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The map label for this gene is leuS [H]

Identifier: 17547463

GI number: 17547463

Start: 2953327

End: 2955960

Strand: Reverse

Name: leuS [H]

Synonym: RSc2744

Alternate gene names: 17547463

Gene position: 2955960-2953327 (Counterclockwise)

Preceding gene: 17547464

Following gene: 17547462

Centisome position: 79.54

GC content: 66.51

Gene sequence:

>2634_bases
ATGCAAGACAAATATTCCCCGTCCGAGGTCGAACAGCAGGCGCAGCAACACTGGCAGGCACAGGATGCCTACCGCGTGAC
CGAACACGCGCGCGCCGCCGACGGCTCGGACAAGCCCAAGTTCTACGCCTGTTCGATGCTGCCGTACCCGTCGGGCAAGC
TGCACATGGGCCACGTGCGCAACTACACCATCAACGACGTGATGATGCGTCAGCTGCGCATGAAGGGGTACAACGTGCTG
ATGCCGATGGGCTGGGACGCCTTCGGCATGCCGGCCGAGAACGCCGCGCTGAACAACGGCGTGGCGCCGGCCGCCTGGAC
CTACGACAACATCGCTTACATGAAGAAGCAGATGCAGTCGATGGGCCTGGCGATCGACTGGTCGCGCGAGGTGGCGACCT
GCAGTCCCGACTACTACAAGTGGAACCAGTGGCTGTTCCTGAAGATGCTCGAGAAGGGCATCGCCTACCGCAAGACCGGC
ACCGTCAACTGGGACCCGATCGACCAGACCGTGCTCGCCAACGAGCAGGTGATCGACGGGCGCGGCTGGCGCTCGGGCGC
GGTGGTGGAAAAGCGCGAGATCCCGATGTACTACCTGCGCATCACCGACTATGCGCAGGAGTTGCTGTCCGACCTGGACC
CGCTGGGCTGGCCCGAGCGCGTCAAGCTGATGCAGCAGAACTGGATCGGCAAGAGCGAGGGTGTGCGCTTCGCCTTCCCG
CACGGCATTCCCGGCGATGACGGCAAGGTGATCGGCGACGGCAAGCTGTACGTCTTCACCACGCGCGCCGACACCATCAT
GGGCGTGACCTTCTGCGCCGTGGCCGCCGAGCACCCGATCGCCGCGCATGCCGCGCAGGGCAATCCCGCGCTTGCCGCGT
TCATCGACGAATGCAAGCATGGCAGCGTGATGGAAGCCGACATGGCGACCATGGAAAAGAAGGGCATGCCGACCGGCCTG
ACCGTCACGCATCCGCTCACCGGCGAGGCCGTGCCCGTGTGGGTCGGCAACTACGTGCTGATGACCTACGGCGACGGCGC
CGTGATGGGCGTGCCCGCGCACGACGAGCGCGACTTCGCCTTCGCCAACAAGTACGGCTTGGCCATCAAGCAGGTCATCG
ACGTGAAGGGCCAGCCGTTCGGCACCGAAGCCTGGCAGGAGTGGTATGCCGACAAGGAGCGCGGCGTGCTGGTCCACAGC
GGCAAGTACGACGGCCTGGACTATCGGCAGGCCGTGGATGCCGTCGCCGCCGACCTGGCCGCCCAGGGCCTGGGCGAGAA
GAAAACCACCTGGCGCCTGCGCGACTGGGGTATCTCGCGCCAGCGCTACTGGGGCACGCCGATCCCGCTGATCCATTGCG
ACAGCTGCGGCGTGGTGCCGGTGCCGGAACAGGACCTGCCGGTGCGTCTGCCCGAAGACCTGGTGCCGGACGGCAGCGGC
AACCCGCTCGCCAAGGACGCGCGCTTCCTGGAGTGCACGTGCCCGTCGTGCGGCAAGCCTGCGCGCCGCGAGACCGACAC
GATGGATACCTTCATCGATTCGTGCTGGTACTACATGCGCTATACGTGCCCGGACGGCGCCACCATGGTCGACGGCCGCA
ACGATTACTGGATGCCGATGGACCAGTACATCGGCGGCATCGAGCACGCGATCCTGCACCTGCTGTACGCGCGCTTCTGG
ACCAAGGTCATGCGTGATCTGGGCCTGGTCAAGTTCGACGAGCCGTTCACCAAGCTGCTGACGCAGGGCATGGTGCTCAA
CGAGACGTACTACCGCGAAGACGCGGCCGGCAAGAAGCAGTGGATCAACCCGGCCGACGTGGATGTACAGACCGACGACC
GCGGCCGCCCGATCGGCGCGACGCTCAAGGCCGACGGCCAGCCGGTGGTGATCGGCGGCGTTGAGAAGATGTCGAAGTCG
AAGAACAACGGCATCGATCCGCAGGCCCTGATCGACCAGTACGGTGCAGACACCGCGCGCCTGTTCACGATGTTTGCCGC
GCCGCCCGAGCAGCAGCTGGAGTGGAGCGATGCCGGCGTGGAGGGCGCCTCGCGCTTCCTGCGCCGGGCGTGGAACTTCG
GCGTGGCGCATGCGGAGTCCATCCGTGCCGGCCACGGCAACGGCGTGGTCAACGGCGCAACGGATGCCGATCGCGCGCTG
CGCCGCGAGCTGCACACCGTGCTCAAGCAAGCCAACTACGATTACGAGCGCCTGCAGTACAACACCGTCGTCTCGGCGGC
GATGAAGATGCTCAACGCGCTGGAAGGCGCCAAGGACGCCGGCGCGGATGCGCGCCGTGAGGGCCTGGGCATCCTGCTGC
GCGTGCTGTATCCGGTGGTGCCGCACATCACGCATGTGCTGTGGCAGGAGCTCGGTTACGCGGGTGCCTACGGCGGTCTG
CTCGACGCGCCCTGGCCGCAGGTCGACGAGGGCGCCCTGGTGCAGAGTGAGATCGAGCTCGTGCTGCAGGTCAACGGCAA
GGTGCGCGGCAGCATCGTGGTGCCGGCCGATGCCGACCGCGCCGCCATCGAGGCGATCGCGGCCAAGGATGAGGCCGTGC
ATCGCTTTGCCGAGGGCAAGCCGCCCAAGAAGATCATCGTGGTGCCGGGCCGCCTGGTCAACGTGGTGGCCTGA

Upstream 100 bases:

>100_bases
GGTATAATCGGGCCTTTTCCGTCATCGTCATTCAATCCCGGCTGCGCGCACTGGCGTCGCGGCCGCCATCGCCCCGGGGT
CTCCGGCGCGCTACGTCATC

Downstream 100 bases:

>100_bases
GCGCCGCCCATCCGCATCGAACGCAAGGAACGCATGGTTATGCCGTCTCGTCGCCGTTTCGTTCTCGCCCTGGCCGCTGC
GCTGCCGGCGGCGGGCCTGC

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 877; Mature: 877

Protein sequence:

>877_residues
MQDKYSPSEVEQQAQQHWQAQDAYRVTEHARAADGSDKPKFYACSMLPYPSGKLHMGHVRNYTINDVMMRQLRMKGYNVL
MPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQSMGLAIDWSREVATCSPDYYKWNQWLFLKMLEKGIAYRKTG
TVNWDPIDQTVLANEQVIDGRGWRSGAVVEKREIPMYYLRITDYAQELLSDLDPLGWPERVKLMQQNWIGKSEGVRFAFP
HGIPGDDGKVIGDGKLYVFTTRADTIMGVTFCAVAAEHPIAAHAAQGNPALAAFIDECKHGSVMEADMATMEKKGMPTGL
TVTHPLTGEAVPVWVGNYVLMTYGDGAVMGVPAHDERDFAFANKYGLAIKQVIDVKGQPFGTEAWQEWYADKERGVLVHS
GKYDGLDYRQAVDAVAADLAAQGLGEKKTTWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVRLPEDLVPDGSG
NPLAKDARFLECTCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDGATMVDGRNDYWMPMDQYIGGIEHAILHLLYARFW
TKVMRDLGLVKFDEPFTKLLTQGMVLNETYYREDAAGKKQWINPADVDVQTDDRGRPIGATLKADGQPVVIGGVEKMSKS
KNNGIDPQALIDQYGADTARLFTMFAAPPEQQLEWSDAGVEGASRFLRRAWNFGVAHAESIRAGHGNGVVNGATDADRAL
RRELHTVLKQANYDYERLQYNTVVSAAMKMLNALEGAKDAGADARREGLGILLRVLYPVVPHITHVLWQELGYAGAYGGL
LDAPWPQVDEGALVQSEIELVLQVNGKVRGSIVVPADADRAAIEAIAAKDEAVHRFAEGKPPKKIIVVPGRLVNVVA

Sequences:

>Translated_877_residues
MQDKYSPSEVEQQAQQHWQAQDAYRVTEHARAADGSDKPKFYACSMLPYPSGKLHMGHVRNYTINDVMMRQLRMKGYNVL
MPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQSMGLAIDWSREVATCSPDYYKWNQWLFLKMLEKGIAYRKTG
TVNWDPIDQTVLANEQVIDGRGWRSGAVVEKREIPMYYLRITDYAQELLSDLDPLGWPERVKLMQQNWIGKSEGVRFAFP
HGIPGDDGKVIGDGKLYVFTTRADTIMGVTFCAVAAEHPIAAHAAQGNPALAAFIDECKHGSVMEADMATMEKKGMPTGL
TVTHPLTGEAVPVWVGNYVLMTYGDGAVMGVPAHDERDFAFANKYGLAIKQVIDVKGQPFGTEAWQEWYADKERGVLVHS
GKYDGLDYRQAVDAVAADLAAQGLGEKKTTWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVRLPEDLVPDGSG
NPLAKDARFLECTCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDGATMVDGRNDYWMPMDQYIGGIEHAILHLLYARFW
TKVMRDLGLVKFDEPFTKLLTQGMVLNETYYREDAAGKKQWINPADVDVQTDDRGRPIGATLKADGQPVVIGGVEKMSKS
KNNGIDPQALIDQYGADTARLFTMFAAPPEQQLEWSDAGVEGASRFLRRAWNFGVAHAESIRAGHGNGVVNGATDADRAL
RRELHTVLKQANYDYERLQYNTVVSAAMKMLNALEGAKDAGADARREGLGILLRVLYPVVPHITHVLWQELGYAGAYGGL
LDAPWPQVDEGALVQSEIELVLQVNGKVRGSIVVPADADRAAIEAIAAKDEAVHRFAEGKPPKKIIVVPGRLVNVVA
>Mature_877_residues
MQDKYSPSEVEQQAQQHWQAQDAYRVTEHARAADGSDKPKFYACSMLPYPSGKLHMGHVRNYTINDVMMRQLRMKGYNVL
MPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQSMGLAIDWSREVATCSPDYYKWNQWLFLKMLEKGIAYRKTG
TVNWDPIDQTVLANEQVIDGRGWRSGAVVEKREIPMYYLRITDYAQELLSDLDPLGWPERVKLMQQNWIGKSEGVRFAFP
HGIPGDDGKVIGDGKLYVFTTRADTIMGVTFCAVAAEHPIAAHAAQGNPALAAFIDECKHGSVMEADMATMEKKGMPTGL
TVTHPLTGEAVPVWVGNYVLMTYGDGAVMGVPAHDERDFAFANKYGLAIKQVIDVKGQPFGTEAWQEWYADKERGVLVHS
GKYDGLDYRQAVDAVAADLAAQGLGEKKTTWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVRLPEDLVPDGSG
NPLAKDARFLECTCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDGATMVDGRNDYWMPMDQYIGGIEHAILHLLYARFW
TKVMRDLGLVKFDEPFTKLLTQGMVLNETYYREDAAGKKQWINPADVDVQTDDRGRPIGATLKADGQPVVIGGVEKMSKS
KNNGIDPQALIDQYGADTARLFTMFAAPPEQQLEWSDAGVEGASRFLRRAWNFGVAHAESIRAGHGNGVVNGATDADRAL
RRELHTVLKQANYDYERLQYNTVVSAAMKMLNALEGAKDAGADARREGLGILLRVLYPVVPHITHVLWQELGYAGAYGGL
LDAPWPQVDEGALVQSEIELVLQVNGKVRGSIVVPADADRAAIEAIAAKDEAVHRFAEGKPPKKIIVVPGRLVNVVA

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=883, Percent_Identity=37.2593431483579, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI5454158, Length=904, Percent_Identity=22.1238938053097, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1786861, Length=883, Percent_Identity=50.6228765571914, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=400, Percent_Identity=22.75, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71997510, Length=851, Percent_Identity=29.4947121034078, Blast_Score=349, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI71997517, Length=844, Percent_Identity=29.5023696682464, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI212645227, Length=371, Percent_Identity=28.8409703504043, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323414, Length=823, Percent_Identity=40.8262454434994, Blast_Score=578, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6321531, Length=404, Percent_Identity=25.2475247524752, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355409, Length=848, Percent_Identity=35.1415094339623, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281366294, Length=889, Percent_Identity=20.5849268841395, Blast_Score=90, Evalue=9e-18,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 97369; Mature: 97369

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKYSPSEVEQQAQQHWQAQDAYRVTEHARAADGSDKPKFYACSMLPYPSGKLHMGHVR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEECCCC
NYTINDVMMRQLRMKGYNVLMPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQS
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHH
MGLAIDWSREVATCSPDYYKWNQWLFLKMLEKGIAYRKTGTVNWDPIDQTVLANEQVIDG
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHCCCEEECC
RGWRSGAVVEKREIPMYYLRITDYAQELLSDLDPLGWPERVKLMQQNWIGKSEGVRFAFP
CCCCCCCEEEECCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECC
HGIPGDDGKVIGDGKLYVFTTRADTIMGVTFCAVAAEHPIAAHAAQGNPALAAFIDECKH
CCCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCC
GSVMEADMATMEKKGMPTGLTVTHPLTGEAVPVWVGNYVLMTYGDGAVMGVPAHDERDFA
CCEEHHHHHHHHHCCCCCCCEEECCCCCCEEEEEECCEEEEEECCCEEEECCCCCCCCCC
FANKYGLAIKQVIDVKGQPFGTEAWQEWYADKERGVLVHSGKYDGLDYRQAVDAVAADLA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
AQGLGEKKTTWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVRLPEDLVPDGSG
HHCCCCCCCEEEEHHCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCCCC
NPLAKDARFLECTCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDGATMVDGRNDYWMPM
CCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHEEEEEEECCCCCEEECCCCCCCCCH
DQYIGGIEHAILHLLYARFWTKVMRDLGLVKFDEPFTKLLTQGMVLNETYYREDAAGKKQ
HHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCEEECHHHHHCCCCCHHH
WINPADVDVQTDDRGRPIGATLKADGQPVVIGGVEKMSKSKNNGIDPQALIDQYGADTAR
CCCCCCCEEEECCCCCCCCEEEECCCCEEEEECHHHHHCCCCCCCCHHHHHHHHCCCHHH
LFTMFAAPPEQQLEWSDAGVEGASRFLRRAWNFGVAHAESIRAGHGNGVVNGATDADRAL
HHHEECCCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHH
RRELHTVLKQANYDYERLQYNTVVSAAMKMLNALEGAKDAGADARREGLGILLRVLYPVV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
PHITHVLWQELGYAGAYGGLLDAPWPQVDEGALVQSEIELVLQVNGKVRGSIVVPADADR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEEEEEEECCCEEEEEEECCCCCH
AAIEAIAAKDEAVHRFAEGKPPKKIIVVPGRLVNVVA
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCC
>Mature Secondary Structure
MQDKYSPSEVEQQAQQHWQAQDAYRVTEHARAADGSDKPKFYACSMLPYPSGKLHMGHVR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEECCCC
NYTINDVMMRQLRMKGYNVLMPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQS
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHH
MGLAIDWSREVATCSPDYYKWNQWLFLKMLEKGIAYRKTGTVNWDPIDQTVLANEQVIDG
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHCCCEEECC
RGWRSGAVVEKREIPMYYLRITDYAQELLSDLDPLGWPERVKLMQQNWIGKSEGVRFAFP
CCCCCCCEEEECCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEECC
HGIPGDDGKVIGDGKLYVFTTRADTIMGVTFCAVAAEHPIAAHAAQGNPALAAFIDECKH
CCCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCC
GSVMEADMATMEKKGMPTGLTVTHPLTGEAVPVWVGNYVLMTYGDGAVMGVPAHDERDFA
CCEEHHHHHHHHHCCCCCCCEEECCCCCCEEEEEECCEEEEEECCCEEEECCCCCCCCCC
FANKYGLAIKQVIDVKGQPFGTEAWQEWYADKERGVLVHSGKYDGLDYRQAVDAVAADLA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
AQGLGEKKTTWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVRLPEDLVPDGSG
HHCCCCCCCEEEEHHCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHCCCCCC
NPLAKDARFLECTCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDGATMVDGRNDYWMPM
CCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHEEEEEEECCCCCEEECCCCCCCCCH
DQYIGGIEHAILHLLYARFWTKVMRDLGLVKFDEPFTKLLTQGMVLNETYYREDAAGKKQ
HHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCEEECHHHHHCCCCCHHH
WINPADVDVQTDDRGRPIGATLKADGQPVVIGGVEKMSKSKNNGIDPQALIDQYGADTAR
CCCCCCCEEEECCCCCCCCEEEECCCCEEEEECHHHHHCCCCCCCCHHHHHHHHCCCHHH
LFTMFAAPPEQQLEWSDAGVEGASRFLRRAWNFGVAHAESIRAGHGNGVVNGATDADRAL
HHHEECCCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHH
RRELHTVLKQANYDYERLQYNTVVSAAMKMLNALEGAKDAGADARREGLGILLRVLYPVV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
PHITHVLWQELGYAGAYGGLLDAPWPQVDEGALVQSEIELVLQVNGKVRGSIVVPADADR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEEEEEEECCCEEEEEEECCCCCH
AAIEAIAAKDEAVHRFAEGKPPKKIIVVPGRLVNVVA
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA