGCACG
CCGCACGGGCGGAGACCTCC

Downstream 100 bases:

>100_bases
CACCGCAGCATCACAACACTTCGTCTCCGGAGACTCGCCCACCATGGCCCTGCGTTCGCTGATCGCCGATGCGCGCCGCC
TCGTCGTCAAGGTCGGTTCC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYRFAKKHLARNGENGRGSDCYG
AAGEDITLRLPVGTAIYDADTDEQIADLTLDGQRLCLARGGEGGWGNIHFKSSTNRAPRQKTDGKPGERRNLRLELKVLA
DVGLLGMPNAGKSTLITAISNARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
LLHVVDLAPFDEGIDPVAEAKAIVGELKKYDAELYDKPRWLVLNKLDMVPEDEREARVKDFIKRFKWKGPVHRISALTHD
GCPGLIHAIQDYLDTLRAEEEAAAAAPDARLDPTLHNVDHDGSANA

Sequences:

>Translated_366_residues
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYRFAKKHLARNGENGRGSDCYG
AAGEDITLRLPVGTAIYDADTDEQIADLTLDGQRLCLARGGEGGWGNIHFKSSTNRAPRQKTDGKPGERRNLRLELKVLA
DVGLLGMPNAGKSTLITAISNARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
LLHVVDLAPFDEGIDPVAEAKAIVGELKKYDAELYDKPRWLVLNKLDMVPEDEREARVKDFIKRFKWKGPVHRISALTHD
GCPGLIHAIQDYLDTLRAEEEAAAAAPDARLDPTLHNVDHDGSANA
>Mature_366_residues
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYRFAKKHLARNGENGRGSDCYG
AAGEDITLRLPVGTAIYDADTDEQIADLTLDGQRLCLARGGEGGWGNIHFKSSTNRAPRQKTDGKPGERRNLRLELKVLA
DVGLLGMPNAGKSTLITAISNARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
LLHVVDLAPFDEGIDPVAEAKAIVGELKKYDAELYDKPRWLVLNKLDMVPEDEREARVKDFIKRFKWKGPVHRISALTHD
GCPGLIHAIQDYLDTLRAEEEAAAAAPDARLDPTLHNVDHDGSANA

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=345, Percent_Identity=38.2608695652174, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI111955139, Length=364, Percent_Identity=34.8901098901099, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI111955063, Length=268, Percent_Identity=33.5820895522388, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4758796, Length=156, Percent_Identity=31.4102564102564, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI58761500, Length=136, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789574, Length=343, Percent_Identity=57.1428571428571, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1787454, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790615, Length=210, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=335, Percent_Identity=38.8059701492537, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17552324, Length=312, Percent_Identity=31.7307692307692, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=31.6546762589928, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=186, Percent_Identity=37.6344086021505, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321773, Length=156, Percent_Identity=29.4871794871795, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=38.9067524115756, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129375, Length=328, Percent_Identity=35.9756097560976, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24640873, Length=135, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24640877, Length=135, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24640875, Length=135, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17981711, Length=156, Percent_Identity=29.4871794871795, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_RALSO (Q8XVL0)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520941.1
- HSSP:   P20964
- ProteinModelPortal:   Q8XVL0
- SMR:   Q8XVL0
- GeneID:   1221667
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2820
- NMPDR:   fig|267608.1.peg.2820
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12299
- BioCyc:   RSOL267608:RSC2820-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 39617; Mature: 39617

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
FAKKHLARNGENGRGSDCYGAAGEDITLRLPVGTAIYDADTDEQIADLTLDGQRLCLARG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHEEEECCCEEEEEEC
GEGGWGNIHFKSSTNRAPRQKTDGKPGERRNLRLELKVLADVGLLGMPNAGKSTLITAIS
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEHH
NARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
CCCCCCCCCCCEEECCCCCEEEECCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPFDEGIDPVAEAKAIVGELKKYDAELYDKPRWLVLNKLDMVPEDEREARVKD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
FIKRFKWKGPVHRISALTHDGCPGLIHAIQDYLDTLRAEEEAAAAAPDARLDPTLHNVDH
HHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DGSANA
CCCCCC
>Mature Secondary Structure
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
FAKKHLARNGENGRGSDCYGAAGEDITLRLPVGTAIYDADTDEQIADLTLDGQRLCLARG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHEEEECCCEEEEEEC
GEGGWGNIHFKSSTNRAPRQKTDGKPGERRNLRLELKVLADVGLLGMPNAGKSTLITAIS
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEHH
NARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
CCCCCCCCCCCEEECCCCCEEEECCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPFDEGIDPVAEAKAIVGELKKYDAELYDKPRWLVLNKLDMVPEDEREARVKD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHH
FIKRFKWKGPVHRISALTHDGCPGLIHAIQDYLDTLRAEEEAAAAAPDARLDPTLHNVDH
HHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DGSANA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852