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The map label for this gene is ydgK [H]

Identifier: 17546891

GI number: 17546891

Start: 2354779

End: 2356002

Strand: Reverse

Name: ydgK [H]

Synonym: RSc2172

Alternate gene names: 17546891

Gene position: 2356002-2354779 (Counterclockwise)

Preceding gene: 17546897

Following gene: 17546890

Centisome position: 63.39

GC content: 71.57

Gene sequence:

>1224_bases
ATGACTGCTCCCGATTCCAGACGCGCTCGCCTGCCCCGCCTGCGCGGCGCCATTCCCGGCTGGCTTCTGCTGCTGGGCGC
GCTGACCGCCATCGGTCCGCTATCGGTCGACATGTACCTGCCGAGCCTGCCCACCATCGCGCGCGATCTCAGGACGTCGT
CGGCAGCGGCGGGGATCACGCTCACGGCGTTCCTGGTCAGCCTGGCGATCGGCCAGCTGATCTACGGCCCGGCCAGCGAC
CGCTTCGGCCGCAAGCCCCCGCTCTATATCGGCCTGGCCCTGTACGTGGCGGCGTCGGTCGGCTGCGCGTTCGCCACCGA
TGCCACCATGCTGGCCGTGCTGCGCGCCGTGCAGGGGTTCGGCGGCTGCGCGGGCATGGTGATCTCGCGCGCGGCCGTGC
GCGACCGGATGGACCCGGCCGGCGCGGCGCAGGCCTACTCCACGCTGATGCTGGTGATGGGCGTGGCGCCCATTCTCGCG
CCGATGATCGGCGGGGCGGTGCTGCAGGTGACCTCGTGGCGGATGATCTTCGCGGTGCTGGCGGCGTTCGGCGTGCTGTC
GCTGGCGGCGGTGCATTTTCTGATGCGCGAGTCGCTGGATGCGGCGCACGCGCGGCCGCTGGCCGTCGGCCGGGTGCTGC
GCGACTACTGGGAACTGCTGCGCGATCGCCATTACGCCGCCTATACGGCGTGCGGCGCGGTATTCGTGTCGGGCATGTTC
GCCTACATCACCGCCTCGCCGTTCGTGCTGATCGACCATTACGGATTGAGCCCGTCGCACTATGCGTGGGTGTTCGGCAG
CAATGCGGCGGGCATGATTGCAGCCTCCCGGATCAATGTGCGGCTGATGCGCCGGTCTACGCCGGCCCGGGTGCTGCGCC
GCGCGCTGTGGATGCCGGCCGCGACGAGCGTGGCGGCTGCCGCGGTGGTCGGCGCCGGTTTCATGCCGCTGCCGCTGGTG
CTGGCGGCGCTGTTCTGTTACGTCGCCTCGATCGGCTGCATTTCGCCCAACACGGGCGCGCTTGCCATGGCCGGGCAGGG
GGCCCGCGCCGGCACGGGCTCGGCGCTGATGGGCGCCATGCAGTTCGGCCTGGGCATGGTCACCGGCACGGTGGTCGCCG
CGTTCGGGCAGGGCGCGGCACCGTTGCTGGGCATGATGGCGGTCAGCGCCGTGCTGGCCCTGTGGCTCGGCCTGCGCGCC
ACGCAGCACGAGCACGGCGGCTGA

Upstream 100 bases:

>100_bases
TCCGGCGGGCGATGCGGCTTTGCGCTACAGTTTGACGTTTGCTCCGGCGCGATCCCGATCCGTTTCCGTGCGCGATCGCT
GCCGTGTTTCCCGCGCCCCC

Downstream 100 bases:

>100_bases
AGACGGCGGCGCGGTGCCGTTTTCGGCTGCCGCTTCGGTTCGAGATGACGCAGGCACGGTCGGCTGTCCATCCGGGGCAT
CGCCTTGCCTATGATGAACG

Product: drug transport transmembrane protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTAPDSRRARLPRLRGAIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLRTSSAAAGITLTAFLVSLAIGQLIYGPASD
RFGRKPPLYIGLALYVAASVGCAFATDATMLAVLRAVQGFGGCAGMVISRAAVRDRMDPAGAAQAYSTLMLVMGVAPILA
PMIGGAVLQVTSWRMIFAVLAAFGVLSLAAVHFLMRESLDAAHARPLAVGRVLRDYWELLRDRHYAAYTACGAVFVSGMF
AYITASPFVLIDHYGLSPSHYAWVFGSNAAGMIAASRINVRLMRRSTPARVLRRALWMPAATSVAAAAVVGAGFMPLPLV
LAALFCYVASIGCISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAFGQGAAPLLGMMAVSAVLALWLGLRA
TQHEHGG

Sequences:

>Translated_407_residues
MTAPDSRRARLPRLRGAIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLRTSSAAAGITLTAFLVSLAIGQLIYGPASD
RFGRKPPLYIGLALYVAASVGCAFATDATMLAVLRAVQGFGGCAGMVISRAAVRDRMDPAGAAQAYSTLMLVMGVAPILA
PMIGGAVLQVTSWRMIFAVLAAFGVLSLAAVHFLMRESLDAAHARPLAVGRVLRDYWELLRDRHYAAYTACGAVFVSGMF
AYITASPFVLIDHYGLSPSHYAWVFGSNAAGMIAASRINVRLMRRSTPARVLRRALWMPAATSVAAAAVVGAGFMPLPLV
LAALFCYVASIGCISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAFGQGAAPLLGMMAVSAVLALWLGLRA
TQHEHGG
>Mature_406_residues
TAPDSRRARLPRLRGAIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLRTSSAAAGITLTAFLVSLAIGQLIYGPASDR
FGRKPPLYIGLALYVAASVGCAFATDATMLAVLRAVQGFGGCAGMVISRAAVRDRMDPAGAAQAYSTLMLVMGVAPILAP
MIGGAVLQVTSWRMIFAVLAAFGVLSLAAVHFLMRESLDAAHARPLAVGRVLRDYWELLRDRHYAAYTACGAVFVSGMFA
YITASPFVLIDHYGLSPSHYAWVFGSNAAGMIAASRINVRLMRRSTPARVLRRALWMPAATSVAAAAVVGAGFMPLPLVL
AALFCYVASIGCISPNTGALAMAGQGARAGTGSALMGAMQFGLGMVTGTVVAAFGQGAAPLLGMMAVSAVLALWLGLRAT
QHEHGG

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=384, Percent_Identity=31.5104166666667, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI48994889, Length=396, Percent_Identity=32.3232323232323, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790146, Length=246, Percent_Identity=30.8943089430894, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790794, Length=324, Percent_Identity=25.6172839506173, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1787065, Length=356, Percent_Identity=27.247191011236, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082312, Length=387, Percent_Identity=28.1653746770026, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081983, Length=165, Percent_Identity=27.8787878787879, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=26.6272189349112, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42241; Mature: 42109

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPDSRRARLPRLRGAIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLRTSSAAAGIT
CCCCCCHHHHCCHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
LTAFLVSLAIGQLIYGPASDRFGRKPPLYIGLALYVAASVGCAFATDATMLAVLRAVQGF
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
GGCAGMVISRAAVRDRMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQVTSWRMIFAVL
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AAFGVLSLAAVHFLMRESLDAAHARPLAVGRVLRDYWELLRDRHYAAYTACGAVFVSGMF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AYITASPFVLIDHYGLSPSHYAWVFGSNAAGMIAASRINVRLMRRSTPARVLRRALWMPA
HHHHCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
ATSVAAAAVVGAGFMPLPLVLAALFCYVASIGCISPNTGALAMAGQGARAGTGSALMGAM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHH
QFGLGMVTGTVVAAFGQGAAPLLGMMAVSAVLALWLGLRATQHEHGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAPDSRRARLPRLRGAIPGWLLLLGALTAIGPLSVDMYLPSLPTIARDLRTSSAAAGIT
CCCCCHHHHCCHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
LTAFLVSLAIGQLIYGPASDRFGRKPPLYIGLALYVAASVGCAFATDATMLAVLRAVQGF
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
GGCAGMVISRAAVRDRMDPAGAAQAYSTLMLVMGVAPILAPMIGGAVLQVTSWRMIFAVL
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AAFGVLSLAAVHFLMRESLDAAHARPLAVGRVLRDYWELLRDRHYAAYTACGAVFVSGMF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AYITASPFVLIDHYGLSPSHYAWVFGSNAAGMIAASRINVRLMRRSTPARVLRRALWMPA
HHHHCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
ATSVAAAAVVGAGFMPLPLVLAALFCYVASIGCISPNTGALAMAGQGARAGTGSALMGAM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHH
QFGLGMVTGTVVAAFGQGAAPLLGMMAVSAVLALWLGLRATQHEHGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]