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The map label for this gene is nuoN [H]

Identifier: 17546768

GI number: 17546768

Start: 2221198

End: 2222670

Strand: Reverse

Name: nuoN [H]

Synonym: RSc2049

Alternate gene names: 17546768

Gene position: 2222670-2221198 (Counterclockwise)

Preceding gene: 17546769

Following gene: 17546767

Centisome position: 59.81

GC content: 65.24

Gene sequence:

>1473_bases
ATGCAAAACATGAACTGGGCACCGTTGTTGCCGATTATTTTCCTGTCGGTGATGATCGCCGTGATCCAACTGGCCGACGT
GTTCCGCCGCGAGCAGGGCAGCAGCCCGGCCTACGGCCTGAGCCTGTTCGCCACGCTCGCGCTGACCCTCTGGTTTGCCG
TGCAGGCCGCCTCGGGCGAGACACACTACGTGTTCAGCAACATGGCCGTGTTCGATCCGATGGCGCAGGTGCTGTCTTCG
TTCTGCGCGCTGGCGACGCTGGTGACCTTCGTCTACACCCGCGGCTACCTGGCTGACCGCGAGATGTTCAACGGCGAGTT
CTACATCCTCGCGCTGTTCACGCTGCTGGGCCAGATCGTGATGATCTCGGGCAACAACTTCCTGACCCTGTACCTGGGCC
TGGAGCTGCTGTCGCTGGGCTCGTACGCGCTGGTGGCGCTGCGCCGCGGCTCGAACGTGTCGTCGGAATCGGGCATGAAG
TACTTCATCCTCGGCGCGCTGGCCTCGGGCCTGCTGCTGTACGGCATGTCGATGCTGTACGGCGCGACCGGCTCGCTTGA
CCTGGGCAAGGTCTTCCACGCGATCGAGACCGGCGACATCAACAAGACCATCCTGGTGTTCGGTGTCGTGTTCATCGTGG
CCGGCCTGGCGTTCAAGCTGGGTGTCGCACCGTTCCACATGTGGGTGCCGGATGTGTACCAGGGCTCGCCGACGGCGGTG
ACGCTGCTGATCGCCGGCGCGCCCAAGGTCGCGGCGTTCGCGATGACGCTGCGCATCCTGGTGGAAGGGCTGCTGCCGCT
GGCGTTCGACTGGCAGAACATGCTGATCGTGCTGGCCATCGCGTCGCTGGCCATCGGCAACATCACCGGCGTGGTGCAGA
CCAACTTCAAGCGTCTGCTGGCGTATTCGACGGTGTCCCACATGGGCTTCCTGCTGCTGGGCCTGCTGTCGGGCGTGAGC
AGCGGCAAGCCGGACCTGACCGCGCAGGCGTACAGCGCGTCGATGTTCTACGCCATCACCTACGTGCTGACCGCGCTGGG
TGCCTTCGGCGTCATCCTGCTGCTGGCGCGCAAGGGCTATGAGGCCGAGGAGATCGCCGACCTGAAGGGCTTGTCGAAGA
AGAGCCCGTGGTTCGCGCTGCTGACGCTGTTCATGATGATGTCGCTGGCGGGCCTGCCGCCGACGGTGGGCTTCTACGCC
AAGCTGTCGGTGCTGGGCGCGGTGGTCGACGCCGGCATGTCGTGGCTGGCCATCGTGGCGGTGCTGTTCTCGCTGGTGGG
CGCGTTCTACTACCTGCGCGTCGTCAAGGCGATGTATTTCGACGCGCCGGCCGACGAAGGCCCGGTGCAGGCGACGTTCG
GCCTGCGTTCGCTGCTGTCGGTCAACGGTCTGCTGGTGCTGCTGCTGGGCATCTTCCCGGCCAGCCTGATGGGCCTGTGC
TACCAGGCGATCCGCCTGACGCTGGCGTCCTGA

Upstream 100 bases:

>100_bases
CTGTATCCGAAGCCTTTCACCGATGTCATGCATGCGTCCGTGGTGAATCTCCTCACCCACGTGGCCCAGACCAAGCTGTA
AGCGGGGAGTCGAAACGATC

Downstream 100 bases:

>100_bases
GTCGGCGGCGAACGGCATGGGCACTTCGACAGGCAGCCTGTTTGTCATCGTGCTGGCATTGATCTGTGCCAACCTGCCGT
TCGTCAACCAGCGCGTGCTG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MQNMNWAPLLPIIFLSVMIAVIQLADVFRREQGSSPAYGLSLFATLALTLWFAVQAASGETHYVFSNMAVFDPMAQVLSS
FCALATLVTFVYTRGYLADREMFNGEFYILALFTLLGQIVMISGNNFLTLYLGLELLSLGSYALVALRRGSNVSSESGMK
YFILGALASGLLLYGMSMLYGATGSLDLGKVFHAIETGDINKTILVFGVVFIVAGLAFKLGVAPFHMWVPDVYQGSPTAV
TLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAIASLAIGNITGVVQTNFKRLLAYSTVSHMGFLLLGLLSGVS
SGKPDLTAQAYSASMFYAITYVLTALGAFGVILLLARKGYEAEEIADLKGLSKKSPWFALLTLFMMMSLAGLPPTVGFYA
KLSVLGAVVDAGMSWLAIVAVLFSLVGAFYYLRVVKAMYFDAPADEGPVQATFGLRSLLSVNGLLVLLLGIFPASLMGLC
YQAIRLTLAS

Sequences:

>Translated_490_residues
MQNMNWAPLLPIIFLSVMIAVIQLADVFRREQGSSPAYGLSLFATLALTLWFAVQAASGETHYVFSNMAVFDPMAQVLSS
FCALATLVTFVYTRGYLADREMFNGEFYILALFTLLGQIVMISGNNFLTLYLGLELLSLGSYALVALRRGSNVSSESGMK
YFILGALASGLLLYGMSMLYGATGSLDLGKVFHAIETGDINKTILVFGVVFIVAGLAFKLGVAPFHMWVPDVYQGSPTAV
TLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAIASLAIGNITGVVQTNFKRLLAYSTVSHMGFLLLGLLSGVS
SGKPDLTAQAYSASMFYAITYVLTALGAFGVILLLARKGYEAEEIADLKGLSKKSPWFALLTLFMMMSLAGLPPTVGFYA
KLSVLGAVVDAGMSWLAIVAVLFSLVGAFYYLRVVKAMYFDAPADEGPVQATFGLRSLLSVNGLLVLLLGIFPASLMGLC
YQAIRLTLAS
>Mature_490_residues
MQNMNWAPLLPIIFLSVMIAVIQLADVFRREQGSSPAYGLSLFATLALTLWFAVQAASGETHYVFSNMAVFDPMAQVLSS
FCALATLVTFVYTRGYLADREMFNGEFYILALFTLLGQIVMISGNNFLTLYLGLELLSLGSYALVALRRGSNVSSESGMK
YFILGALASGLLLYGMSMLYGATGSLDLGKVFHAIETGDINKTILVFGVVFIVAGLAFKLGVAPFHMWVPDVYQGSPTAV
TLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAIASLAIGNITGVVQTNFKRLLAYSTVSHMGFLLLGLLSGVS
SGKPDLTAQAYSASMFYAITYVLTALGAFGVILLLARKGYEAEEIADLKGLSKKSPWFALLTLFMMMSLAGLPPTVGFYA
KLSVLGAVVDAGMSWLAIVAVLFSLVGAFYYLRVVKAMYFDAPADEGPVQATFGLRSLLSVNGLLVLLLGIFPASLMGLC
YQAIRLTLAS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=242, Percent_Identity=26.8595041322314, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI145693160, Length=488, Percent_Identity=32.5819672131148, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1788827, Length=332, Percent_Identity=26.5060240963855, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788614, Length=374, Percent_Identity=24.8663101604278, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788831, Length=325, Percent_Identity=25.5384615384615, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788613, Length=322, Percent_Identity=26.7080745341615, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367154, Length=269, Percent_Identity=28.2527881040892, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52564; Mature: 52564

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNMNWAPLLPIIFLSVMIAVIQLADVFRREQGSSPAYGLSLFATLALTLWFAVQAASGE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
THYVFSNMAVFDPMAQVLSSFCALATLVTFVYTRGYLADREMFNGEFYILALFTLLGQIV
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHEE
MISGNNFLTLYLGLELLSLGSYALVALRRGSNVSSESGMKYFILGALASGLLLYGMSMLY
EEECCCEEEEHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GATGSLDLGKVFHAIETGDINKTILVFGVVFIVAGLAFKLGVAPFHMWVPDVYQGSPTAV
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEE
TLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAIASLAIGNITGVVQTNFKRLL
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AYSTVSHMGFLLLGLLSGVSSGKPDLTAQAYSASMFYAITYVLTALGAFGVILLLARKGY
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EAEEIADLKGLSKKSPWFALLTLFMMMSLAGLPPTVGFYAKLSVLGAVVDAGMSWLAIVA
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
VLFSLVGAFYYLRVVKAMYFDAPADEGPVQATFGLRSLLSVNGLLVLLLGIFPASLMGLC
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQAIRLTLAS
HHHHHHHHCC
>Mature Secondary Structure
MQNMNWAPLLPIIFLSVMIAVIQLADVFRREQGSSPAYGLSLFATLALTLWFAVQAASGE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
THYVFSNMAVFDPMAQVLSSFCALATLVTFVYTRGYLADREMFNGEFYILALFTLLGQIV
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHEE
MISGNNFLTLYLGLELLSLGSYALVALRRGSNVSSESGMKYFILGALASGLLLYGMSMLY
EEECCCEEEEHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GATGSLDLGKVFHAIETGDINKTILVFGVVFIVAGLAFKLGVAPFHMWVPDVYQGSPTAV
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEE
TLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAIASLAIGNITGVVQTNFKRLL
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
AYSTVSHMGFLLLGLLSGVSSGKPDLTAQAYSASMFYAITYVLTALGAFGVILLLARKGY
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EAEEIADLKGLSKKSPWFALLTLFMMMSLAGLPPTVGFYAKLSVLGAVVDAGMSWLAIVA
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
VLFSLVGAFYYLRVVKAMYFDAPADEGPVQATFGLRSLLSVNGLLVLLLGIFPASLMGLC
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQAIRLTLAS
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA