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The map label for this gene is nadC [H]

Identifier: 17547167

GI number: 17547167

Start: 2653296

End: 2654183

Strand: Reverse

Name: nadC [H]

Synonym: RSc2448

Alternate gene names: 17547167

Gene position: 2654183-2653296 (Counterclockwise)

Preceding gene: 17547168

Following gene: 17547162

Centisome position: 71.42

GC content: 70.27

Gene sequence:

>888_bases
ATGACGGCAACCCAGATGACCACCAGCGCAGCGCAGGCGACGTTCGACAGCTTCGGCTCGGCGCTGCGCGAGGCGTTGGC
CGCCAACGTGGCGGCCGCCATCCGCGAGGACGTCGGCACGGGTGATCGCACCGGCCTGCTGATTCCCGCCGACCGCCATG
CCCGTGCCCGCGTGATCGTGCGCGAAGCAGCGGTGCTGTGCGGCGCGCCGTGGTTCGATGCCTGCATGCCGGCTGTCGAT
CCGGCGCTGCGCGTGACCTGGCTGCAGCACGAAGGCGACCGCATGGCGCCCGATTCCGTGGTGTGCGAGATCGAGGGCCC
GGCGCGTTCGCTGTTGACCGCCGAGCGCGCGTCGCTGAACTTCCTGCAACTGCTGTCCGGCGTGGCGACGGCGACGTCGC
GCTATGCCGAGGCCATCGCCGGCACGCGCGCCCGCGTGCTGGATACGCGCAAGACCTTGCCGGGCCTGCGCTTGGCGCAG
AAGTACGCGGTGCGCATCGGTGGCGGCGAGAACCAGCGGCTGGCGCTGTACGACGGCATCCTCATCAAGGAAAACCACAT
TGCGGCGGCTGGCGGCGTGACGGCGGCCCTGCGCGCGGCGCAGGCGCTCAATGCCGGCGTGCCGATCCAGGTCGAGGTGG
AAACGCTTGCGGAGCTGGAAGAGGCGCTGGCGGCGGGGGCGACTTCCGTGCTGCTCGACAATTTTGACGAGCCAGCCATG
CATGAGGCTGTGCGCGTGACGGCGGGCAGGGCGCTGCTGGAGGTGTCCGGCGGCGTGAGCATGGCCACCATCCGCGCGTT
TGCGCAGACCGGTGTGGACCGCATCTCCGTCGGTGCGCTGACCAAGGACGTGCGCGCGACCGACTACTCCCTGCGCGTCG
TCGAATAA

Upstream 100 bases:

>100_bases
TTACGCGCATGCTGGACTTCGCCGCGCGCGAGAAAACGACAGTCCGGCCCCAGGGCGATCTGGCGGCCAATACGCAACTC
TTCCAAGGAGTCGGTCCGGC

Downstream 100 bases:

>100_bases
GACGGCTCAGTGCTTGCGCGAGGTGCGCCGATGCGCGGGTTGCATCACCGTCGGCAGCGCCTTGGGCAGGGTCTGCGGGT
AGTCGCGCGAGAAATGCAGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTATQMTTSAAQATFDSFGSALREALAANVAAAIREDVGTGDRTGLLIPADRHARARVIVREAAVLCGAPWFDACMPAVD
PALRVTWLQHEGDRMAPDSVVCEIEGPARSLLTAERASLNFLQLLSGVATATSRYAEAIAGTRARVLDTRKTLPGLRLAQ
KYAVRIGGGENQRLALYDGILIKENHIAAAGGVTAALRAAQALNAGVPIQVEVETLAELEEALAAGATSVLLDNFDEPAM
HEAVRVTAGRALLEVSGGVSMATIRAFAQTGVDRISVGALTKDVRATDYSLRVVE

Sequences:

>Translated_295_residues
MTATQMTTSAAQATFDSFGSALREALAANVAAAIREDVGTGDRTGLLIPADRHARARVIVREAAVLCGAPWFDACMPAVD
PALRVTWLQHEGDRMAPDSVVCEIEGPARSLLTAERASLNFLQLLSGVATATSRYAEAIAGTRARVLDTRKTLPGLRLAQ
KYAVRIGGGENQRLALYDGILIKENHIAAAGGVTAALRAAQALNAGVPIQVEVETLAELEEALAAGATSVLLDNFDEPAM
HEAVRVTAGRALLEVSGGVSMATIRAFAQTGVDRISVGALTKDVRATDYSLRVVE
>Mature_294_residues
TATQMTTSAAQATFDSFGSALREALAANVAAAIREDVGTGDRTGLLIPADRHARARVIVREAAVLCGAPWFDACMPAVDP
ALRVTWLQHEGDRMAPDSVVCEIEGPARSLLTAERASLNFLQLLSGVATATSRYAEAIAGTRARVLDTRKTLPGLRLAQK
YAVRIGGGENQRLALYDGILIKENHIAAAGGVTAALRAAQALNAGVPIQVEVETLAELEEALAAGATSVLLDNFDEPAMH
EAVRVTAGRALLEVSGGVSMATIRAFAQTGVDRISVGALTKDVRATDYSLRVVE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=274, Percent_Identity=36.8613138686131, Blast_Score=151, Evalue=7e-37,
Organism=Escherichia coli, GI1786299, Length=269, Percent_Identity=50.5576208178439, Blast_Score=235, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6321162, Length=289, Percent_Identity=32.5259515570934, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30973; Mature: 30841

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATQMTTSAAQATFDSFGSALREALAANVAAAIREDVGTGDRTGLLIPADRHARARVIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHH
REAAVLCGAPWFDACMPAVDPALRVTWLQHEGDRMAPDSVVCEIEGPARSLLTAERASLN
HHHHHHCCCCHHHHHHHHCCHHHEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
FLQLLSGVATATSRYAEAIAGTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDGI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCE
LIKENHIAAAGGVTAALRAAQALNAGVPIQVEVETLAELEEALAAGATSVLLDNFDEPAM
EEECCCEEECCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHCCCCCHHH
HEAVRVTAGRALLEVSGGVSMATIRAFAQTGVDRISVGALTKDVRATDYSLRVVE
HHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCCEEHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
TATQMTTSAAQATFDSFGSALREALAANVAAAIREDVGTGDRTGLLIPADRHARARVIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHH
REAAVLCGAPWFDACMPAVDPALRVTWLQHEGDRMAPDSVVCEIEGPARSLLTAERASLN
HHHHHHCCCCHHHHHHHHCCHHHEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
FLQLLSGVATATSRYAEAIAGTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDGI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCE
LIKENHIAAAGGVTAALRAAQALNAGVPIQVEVETLAELEEALAAGATSVLLDNFDEPAM
EEECCCEEECCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHCCCCCHHH
HEAVRVTAGRALLEVSGGVSMATIRAFAQTGVDRISVGALTKDVRATDYSLRVVE
HHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCCEEHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]