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The map label for this gene is hutI

Identifier: 17547363

GI number: 17547363

Start: 2844130

End: 2845356

Strand: Reverse

Name: hutI

Synonym: RSc2644

Alternate gene names: 17547363

Gene position: 2845356-2844130 (Counterclockwise)

Preceding gene: 17547364

Following gene: 17547362

Centisome position: 76.56

GC content: 73.11

Gene sequence:

>1227_bases
ATGGCTGACATCCGATGGGATGCGCTGTGGACCCATGTCCACCTTGCCACGCTGGCGGCCGATGCCGACGGCTACGGCGA
AATCCGCGACGGTGCCATCGCCGTCCGGGACGGCCGCATCGCCTGGCTCGGCGCGCGCGCGGACCTGCCCGCCGGCGCCC
GCGCCGAACGCGAGCACGATGGCGGCGGCGCCTGGCTTACGCCGGGCCTGATCGATTGCCACACGCACCTCGTCCATGCC
GGCAACCGCAGCAATGAATTCGAGGCGCGGCTCAACGGCGTGCCGTACGAGCACATCGCCCGGGCCGGGGGCGGCATCCT
GTCCACCGTCCGTGCCACGCGCGCGGCCAGCGAAGACGCGCTTGCCCAAGCGAGCCTGCCGCGCCTGAATGCGCTGCGCG
CGGAGGGCGTGACGACCGTCGAAATCAAATCCGGCTACGGGCTCGACCTGGAAACCGAGCGCCGCATGCTGCGCGTCGCG
CGCCGCTTCGGCCAGACGCTGCGGGTGCGGGTGCGGACCACCTTCCTCGGCGCCCACGCCGTGCCGCCCGAATTCGCCGG
CCGCGCGGACGACTACATCGGCCACCTGTGCGCCGACGTACTGCCCGCATTGGCGGCGGAAGGGCTGGTCGATGCGGTCG
ACGCGTTCTGCGAAACCATCGGCTTTTCTCCCGCGCAGACGGCGCGCATGTTCGATGCCGCGCAGGCGCTCGGCCTGCCG
GTCAAGCTGCATGCCGAGCAGTTGTCCGACCAGGGCGGCGCGGCGCTGGTGGCGCGCTACGGCGGCCTGTCGGCGGACCA
CCTCGAATGCCTGACCGATGCCGGCGTCGCCGCCATGGCCGAGGCGGGCACCGTGGCCGTGCTGCTGCCCGGCGCGTTCT
ACTGCCTGCGCGAGACGCGCCTGCCGCCGCTGCAAGCGCTGCGCCAGGCGGGCGTGCCGATGGCGGTCTCGACCGACTGC
AACCCCGGCACTTCGCCGCTGTCATCGCTGCTGCTGGCGATGAACATGGCCTGCACGCTGTTCCGCCTGACCCCGCTGGA
GGCGTTGACCGGTGCCACGCGCCACGCTGCGGCCGCGCTGGGCCTGGCCGGCACCTGCGGCGTGCTGGCTCCCGGCTGCG
TCGCCGACTTCGCGCTGTGGCGCATCGACCGGCCGGCGGACCTGGCCTACGCGATGGGCCTCAACCCCTGCGCCGGCGTG
GTCAAGGACGGCGCGCCGGCACGCTGA

Upstream 100 bases:

>100_bases
GAGCTGAATCCGTCGCTGGACATCGACCACCGCACGGCGCGGGTCGCCGCGCGCCTCGTGGCGCGCGTCGTCGACGGGGT
CGCCCCGCAGGGAGCCGCGC

Downstream 100 bases:

>100_bases
GCGCGGCCTGGCGGACCGGCTCGTATAATCGACCGGATCATCCGCAAAGCCGCGCCCCATGCCCTTTTTGCCCGAACCCC
TGTTCCAGCACGGCCAGCCC

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MADIRWDALWTHVHLATLAADADGYGEIRDGAIAVRDGRIAWLGARADLPAGARAEREHDGGGAWLTPGLIDCHTHLVHA
GNRSNEFEARLNGVPYEHIARAGGGILSTVRATRAASEDALAQASLPRLNALRAEGVTTVEIKSGYGLDLETERRMLRVA
RRFGQTLRVRVRTTFLGAHAVPPEFAGRADDYIGHLCADVLPALAAEGLVDAVDAFCETIGFSPAQTARMFDAAQALGLP
VKLHAEQLSDQGGAALVARYGGLSADHLECLTDAGVAAMAEAGTVAVLLPGAFYCLRETRLPPLQALRQAGVPMAVSTDC
NPGTSPLSSLLLAMNMACTLFRLTPLEALTGATRHAAAALGLAGTCGVLAPGCVADFALWRIDRPADLAYAMGLNPCAGV
VKDGAPAR

Sequences:

>Translated_408_residues
MADIRWDALWTHVHLATLAADADGYGEIRDGAIAVRDGRIAWLGARADLPAGARAEREHDGGGAWLTPGLIDCHTHLVHA
GNRSNEFEARLNGVPYEHIARAGGGILSTVRATRAASEDALAQASLPRLNALRAEGVTTVEIKSGYGLDLETERRMLRVA
RRFGQTLRVRVRTTFLGAHAVPPEFAGRADDYIGHLCADVLPALAAEGLVDAVDAFCETIGFSPAQTARMFDAAQALGLP
VKLHAEQLSDQGGAALVARYGGLSADHLECLTDAGVAAMAEAGTVAVLLPGAFYCLRETRLPPLQALRQAGVPMAVSTDC
NPGTSPLSSLLLAMNMACTLFRLTPLEALTGATRHAAAALGLAGTCGVLAPGCVADFALWRIDRPADLAYAMGLNPCAGV
VKDGAPAR
>Mature_407_residues
ADIRWDALWTHVHLATLAADADGYGEIRDGAIAVRDGRIAWLGARADLPAGARAEREHDGGGAWLTPGLIDCHTHLVHAG
NRSNEFEARLNGVPYEHIARAGGGILSTVRATRAASEDALAQASLPRLNALRAEGVTTVEIKSGYGLDLETERRMLRVAR
RFGQTLRVRVRTTFLGAHAVPPEFAGRADDYIGHLCADVLPALAAEGLVDAVDAFCETIGFSPAQTARMFDAAQALGLPV
KLHAEQLSDQGGAALVARYGGLSADHLECLTDAGVAAMAEAGTVAVLLPGAFYCLRETRLPPLQALRQAGVPMAVSTDCN
PGTSPLSSLLLAMNMACTLFRLTPLEALTGATRHAAAALGLAGTCGVLAPGCVADFALWRIDRPADLAYAMGLNPCAGVV
KDGAPAR

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=369, Percent_Identity=37.940379403794, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17555004, Length=381, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_RALSO (Q8XW31)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520765.1
- ProteinModelPortal:   Q8XW31
- SMR:   Q8XW31
- GeneID:   1221491
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2644
- NMPDR:   fig|267608.1.peg.2644
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   RSOL267608:RSC2644-MONOMER
- BRENDA:   3.5.2.7
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 42689; Mature: 42558

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: BINDING 83-83 BINDING 96-96 BINDING 146-146 BINDING 179-179 BINDING 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRWDALWTHVHLATLAADADGYGEIRDGAIAVRDGRIAWLGARADLPAGARAEREHD
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCC
GGGAWLTPGLIDCHTHLVHAGNRSNEFEARLNGVPYEHIARAGGGILSTVRATRAASEDA
CCCCEECCCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCHHH
LAQASLPRLNALRAEGVTTVEIKSGYGLDLETERRMLRVARRFGQTLRVRVRTTFLGAHA
HHHHCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCHHEEEEEEEEEECCCC
VPPEFAGRADDYIGHLCADVLPALAAEGLVDAVDAFCETIGFSPAQTARMFDAAQALGLP
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
VKLHAEQLSDQGGAALVARYGGLSADHLECLTDAGVAAMAEAGTVAVLLPGAFYCLRETR
EEEEHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHCCCEEEEECCCHHHHHHHCC
LPPLQALRQAGVPMAVSTDCNPGTSPLSSLLLAMNMACTLFRLTPLEALTGATRHAAAAL
CCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
GLAGTCGVLAPGCVADFALWRIDRPADLAYAMGLNPCAGVVKDGAPAR
CCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
ADIRWDALWTHVHLATLAADADGYGEIRDGAIAVRDGRIAWLGARADLPAGARAEREHD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCC
GGGAWLTPGLIDCHTHLVHAGNRSNEFEARLNGVPYEHIARAGGGILSTVRATRAASEDA
CCCCEECCCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCHHH
LAQASLPRLNALRAEGVTTVEIKSGYGLDLETERRMLRVARRFGQTLRVRVRTTFLGAHA
HHHHCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCHHEEEEEEEEEECCCC
VPPEFAGRADDYIGHLCADVLPALAAEGLVDAVDAFCETIGFSPAQTARMFDAAQALGLP
CCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
VKLHAEQLSDQGGAALVARYGGLSADHLECLTDAGVAAMAEAGTVAVLLPGAFYCLRETR
EEEEHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHCCCEEEEECCCHHHHHHHCC
LPPLQALRQAGVPMAVSTDCNPGTSPLSSLLLAMNMACTLFRLTPLEALTGATRHAAAAL
CCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
GLAGTCGVLAPGCVADFALWRIDRPADLAYAMGLNPCAGVVKDGAPAR
CCCCHHHHCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852