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The map label for this gene is hutH [H]

Identifier: 17547365

GI number: 17547365

Start: 2846329

End: 2847885

Strand: Reverse

Name: hutH [H]

Synonym: RSc2646

Alternate gene names: 17547365

Gene position: 2847885-2846329 (Counterclockwise)

Preceding gene: 17547366

Following gene: 17547364

Centisome position: 76.63

GC content: 72.06

Gene sequence:

>1557_bases
ATGAATACCATGACCACGCCTTCCATCCTGACGCTGCATCCGGGCGAGATGACCTTTGCCGACCTGCGCCGCGTCTGGCT
GGCTCCCACGCCGGTGACGCTGTCGGGCGATTGCGCCGCGGCCATCGAGGCCTCGGCGGCGACCGTGCAGGCCATCGTCG
CCAGGGGCGAGCCCGCCTACGGCATCAATACCGGCTTCGGCAAGCTGGCCAGGACGCAGATCGCCACGCACGAGCTGGAG
CACCTGCAGCGCAACCTGATCCTGTCGCACGCGGTCGGCACCGGCCAGGATCTCGACGACAATGTCGCGCGCCTGGTGCT
GCTGATGAAGGCCGCCAGCCTCGCGCGCGGCTACTCCGGGGTGCGCCGCGTCGTCATCGACACGCTGCTGGCGATGCTCA
ACGCGGGCATCGTGCCGTGCATTCCGTCCAAGGGCTCGGTGGGCGCCTCCGGCGACCTGGCGCCGCTCGCGCACATGACC
CTGGCCATGCTGGGCGAGGGCGACGCGCGCGTGAACGGCGTGCGCAAGCCGGCACGCGAAGCCCTGGCCGCGGCGGGTAT
CGCGCCCATCGCGCTGGCCGCCAAAGAGGGGCTGGCGCTGATCAACGGCACCCAGGTGTCGACCGCGCTGGCGCTCAACG
GCCTGTTCCTGGCCGAGCGCCTGCTGCAGGCGGCCACCGTGGCCGGCGCGCTGTCGGTCGATGCGGCCAAGGGCAGCGAC
GCGCCGTTCGACCCGCGCGTGCACACGGTGCGCGGGCAGGCCGGGCAGATCGCCACCGCCGCGGTCTATCGCGGCCTGCT
GGCCGGCAGCGCCATCCGCCGCTCGCACCTGGTCGGCGACACGCGCGTGCAGGACCCGTACAGCCTGCGCTGCCAGCCGC
AGGTGATGGGCGCGTGCCTGGACCTGATCCGCCAGGCCGGCGCCACGCTGCTCACCGAAGCCAACGCCGTCACCGACAAC
CCGCTGGTCTACGCCGATGCGGGCGAGGTGATCTCGGGCGGCAACTTCCACGCCGAGCCGGTCGCCTTTGCCGCCGACAT
GCTGGCACTGGCGATCGCCGAGATCGGCGCGCTGTCGGAGCGGCGGATCGCGCTGCTGATCGATTCCACGCTGTCGGGCC
TGCCGCCGTTCCTGGTCGAGCAGCCGGGGCTGAATTCCGGCTTCATGATCGCGCACGTGACAGCGGCCGCGCTGGCCTCG
GAGAACAAGTCGCTGGCGCATCCGGCCAGCGTCGACAGCCTGCCGACCTCCGCCAACCAGGAAGACCACGTCAGCATGGC
CACCTTCGCCGGCCGCCGCCTGGCCGAGATGGCCGGCAACACCGCCACCATCGTCGGCATCGAGGCGCTGGCCGCCGCGC
AGGGCATCGACTTCCACCGGCCGCTCGCCACCTCCGACGCGCTGGCGCGCGCCCACACGTGCATCCGCTCGCGCGTGGCG
TACTACGGTGAAGACCGTCTGTTCGCGCCCGACATCGAAGCGGCCCGCCGCCTCGTGCTCGACGGCGACCTGGGCGACAG
CTGCCGCGCGCACCTGGCCGATCTGGCGCTCGCATGA

Upstream 100 bases:

>100_bases
TGATGCGCCATGCCGATGCCGGCTACGAGACCGCCGTCGCCTGCGCCAAGCGCAATGGCCTCAAATTGCCCATGATTGGT
TAACCGGATCCCGCATTGCC

Downstream 100 bases:

>100_bases
TCATGCACACCGAGGCCGATCCGACCGTCTGGCAAGGCCGCGTCGACGCGGAAGAGGGGGCGCTGGGCCAGCGCTGGCAC
CAGGTCGTGCGCAGCGCCGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNTMTTPSILTLHPGEMTFADLRRVWLAPTPVTLSGDCAAAIEASAATVQAIVARGEPAYGINTGFGKLARTQIATHELE
HLQRNLILSHAVGTGQDLDDNVARLVLLMKAASLARGYSGVRRVVIDTLLAMLNAGIVPCIPSKGSVGASGDLAPLAHMT
LAMLGEGDARVNGVRKPAREALAAAGIAPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVAGALSVDAAKGSD
APFDPRVHTVRGQAGQIATAAVYRGLLAGSAIRRSHLVGDTRVQDPYSLRCQPQVMGACLDLIRQAGATLLTEANAVTDN
PLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSERRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALAS
ENKSLAHPASVDSLPTSANQEDHVSMATFAGRRLAEMAGNTATIVGIEALAAAQGIDFHRPLATSDALARAHTCIRSRVA
YYGEDRLFAPDIEAARRLVLDGDLGDSCRAHLADLALA

Sequences:

>Translated_518_residues
MNTMTTPSILTLHPGEMTFADLRRVWLAPTPVTLSGDCAAAIEASAATVQAIVARGEPAYGINTGFGKLARTQIATHELE
HLQRNLILSHAVGTGQDLDDNVARLVLLMKAASLARGYSGVRRVVIDTLLAMLNAGIVPCIPSKGSVGASGDLAPLAHMT
LAMLGEGDARVNGVRKPAREALAAAGIAPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVAGALSVDAAKGSD
APFDPRVHTVRGQAGQIATAAVYRGLLAGSAIRRSHLVGDTRVQDPYSLRCQPQVMGACLDLIRQAGATLLTEANAVTDN
PLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSERRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALAS
ENKSLAHPASVDSLPTSANQEDHVSMATFAGRRLAEMAGNTATIVGIEALAAAQGIDFHRPLATSDALARAHTCIRSRVA
YYGEDRLFAPDIEAARRLVLDGDLGDSCRAHLADLALA
>Mature_518_residues
MNTMTTPSILTLHPGEMTFADLRRVWLAPTPVTLSGDCAAAIEASAATVQAIVARGEPAYGINTGFGKLARTQIATHELE
HLQRNLILSHAVGTGQDLDDNVARLVLLMKAASLARGYSGVRRVVIDTLLAMLNAGIVPCIPSKGSVGASGDLAPLAHMT
LAMLGEGDARVNGVRKPAREALAAAGIAPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVAGALSVDAAKGSD
APFDPRVHTVRGQAGQIATAAVYRGLLAGSAIRRSHLVGDTRVQDPYSLRCQPQVMGACLDLIRQAGATLLTEANAVTDN
PLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSERRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALAS
ENKSLAHPASVDSLPTSANQEDHVSMATFAGRRLAEMAGNTATIVGIEALAAAQGIDFHRPLATSDALARAHTCIRSRVA
YYGEDRLFAPDIEAARRLVLDGDLGDSCRAHLADLALA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=495, Percent_Identity=44.2424242424242, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567831, Length=513, Percent_Identity=41.5204678362573, Blast_Score=352, Evalue=4e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53593; Mature: 53593

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTTPSILTLHPGEMTFADLRRVWLAPTPVTLSGDCAAAIEASAATVQAIVARGEPAY
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCC
GINTGFGKLARTQIATHELEHLQRNLILSHAVGTGQDLDDNVARLVLLMKAASLARGYSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VRRVVIDTLLAMLNAGIVPCIPSKGSVGASGDLAPLAHMTLAMLGEGDARVNGVRKPARE
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHH
ALAAAGIAPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVAGALSVDAAKGSD
HHHHCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
APFDPRVHTVRGQAGQIATAAVYRGLLAGSAIRRSHLVGDTRVQDPYSLRCQPQVMGACL
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
DLIRQAGATLLTEANAVTDNPLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSE
HHHHHCCCCEEECCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALASENKSLAHPASVDSLPTSANQ
CEEEEEEECHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
EDHVSMATFAGRRLAEMAGNTATIVGIEALAAAQGIDFHRPLATSDALARAHTCIRSRVA
CHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
YYGEDRLFAPDIEAARRLVLDGDLGDSCRAHLADLALA
HCCCCCCCCCCHHHHCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNTMTTPSILTLHPGEMTFADLRRVWLAPTPVTLSGDCAAAIEASAATVQAIVARGEPAY
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCC
GINTGFGKLARTQIATHELEHLQRNLILSHAVGTGQDLDDNVARLVLLMKAASLARGYSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VRRVVIDTLLAMLNAGIVPCIPSKGSVGASGDLAPLAHMTLAMLGEGDARVNGVRKPARE
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHH
ALAAAGIAPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVAGALSVDAAKGSD
HHHHCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
APFDPRVHTVRGQAGQIATAAVYRGLLAGSAIRRSHLVGDTRVQDPYSLRCQPQVMGACL
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
DLIRQAGATLLTEANAVTDNPLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSE
HHHHHCCCCEEECCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALASENKSLAHPASVDSLPTSANQ
CEEEEEEECHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
EDHVSMATFAGRRLAEMAGNTATIVGIEALAAAQGIDFHRPLATSDALARAHTCIRSRVA
CHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
YYGEDRLFAPDIEAARRLVLDGDLGDSCRAHLADLALA
HCCCCCCCCCCHHHHCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]