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The map label for this gene is dgoAb [H]

Identifier: 17547470

GI number: 17547470

Start: 2962960

End: 2964108

Strand: Reverse

Name: dgoAb [H]

Synonym: RSc2751

Alternate gene names: 17547470

Gene position: 2964108-2962960 (Counterclockwise)

Preceding gene: 17547471

Following gene: 17547469

Centisome position: 79.76

GC content: 69.97

Gene sequence:

>1149_bases
ATGAAGATCACCCGACTGACCACCTACCGCCTGCCGCCGCGCTGGATGTTCCTGAAGATCGAGACCGACGAGGGCGTCGC
CGGCTGGGGCGAGCCCGTCATCGAAGGCCGCGCGCGTACGGTGGAAGCGGCGGTGCACGAACTGGCCGACTACCTCGTCG
GCCAGGACCCGCGCCGCATCAACGACCTGTGGCAGACGCTGTACCGCGGCGGCTTCTATCGGGGCGGGCCGATCCTGATG
AGCGCCATCGCCGGCATCGACCAGGCGTTGTGGGACATCAAGGGCAAGGTGCTGGGCGTGCCGGTGTACGAGCTGCTCGG
CGGCCTGGTGCGCGACCGCATGCGCACCTACAGCTGGGTCGGCGGCGACCGCCCCGCCGACGTGATCGCCGGCATGAAGG
CGCTGCAGGCCGGCGGCTTCGACCATTTCAAGCTCAACGGCTGCGAGGAGATGGGCATCATCGACAGCGCGCGCGCCGTG
GATGCCGCGGTGGCGCGCGTAGCGGAGATCCGCGCGGCTTTCGGCAACACGGTCGAGTTCGGGCTGGATTTCCACGGCCG
CGTGTCGGCGCCGATGGCCAAGGTGCTGATCCGGGCGCTGGAGCCGTACCGCCCGCTGTTCATCGAGGAACCCGTGCTGG
CCGAACAGGCCGAGAGCTATGCCCGCCTGGCCGCGCAGACCCACCTGCCGATCGCGGCCGGCGAGCGCATGTTCTCGCGC
TTCGAGTTCAAGCGGGTGCTGGAGGCGGGTGGCCTGGCGATCCTGCAGCCGGACCTGTCGCACGCCGGCGGCATCACCGA
ATGCCTGAAGATCGCCGGCATGGCCGAGGCCTACGATGTGGCGCTGGCGCCGCACTGCCCGCTCGGGCCGATCGCGCTGG
CGGCCTGCCTGCACATCGACTTCGTCAGCTGGAACGCCACGCTGCAGGAGCAGAGCATGGGCATCCACTACAACCAGGGC
GCCGAACTGCTCGACTATGTGCGCAACAAGGCCGATTTCGCGCTGGAAGGCGGCTACATCCGGCCGCCGCGCCTGCCCGG
ACTGGGCGTGGACATCGACGAGGCGCTGGTCATCGAGCGCAGCCGCAGCGCGCCGGACTGGCGCAACCCGGTCTGGCGGC
ACGCGGACGGGTCCGTGGCGGAGTGGTGA

Upstream 100 bases:

>100_bases
ATCTGTACCGCCCGGGCCAGGCCGCCGACGAGACGGCCGATCGTGCCCGGCGGTTCGTCCAGGCTTACCGCACCGTCCAA
TCCGACCGCACCATCCACCC

Downstream 100 bases:

>100_bases
GCCTCGCGGGCGGCGGGGGTGCAGCGGTTTGCCGCAAACGTCAAAGCTGCCCCGGCCGGGTGATCTCTGTCTGGTAAAAT
CGCGCTTTTCCCGCCTTCCA

Product: galactonate dehydratase

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKITRLTTYRLPPRWMFLKIETDEGVAGWGEPVIEGRARTVEAAVHELADYLVGQDPRRINDLWQTLYRGGFYRGGPILM
SAIAGIDQALWDIKGKVLGVPVYELLGGLVRDRMRTYSWVGGDRPADVIAGMKALQAGGFDHFKLNGCEEMGIIDSARAV
DAAVARVAEIRAAFGNTVEFGLDFHGRVSAPMAKVLIRALEPYRPLFIEEPVLAEQAESYARLAAQTHLPIAAGERMFSR
FEFKRVLEAGGLAILQPDLSHAGGITECLKIAGMAEAYDVALAPHCPLGPIALAACLHIDFVSWNATLQEQSMGIHYNQG
AELLDYVRNKADFALEGGYIRPPRLPGLGVDIDEALVIERSRSAPDWRNPVWRHADGSVAEW

Sequences:

>Translated_382_residues
MKITRLTTYRLPPRWMFLKIETDEGVAGWGEPVIEGRARTVEAAVHELADYLVGQDPRRINDLWQTLYRGGFYRGGPILM
SAIAGIDQALWDIKGKVLGVPVYELLGGLVRDRMRTYSWVGGDRPADVIAGMKALQAGGFDHFKLNGCEEMGIIDSARAV
DAAVARVAEIRAAFGNTVEFGLDFHGRVSAPMAKVLIRALEPYRPLFIEEPVLAEQAESYARLAAQTHLPIAAGERMFSR
FEFKRVLEAGGLAILQPDLSHAGGITECLKIAGMAEAYDVALAPHCPLGPIALAACLHIDFVSWNATLQEQSMGIHYNQG
AELLDYVRNKADFALEGGYIRPPRLPGLGVDIDEALVIERSRSAPDWRNPVWRHADGSVAEW
>Mature_382_residues
MKITRLTTYRLPPRWMFLKIETDEGVAGWGEPVIEGRARTVEAAVHELADYLVGQDPRRINDLWQTLYRGGFYRGGPILM
SAIAGIDQALWDIKGKVLGVPVYELLGGLVRDRMRTYSWVGGDRPADVIAGMKALQAGGFDHFKLNGCEEMGIIDSARAV
DAAVARVAEIRAAFGNTVEFGLDFHGRVSAPMAKVLIRALEPYRPLFIEEPVLAEQAESYARLAAQTHLPIAAGERMFSR
FEFKRVLEAGGLAILQPDLSHAGGITECLKIAGMAEAYDVALAPHCPLGPIALAACLHIDFVSWNATLQEQSMGIHYNQG
AELLDYVRNKADFALEGGYIRPPRLPGLGVDIDEALVIERSRSAPDWRNPVWRHADGSVAEW

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=416, Percent_Identity=24.2788461538462, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI186972148, Length=359, Percent_Identity=23.3983286908078, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994953, Length=382, Percent_Identity=81.6753926701571, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1787864, Length=414, Percent_Identity=29.951690821256, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI226510960, Length=275, Percent_Identity=30.5454545454545, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 42031; Mature: 42031

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00908 MR_MLE_1 ; PS00909 MR_MLE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITRLTTYRLPPRWMFLKIETDEGVAGWGEPVIEGRARTVEAAVHELADYLVGQDPRRI
CCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCHHH
NDLWQTLYRGGFYRGGPILMSAIAGIDQALWDIKGKVLGVPVYELLGGLVRDRMRTYSWV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCC
GGDRPADVIAGMKALQAGGFDHFKLNGCEEMGIIDSARAVDAAVARVAEIRAAFGNTVEF
CCCCHHHHHHHHHHHHCCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
GLDFHGRVSAPMAKVLIRALEPYRPLFIEEPVLAEQAESYARLAAQTHLPIAAGERMFSR
CCCCCCCCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FEFKRVLEAGGLAILQPDLSHAGGITECLKIAGMAEAYDVALAPHCPLGPIALAACLHID
HHHHHHHHHCCEEEECCCCHHCCCHHHHHHHHCCHHHHHEEECCCCCCHHHHHHHHHHHH
FVSWNATLQEQSMGIHYNQGAELLDYVRNKADFALEGGYIRPPRLPGLGVDIDEALVIER
EEECCCCHHHHCCCCEECCCHHHHHHHHCCCCEEEECCEECCCCCCCCCCCCCHHHEEEC
SRSAPDWRNPVWRHADGSVAEW
CCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKITRLTTYRLPPRWMFLKIETDEGVAGWGEPVIEGRARTVEAAVHELADYLVGQDPRRI
CCCEEEEEEECCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCHHH
NDLWQTLYRGGFYRGGPILMSAIAGIDQALWDIKGKVLGVPVYELLGGLVRDRMRTYSWV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCC
GGDRPADVIAGMKALQAGGFDHFKLNGCEEMGIIDSARAVDAAVARVAEIRAAFGNTVEF
CCCCHHHHHHHHHHHHCCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
GLDFHGRVSAPMAKVLIRALEPYRPLFIEEPVLAEQAESYARLAAQTHLPIAAGERMFSR
CCCCCCCCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FEFKRVLEAGGLAILQPDLSHAGGITECLKIAGMAEAYDVALAPHCPLGPIALAACLHID
HHHHHHHHHCCEEEECCCCHHCCCHHHHHHHHCCHHHHHEEECCCCCCHHHHHHHHHHHH
FVSWNATLQEQSMGIHYNQGAELLDYVRNKADFALEGGYIRPPRLPGLGVDIDEALVIER
EEECCCCHHHHCCCCEECCCHHHHHHHHCCCCEEEECCEECCCCCCCCCCCCCHHHEEEC
SRSAPDWRNPVWRHADGSVAEW
CCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA