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The map label for this gene is upp [H]

Identifier: 17546907

GI number: 17546907

Start: 2370069

End: 2370719

Strand: Direct

Name: upp [H]

Synonym: RSc2188

Alternate gene names: 17546907

Gene position: 2370069-2370719 (Clockwise)

Preceding gene: 17546902

Following gene: 17546909

Centisome position: 63.77

GC content: 68.05

Gene sequence:

>651_bases
ATGACACAAGATCCGCGCTTTCCCAACCTGTTCATCCTCAACCACCCGCTGATCCAGCACAAGCTCACGCACATGCGCGA
CAAGGACACGTCCACGCGCACCTTCCGCGAGCTGCTGCGCGAGATCACGCTGCTGATGGGCTACGAGATCACGCGCAACC
TGCCGCTGACCACGCGCCACATCGAGACGCCGATGGGCCCGATGGACGCCCCCGTCATCGCCGGCCGCAAGCTGGCGGTG
GTGCCGGTGCTGCGGGCGGGCGTGGGCATGAGCGACGGGCTGCTGGAGCTGATCCCGTCGGCGCGCGTCGGGCATATCGG
CGTGTACCGCGACGAGCAGCACCGCCCGGTCGAATACCTGGTGCGGCTGCCGGACCTGGAAGAGCGCACCTTCATCCTGT
GCGATCCGATGGTCGCCACCGGCCACTCGGCCGTGCACGCCGTCGACGTGATGAAGCAGCGCGGCGTGCCGGACGAGCAC
ATCCTGTTCCTCGCGCTGGTGGCGGCGCCGGAAGGCGTGGAGGTGTTCCAGCAGGCGCACCCCGGCGTGAAGCTGTACGT
CGCCTCGCTCGATTCGCACCTCAACGAGCACGCCTACATCATCCCCGGCCTGGGCGACGCGGGCGACCGGCTGTTCGGCA
CCAAGAACTGA

Upstream 100 bases:

>100_bases
GTATGTGAATTCGGCAAAACGTTCCGGCCCGCGCGGGCCGCGCCACCCGGCGCCGGAGCACGCCGGTACAATGCCCCACA
TTCCTGCCGGACCCGCTGCC

Downstream 100 bases:

>100_bases
TCGCGCCGGCACGCGCGCAGACAGAAACAGCTGGTCATGCCGGCTGTTTTGCCGCTCATGCCGGCTGTTTTCGTTGCGCG
GTGCGGCAGCCTCAGCGCCG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTQDPRFPNLFILNHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPLTTRHIETPMGPMDAPVIAGRKLAV
VPVLRAGVGMSDGLLELIPSARVGHIGVYRDEQHRPVEYLVRLPDLEERTFILCDPMVATGHSAVHAVDVMKQRGVPDEH
ILFLALVAAPEGVEVFQQAHPGVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN

Sequences:

>Translated_216_residues
MTQDPRFPNLFILNHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPLTTRHIETPMGPMDAPVIAGRKLAV
VPVLRAGVGMSDGLLELIPSARVGHIGVYRDEQHRPVEYLVRLPDLEERTFILCDPMVATGHSAVHAVDVMKQRGVPDEH
ILFLALVAAPEGVEVFQQAHPGVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN
>Mature_215_residues
TQDPRFPNLFILNHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPLTTRHIETPMGPMDAPVIAGRKLAVV
PVLRAGVGMSDGLLELIPSARVGHIGVYRDEQHRPVEYLVRLPDLEERTFILCDPMVATGHSAVHAVDVMKQRGVPDEHI
LFLALVAAPEGVEVFQQAHPGVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=32.6732673267327, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=32.6732673267327, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=28.8235294117647, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=49.7560975609756, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17539892, Length=212, Percent_Identity=29.7169811320755, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17539894, Length=212, Percent_Identity=29.7169811320755, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17506069, Length=182, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506071, Length=149, Percent_Identity=28.1879194630872, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=217, Percent_Identity=36.405529953917, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550449, Length=222, Percent_Identity=32.8828828828829, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573516, Length=222, Percent_Identity=32.8828828828829, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573514, Length=222, Percent_Identity=32.8828828828829, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573512, Length=222, Percent_Identity=32.8828828828829, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358379, Length=171, Percent_Identity=29.2397660818713, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005765 [H]

Pfam domain/function: NA

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24111; Mature: 23980

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDPRFPNLFILNHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPLTTRH
CCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHCCCCCCCCC
IETPMGPMDAPVIAGRKLAVVPVLRAGVGMSDGLLELIPSARVGHIGVYRDEQHRPVEYL
CCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHH
VRLPDLEERTFILCDPMVATGHSAVHAVDVMKQRGVPDEHILFLALVAAPEGVEVFQQAH
EECCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCHHEEEEHEECCCCHHHHHHHCC
PGVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN
CCEEEEEEEHHHCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQDPRFPNLFILNHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPLTTRH
CCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHCCCCCCCCC
IETPMGPMDAPVIAGRKLAVVPVLRAGVGMSDGLLELIPSARVGHIGVYRDEQHRPVEYL
CCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHH
VRLPDLEERTFILCDPMVATGHSAVHAVDVMKQRGVPDEHILFLALVAAPEGVEVFQQAH
EECCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCHHEEEEHEECCCCHHHHHHHCC
PGVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN
CCEEEEEEEHHHCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA