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The map label for this gene is hemH [H]

Identifier: 17547362

GI number: 17547362

Start: 2842956

End: 2844071

Strand: Reverse

Name: hemH [H]

Synonym: RSc2643

Alternate gene names: 17547362

Gene position: 2844071-2842956 (Counterclockwise)

Preceding gene: 17547363

Following gene: 17547361

Centisome position: 76.53

GC content: 69.35

Gene sequence:

>1116_bases
ATGCCCTTTTTGCCCGAACCCCTGTTCCAGCACGGCCAGCCCGATCGCACCGCGATCCTGCTGGTCAACCTCGGCACGCC
CGACGGCACCTCGCCGCGCGAGGTCGGCCGCTACCTGCGCCAGTTCCTGTCCGACCCGCGCGTGGTGGAGATTCCGCGGG
CGGCGTGGTGGTTCATCCTCAACGTGCTGATCCTGCCGCTGCGCTCGCGCGCCTCGGCGCACAAGTACGAGACGGTCTGG
CTGCGCGAGGCCAACATGACGGGCTCGCCGCTGCTGGTCTACAGCGAGCGCCAGGCGCACGCCTTGCAGCAACTGCTCGA
TGCGCAGGGGCACGACGTGGTGGTGGCCTGCGCGATGCGCTACGGCAACCCGTCGATCCCCTCGGTGATGCAGACACTGC
GCAAGCAGGGCGTGGAGCGCATCCTGGTGCTGCCGATGTATCCGCAGTATTCCGGCACCACCACCGCCACCGCGTTCGAC
GAGGTCTTCCGCGTGATGGGCCAGATGCGCAACCAGCCGGAGCTGCGGCTGGTCAAGCATTTCCACGATCATCCGGCCTA
CATCAACGCGCTGCACCAGCAGGTGGGCGCGTACTGGGCGCAGCACGGCGCGCCGGATTTCGCGCGCGGCGACAAGCTGC
TGCTGTCGTTCCACGGCGTGCCGCGCCGCACGCTCGAGCTTGGCGATCCGTACCACTGCGCGTGCCTGAAGACCGGCCGC
CTGCTCGGCGAGGCGCTTGGCCTGCAGCCGGGCCAGTACCTGGTGACGTTCCAGTCGCGCTTTGGCCGCGCCGAGTGGCT
GCAGCCGTATACCGCGCCCACGCTCGAAGAGCTCGGTCGCGTCGGCACCGGCCGCGTCGACGTGTTCTGCCCGGGCTTTC
CGGCCGACTGCCTGGAGACGCTGGAGGAGATCGCCATGGAAGGGCAGTCCACCTTCCGTGTCGCCGGCGGCAAGGACTTC
CACTACATCCCGTGCCTGAACGACAGCGAGCCCTGGATTGCCGGCCTGGCCGATATCGCGCAGGCGCACCTGCAGGGCTG
GCCGCTCGCGCTGCCGCATCCGCATGTGCTGGAAGCCAGCCGCACGCGCGCGCAGAGCAAGGGGGCCGCGGCATGA

Upstream 100 bases:

>100_bases
CCCTGCGCCGGCGTGGTCAAGGACGGCGCGCCGGCACGCTGAGCGCGGCCTGGCGGACCGGCTCGTATAATCGACCGGAT
CATCCGCAAAGCCGCGCCCC

Downstream 100 bases:

>100_bases
AGGTGAGCACCGACGCGGATGGCCGCGTGCGCATCGACAAATGGCTGTGGGCGGCGCGCTTCTTCAAGACACGCTCGCAG
GCGACCGATGCGGTGGAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAAWWFILNVLILPLRSRASAHKYETVW
LREANMTGSPLLVYSERQAHALQQLLDAQGHDVVVACAMRYGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATAFD
EVFRVMGQMRNQPELRLVKHFHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSFHGVPRRTLELGDPYHCACLKTGR
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTGRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKDF
HYIPCLNDSEPWIAGLADIAQAHLQGWPLALPHPHVLEASRTRAQSKGAAA

Sequences:

>Translated_371_residues
MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAAWWFILNVLILPLRSRASAHKYETVW
LREANMTGSPLLVYSERQAHALQQLLDAQGHDVVVACAMRYGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATAFD
EVFRVMGQMRNQPELRLVKHFHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSFHGVPRRTLELGDPYHCACLKTGR
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTGRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKDF
HYIPCLNDSEPWIAGLADIAQAHLQGWPLALPHPHVLEASRTRAQSKGAAA
>Mature_370_residues
PFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAAWWFILNVLILPLRSRASAHKYETVWL
REANMTGSPLLVYSERQAHALQQLLDAQGHDVVVACAMRYGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATAFDE
VFRVMGQMRNQPELRLVKHFHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSFHGVPRRTLELGDPYHCACLKTGRL
LGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTGRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKDFH
YIPCLNDSEPWIAGLADIAQAHLQGWPLALPHPHVLEASRTRAQSKGAAA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=265, Percent_Identity=23.7735849056604, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI60499025, Length=265, Percent_Identity=23.7735849056604, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=46.6463414634146, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324750, Length=342, Percent_Identity=25.4385964912281, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=23.6842105263158, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=24.7232472324723, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 41412; Mature: 41281

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAAWWFIL
CCCCCCHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
NVLILPLRSRASAHKYETVWLREANMTGSPLLVYSERQAHALQQLLDAQGHDVVVACAMR
HHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCEEEEEEEC
YGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATAFDEVFRVMGQMRNQPELRLVKH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSFHGVPRRTLELGDPYHCACLKTGR
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHHH
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTGRVDVFCPGFPADCLET
HHHHHHCCCCCCEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHH
LEEIAMEGQSTFRVAGGKDFHYIPCLNDSEPWIAGLADIAQAHLQGWPLALPHPHVLEAS
HHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
RTRAQSKGAAA
HHHHCCCCCCC
>Mature Secondary Structure 
PFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAAWWFIL
CCCCCHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
NVLILPLRSRASAHKYETVWLREANMTGSPLLVYSERQAHALQQLLDAQGHDVVVACAMR
HHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCEEEEEEEC
YGNPSIPSVMQTLRKQGVERILVLPMYPQYSGTTTATAFDEVFRVMGQMRNQPELRLVKH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDHPAYINALHQQVGAYWAQHGAPDFARGDKLLLSFHGVPRRTLELGDPYHCACLKTGR
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHHH
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTGRVDVFCPGFPADCLET
HHHHHHCCCCCCEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHH
LEEIAMEGQSTFRVAGGKDFHYIPCLNDSEPWIAGLADIAQAHLQGWPLALPHPHVLEAS
HHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
RTRAQSKGAAA
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA