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The map label for this gene is sdhB [H]

Identifier: 17546712

GI number: 17546712

Start: 2170085

End: 2170786

Strand: Reverse

Name: sdhB [H]

Synonym: RSc1993

Alternate gene names: 17546712

Gene position: 2170786-2170085 (Counterclockwise)

Preceding gene: 17546713

Following gene: 17546711

Centisome position: 58.41

GC content: 63.53

Gene sequence:

>702_bases
ATGAAGCGTATTTTTGAAGTCTATCGCTACGATCCGGACAAGGACGCAGCCCCCCGCATGCAGACCTACGAGGTCGAGCT
CGACGGCCATGAGCGCATGCTGCTCGACGCACTGGTCAAGCTGAAGAAGCTGGACGAGTCGATCGCGTTCCGCCGCTCGT
GCCGCGAAGGCGTGTGCGGCTCCGACGCCATGAACATCAACGGCAAGAATGGTCTGGCCTGCCTGACCAACATGCGCGAG
CTGCCCGAGAAGATCGTGCTGCGTCCGCTGCCGGGCCTGCCCGTGGTGCGCGACCTGATCGTCGACATGACGCAGTTCTT
CAACCAGTACCACTCGATCAAGCCGTTCCTGATCAACGACGAGCCGCCGCCCGAGAAGGAGCGCCTGCAGTCGCCGGAAG
AGCGCGAAGAGCTCGACGGCCTGTACGAGTGCATCCTGTGCGCGAGCTGCTCGACGTCGTGCCCGTCGTTCTGGTGGAAC
CCAGACAAGTTCGTCGGCCCGGCCGGCCTGCTGCAGGCCTACCGTTTCATCGCCGACAGCCGCGACCAGGCGACCAGCGA
GCGCCTCGACAACCTCGAGGACCCGTACCGCCTGTTCCGCTGCCACACCATCATGAACTGCGTCGATGTGTGCCCGAAGG
GTCTGAACCCGACCAAGGCCATCGGCAAGATCAAGGAACTGATGGTGCGCCGCGCGGTGTAA

Upstream 100 bases:

>100_bases
AACCGCCTCGAGTACAAGCCCGTGCAGATGAAGCCGCTGTCGGTGGAAAGCGTGCCGCCCAAGGCGCGGACCTTCTAAGC
ACCGGAAAGGACCCACAAAA

Downstream 100 bases:

>100_bases
GCCGCCAGCCCAGCGTCGCCGGAGCGATTGTTCCGGCGACGCACTTTGTAGAGCATGACCGCCGTGAACACTTCGACGTT
TTCCCACCAGTCCGATCCGC

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPFLINDEPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Sequences:

>Translated_233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPFLINDEPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
>Mature_233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPFLINDEPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=56.6523605150215, Blast_Score=273, Evalue=1e-73,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=66.1016949152542, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1790596, Length=226, Percent_Identity=36.7256637168142, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=52.1551724137931, Blast_Score=256, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6322987, Length=228, Percent_Identity=53.0701754385965, Blast_Score=251, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=54.3103448275862, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=54.5454545454545, Blast_Score=264, Evalue=4e-71,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26775; Mature: 26775

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCG
CHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMRELPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPFLIND
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
EPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCC
RDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCG
CHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMRELPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPFLIND
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
EPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCC
RDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]