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The map label for this gene is argD

Identifier: 17547154

GI number: 17547154

Start: 2641357

End: 2642556

Strand: Direct

Name: argD

Synonym: RSc2435

Alternate gene names: 17547154

Gene position: 2641357-2642556 (Clockwise)

Preceding gene: 17547153

Following gene: 17547155

Centisome position: 71.07

GC content: 65.75

Gene sequence:

>1200_bases
ATGGCGTTTGCTGATTACCCCGTCCAGTCCCTGATGTACATCACCAACCGGCCCGAGATCGTCTTCACCGAAGGCAAGGG
CTCGTGGCTGACGGACCACAACGGCAAGCGATACCTGGATTTCGTGCAAGGCTGGGCCGTCAACTGCCTCGGCCACTCCA
ACGACGGCATGATCGAAGCGCTCAATGCGCAGGCAAAGAAGCTCATCAACCCGAGCCCGGCCTTCTACAACGAGCCGATG
GCCAAGCTGGCCGGCCTGCTGAGCGCGCACAGCTGCTTCGACAAGGTGTTCTTCGCCAACAGCGGCGCCGAGGCCAACGA
AGGCGCCATCAAGCTCGCGCGCAAGTGGGGCAAGAAGCATAAGAGCGGCGCAGGAAAGAATCGATTCGAGATCATCACCT
TCGACCACAGCTTTCACGGCCGCACGCTCGCCACCATGAGCGCATCGGGCAAGGCCGGCTGGGACACCATCTTCGCGCCG
CAGGTGCCGGGCTTCCCGAAGGCCATCCTCAACGACATCGCCTCGGTGGAAGCACTCATCACCGACGAGACCGTCGGCGT
GATGCTCGAGCCGGTGCAGGGCGAAGGCGGCGTGCTGCCCGCCACGCAGGAATTCATGCAGCAGCTGCGCGCGCTGACCA
GGAAACACAAGCTGCTGCTGATCGTCGATGAAGTGCAAGCCGGGTGCGGGCGCTGCGGCACGCTCTTCGCCTACCAGCTC
TCGAACATCGAGCCGGACATCATGACGCTGGGCAAGGGCATCGGCGGCGGCGTGCCGCTCTCGGCCCTGCTGTGCACGGA
TGAAGTCGCCAGCTTCGAGGCCGGCGACCAGGGCGGTACCTACAACGGCAACCCGCTGATGACGGCCGTGGGCTGCTCGG
TGATCGAGCAGCTGCTCGCCCCGGGCTTCCTTGCCGGCGTGCAGGAGCGCGGCGCCTACCTGCGCGCGCAACTGCTCGAG
CTGTCGGAAGCATTCGGCCTGGCCGGCGAACGCGGCGAGGGCCTGCTGCGCGCCCTGCTGCTCGGCAAGGACATCGGCGG
CCAACTGGTCGAGGCCGCGCGCGAGATGAACCCGACGGGTCTGCTGCTCAACGCGCCGCGCCCCAACATCCTGCGCTTCA
TGCCGGCGCTGAACGTCACGACCGACGAGATCGACACGATGATCGGCATGCTGCGCACGCTGCTCAAGGCACACGGCTGA

Upstream 100 bases:

>100_bases
GAGAATTCGACGATCACAAGGCCACGGGCAATCCCCGTGGCCTTTGTCTTTTCCAACCACCGGTTTCATCTTCCTGCCGC
CTTTTTCTGGAGCCTCTGCC

Downstream 100 bases:

>100_bases
GCTTCAACGCTTCACCCCGGGCGGCGCGCGCGGCGCCGCCCTCCATCGCTGTTCCCAACCCGAGGTTTGCCATGGCCGTG
ACGCACGCAGTTCCGGCCAC

Product: acetylornithine transaminase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAFADYPVQSLMYITNRPEIVFTEGKGSWLTDHNGKRYLDFVQGWAVNCLGHSNDGMIEALNAQAKKLINPSPAFYNEPM
AKLAGLLSAHSCFDKVFFANSGAEANEGAIKLARKWGKKHKSGAGKNRFEIITFDHSFHGRTLATMSASGKAGWDTIFAP
QVPGFPKAILNDIASVEALITDETVGVMLEPVQGEGGVLPATQEFMQQLRALTRKHKLLLIVDEVQAGCGRCGTLFAYQL
SNIEPDIMTLGKGIGGGVPLSALLCTDEVASFEAGDQGGTYNGNPLMTAVGCSVIEQLLAPGFLAGVQERGAYLRAQLLE
LSEAFGLAGERGEGLLRALLLGKDIGGQLVEAAREMNPTGLLLNAPRPNILRFMPALNVTTDEIDTMIGMLRTLLKAHG

Sequences:

>Translated_399_residues
MAFADYPVQSLMYITNRPEIVFTEGKGSWLTDHNGKRYLDFVQGWAVNCLGHSNDGMIEALNAQAKKLINPSPAFYNEPM
AKLAGLLSAHSCFDKVFFANSGAEANEGAIKLARKWGKKHKSGAGKNRFEIITFDHSFHGRTLATMSASGKAGWDTIFAP
QVPGFPKAILNDIASVEALITDETVGVMLEPVQGEGGVLPATQEFMQQLRALTRKHKLLLIVDEVQAGCGRCGTLFAYQL
SNIEPDIMTLGKGIGGGVPLSALLCTDEVASFEAGDQGGTYNGNPLMTAVGCSVIEQLLAPGFLAGVQERGAYLRAQLLE
LSEAFGLAGERGEGLLRALLLGKDIGGQLVEAAREMNPTGLLLNAPRPNILRFMPALNVTTDEIDTMIGMLRTLLKAHG
>Mature_398_residues
AFADYPVQSLMYITNRPEIVFTEGKGSWLTDHNGKRYLDFVQGWAVNCLGHSNDGMIEALNAQAKKLINPSPAFYNEPMA
KLAGLLSAHSCFDKVFFANSGAEANEGAIKLARKWGKKHKSGAGKNRFEIITFDHSFHGRTLATMSASGKAGWDTIFAPQ
VPGFPKAILNDIASVEALITDETVGVMLEPVQGEGGVLPATQEFMQQLRALTRKHKLLLIVDEVQAGCGRCGTLFAYQLS
NIEPDIMTLGKGIGGGVPLSALLCTDEVASFEAGDQGGTYNGNPLMTAVGCSVIEQLLAPGFLAGVQERGAYLRAQLLEL
SEAFGLAGERGEGLLRALLLGKDIGGQLVEAAREMNPTGLLLNAPRPNILRFMPALNVTTDEIDTMIGMLRTLLKAHG

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=380, Percent_Identity=33.4210526315789, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI284507298, Length=300, Percent_Identity=34.6666666666667, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI13994255, Length=435, Percent_Identity=27.1264367816092, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=26.8585131894484, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=26.378896882494, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=26.8733850129199, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=25.1798561151079, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI188536080, Length=409, Percent_Identity=24.6943765281174, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679950, Length=409, Percent_Identity=24.6943765281174, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679946, Length=409, Percent_Identity=24.6943765281174, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1788044, Length=370, Percent_Identity=44.3243243243243, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1789759, Length=381, Percent_Identity=39.1076115485564, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI145693181, Length=390, Percent_Identity=31.7948717948718, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1789016, Length=386, Percent_Identity=32.3834196891192, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787560, Length=402, Percent_Identity=29.6019900497512, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786349, Length=337, Percent_Identity=31.1572700296736, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786991, Length=345, Percent_Identity=30.1449275362319, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=369, Percent_Identity=33.0623306233062, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32564660, Length=434, Percent_Identity=27.8801843317972, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=272, Percent_Identity=33.0882352941176, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=28.0182232346241, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71981843, Length=160, Percent_Identity=31.25, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=24.5977011494253, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324432, Length=389, Percent_Identity=33.9331619537275, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6323470, Length=386, Percent_Identity=32.9015544041451, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=425, Percent_Identity=24, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=33.7730870712401, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=25.9090909090909, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI28574759, Length=361, Percent_Identity=27.4238227146814, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=25.635103926097, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI281366494, Length=369, Percent_Identity=24.6612466124661, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667139, Length=369, Percent_Identity=24.6612466124661, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667143, Length=369, Percent_Identity=24.6612466124661, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_RALSO (Q8XWN8)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520556.1
- ProteinModelPortal:   Q8XWN8
- SMR:   Q8XWN8
- GeneID:   1221282
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2435
- NMPDR:   fig|267608.1.peg.2435
- HOGENOM:   HBG725944
- OMA:   LFAYELS
- ProtClustDB:   PRK03715
- BioCyc:   RSOL267608:RSC2435-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 42779; Mature: 42648

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00600 AA_TRANSFER_CLASS_3; PS00196 COPPER_BLUE

Important sites: BINDING 138-138 BINDING 141-141 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFADYPVQSLMYITNRPEIVFTEGKGSWLTDHNGKRYLDFVQGWAVNCLGHSNDGMIEA
CCCCCCCHHHHHEEECCCCEEEECCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHH
LNAQAKKLINPSPAFYNEPMAKLAGLLSAHSCFDKVFFANSGAEANEGAIKLARKWGKKH
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
KSGAGKNRFEIITFDHSFHGRTLATMSASGKAGWDTIFAPQVPGFPKAILNDIASVEALI
CCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHH
TDETVGVMLEPVQGEGGVLPATQEFMQQLRALTRKHKLLLIVDEVQAGCGRCGTLFAYQL
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECHHCCCCCHHHHHHHHH
SNIEPDIMTLGKGIGGGVPLSALLCTDEVASFEAGDQGGTYNGNPLMTAVGCSVIEQLLA
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
PGFLAGVQERGAYLRAQLLELSEAFGLAGERGEGLLRALLLGKDIGGQLVEAAREMNPTG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCE
LLLNAPRPNILRFMPALNVTTDEIDTMIGMLRTLLKAHG
EEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFADYPVQSLMYITNRPEIVFTEGKGSWLTDHNGKRYLDFVQGWAVNCLGHSNDGMIEA
CCCCCCHHHHHEEECCCCEEEECCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHH
LNAQAKKLINPSPAFYNEPMAKLAGLLSAHSCFDKVFFANSGAEANEGAIKLARKWGKKH
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
KSGAGKNRFEIITFDHSFHGRTLATMSASGKAGWDTIFAPQVPGFPKAILNDIASVEALI
CCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHH
TDETVGVMLEPVQGEGGVLPATQEFMQQLRALTRKHKLLLIVDEVQAGCGRCGTLFAYQL
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECHHCCCCCHHHHHHHHH
SNIEPDIMTLGKGIGGGVPLSALLCTDEVASFEAGDQGGTYNGNPLMTAVGCSVIEQLLA
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
PGFLAGVQERGAYLRAQLLELSEAFGLAGERGEGLLRALLLGKDIGGQLVEAAREMNPTG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCE
LLLNAPRPNILRFMPALNVTTDEIDTMIGMLRTLLKAHG
EEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852