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The map label for this gene is thrB

Identifier: 17546952

GI number: 17546952

Start: 2422915

End: 2423919

Strand: Direct

Name: thrB

Synonym: RSc2233

Alternate gene names: 17546952

Gene position: 2422915-2423919 (Clockwise)

Preceding gene: 17546951

Following gene: 17546953

Centisome position: 65.19

GC content: 68.16

Gene sequence:

>1005_bases
ATGGCTGTTTTCACCCCGGTCACCAACGCCGAGATCGCCCTCTGGCTGGAGCAATACGACGTGGGCACGGTCCGCGCGCT
GCGCGGCATTCCCTCGGGGATCGAAAACACCAACTTCTTCCTGACCACGGAGAAGGACGGCGCCACGCACGAGTACGTCG
TCACGCTGTTCGAGCGGCTGACCAGCGAGCAACTGCCGTTCTACCTGTACCTGATGCAGCATCTGGCGCAGCACGGCATC
TGCGTGCCGGCGCCGATTCCCGGCCGCGACGGCGCGATCCTGCGCCCGCTCAAGGGCAAGCCGGCGACCATCGTGACGCG
CCTGCCCGGACGCTCGAACCTGGCGCCCACGACGAGCGAATGCGCCATCGTCGGCGACATGCTGGCGCGCATGCACCTGG
CCGGCCGCGACTACCCGCGGCACCAGCCCAACCTGCGCAGCCTGCCGTGGTGGAACGAAGTGGTGCCCGACATCCAGCCC
TTCGTGCAGGGCGCCACGCGCGAGCTGCTGGTCGCCGAGCTGGCCCACCAGCAGCGCTTCTTCGGCAGCGCCGACTATGC
CGCCCTGCCCGAGGGCCCGTGCCACTGCGACCTGTTCCGCGACAACGTGCTGTTCGAGCCGGCCACTGACAGCCAGCCCG
AGCGCCTGGGCGGGTTCTTCGATTTCTATTTCGCCGGCGTCGACAAATGGCTGTTCGACGTGGCCGTGACCGTCAACGAC
TGGTGCGTCGACCTCGCCACGGGTGCGCTCGATGCCGAACGGATGCGCGCCATGCTGCGCGCCTATCACGCGGTGCGGCC
TTTCACCGACGCGGAGGCCCGTCACTGGCGGGACATGCTGCGCGCCGCGGCCTATCGCTTCTGGGTATCGCGCCTGTGGG
ACTTCCACCTGCCGCGCGACGCCGAACTGCTGCAGCCGCATGATCCGACCCACTTCGAGCGCGTGCTGCGCGAACGGGTG
CGCGCCGAGGGGCTGACATTGGATATTCCCGAACCATGCAACTGA

Upstream 100 bases:

>100_bases
CATCCTGAAGTTCTGAGATCCGCGCCGCATTGCCGGCGCCGAGCGGCGGTCCAGCCCATCTGGCCGCCGCGTTTCCTTTT
ACCGTTTTCCGTTTCATAGC

Downstream 100 bases:

>100_bases
TTGAAGTCTCCGGCAAGCAGGGCTACGTCTGGCTGCGCCAGGGTGCGTGGCTGTTCCGCAAGAACCCGATCGGGTTCCTG
CTGCTGCTGTTCATCTACCT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAVFTPVTNAEIALWLEQYDVGTVRALRGIPSGIENTNFFLTTEKDGATHEYVVTLFERLTSEQLPFYLYLMQHLAQHGI
CVPAPIPGRDGAILRPLKGKPATIVTRLPGRSNLAPTTSECAIVGDMLARMHLAGRDYPRHQPNLRSLPWWNEVVPDIQP
FVQGATRELLVAELAHQQRFFGSADYAALPEGPCHCDLFRDNVLFEPATDSQPERLGGFFDFYFAGVDKWLFDVAVTVND
WCVDLATGALDAERMRAMLRAYHAVRPFTDAEARHWRDMLRAAAYRFWVSRLWDFHLPRDAELLQPHDPTHFERVLRERV
RAEGLTLDIPEPCN

Sequences:

>Translated_334_residues
MAVFTPVTNAEIALWLEQYDVGTVRALRGIPSGIENTNFFLTTEKDGATHEYVVTLFERLTSEQLPFYLYLMQHLAQHGI
CVPAPIPGRDGAILRPLKGKPATIVTRLPGRSNLAPTTSECAIVGDMLARMHLAGRDYPRHQPNLRSLPWWNEVVPDIQP
FVQGATRELLVAELAHQQRFFGSADYAALPEGPCHCDLFRDNVLFEPATDSQPERLGGFFDFYFAGVDKWLFDVAVTVND
WCVDLATGALDAERMRAMLRAYHAVRPFTDAEARHWRDMLRAAAYRFWVSRLWDFHLPRDAELLQPHDPTHFERVLRERV
RAEGLTLDIPEPCN
>Mature_333_residues
AVFTPVTNAEIALWLEQYDVGTVRALRGIPSGIENTNFFLTTEKDGATHEYVVTLFERLTSEQLPFYLYLMQHLAQHGIC
VPAPIPGRDGAILRPLKGKPATIVTRLPGRSNLAPTTSECAIVGDMLARMHLAGRDYPRHQPNLRSLPWWNEVVPDIQPF
VQGATRELLVAELAHQQRFFGSADYAALPEGPCHCDLFRDNVLFEPATDSQPERLGGFFDFYFAGVDKWLFDVAVTVNDW
CVDLATGALDAERMRAMLRAYHAVRPFTDAEARHWRDMLRAAAYRFWVSRLWDFHLPRDAELLQPHDPTHFERVLRERVR
AEGLTLDIPEPCN

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_RALSO (Q8XX83)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520354.1
- ProteinModelPortal:   Q8XX83
- SMR:   Q8XX83
- GeneID:   1221078
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2233
- NMPDR:   fig|267608.1.peg.2233
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   PRK05231
- BioCyc:   RSOL267608:RSC2233-MONOMER
- BRENDA:   2.7.1.39
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 37995; Mature: 37864

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVFTPVTNAEIALWLEQYDVGTVRALRGIPSGIENTNFFLTTEKDGATHEYVVTLFERL
CEEECCCCCCEEEEEEHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
TSEQLPFYLYLMQHLAQHGICVPAPIPGRDGAILRPLKGKPATIVTRLPGRSNLAPTTSE
HHCCCCHHHHHHHHHHHCCCEECCCCCCCCCCEECCCCCCCCEEEEECCCCCCCCCCCHH
CAIVGDMLARMHLAGRDYPRHQPNLRSLPWWNEVVPDIQPFVQGATRELLVAELAHQQRF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGSADYAALPEGPCHCDLFRDNVLFEPATDSQPERLGGFFDFYFAGVDKWLFDVAVTVND
CCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WCVDLATGALDAERMRAMLRAYHAVRPFTDAEARHWRDMLRAAAYRFWVSRLWDFHLPRD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AELLQPHDPTHFERVLRERVRAEGLTLDIPEPCN
CHHCCCCCCHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
AVFTPVTNAEIALWLEQYDVGTVRALRGIPSGIENTNFFLTTEKDGATHEYVVTLFERL
EEECCCCCCEEEEEEHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
TSEQLPFYLYLMQHLAQHGICVPAPIPGRDGAILRPLKGKPATIVTRLPGRSNLAPTTSE
HHCCCCHHHHHHHHHHHCCCEECCCCCCCCCCEECCCCCCCCEEEEECCCCCCCCCCCHH
CAIVGDMLARMHLAGRDYPRHQPNLRSLPWWNEVVPDIQPFVQGATRELLVAELAHQQRF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGSADYAALPEGPCHCDLFRDNVLFEPATDSQPERLGGFFDFYFAGVDKWLFDVAVTVND
CCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WCVDLATGALDAERMRAMLRAYHAVRPFTDAEARHWRDMLRAAAYRFWVSRLWDFHLPRD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AELLQPHDPTHFERVLRERVRAEGLTLDIPEPCN
CHHCCCCCCHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852