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The map label for this gene is pepA

Identifier: 17547134

GI number: 17547134

Start: 2619416

End: 2620936

Strand: Reverse

Name: pepA

Synonym: RSc2415

Alternate gene names: 17547134

Gene position: 2620936-2619416 (Counterclockwise)

Preceding gene: 17547138

Following gene: 17547133

Centisome position: 70.52

GC content: 69.17

Gene sequence:

>1521_bases
ATGGAATTTAGCACAAAAGCCTTGGACTGGGCCAAAGCCGGCCCGAGCGGTGCCCTGGCGGCCAAGAGCGATTGCCTCGT
GATCGGTCTGTTCGAGTCGCAGACCCTGGCCGGCGCAGCCAAGGCGCTGGACGTGGCCACCAAGGGCCTGGTCGGCCGCC
TCGTCAAGCTGGGCGACTTTGAAGGCAAGCGCGGCACCTCGCTGCTGCTGCACGAAGTGGCCGGCGTGGGCGCGGCCCGC
GTGCTGCTGGTGGGCCTGGGCAAGGAAGCCGAATTCACCGACCGTGCCTATGCCGAGGCCGTGCGCACCGCGCTGCGCGC
ACTGTCGGGCACCAAGGCCGCCAACGTCACCTGGACGCTGACCCAGCAGCCCGCCCGCGACAAGGATGCCGCCTGGGCCG
TGCTGACCGCCGTCACGCTGATCCGCGAAGCGGGCTACCGCTTCATCGAGCGCCATCCCGAGCTCAAGAGCAAGCGCGAC
AAGAGCGGCGGCGGCCTGCGCAAGGTCATGCTGACGGTCGATGCCGCCGATGCCAAGGCCGCCGCCGTGGCCGCCGCACG
CGGCGCCGCCATCGCCAACGGCATGGAGCTGACGCGCGATCTGGGCAACCTGCCGTCCAACATCTGCACGCCGACCTACC
TGGCCAACACCGCGCGGCAGATCGCCAAGGACTTCAAGCTCAAGGTCGAGGTGCTCGGCCGCAAGCAGATCGAGGCGCTG
AAGATGGGCGCCTTCCTGGCCGTCACCAAGGGCAGCCAGGAGCCGCCGCAGTTCATCGTGCTGCGCTATGAGGGCGGCCC
GGCCAAGCAGGCGCCGGTGGTGCTGGTCGGCAAGGGCATCACGTTCGATACCGGCGGCATCTCGCTCAAGCCGGGCGAGG
GCATGGACGAGATGAAGTTCGACATGTGCGGCGCCGCCTCGGTGCTGGGTACGCTGCGCGCCGTCGCCGAGATGGGCCTG
AAGCTGAACGTCATCGCCGTGGTGCCGACCTGCGAGAACATGCCCAGCGGCATCGCTACCAAGCCGGGCGACGTGGTCAC
CAGCATGTCGGGCCAGACCATCGAGATCCTCAACACCGACGCCGAGGGCCGCCTGATCCTGTGCGATGCGCTGACCTACG
TGGAGCGCTTCAGGCCCGCCGCGGTGATCGACGTGGCGACGCTGACGGGCGCGGTCATCATTGCGCTCGGCCACATCAAC
ACCGGCGTCTATGCGCGCAGCGACGCGCTGGCCAATGCGCTGCTGGCCGCCGGCAAGCAGTCGCTCGACACCGGCTGGCG
CATGCCGCTGGACGAGGAATACCAGGAGCTGCTCAAGTCCAACTTCGCCGATATGGGCAACATCGGCGGCCGCCCGGCCG
CCAGCGTGACGGCGGCCTGCTTCCTGGCGCGCTTCACCGAGAAGTACGACTGGGCCCACCTCGATATCGCCGGCACCGCC
TGGAAGAGCGGCGCGGCCAAGGGCGCCACCGGCCGCCCGGTGCCGCTGCTCACGCGCTTCCTGATGGATCGCGCCGGCTG
A

Upstream 100 bases:

>100_bases
GGGAGCGAAGTCCGGCCGATGTGCGTACCATCGGAGCCCACGCGCAAAATCGCGGATAATGTGGGCTTTCGTTGACTCGC
CTCAAAGAGAGAAAAGCGCG

Downstream 100 bases:

>100_bases
TGCGCTGACCGGAGCAGGCCCGCCCATGACCCGTGTCGATTTCCATAGCAACGTGCCCGGCAAGCTGGCTTATGCCTGCC
GCCTGGTGCGCAAGGCCTAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MEFSTKALDWAKAGPSGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVGRLVKLGDFEGKRGTSLLLHEVAGVGAAR
VLLVGLGKEAEFTDRAYAEAVRTALRALSGTKAANVTWTLTQQPARDKDAAWAVLTAVTLIREAGYRFIERHPELKSKRD
KSGGGLRKVMLTVDAADAKAAAVAAARGAAIANGMELTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEAL
KMGAFLAVTKGSQEPPQFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKFDMCGAASVLGTLRAVAEMGL
KLNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFRPAAVIDVATLTGAVIIALGHIN
TGVYARSDALANALLAAGKQSLDTGWRMPLDEEYQELLKSNFADMGNIGGRPAASVTAACFLARFTEKYDWAHLDIAGTA
WKSGAAKGATGRPVPLLTRFLMDRAG

Sequences:

>Translated_506_residues
MEFSTKALDWAKAGPSGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVGRLVKLGDFEGKRGTSLLLHEVAGVGAAR
VLLVGLGKEAEFTDRAYAEAVRTALRALSGTKAANVTWTLTQQPARDKDAAWAVLTAVTLIREAGYRFIERHPELKSKRD
KSGGGLRKVMLTVDAADAKAAAVAAARGAAIANGMELTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEAL
KMGAFLAVTKGSQEPPQFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKFDMCGAASVLGTLRAVAEMGL
KLNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFRPAAVIDVATLTGAVIIALGHIN
TGVYARSDALANALLAAGKQSLDTGWRMPLDEEYQELLKSNFADMGNIGGRPAASVTAACFLARFTEKYDWAHLDIAGTA
WKSGAAKGATGRPVPLLTRFLMDRAG
>Mature_506_residues
MEFSTKALDWAKAGPSGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVGRLVKLGDFEGKRGTSLLLHEVAGVGAAR
VLLVGLGKEAEFTDRAYAEAVRTALRALSGTKAANVTWTLTQQPARDKDAAWAVLTAVTLIREAGYRFIERHPELKSKRD
KSGGGLRKVMLTVDAADAKAAAVAAARGAAIANGMELTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEAL
KMGAFLAVTKGSQEPPQFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKFDMCGAASVLGTLRAVAEMGL
KLNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFRPAAVIDVATLTGAVIIALGHIN
TGVYARSDALANALLAAGKQSLDTGWRMPLDEEYQELLKSNFADMGNIGGRPAASVTAACFLARFTEKYDWAHLDIAGTA
WKSGAAKGATGRPVPLLTRFLMDRAG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=328, Percent_Identity=46.3414634146341, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI47155554, Length=315, Percent_Identity=35.5555555555556, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790710, Length=510, Percent_Identity=50.5882352941176, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=39.375, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=326, Percent_Identity=34.0490797546012, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=350, Percent_Identity=28.8571428571429, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129969, Length=503, Percent_Identity=32.0079522862823, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI21355725, Length=321, Percent_Identity=37.6947040498442, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI161077148, Length=331, Percent_Identity=36.5558912386707, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20130057, Length=331, Percent_Identity=36.5558912386707, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=37.6947040498442, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24662227, Length=328, Percent_Identity=36.280487804878, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355645, Length=328, Percent_Identity=36.280487804878, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24662223, Length=328, Percent_Identity=36.280487804878, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI19922386, Length=331, Percent_Identity=35.9516616314199, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20129963, Length=501, Percent_Identity=30.1397205588822, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=33.5483870967742, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=33.5483870967742, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=33.5483870967742, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646701, Length=359, Percent_Identity=27.5766016713092, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646703, Length=359, Percent_Identity=27.5766016713092, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358201, Length=359, Percent_Identity=27.5766016713092, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_RALSO (Q8XWQ8)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520536.1
- ProteinModelPortal:   Q8XWQ8
- SMR:   Q8XWQ8
- MEROPS:   M17.003
- GeneID:   1221261
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2415
- NMPDR:   fig|267608.1.peg.2415
- HOGENOM:   HBG742580
- OMA:   LGHHISG
- ProtClustDB:   PRK00913
- BioCyc:   RSOL267608:RSC2415-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53189; Mature: 53189

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 290-290 ACT_SITE 364-364

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSTKALDWAKAGPSGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVGRLVKLGDF
CCCCCCHHHHHCCCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EGKRGTSLLLHEVAGVGAARVLLVGLGKEAEFTDRAYAEAVRTALRALSGTKAANVTWTL
CCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
TQQPARDKDAAWAVLTAVTLIREAGYRFIERHPELKSKRDKSGGGLRKVMLTVDAADAKA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEEECCCCHH
AAVAAARGAAIANGMELTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEAL
HHHHHHHCHHHHCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
KMGAFLAVTKGSQEPPQFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKF
HHCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHH
DMCGAASVLGTLRAVAEMGLKLNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTD
HHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECC
AEGRLILCDALTYVERFRPAAVIDVATLTGAVIIALGHINTGVYARSDALANALLAAGKQ
CCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCEECHHHHHHHHHHCCCH
SLDTGWRMPLDEEYQELLKSNFADMGNIGGRPAASVTAACFLARFTEKYDWAHLDIAGTA
HCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
WKSGAAKGATGRPVPLLTRFLMDRAG
CCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEFSTKALDWAKAGPSGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVGRLVKLGDF
CCCCCCHHHHHCCCCCCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
EGKRGTSLLLHEVAGVGAARVLLVGLGKEAEFTDRAYAEAVRTALRALSGTKAANVTWTL
CCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
TQQPARDKDAAWAVLTAVTLIREAGYRFIERHPELKSKRDKSGGGLRKVMLTVDAADAKA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEEECCCCHH
AAVAAARGAAIANGMELTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEAL
HHHHHHHCHHHHCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
KMGAFLAVTKGSQEPPQFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKF
HHCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHH
DMCGAASVLGTLRAVAEMGLKLNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTD
HHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECC
AEGRLILCDALTYVERFRPAAVIDVATLTGAVIIALGHINTGVYARSDALANALLAAGKQ
CCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCEECHHHHHHHHHHCCCH
SLDTGWRMPLDEEYQELLKSNFADMGNIGGRPAASVTAACFLARFTEKYDWAHLDIAGTA
HCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
WKSGAAKGATGRPVPLLTRFLMDRAG
CCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852