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The map label for this gene is cobT

Identifier: 17547116

GI number: 17547116

Start: 2603895

End: 2604959

Strand: Reverse

Name: cobT

Synonym: RSc2397

Alternate gene names: 17547116

Gene position: 2604959-2603895 (Counterclockwise)

Preceding gene: 17547117

Following gene: 17547115

Centisome position: 70.09

GC content: 73.43

Gene sequence:

>1065_bases
ATGCACACTGATATTTCTTCCTTCGATCCCGCGCTCGCTGCCCGCCTGCGGGCCGCCGTCGACAGCAAGACCAAGCCGCT
CGGGGCGCTCGGCCGGCTGGAGTCGCTGGCCGTGCAGATCGGCCTGATCCAGGACACCGAAGCGCCCGTGCTGATCCGGC
CGGCCATGGTGGTGTTCGCCGCCGACCACGGCGTCGCGCAGGCGGGCGTCAGCGCTTACCCGCAGGCGGTGACGGCGCAG
ATGGTGCTCAACTTCATCGCCGGCGGCGCGGCGGTCAACGTGTTCTGCCGCCAGCACGGCTTCGCGTTGGAGATCGTCAA
TGCGGGCGTGGCCATGCCGCTGTGGTCGCTGGGCGTGCCCGGCCTGATCGATGCGCCCATCGGCGCCGGTACCCGCAACT
TCGCGCACGAACCGGCGATGACCGCGGCGGAGCGCGACCGCGCCATGGCGCTGGGCGCGCAGCGCGTGGCGGCGCACGCC
GAGCTCGGTTCCAACGTGATCGCGCTGGGCGAGATGGGCATCGGCAACACGGCCTCGGCGGCCTGCCTGATGGCGCGGCT
GTGCGATCTGCCGCTCGCGCAATGCGTCGGGCGCGGCGCCGGCCTCGACGATGCGGGGCTGGCCCGCAAGTGCGCGGTGC
TGGAGGCCGCGCTGGCCGCGCACGCCGATGCCCGCGCGCCGCTGGACGCGCTCGCCTGCTTCGGCGGTTTCGAGATCGCG
GCCATGGCCGGCGCGATGCTGGAAGCCGCGCGGCGCCGCATGGTGATCCTGGTGGACGGCTTCATCGCTTCGGCCGCGGC
GCTGGTGGCCACGCGCGTCGCCCCCGAGGTGCAGCGCTTCTGCGTGTTCGCGCATCTGTCGGACGAGCACGGCCATCGCG
CGTTGCTGGCCGCGCTGGGCGCCGAACCGCTGCTGCAGCTGTCGATGCGGCTGGGCGAGGGCAGCGGCGCGGTGCTGGCG
TATCCGCTGGTGGTCTCGGCGGTCGCCTTCCTGCGCGAGATGGCGACGTTCGCCAGCGCCGGCGTGAGCGAGCAGGCGCC
GCCGGCGCTGGATCCGGCGGCATGA

Upstream 100 bases:

>100_bases
TTGACGTGGCCGATTCCGCGACGGACATGAGGCTCGTCAAGCGCACGTTTCCCCAAGGCATCCTGGCGCAGCCCGGTGCC
GAACCCTAGGTGTTCCATCC

Downstream 100 bases:

>100_bases
TGGCGGCCCTGCGCGAGGCCTGCCGGTCGCTGTGGATCGCGATCGGCTATTTCACGCGCATTCCCGTGCCCGCATCGGTC
GGCTTCTCGCAGGACGGGCT

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MHTDISSFDPALAARLRAAVDSKTKPLGALGRLESLAVQIGLIQDTEAPVLIRPAMVVFAADHGVAQAGVSAYPQAVTAQ
MVLNFIAGGAAVNVFCRQHGFALEIVNAGVAMPLWSLGVPGLIDAPIGAGTRNFAHEPAMTAAERDRAMALGAQRVAAHA
ELGSNVIALGEMGIGNTASAACLMARLCDLPLAQCVGRGAGLDDAGLARKCAVLEAALAAHADARAPLDALACFGGFEIA
AMAGAMLEAARRRMVILVDGFIASAAALVATRVAPEVQRFCVFAHLSDEHGHRALLAALGAEPLLQLSMRLGEGSGAVLA
YPLVVSAVAFLREMATFASAGVSEQAPPALDPAA

Sequences:

>Translated_354_residues
MHTDISSFDPALAARLRAAVDSKTKPLGALGRLESLAVQIGLIQDTEAPVLIRPAMVVFAADHGVAQAGVSAYPQAVTAQ
MVLNFIAGGAAVNVFCRQHGFALEIVNAGVAMPLWSLGVPGLIDAPIGAGTRNFAHEPAMTAAERDRAMALGAQRVAAHA
ELGSNVIALGEMGIGNTASAACLMARLCDLPLAQCVGRGAGLDDAGLARKCAVLEAALAAHADARAPLDALACFGGFEIA
AMAGAMLEAARRRMVILVDGFIASAAALVATRVAPEVQRFCVFAHLSDEHGHRALLAALGAEPLLQLSMRLGEGSGAVLA
YPLVVSAVAFLREMATFASAGVSEQAPPALDPAA
>Mature_354_residues
MHTDISSFDPALAARLRAAVDSKTKPLGALGRLESLAVQIGLIQDTEAPVLIRPAMVVFAADHGVAQAGVSAYPQAVTAQ
MVLNFIAGGAAVNVFCRQHGFALEIVNAGVAMPLWSLGVPGLIDAPIGAGTRNFAHEPAMTAAERDRAMALGAQRVAAHA
ELGSNVIALGEMGIGNTASAACLMARLCDLPLAQCVGRGAGLDDAGLARKCAVLEAALAAHADARAPLDALACFGGFEIA
AMAGAMLEAARRRMVILVDGFIASAAALVATRVAPEVQRFCVFAHLSDEHGHRALLAALGAEPLLQLSMRLGEGSGAVLA
YPLVVSAVAFLREMATFASAGVSEQAPPALDPAA

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=345, Percent_Identity=35.3623188405797, Blast_Score=181, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_RALSO (Q8XWS3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520518.1
- ProteinModelPortal:   Q8XWS3
- SMR:   Q8XWS3
- GeneID:   1221243
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2397
- NMPDR:   fig|267608.1.peg.2397
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   PRK00105
- BioCyc:   RSOL267608:RSC2397-MONOMER
- BRENDA:   2.4.2.21
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 36092; Mature: 36092

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: ACT_SITE 313-313

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTDISSFDPALAARLRAAVDSKTKPLGALGRLESLAVQIGLIQDTEAPVLIRPAMVVFA
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEECCCCCEEEECEEEEEE
ADHGVAQAGVSAYPQAVTAQMVLNFIAGGAAVNVFCRQHGFALEIVNAGVAMPLWSLGVP
CCCCHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCHHHHHHHCCCC
GLIDAPIGAGTRNFAHEPAMTAAERDRAMALGAQRVAAHAELGSNVIALGEMGIGNTASA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
ACLMARLCDLPLAQCVGRGAGLDDAGLARKCAVLEAALAAHADARAPLDALACFGGFEIA
HHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHH
AMAGAMLEAARRRMVILVDGFIASAAALVATRVAPEVQRFCVFAHLSDEHGHRALLAALG
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHC
AEPLLQLSMRLGEGSGAVLAYPLVVSAVAFLREMATFASAGVSEQAPPALDPAA
CHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHTDISSFDPALAARLRAAVDSKTKPLGALGRLESLAVQIGLIQDTEAPVLIRPAMVVFA
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEECCCCCEEEECEEEEEE
ADHGVAQAGVSAYPQAVTAQMVLNFIAGGAAVNVFCRQHGFALEIVNAGVAMPLWSLGVP
CCCCHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCHHHHHHHCCCC
GLIDAPIGAGTRNFAHEPAMTAAERDRAMALGAQRVAAHAELGSNVIALGEMGIGNTASA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
ACLMARLCDLPLAQCVGRGAGLDDAGLARKCAVLEAALAAHADARAPLDALACFGGFEIA
HHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHH
AMAGAMLEAARRRMVILVDGFIASAAALVATRVAPEVQRFCVFAHLSDEHGHRALLAALG
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHC
AEPLLQLSMRLGEGSGAVLAYPLVVSAVAFLREMATFASAGVSEQAPPALDPAA
CHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852