Click here to switch to the map view.

The map label for this gene is mcl1 [H]

Identifier: 17546718

GI number: 17546718

Start: 2175899

End: 2176861

Strand: Direct

Name: mcl1 [H]

Synonym: RSc1999

Alternate gene names: 17546718

Gene position: 2175899-2176861 (Clockwise)

Preceding gene: 17546717

Following gene: 17546719

Centisome position: 58.55

GC content: 70.09

Gene sequence:

>963_bases
TTGTTCCAGGACGATGCCGCACCGGCCCAGTTGCCGGTCTGCGACCACTATGCCGGCGCAGAAAAGCTCATGCGCAAGTC
GCTCGCCCTGCAACAAGCGCTTGGACCGGTCTTCGACATCACCTTCGATTGCGAGGACGGCGCCGCCGTCGGCCAGGAGC
GCGCGCATGCCGAACTGGCCGCGCGGCTCATCAACAGCGACGACAACCGCTTCAACCGCGTGGGCGTGCGCATCCACGAC
CCGAACCATGATGCCTGGGCCCAGGACGTCGACATCCTGGTCGGCCAGGCCGGGCGCCGGCTGGCCTACGTGACCGTGCC
CAAGGTGCGCGACGTGGTGGAAGTCGCGCGCGTGACCGACCGGGTCAACCAGGCGGCCCGCGCGGCCGGCATCGCGCGGC
ACCTGCCGATCCACGTGCTGATCGAGACGCACGGCGCGCTGGCGCAGGTGTTCGACATCGCCGCGCTGGTACAGGTGGAG
TGCCTGAGCTTCGGCCTGATGGACTTCGTCTCGGCGCACAACGGCGCGATTCCCGGCGCGGCGATGGGCTCGCCGGAGCA
GTTCGAGCATCCGCTGATCCGCCGCGCGCTGACGGACATCGCCGCGGCCTGCCACGCGCACGGCAAGGTGCCATCGCACA
ACGTGAGCACCGACATCAAGCGCCCAGACCGCGCCGGCACGGACGCGGCCCGCGCGCGCAACGCATTCGGCTATCTGCGC
AAGTGGAGCATCCACCCGGACCAGATCGAACCGATCGTCGCCGCGTTCCGCCCGTCGCACGATGAAGTGGCGCAGGCCGC
CGCCATCCTGACAGCCGCGCAGGACGCGTCGTGGGGGCCGATCCAGCATGAAGGACGCCTGCACGACCGCGCCAGCTACC
GCTACTGGTGGGCCGTGCTGCAACGGGCGCACACCACCGGCGTGACCGTGCCGCCCGAAGCCGCCGCGCGCTTCTTCGGA
TGA

Upstream 100 bases:

>100_bases
GCGGATCGGCAGCGAACCCTCCGGTTTTTTTACATCCCAACCCGGCGCCGGAAACGTCCGCGCCCCCACCCGATACAATG
CAGTGCACCCGACCGAGGTC

Downstream 100 bases:

>100_bases
CGCGCGCGCAACCGCATTGAGGAGACCGGACATGACCCTCGCCCCGCAAGCCAGCCCCGGCGCCCGCTTCCGCCAGGCCC
TGGCCGACGAATCGCCGCTG

Product: lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MFQDDAAPAQLPVCDHYAGAEKLMRKSLALQQALGPVFDITFDCEDGAAVGQERAHAELAARLINSDDNRFNRVGVRIHD
PNHDAWAQDVDILVGQAGRRLAYVTVPKVRDVVEVARVTDRVNQAARAAGIARHLPIHVLIETHGALAQVFDIAALVQVE
CLSFGLMDFVSAHNGAIPGAAMGSPEQFEHPLIRRALTDIAAACHAHGKVPSHNVSTDIKRPDRAGTDAARARNAFGYLR
KWSIHPDQIEPIVAAFRPSHDEVAQAAAILTAAQDASWGPIQHEGRLHDRASYRYWWAVLQRAHTTGVTVPPEAAARFFG

Sequences:

>Translated_320_residues
MFQDDAAPAQLPVCDHYAGAEKLMRKSLALQQALGPVFDITFDCEDGAAVGQERAHAELAARLINSDDNRFNRVGVRIHD
PNHDAWAQDVDILVGQAGRRLAYVTVPKVRDVVEVARVTDRVNQAARAAGIARHLPIHVLIETHGALAQVFDIAALVQVE
CLSFGLMDFVSAHNGAIPGAAMGSPEQFEHPLIRRALTDIAAACHAHGKVPSHNVSTDIKRPDRAGTDAARARNAFGYLR
KWSIHPDQIEPIVAAFRPSHDEVAQAAAILTAAQDASWGPIQHEGRLHDRASYRYWWAVLQRAHTTGVTVPPEAAARFFG
>Mature_320_residues
MFQDDAAPAQLPVCDHYAGAEKLMRKSLALQQALGPVFDITFDCEDGAAVGQERAHAELAARLINSDDNRFNRVGVRIHD
PNHDAWAQDVDILVGQAGRRLAYVTVPKVRDVVEVARVTDRVNQAARAAGIARHLPIHVLIETHGALAQVFDIAALVQVE
CLSFGLMDFVSAHNGAIPGAAMGSPEQFEHPLIRRALTDIAAACHAHGKVPSHNVSTDIKRPDRAGTDAARARNAFGYLR
KWSIHPDQIEPIVAAFRPSHDEVAQAAAILTAAQDASWGPIQHEGRLHDRASYRYWWAVLQRAHTTGVTVPPEAAARFFG

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 34853; Mature: 34853

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDDAAPAQLPVCDHYAGAEKLMRKSLALQQALGPVFDITFDCEDGAAVGQERAHAELA
CCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
ARLINSDDNRFNRVGVRIHDPNHDAWAQDVDILVGQAGRRLAYVTVPKVRDVVEVARVTD
HHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHH
RVNQAARAAGIARHLPIHVLIETHGALAQVFDIAALVQVECLSFGLMDFVSAHNGAIPGA
HHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AMGSPEQFEHPLIRRALTDIAAACHAHGKVPSHNVSTDIKRPDRAGTDAARARNAFGYLR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KWSIHPDQIEPIVAAFRPSHDEVAQAAAILTAAQDASWGPIQHEGRLHDRASYRYWWAVL
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
QRAHTTGVTVPPEAAARFFG
HHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MFQDDAAPAQLPVCDHYAGAEKLMRKSLALQQALGPVFDITFDCEDGAAVGQERAHAELA
CCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
ARLINSDDNRFNRVGVRIHDPNHDAWAQDVDILVGQAGRRLAYVTVPKVRDVVEVARVTD
HHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHH
RVNQAARAAGIARHLPIHVLIETHGALAQVFDIAALVQVECLSFGLMDFVSAHNGAIPGA
HHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AMGSPEQFEHPLIRRALTDIAAACHAHGKVPSHNVSTDIKRPDRAGTDAARARNAFGYLR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
KWSIHPDQIEPIVAAFRPSHDEVAQAAAILTAAQDASWGPIQHEGRLHDRASYRYWWAVL
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
QRAHTTGVTVPPEAAARFFG
HHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA