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The map label for this gene is sdhA [H]

Identifier: 17546713

GI number: 17546713

Start: 2170809

End: 2172587

Strand: Reverse

Name: sdhA [H]

Synonym: RSc1994

Alternate gene names: 17546713

Gene position: 2172587-2170809 (Counterclockwise)

Preceding gene: 17546714

Following gene: 17546712

Centisome position: 58.46

GC content: 65.88

Gene sequence:

>1779_bases
ATGGTCGCAGTCAAGACTGGGCTGCCGCGCCGCAAGTTCGACGTCGTGATCGTCGGCGCGGGCGGCGCGGGCATGCGCGC
ATCGCTGCAGCTCGCTGAAGCCGGCCTTTCCGTGGCCGTGCTGTCCAAGGTTTTCCCCACCCGCTCCCACACCGTGGCGG
CGCAAGGTGGCATCGGTGCTTCGCTGGGCAACATGAGCGAAGACAACTGGCACTATCACTTCTACGACACCATCAAGGGT
TCCGACTGGCTCGGCGACCAGGATGCGATCGAGTTCATGTGCCGCCAGGCGCCGCAAGTGGTCTATGAACTGGAGCACTT
CGGCATGCCGTTCGACCGCAATGCCGACGGCACCATCTACCAGCGCCCGTTCGGCGGCCACACGTCCAACTACGGCGAGA
AGCCGGTGCAGCGTGCCTGCGCCGCCGCCGACCGGACCGGCCACGCGCTGCTGCACACGCTGTACCAGCGCAACGTGCGT
GCCAAGACCCACTTCTTCGTCGAATGGATGGCGCTGGACCTGATCCGCGACCAGGACGGCGACGTGCTGGGCGTGACCGC
GCTGGAAATGGAAACCGGCGAGGTCTACATCCTCGAAGCCAAGACCACGCTGTTCGCCACGGGCGGTGCCGGCCGTATCT
ACGCAGCTTCCACCAACGCCTTCATCAACACGGGTGACGGCCTGGGCATGGCGGCGCGCGCCGGCATCCCGCTGGAAGAC
ATGGAGTTCTGGCAGTTCCACCCGACCGGCGTGGCCGGCGCGGGCGTGCTGATCACCGAAGGCGTGCGCGGCGAGGGCGG
TATCCTGCGTAACAAGGACGGCGAGCGCTTCATGGAGCGCTATGCCCCGACGCTGAAGGATCTGGCGCCGCGTGACTTCG
TGTCGCGCTCGATGGACCAGGAAATCAAGGAAGGCCGCGGCTGCGGCCCGAACGGCGACTACGTGCTGCTCGACCTGACC
CACGTCGGTGCCGAGACCATCATGAAGCGCCTGCCGTCCATCCGCGAGATCGGCCTGAAGTTCGCCAACGTGGACGCCAT
CAAGGAACCGATCCCGGTGGTGCCGACCATCCACTACCAGATGGGCGGTATCCCGACCAACTATCACGGTCAGGTCGTGG
TGCCGAAGAACGGCAGCCCGAACGAAGTCGTGAACGGCTTCTACGCGATCGGCGAATGCTCGTGCGTGTCGGTGCACGGC
GCCAACCGCCTGGGCACGAACTCGCTGCTCGACCTGGTGGTGTTCGGCCGCTCGGCCGGTAACCACATCGTCGCGCAGAA
CCTGAAGAACCGCGAACACAAGCCGCTGCCGGCCGATGCCGCCGACCGCGCGCTGGCCCGCCTGGCCAAGCTGGACAGCT
CCAGCTCGGGCGAGTACGCGCAGGACGTCGCCAACGATATCCGCCGCAACATGCAGGCGCATGCCGGCGTGTTCCGCACG
CAGAAGCTGATGGACGAAGGCGTCGAGCGCATCATGGAAGTGACCGAGCGCGCCGCCAACATCCACCTGAAGGACAAGTC
GAAGGTGTTCAACACCGCGCGCGTCGAAGCGCTGGAAGTGGCCAACCTGGTGGAAGTCGCCAAGGCGACGATGGTGTCGG
CCGCCGCCCGCAGGGAATCGCGCGGCGCACACGCCCACAGCGATTTCCCGAACCGTGACGACGACAACTGGCTCAAGCAC
ACGCTGTTCTACAGCGAAGGCAACCGCCTCGAGTACAAGCCCGTGCAGATGAAGCCGCTGTCGGTGGAAAGCGTGCCGCC
CAAGGCGCGGACCTTCTAA

Upstream 100 bases:

>100_bases
GAAGCCCGTGGCAGTGCGTTTGACGCTGCAAGTGTTGACGATTCTGTGGCTCGTCGGTTGCGCGGGCTACGCAGCTCAGA
TTCTCTGGAGGGTTTAAGAC

Downstream 100 bases:

>100_bases
GCACCGGAAAGGACCCACAAAAATGAAGCGTATTTTTGAAGTCTATCGCTACGATCCGGACAAGGACGCAGCCCCCCGCA
TGCAGACCTACGAGGTCGAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLSVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCRQAPQVVYELEHFGMPFDRNADGTIYQRPFGGHTSNYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDQDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGIPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGLKFANVDAIKEPIPVVPTIHYQMGGIPTNYHGQVVVPKNGSPNEVVNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRSAGNHIVAQNLKNREHKPLPADAADRALARLAKLDSSSSGEYAQDVANDIRRNMQAHAGVFRT
QKLMDEGVERIMEVTERAANIHLKDKSKVFNTARVEALEVANLVEVAKATMVSAAARRESRGAHAHSDFPNRDDDNWLKH
TLFYSEGNRLEYKPVQMKPLSVESVPPKARTF

Sequences:

>Translated_592_residues
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLSVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCRQAPQVVYELEHFGMPFDRNADGTIYQRPFGGHTSNYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDQDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGIPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGLKFANVDAIKEPIPVVPTIHYQMGGIPTNYHGQVVVPKNGSPNEVVNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRSAGNHIVAQNLKNREHKPLPADAADRALARLAKLDSSSSGEYAQDVANDIRRNMQAHAGVFRT
QKLMDEGVERIMEVTERAANIHLKDKSKVFNTARVEALEVANLVEVAKATMVSAAARRESRGAHAHSDFPNRDDDNWLKH
TLFYSEGNRLEYKPVQMKPLSVESVPPKARTF
>Mature_592_residues
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLSVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCRQAPQVVYELEHFGMPFDRNADGTIYQRPFGGHTSNYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDQDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGIPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGLKFANVDAIKEPIPVVPTIHYQMGGIPTNYHGQVVVPKNGSPNEVVNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRSAGNHIVAQNLKNREHKPLPADAADRALARLAKLDSSSSGEYAQDVANDIRRNMQAHAGVFRT
QKLMDEGVERIMEVTERAANIHLKDKSKVFNTARVEALEVANLVEVAKATMVSAAARRESRGAHAHSDFPNRDDDNWLKH
TLFYSEGNRLEYKPVQMKPLSVESVPPKARTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=50.9369676320273, Blast_Score=583, Evalue=1e-166,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=56.1433447098976, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=40.5217391304348, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=32.9768270944742, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=49.9151103565365, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17505833, Length=590, Percent_Identity=49.6610169491525, Blast_Score=569, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322701, Length=591, Percent_Identity=51.9458544839255, Blast_Score=608, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=51.864406779661, Blast_Score=603, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6322511, Length=490, Percent_Identity=24.4897959183673, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320788, Length=491, Percent_Identity=26.4765784114053, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=49.5033112582781, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=49.5033112582781, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=49.5033112582781, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=48.1054365733114, Blast_Score=561, Evalue=1e-160,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64702; Mature: 64702

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLSVAVLSKVFPTRSHTVAAQGGIGA
CEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCRQAPQVVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTSNYGEKPVQRACAAADRTGHALLHTLYQRNVRAKTHFFVEWMALDLIRDQDG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGIPLED
CEEEEEEEEECCCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNGDYVLLDLTHVGAETIMKRLPSIREIGLKFANVDAIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCCCHHHHCCCCCCCHHHHCCCCCCEEEEEE
MGGIPTNYHGQVVVPKNGSPNEVVNGFYAIGECSCVSVHGANRLGTNSLLDLVVFGRSAG
ECCCCCCCCCEEEECCCCCCHHHHHHHEEECCEEEEEECCCCCCCHHHHHHHHEECCCCC
NHIVAQNLKNREHKPLPADAADRALARLAKLDSSSSGEYAQDVANDIRRNMQAHAGVFRT
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QKLMDEGVERIMEVTERAANIHLKDKSKVFNTARVEALEVANLVEVAKATMVSAAARRES
HHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHAHSDFPNRDDDNWLKHTLFYSEGNRLEYKPVQMKPLSVESVPPKARTF
CCCCCCCCCCCCCCCCHHEEEEEEECCCEEEECCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLSVAVLSKVFPTRSHTVAAQGGIGA
CEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCRQAPQVVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTSNYGEKPVQRACAAADRTGHALLHTLYQRNVRAKTHFFVEWMALDLIRDQDG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGIPLED
CEEEEEEEEECCCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNGDYVLLDLTHVGAETIMKRLPSIREIGLKFANVDAIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCCCHHHHCCCCCCCHHHHCCCCCCEEEEEE
MGGIPTNYHGQVVVPKNGSPNEVVNGFYAIGECSCVSVHGANRLGTNSLLDLVVFGRSAG
ECCCCCCCCCEEEECCCCCCHHHHHHHEEECCEEEEEECCCCCCCHHHHHHHHEECCCCC
NHIVAQNLKNREHKPLPADAADRALARLAKLDSSSSGEYAQDVANDIRRNMQAHAGVFRT
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QKLMDEGVERIMEVTERAANIHLKDKSKVFNTARVEALEVANLVEVAKATMVSAAARRES
HHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHAHSDFPNRDDDNWLKHTLFYSEGNRLEYKPVQMKPLSVESVPPKARTF
CCCCCCCCCCCCCCCCHHEEEEEEECCCEEEECCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]