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The map label for this gene is ptxR [H]

Identifier: 17547254

GI number: 17547254

Start: 2742649

End: 2743620

Strand: Reverse

Name: ptxR [H]

Synonym: RSc2535

Alternate gene names: 17547254

Gene position: 2743620-2742649 (Counterclockwise)

Preceding gene: 17547256

Following gene: 17547246

Centisome position: 73.82

GC content: 69.14

Gene sequence:

>972_bases
GTGAACAATCAAACGATGAATCCGCAAAATATCCAGACGCTGCTGCCGCACATCCATTCGCTGACGGTGCTCGCGACGAC
GAACAGCTTCACCGCCGCGGCCCAACGTCTGGGCATCAGCAAGGCGGCCATGAGCCAGCGCGTTGCCGACCTCGAGAAGG
CGGCAGGGGTGCCGCTGGTGCGACGGACGACGCGCAGCGTACGCCTGACCGAGGCCGGGCAGACGCTGGTCGACAGCACG
CGCGACGCCTACGAGACGATCGCCGTGCATTTCGCGCGCGTGAAGGATCTGGCCGGCGAGCCGCGCGGGCTCGTGCGCGT
GACCGTGCCGGTCGCGCTCGGCCGGCAGCAGATCGTGCCGCTGCTGCCGGCCTTCCTGCAGCGCTGCCCCGGCGTGCGCA
TTGAGCTGGACCTGTCGGATCGGTTGCACTCGCTCACGCAGGAGGGCTTTGACCTGGCGATCCGTCATGTGACGGCCGCG
CCGGAAACGCACGTCGCCTGGACGCTGTGCCGGACGCAAGCCGTGCTCGTGGCCAGCCGGGATTACCTGGCACGGCGCGG
CACGCCCGAGCATCCGCAGGCGCTGGTGGATCACGATTGTCTGTATTACCTGCGCGGCAATGAGCCGGCGGCGTGGAGTT
TCGAACCGCGTGGCCGAAAGCGCGGCCGCGTCAGCGTGCCCATCCGCGGCTGCTTTGCCGCCAACAACAGCGAGGCGATG
CGCGAGGCGGCGCTCGGCGGGCTTGGCATCGCGCTGTTGCCGGACTTCAGTGCTCAACACGACATCGATGCGGGCCGGCT
CGTGCCGGTGCTTGAAGCGTGGCGACCGGTCGGGGTGTTTGGCGAGCAGATCCTTGCCATCCGGCCGTACAGCCCGGTCG
TGCCGAGCGCTGTCAGCGCGCTGGTGCAGCACTTGCGCACGCAGCTTGCCGGGGGTTTTTCGGGGCCGCCGCGGGGTGGA
GCGGCGGGCTGA

Upstream 100 bases:

>100_bases
GCGGGGTGCATCGTGTCTCCTGTTGGTTGGGGGAAGCTGCAGTCTAGGCAGCCGCCCGGCACCGGAGAAGCCCGGTACGC
TTGAATCACTGTTTGGATTG

Downstream 100 bases:

>100_bases
AAAAGGCGCCTGCATGACAGGCCGAAGGCGGGGGCGCTGCCCGCGATAGATCGCGGCCGAGCAGGCCAAGCGCGCCGGTT
TGCCGTTAGCTAAAACCGTT

Product: transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MNNQTMNPQNIQTLLPHIHSLTVLATTNSFTAAAQRLGISKAAMSQRVADLEKAAGVPLVRRTTRSVRLTEAGQTLVDST
RDAYETIAVHFARVKDLAGEPRGLVRVTVPVALGRQQIVPLLPAFLQRCPGVRIELDLSDRLHSLTQEGFDLAIRHVTAA
PETHVAWTLCRTQAVLVASRDYLARRGTPEHPQALVDHDCLYYLRGNEPAAWSFEPRGRKRGRVSVPIRGCFAANNSEAM
REAALGGLGIALLPDFSAQHDIDAGRLVPVLEAWRPVGVFGEQILAIRPYSPVVPSAVSALVQHLRTQLAGGFSGPPRGG
AAG

Sequences:

>Translated_323_residues
MNNQTMNPQNIQTLLPHIHSLTVLATTNSFTAAAQRLGISKAAMSQRVADLEKAAGVPLVRRTTRSVRLTEAGQTLVDST
RDAYETIAVHFARVKDLAGEPRGLVRVTVPVALGRQQIVPLLPAFLQRCPGVRIELDLSDRLHSLTQEGFDLAIRHVTAA
PETHVAWTLCRTQAVLVASRDYLARRGTPEHPQALVDHDCLYYLRGNEPAAWSFEPRGRKRGRVSVPIRGCFAANNSEAM
REAALGGLGIALLPDFSAQHDIDAGRLVPVLEAWRPVGVFGEQILAIRPYSPVVPSAVSALVQHLRTQLAGGFSGPPRGG
AAG
>Mature_323_residues
MNNQTMNPQNIQTLLPHIHSLTVLATTNSFTAAAQRLGISKAAMSQRVADLEKAAGVPLVRRTTRSVRLTEAGQTLVDST
RDAYETIAVHFARVKDLAGEPRGLVRVTVPVALGRQQIVPLLPAFLQRCPGVRIELDLSDRLHSLTQEGFDLAIRHVTAA
PETHVAWTLCRTQAVLVASRDYLARRGTPEHPQALVDHDCLYYLRGNEPAAWSFEPRGRKRGRVSVPIRGCFAANNSEAM
REAALGGLGIALLPDFSAQHDIDAGRLVPVLEAWRPVGVFGEQILAIRPYSPVVPSAVSALVQHLRTQLAGGFSGPPRGG
AAG

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787128, Length=293, Percent_Identity=29.0102389078498, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=29.1666666666667, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789440, Length=268, Percent_Identity=28.7313432835821, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87081978, Length=270, Percent_Identity=30, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI145693193, Length=263, Percent_Identity=29.277566539924, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787589, Length=274, Percent_Identity=29.5620437956204, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790011, Length=321, Percent_Identity=25.5451713395639, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789639, Length=239, Percent_Identity=26.7782426778243, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789173, Length=266, Percent_Identity=25.9398496240602, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786448, Length=290, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI157672245, Length=120, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786713, Length=283, Percent_Identity=29.3286219081272, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788706, Length=262, Percent_Identity=24.0458015267176, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34934; Mature: 34934

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQTMNPQNIQTLLPHIHSLTVLATTNSFTAAAQRLGISKAAMSQRVADLEKAAGVPLV
CCCCCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHH
RRTTRSVRLTEAGQTLVDSTRDAYETIAVHFARVKDLAGEPRGLVRVTVPVALGRQQIVP
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCHHHHHH
LLPAFLQRCPGVRIELDLSDRLHSLTQEGFDLAIRHVTAAPETHVAWTLCRTQAVLVASR
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECH
DYLARRGTPEHPQALVDHDCLYYLRGNEPAAWSFEPRGRKRGRVSVPIRGCFAANNSEAM
HHHHHCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEECCEEEEEECCCHHHH
REAALGGLGIALLPDFSAQHDIDAGRLVPVLEAWRPVGVFGEQILAIRPYSPVVPSAVSA
HHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHH
LVQHLRTQLAGGFSGPPRGGAAG
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNNQTMNPQNIQTLLPHIHSLTVLATTNSFTAAAQRLGISKAAMSQRVADLEKAAGVPLV
CCCCCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHH
RRTTRSVRLTEAGQTLVDSTRDAYETIAVHFARVKDLAGEPRGLVRVTVPVALGRQQIVP
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCHHHHHH
LLPAFLQRCPGVRIELDLSDRLHSLTQEGFDLAIRHVTAAPETHVAWTLCRTQAVLVASR
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECH
DYLARRGTPEHPQALVDHDCLYYLRGNEPAAWSFEPRGRKRGRVSVPIRGCFAANNSEAM
HHHHHCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEECCEEEEEECCCHHHH
REAALGGLGIALLPDFSAQHDIDAGRLVPVLEAWRPVGVFGEQILAIRPYSPVVPSAVSA
HHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHH
LVQHLRTQLAGGFSGPPRGGAAG
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]