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The map label for this gene is ureC

Identifier: 17546751

GI number: 17546751

Start: 2206070

End: 2207788

Strand: Reverse

Name: ureC

Synonym: RSc2032

Alternate gene names: 17546751

Gene position: 2207788-2206070 (Counterclockwise)

Preceding gene: 17546752

Following gene: 17546750

Centisome position: 59.41

GC content: 67.89

Gene sequence:

>1719_bases
ATGACACTCAAGATCACCCGCCGCGCCTATGCGGAGATGTTCGGCCCGACCACCGGCGACCGCGTCCGCCTGGCCGACAC
CGACCTCATCGTCGAGGTCGAGCGCGACTACACGATCTACGGCGAAGAGGTGAAATTCGGCGGCGGCAAGGTCATCCGCG
ACGGCATGGGCCAGAGCCAGCGCGAATCGAAGGACTGCGCCGACACGGTCATCACCAACGCGCTGATCATCGACCACTGG
GGCATCGTCAAGGCCGACATCGGCCTGAAGCACGGCCGCATTGCCGCCATCGGCAAGGCGGGCAATCCGGACATCCAGCC
GGGCGTGACCATCGTCATCGGGCCGGGCACCGAGATCATCGCGGGCGAAGGCATGATCGTCACGGCGGGCGGGGTCGATA
CGCATATCCATTTCATCTGCCCGCAGCAGATCGACGAGGCGCTCAACAGCGGCGTGACGACCATGATCGGCGGCGGCACC
GGGCCGGCCACAGGCACCTACGCGACCACCTGCACGCCGGGGCCGTGGCACCTGCAGCGCATGCTGCAGGCGGCCGATGC
CTACCCGATGAACATCGGTTTCCTGGGCAAGGGCAACGGCAGCCTGCCCGGCGCGCTGCGCGAGCAGATCGATGCCGGCG
CCATCGGCCTGAAGCTGCACGAAGACTGGGGCTCGACGCCCGCCGCCATCGACTGCTGCCTGGGCGTGGCCGACGACACC
GACACGCAGGTCGCCATCCACACCGACACGCTCAACGAATCGGGCTTCGTCGAGGCGACCATCGCCGCGTTCAAGGGCCG
CACCATCCACACGTATCACACCGAGGGGGCGGGCGGCGGCCATGCGCCGGACATCATCCGCGTGTGCGGCGAGTCCAACG
TGCTGCCCTCGTCGACCAACCCGACGCGGCCGTTCACCGTCAACACGCTGGACGAGCACCTCGATATGCTGATGGTGTGC
CACCATCTGGACGCCTCCATCGCCGAGGACATCGCCTTCGCCGAGAGCCGCATCCGCCGAGAAACCATCGCCGCCGAAGA
CATCCTGCACGACCTGGGCGCGTTCTCGATGCTCTCGAGCGACTCGCAGGCCATGGGCCGCGTCGGCGAGGTGATCCTGC
GCACCTGGCAGACCGCGCACAAGATGAAGGCGCAGCGCGGCAAGCTGGCCGGCGACCCGAACGACGCGCGCGGCGGGCAC
GACAACTTCCGCGTCAAGCGCTACGTCGCCAAGTACACGATCAACCCCGCCATCACGCACGGTATTGCGCACGAGGTCGG
CTCGATCGAGGTCGGCAAGTGGGCCGACCTAGTGCTGTGGAAGCCTGCCTTCTTCGGCGTCAAGCCGAGCCTGATTCTCA
AGGGCGGCATGATTGCTTCGGCGGCGATGGGCGATGCCAATGCGTCGATCCCGACGCCGCAGCCGGTGCACTACCGGCCG
ATGTTCGCGGCGGCGGGCGGCGCGCTGGCGCGGTCGTCGCTGAGCTTCCTCTCGCAATCGGCGGCGCAGGCCGGCGTGGC
CGAGCGCTACGGCCTCGCCAAGACGACCGCCGTCGTTCGGGGCACGCGCGCGGTCACCAAGGCGCAGATGATCCACAACG
ACTGGCAGCCCAGCATCACGGTCGATCCCGAGACCTACCAGGTCGTCGCCGACGGCATGCTGCTGACCTGCGAGCCGGCC
GAGGTGCTGCCGATGGCGCAGCGCTATTTCCTGTTCTGA

Upstream 100 bases:

>100_bases
CAGGAGCGCACCGTGGAACTGGTGGCGCTGGCCGGGGACCGCGTGGTCTACGGCTTTGCCGGCCGCGTGATGGGCAAGCT
CTGAGGTTGAGGGAACCGAT

Downstream 100 bases:

>100_bases
ACATGCTGTCGATCGATAAACATCTTCCCGCGCCGCATGGCCTGGCCGCCGTGCTGGTCAGGCGCGCGCCCAAGCTGGTG
CTGCCGTTCCTGGCGCGCAG

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MTLKITRRAYAEMFGPTTGDRVRLADTDLIVEVERDYTIYGEEVKFGGGKVIRDGMGQSQRESKDCADTVITNALIIDHW
GIVKADIGLKHGRIAAIGKAGNPDIQPGVTIVIGPGTEIIAGEGMIVTAGGVDTHIHFICPQQIDEALNSGVTTMIGGGT
GPATGTYATTCTPGPWHLQRMLQAADAYPMNIGFLGKGNGSLPGALREQIDAGAIGLKLHEDWGSTPAAIDCCLGVADDT
DTQVAIHTDTLNESGFVEATIAAFKGRTIHTYHTEGAGGGHAPDIIRVCGESNVLPSSTNPTRPFTVNTLDEHLDMLMVC
HHLDASIAEDIAFAESRIRRETIAAEDILHDLGAFSMLSSDSQAMGRVGEVILRTWQTAHKMKAQRGKLAGDPNDARGGH
DNFRVKRYVAKYTINPAITHGIAHEVGSIEVGKWADLVLWKPAFFGVKPSLILKGGMIASAAMGDANASIPTPQPVHYRP
MFAAAGGALARSSLSFLSQSAAQAGVAERYGLAKTTAVVRGTRAVTKAQMIHNDWQPSITVDPETYQVVADGMLLTCEPA
EVLPMAQRYFLF

Sequences:

>Translated_572_residues
MTLKITRRAYAEMFGPTTGDRVRLADTDLIVEVERDYTIYGEEVKFGGGKVIRDGMGQSQRESKDCADTVITNALIIDHW
GIVKADIGLKHGRIAAIGKAGNPDIQPGVTIVIGPGTEIIAGEGMIVTAGGVDTHIHFICPQQIDEALNSGVTTMIGGGT
GPATGTYATTCTPGPWHLQRMLQAADAYPMNIGFLGKGNGSLPGALREQIDAGAIGLKLHEDWGSTPAAIDCCLGVADDT
DTQVAIHTDTLNESGFVEATIAAFKGRTIHTYHTEGAGGGHAPDIIRVCGESNVLPSSTNPTRPFTVNTLDEHLDMLMVC
HHLDASIAEDIAFAESRIRRETIAAEDILHDLGAFSMLSSDSQAMGRVGEVILRTWQTAHKMKAQRGKLAGDPNDARGGH
DNFRVKRYVAKYTINPAITHGIAHEVGSIEVGKWADLVLWKPAFFGVKPSLILKGGMIASAAMGDANASIPTPQPVHYRP
MFAAAGGALARSSLSFLSQSAAQAGVAERYGLAKTTAVVRGTRAVTKAQMIHNDWQPSITVDPETYQVVADGMLLTCEPA
EVLPMAQRYFLF
>Mature_571_residues
TLKITRRAYAEMFGPTTGDRVRLADTDLIVEVERDYTIYGEEVKFGGGKVIRDGMGQSQRESKDCADTVITNALIIDHWG
IVKADIGLKHGRIAAIGKAGNPDIQPGVTIVIGPGTEIIAGEGMIVTAGGVDTHIHFICPQQIDEALNSGVTTMIGGGTG
PATGTYATTCTPGPWHLQRMLQAADAYPMNIGFLGKGNGSLPGALREQIDAGAIGLKLHEDWGSTPAAIDCCLGVADDTD
TQVAIHTDTLNESGFVEATIAAFKGRTIHTYHTEGAGGGHAPDIIRVCGESNVLPSSTNPTRPFTVNTLDEHLDMLMVCH
HLDASIAEDIAFAESRIRRETIAAEDILHDLGAFSMLSSDSQAMGRVGEVILRTWQTAHKMKAQRGKLAGDPNDARGGHD
NFRVKRYVAKYTINPAITHGIAHEVGSIEVGKWADLVLWKPAFFGVKPSLILKGGMIASAAMGDANASIPTPQPVHYRPM
FAAAGGALARSSLSFLSQSAAQAGVAERYGLAKTTAVVRGTRAVTKAQMIHNDWQPSITVDPETYQVVADGMLLTCEPAE
VLPMAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_RALSO (Q8XXT1)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520153.1
- ProteinModelPortal:   Q8XXT1
- SMR:   Q8XXT1
- MEROPS:   M38.982
- GeneID:   1220872
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2032
- NMPDR:   fig|267608.1.peg.2032
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   RSOL267608:RSC2032-MONOMER
- BRENDA:   3.5.1.5
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60945; Mature: 60814

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 321-321 BINDING 220-220

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKITRRAYAEMFGPTTGDRVRLADTDLIVEVERDYTIYGEEVKFGGGKVIRDGMGQSQ
CEEEEHHHHHHHHHCCCCCCEEEEECCEEEEEEECCEEEECCEEEECCCEEEECCCCCCH
RESKDCADTVITNALIIDHWGIVKADIGLKHGRIAAIGKAGNPDIQPGVTIVIGPGTEII
HHHHHHHHHHHHHEEEEECCCEEEECCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEE
AGEGMIVTAGGVDTHIHFICPQQIDEALNSGVTTMIGGGTGPATGTYATTCTPGPWHLQR
ECCCEEEEECCCCEEEEEECHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCHHHHHH
MLQAADAYPMNIGFLGKGNGSLPGALREQIDAGAIGLKLHEDWGSTPAAIDCCLGVADDT
HHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHEEECCCCC
DTQVAIHTDTLNESGFVEATIAAFKGRTIHTYHTEGAGGGHAPDIIRVCGESNVLPSSTN
CCEEEEEECCCCCCCCEEEEHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCC
PTRPFTVNTLDEHLDMLMVCHHLDASIAEDIAFAESRIRRETIAAEDILHDLGAFSMLSS
CCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSQAMGRVGEVILRTWQTAHKMKAQRGKLAGDPNDARGGHDNFRVKRYVAKYTINPAITH
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEEEEEEHEECCHHHHH
GIAHEVGSIEVGKWADLVLWKPAFFGVKPSLILKGGMIASAAMGDANASIPTPQPVHYRP
HHHHHCCCEECCCCEEEEEECCHHHCCCHHHEEECCEEEEEECCCCCCCCCCCCCCCCCC
MFAAAGGALARSSLSFLSQSAAQAGVAERYGLAKTTAVVRGTRAVTKAQMIHNDWQPSIT
HHHHCCCHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHCHHHHHHHHHHHCCCCCCEE
VDPETYQVVADGMLLTCEPAEVLPMAQRYFLF
ECCCCEEEEECCEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
TLKITRRAYAEMFGPTTGDRVRLADTDLIVEVERDYTIYGEEVKFGGGKVIRDGMGQSQ
EEEEHHHHHHHHHCCCCCCEEEEECCEEEEEEECCEEEECCEEEECCCEEEECCCCCCH
RESKDCADTVITNALIIDHWGIVKADIGLKHGRIAAIGKAGNPDIQPGVTIVIGPGTEII
HHHHHHHHHHHHHEEEEECCCEEEECCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEE
AGEGMIVTAGGVDTHIHFICPQQIDEALNSGVTTMIGGGTGPATGTYATTCTPGPWHLQR
ECCCEEEEECCCCEEEEEECHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCHHHHHH
MLQAADAYPMNIGFLGKGNGSLPGALREQIDAGAIGLKLHEDWGSTPAAIDCCLGVADDT
HHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHEEECCCCC
DTQVAIHTDTLNESGFVEATIAAFKGRTIHTYHTEGAGGGHAPDIIRVCGESNVLPSSTN
CCEEEEEECCCCCCCCEEEEHHHHCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCC
PTRPFTVNTLDEHLDMLMVCHHLDASIAEDIAFAESRIRRETIAAEDILHDLGAFSMLSS
CCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSQAMGRVGEVILRTWQTAHKMKAQRGKLAGDPNDARGGHDNFRVKRYVAKYTINPAITH
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEEEEEEHEECCHHHHH
GIAHEVGSIEVGKWADLVLWKPAFFGVKPSLILKGGMIASAAMGDANASIPTPQPVHYRP
HHHHHCCCEECCCCEEEEEECCHHHCCCHHHEEECCEEEEEECCCCCCCCCCCCCCCCCC
MFAAAGGALARSSLSFLSQSAAQAGVAERYGLAKTTAVVRGTRAVTKAQMIHNDWQPSIT
HHHHCCCHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHCHHHHHHHHHHHCCCCCCEE
VDPETYQVVADGMLLTCEPAEVLPMAQRYFLF
ECCCCEEEEECCEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852