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The map label for this gene is tktA [H]

Identifier: 17547469

GI number: 17547469

Start: 2960819

End: 2962846

Strand: Reverse

Name: tktA [H]

Synonym: RSc2750

Alternate gene names: 17547469

Gene position: 2962846-2960819 (Counterclockwise)

Preceding gene: 17547470

Following gene: 17547468

Centisome position: 79.72

GC content: 68.54

Gene sequence:

>2028_bases
ATGTCCGCTCCCGCCCTCCATTCGATCACCTCACTGCCCACCCAGCAGATGGCCAATGCCATCCGCGTGCTTGCGATGGA
CGCCGTCCAGCAAGCCAACTCGGGCCACCCCGGCATGCCGATGGGCATGGCGGACATCGCCGTGGCGCTGTGGAGCCGCC
ACCTGCGCCACAACCCGGCGAACCCGCACTGGCCCGACCGCGACCGCTTCGTGCTGTCCAACGGCCACGGTTCGATGCTG
CTGTACGCGCTGCTGCACCTGACCGGCTACGACCTGCCGATGTCGGAACTGAAGAACTTCCGCCAGCTGCACAGCAAGAC
CGCCGGCCACCCCGAATACGGCATCACGCCGGGCGTGGAAACCACCACCGGCCCGCTGGGGCAGGGCCTCACCAACGCGG
TCGGCATGGCGCTGGCCGAGCGCCTGCTGGGCCAGGAATTCAACCGTCCCGGCTTCGACATCGTCAACCACCACACCTAC
GTCTTCCTGGGTGACGGCTGCCTGATGGAAGGCATCAGCCACGAAGCCTGCTCGCTGGCCGGCACGCTCGGTCTGAACAA
GCTGATCGCGCTGTGGGACGACAACGGCATCTCGATCGACGGCGACGTCGTCCACTGGTTCAACGACGACACGCCCAAGC
GCTTCGAAGCCTATGGCTGGAATGTGATCCGCGCCGTCGACGGCCACAATGTCGCCGCCGTGGAAGCCGCCATCGCGCAG
GCCAAGACGTCCGACAAGCCGACCCTGATCTGCTGCCGCACCGTGATCGGCAAGGGCGCGCCCACCAAGGCGGGCGGCCA
CGACGTGCATGGCGCGCCGCTGGGCGGTGCCGAGATCGCCGCCGCGCGCGAGGCGCTGGCCTGGCCGCATGCGCCGTTCG
ACGTGCCGCAGGCCGTGTACGACGCGTGGGATGCGCGCGGCCAGGGTCAGGCGCTCGAAAAGGCCTGGAACGCACTGTTC
GATGCCTATGCCGAGCGCTATCCGGCCGAAGCCGGGCAGTTCCAGCGCCGCATGCGCGGCCAGTTGCCGGAAGCCTTCGA
GCAGGCCGCCGCCGAATTCATCGAGAAGTGCGAGCTGAAGGCCGAGACCATCGCCACCCGCAAGGCCAGCCAGAACACGC
TGGAAGCCTACGGCCCGGTGCTGCCTGAGCTGCTGGGCGGCTCGGCCGACCTGACCGGCTCGAACCTGACCAACTGGAGC
GGCAGCAAGGCCGTGCGCGTGGATGCCTGGGGCAACCACGTCAACTACGGCGTGCGCGAGTTCGGCATGAGCGCCATCAT
GAACGGCATCGCGCTGCACGGCGGCTACATCCCGTACGGCGGCACGTTCCTGACCTTCTCCGACTACAGCCGCAACGCGC
TGCGCATGGCGGCGCTGATGAAGCTCCGCTCGCTGTTCGTCTTCACGCACGATTCCATCGGCCTGGGCGAAGACGGCCCG
ACGCACCAGTCGATCGAGCACGTCGCCAGCCTGCGCCTGATCCCGAACATGGACGTCTGGCGCACGGCCGACACCACTGA
AACCGCCGTCGCCTGGGCCGCCGCCATCGCGCGCCAGAACGGCCCGAGCTGCCTGATCTTCAGCCGCCAGAACCTGCCGT
TCCAGGCGCGCAACCCGGCCACCCGCGAAGCCATTGCCCGAGGCGGTTATGTGCTGCGCGATGCGACCGAAGGCAAGCGC
CCGGACGTGGTCATCATCGCCACCGGCTCGGAAGTGGGCCTGGCCGTCGGCGCCGCCGAGCACCTCGCCGCCGAGGGCAT
CCAGGCGCGCGTGGTGTCGGTGCCGTCGACCACCGTGTTCGACAAGCAGGACGCCGCCTACAAGGCCAGCGTGCTGCCGG
CCGGCGTGCCGCGCATCGCCGTCGAGGCGGGCGTGACCGATTTCTGGTGGAAGTACCAGGTGCAGGCCGTCGTCGGCATC
GACACGTTCGGCGAGTCGGCCCCGGCGGGCGTGCTGTTCAAGCACTTCGGCTTCACCGTCGAGAACGTGGTGAACACAGC
CAAGAGCGTCATCGCTCCGGCTGTCTGA

Upstream 100 bases:

>100_bases
CGGGGGTGCAGCGGTTTGCCGCAAACGTCAAAGCTGCCCCGGCCGGGTGATCTCTGTCTGGTAAAATCGCGCTTTTCCCG
CCTTCCAGCCGCAGGTTCGC

Downstream 100 bases:

>100_bases
CAAGTTACCGCGCGGCACCCTTGAGGTGCCGCGTTGCCATCGTCGATTTCATTTTGCTATCAGGAGACTGATCATGACCA
TCAAGATCGGCATCAACGGC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MSAPALHSITSLPTQQMANAIRVLAMDAVQQANSGHPGMPMGMADIAVALWSRHLRHNPANPHWPDRDRFVLSNGHGSML
LYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGLTNAVGMALAERLLGQEFNRPGFDIVNHHTY
VFLGDGCLMEGISHEACSLAGTLGLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVAAVEAAIAQ
AKTSDKPTLICCRTVIGKGAPTKAGGHDVHGAPLGGAEIAAAREALAWPHAPFDVPQAVYDAWDARGQGQALEKAWNALF
DAYAERYPAEAGQFQRRMRGQLPEAFEQAAAEFIEKCELKAETIATRKASQNTLEAYGPVLPELLGGSADLTGSNLTNWS
GSKAVRVDAWGNHVNYGVREFGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKLRSLFVFTHDSIGLGEDGP
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIARQNGPSCLIFSRQNLPFQARNPATREAIARGGYVLRDATEGKR
PDVVIIATGSEVGLAVGAAEHLAAEGIQARVVSVPSTTVFDKQDAAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGI
DTFGESAPAGVLFKHFGFTVENVVNTAKSVIAPAV

Sequences:

>Translated_675_residues
MSAPALHSITSLPTQQMANAIRVLAMDAVQQANSGHPGMPMGMADIAVALWSRHLRHNPANPHWPDRDRFVLSNGHGSML
LYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGLTNAVGMALAERLLGQEFNRPGFDIVNHHTY
VFLGDGCLMEGISHEACSLAGTLGLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVAAVEAAIAQ
AKTSDKPTLICCRTVIGKGAPTKAGGHDVHGAPLGGAEIAAAREALAWPHAPFDVPQAVYDAWDARGQGQALEKAWNALF
DAYAERYPAEAGQFQRRMRGQLPEAFEQAAAEFIEKCELKAETIATRKASQNTLEAYGPVLPELLGGSADLTGSNLTNWS
GSKAVRVDAWGNHVNYGVREFGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKLRSLFVFTHDSIGLGEDGP
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIARQNGPSCLIFSRQNLPFQARNPATREAIARGGYVLRDATEGKR
PDVVIIATGSEVGLAVGAAEHLAAEGIQARVVSVPSTTVFDKQDAAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGI
DTFGESAPAGVLFKHFGFTVENVVNTAKSVIAPAV
>Mature_674_residues
SAPALHSITSLPTQQMANAIRVLAMDAVQQANSGHPGMPMGMADIAVALWSRHLRHNPANPHWPDRDRFVLSNGHGSMLL
YALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGLTNAVGMALAERLLGQEFNRPGFDIVNHHTYV
FLGDGCLMEGISHEACSLAGTLGLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVAAVEAAIAQA
KTSDKPTLICCRTVIGKGAPTKAGGHDVHGAPLGGAEIAAAREALAWPHAPFDVPQAVYDAWDARGQGQALEKAWNALFD
AYAERYPAEAGQFQRRMRGQLPEAFEQAAAEFIEKCELKAETIATRKASQNTLEAYGPVLPELLGGSADLTGSNLTNWSG
SKAVRVDAWGNHVNYGVREFGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKLRSLFVFTHDSIGLGEDGPT
HQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIARQNGPSCLIFSRQNLPFQARNPATREAIARGGYVLRDATEGKRP
DVVIIATGSEVGLAVGAAEHLAAEGIQARVVSVPSTTVFDKQDAAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGID
TFGESAPAGVLFKHFGFTVENVVNTAKSVIAPAV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=606, Percent_Identity=27.7227722772277, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI4507521, Length=606, Percent_Identity=27.7227722772277, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI133778974, Length=588, Percent_Identity=27.891156462585, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI225637459, Length=263, Percent_Identity=27.7566539923954, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637461, Length=263, Percent_Identity=26.615969581749, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI225637463, Length=228, Percent_Identity=27.6315789473684, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=64.5990922844176, Blast_Score=902, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=664, Percent_Identity=61.2951807228916, Blast_Score=851, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=592, Percent_Identity=27.1959459459459, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=49.2492492492492, Blast_Score=603, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=45.1951951951952, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45551847, Length=689, Percent_Identity=26.2699564586357, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45550715, Length=689, Percent_Identity=26.2699564586357, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24645119, Length=654, Percent_Identity=26.1467889908257, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24666278, Length=278, Percent_Identity=33.0935251798561, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72422; Mature: 72290

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPALHSITSLPTQQMANAIRVLAMDAVQQANSGHPGMPMGMADIAVALWSRHLRHNPA
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
NPHWPDRDRFVLSNGHGSMLLYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVE
CCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
TTTGPLGQGLTNAVGMALAERLLGQEFNRPGFDIVNHHTYVFLGDGCLMEGISHEACSLA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHCCCHHHHHHH
GTLGLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVAAVEAAIAQ
HHHCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHHH
AKTSDKPTLICCRTVIGKGAPTKAGGHDVHGAPLGGAEIAAAREALAWPHAPFDVPQAVY
HCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHH
DAWDARGQGQALEKAWNALFDAYAERYPAEAGQFQRRMRGQLPEAFEQAAAEFIEKCELK
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AETIATRKASQNTLEAYGPVLPELLGGSADLTGSNLTNWSGSKAVRVDAWGNHVNYGVRE
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHH
FGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKLRSLFVFTHDSIGLGEDGP
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCC
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIARQNGPSCLIFSRQNLPFQARNPA
CHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCH
TREAIARGGYVLRDATEGKRPDVVIIATGSEVGLAVGAAEHLAAEGIQARVVSVPSTTVF
HHHHHHHCCEEEEECCCCCCCCEEEEECCCCCCEEHHHHHHHHHCCCEEEEEECCCCEEE
DKQDAAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGIDTFGESAPAGVLFKHFGFTV
CCCCCCHHHHCCCCCCCHHHHHCCCCHHEEEEEEEEEEEEECCCCCCCCHHHHHHHCCCH
ENVVNTAKSVIAPAV
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAPALHSITSLPTQQMANAIRVLAMDAVQQANSGHPGMPMGMADIAVALWSRHLRHNPA
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
NPHWPDRDRFVLSNGHGSMLLYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVE
CCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
TTTGPLGQGLTNAVGMALAERLLGQEFNRPGFDIVNHHTYVFLGDGCLMEGISHEACSLA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHCCCHHHHHHH
GTLGLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVAAVEAAIAQ
HHHCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHHH
AKTSDKPTLICCRTVIGKGAPTKAGGHDVHGAPLGGAEIAAAREALAWPHAPFDVPQAVY
HCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHH
DAWDARGQGQALEKAWNALFDAYAERYPAEAGQFQRRMRGQLPEAFEQAAAEFIEKCELK
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AETIATRKASQNTLEAYGPVLPELLGGSADLTGSNLTNWSGSKAVRVDAWGNHVNYGVRE
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHH
FGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKLRSLFVFTHDSIGLGEDGP
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCC
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIARQNGPSCLIFSRQNLPFQARNPA
CHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCH
TREAIARGGYVLRDATEGKRPDVVIIATGSEVGLAVGAAEHLAAEGIQARVVSVPSTTVF
HHHHHHHCCEEEEECCCCCCCCEEEEECCCCCCEEHHHHHHHHHCCCEEEEEECCCCEEE
DKQDAAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGIDTFGESAPAGVLFKHFGFTV
CCCCCCHHHHCCCCCCCHHHHHCCCCHHEEEEEEEEEEEEECCCCCCCCHHHHHHHCCCH
ENVVNTAKSVIAPAV
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]