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The map label for this gene is uao [H]

Identifier: 17546840

GI number: 17546840

Start: 2298088

End: 2298609

Strand: Direct

Name: uao [H]

Synonym: RSc2121

Alternate gene names: 17546840

Gene position: 2298088-2298609 (Clockwise)

Preceding gene: 17546839

Following gene: 17546841

Centisome position: 61.84

GC content: 71.65

Gene sequence:

>522_bases
ATGAGCCAGACCGCTGCCCCCCTCGCCCAGCTCAACGCCATGGACACCGCGCAGTTCGTGCGCACGCTGGGCGGCATCTA
CGAGCACTCGCCATGGGTGGCCGAGCAGGCCGCCGGGCAGCGCCCGTTCGCCTCGGCCGACGCGCTCGCGGCCGCCATGC
GCCGTGCCGTCGACGGCGCCGGCGAAGGCCCGCAGCTCAAGCTGGTGCGCGCCCACCCGGAACTCGCAGGCAAGGCCGCC
GTGCGCGGCGAGCTGACCGCCGAATCGACCCGCGAGCAGGCGAGCGCCGGCCTGGACCAGTGCTCGCCCGAAGAATTCGC
GCGCCTGCAGGCACTGAACGCGCGCTACAACGACAAGTTCGGCTTCCCGTTCATCCTGGCGGTGCGCGGCTACGACCGGC
ACGGCATCATCGACGTGTTCGCCAGGCGCCTCGAGAACGACCGCGCCACCGAGCTGCGCGCGTCGCTGGAGCAGATCCAC
CGCATCGCCGGCTTCCGTCTGCACGACCTGATTTCAGGCTAG

Upstream 100 bases:

>100_bases
AATCGCACGACAAGGTGTGGATCTGCCGGCGCATCGATATCGCCCGCCACTGGATCGAACACCATCCGTACGCTGGCCAC
CCCGTCCCGAGCACCGCCGC

Downstream 100 bases:

>100_bases
CCATCAAAAGCGGAACGCCGCGGGCGCGGCACCACATCAAGAACACCATCTCGACGGGCGACACGAAGGCCAACGGCGGC
CAGCTGGGCGTGTCGGTGCC

Product: hypothetical protein

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSQTAAPLAQLNAMDTAQFVRTLGGIYEHSPWVAEQAAGQRPFASADALAAAMRRAVDGAGEGPQLKLVRAHPELAGKAA
VRGELTAESTREQASAGLDQCSPEEFARLQALNARYNDKFGFPFILAVRGYDRHGIIDVFARRLENDRATELRASLEQIH
RIAGFRLHDLISG

Sequences:

>Translated_173_residues
MSQTAAPLAQLNAMDTAQFVRTLGGIYEHSPWVAEQAAGQRPFASADALAAAMRRAVDGAGEGPQLKLVRAHPELAGKAA
VRGELTAESTREQASAGLDQCSPEEFARLQALNARYNDKFGFPFILAVRGYDRHGIIDVFARRLENDRATELRASLEQIH
RIAGFRLHDLISG
>Mature_172_residues
SQTAAPLAQLNAMDTAQFVRTLGGIYEHSPWVAEQAAGQRPFASADALAAAMRRAVDGAGEGPQLKLVRAHPELAGKAAV
RGELTAESTREQASAGLDQCSPEEFARLQALNARYNDKFGFPFILAVRGYDRHGIIDVFARRLENDRATELRASLEQIHR
IAGFRLHDLISG

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3195

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Homo sapiens, GI157743280, Length=164, Percent_Identity=40.2439024390244, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 18811; Mature: 18680

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTAAPLAQLNAMDTAQFVRTLGGIYEHSPWVAEQAAGQRPFASADALAAAMRRAVDGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCC
GEGPQLKLVRAHPELAGKAAVRGELTAESTREQASAGLDQCSPEEFARLQALNARYNDKF
CCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
GFPFILAVRGYDRHGIIDVFARRLENDRATELRASLEQIHRIAGFRLHDLISG
CCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure 
SQTAAPLAQLNAMDTAQFVRTLGGIYEHSPWVAEQAAGQRPFASADALAAAMRRAVDGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCC
GEGPQLKLVRAHPELAGKAAVRGELTAESTREQASAGLDQCSPEEFARLQALNARYNDKF
CCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
GFPFILAVRGYDRHGIIDVFARRLENDRATELRASLEQIHRIAGFRLHDLISG
CCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]