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The map label for this gene is acsA [H]

Identifier: 17546671

GI number: 17546671

Start: 2129296

End: 2131278

Strand: Reverse

Name: acsA [H]

Synonym: RSc1952

Alternate gene names: 17546671

Gene position: 2131278-2129296 (Counterclockwise)

Preceding gene: 17546676

Following gene: 17546670

Centisome position: 57.35

GC content: 68.28

Gene sequence:

>1983_bases
ATGGCTGGCATTGAATCTGTTCTGCAGGAAACGCGTGTCTTCGAGCCGCCCGCGTCCTTCGTCAAACAGGCCAACATCGC
CGGCATGGACGCCTACCGCACCCTGTGCGCCGAGGCCGAGCGCGACTACGAAGGCTTCTGGGCGCGTCTGGCGCACGAGC
ACCTGCTGTGGCACAAGCCCTTCTCCAAGGTCCTCGACGAATCCAGGGCGCCGTTCTACACCTGGTTCGAGGACGGTGAG
CTCAACGCCTCGTACAACTGCCTCGAGCGCAACCTGGAGAACGGCAACGCCGACAAGGTCGCCGTGATCTTCGAGGCCGA
CGATGGCTCGGTCGCGCGCATCACCTATCGCGAGCTGCATGCCCGCGTGTGCCGCTTCGCCAATGGCCTGAAGGCACTGG
GCATCCGCAAGGGCGACCGCGTGGTGATCTACATGCCGATGTCGATCGAGGGCGTCGTCGCCATGCAGGCCTGCGCGCGC
ATCGGGGCGACGCACTCGGTGGTGTTCGGCGGGTTCTCGGCCAAGTCGTTGCAGGAGCGGATCGTCGACGTGGGGGCCGT
TGCCGTCATCACGGCCGACGAGCAGATGCGCGGCGGCAAGGCGCTGCCGCTCAAGGCCATCGCCGACGAGGCGCTGGCGA
TGGAGGGCAGCGAGGCCGTCCGCCACGTGATCGTCTATCGGCGCACCGGCGCCGGCGTGAACTGGGTCGAGGGCCGCGAC
CGCGCCATGGACGAAGTCGAAGCCGGCCAGCCCGACACCTGCGAGGTCACCCCGGTCGGCGCCGAGCATCCGCTGTTCAT
CCTCTACACCTCGGGCTCGACCGGCAAGCCCAAGGGCGTGCAGCACAGCACCGGCGGCTACCTGCTGTGGGCGCTGCTGA
CGATGCAGTGGACCTTCGACCTGAAGCCCGACGATGTCTTCTGGTGCACCGCCGACATCGGCTGGGTCACCGGCCACACC
TATATCGCGTATGGCCCGCTCGCCGCCGGCGCCACCCAGGTGGTGTTCGAGGGCGTGCCGACCTACCCGAACGCCGGCCG
CTTCTGGGACATGATCCAGAAGCACCGGGTCAACACCTTCTACACTGCGCCGACGGCGATCCGCTCGCTGATCAAGGCCG
CCGAGGCCGATGAGACGAGCCACCCGAAGCGGTACGACCTGTCCAGCCTGCGCCTGCTGGGCACCGTGGGCGAGCCGATC
AACCCGGAAGCCTGGATGTGGTACCACACGAACATCGGCGGCGGCCGCTGCCCGATCGTCGACACCTTCTGGCAGACCGA
GACCGGCGGCCACATGATCTCGCCGCTGCCGGGCGCGACGCCGCTGGTGCCGGGCTCATGCACGCTGCCGCTGCCGGGCA
TCATGGCCGCCATCGTCGACGAGACCGGGCAGGACCTGCCGGACGGGCAGGGCGGCATCCTCGTCGTCAAGCGGCCGTGG
CCGGCGATGATCCGCACCATCTGGGGCGATCCGGAGCGCTTCCGCAAGAGCTACTTCCCGGCCGAACTGGGCGGCAAGCT
CTACTTGGCCGGCGACGGCTCGGTGCGCGACAAGGAAACCGGCTACTTCACCATCATGGGCCGCATCGACGACGTGCTGA
ACGTCTCGGGCCACCGCATGGGCACGATGGAGATCGAATCGGCGCTGGTGGCCAACCCGCTGGTGGCCGAGGCCGCCGTG
GTGGGCCGCCCGGACGACATGACCGGCGAGGCCATCTGCGCCTTCGTGGTGCTCAAGCGCACGCGCCCGAACGGGGACGA
GGCCCGGCAGATCGCCACCGACCTGCGCAACTGGGTCGGCAAGGAGATCGGCCCGATCGCCAAGCCGAAGGACATCCGCT
TCGGCGACAACCTGCCCAAGACGCGCTCGGGCAAGATCATGCGGCGCCTGCTGCGCTCGATCGCCAAGGGCGAGGACATC
ACGCAGGACACCTCCACGCTGGAGAACCCGGCCATCCTGGAGCAGCTCAAGGAAGCCCGCTGA

Upstream 100 bases:

>100_bases
TGCGGCGGCCGGCGCACGTCGCGCTTGCGTAAGGCTGGAGTAAGGCCGGCTGCTTAGATTCGCGGCAAAACGATCACAGA
CTTCGCTATCAGGAGACATC

Downstream 100 bases:

>100_bases
TCCGGCACCGGCCTGTCTGCCTTGGCCGCCGCCGCCGCTGCCACGGACAGCCGCTTTCGCAGGCGGCTGTTTGTCTATTA
CGGGCTGTACACCGCCGGCC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MAGIESVLQETRVFEPPASFVKQANIAGMDAYRTLCAEAERDYEGFWARLAHEHLLWHKPFSKVLDESRAPFYTWFEDGE
LNASYNCLERNLENGNADKVAVIFEADDGSVARITYRELHARVCRFANGLKALGIRKGDRVVIYMPMSIEGVVAMQACAR
IGATHSVVFGGFSAKSLQERIVDVGAVAVITADEQMRGGKALPLKAIADEALAMEGSEAVRHVIVYRRTGAGVNWVEGRD
RAMDEVEAGQPDTCEVTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWALLTMQWTFDLKPDDVFWCTADIGWVTGHT
YIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIQKHRVNTFYTAPTAIRSLIKAAEADETSHPKRYDLSSLRLLGTVGEPI
NPEAWMWYHTNIGGGRCPIVDTFWQTETGGHMISPLPGATPLVPGSCTLPLPGIMAAIVDETGQDLPDGQGGILVVKRPW
PAMIRTIWGDPERFRKSYFPAELGGKLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPLVAEAAV
VGRPDDMTGEAICAFVVLKRTRPNGDEARQIATDLRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEDI
TQDTSTLENPAILEQLKEAR

Sequences:

>Translated_660_residues
MAGIESVLQETRVFEPPASFVKQANIAGMDAYRTLCAEAERDYEGFWARLAHEHLLWHKPFSKVLDESRAPFYTWFEDGE
LNASYNCLERNLENGNADKVAVIFEADDGSVARITYRELHARVCRFANGLKALGIRKGDRVVIYMPMSIEGVVAMQACAR
IGATHSVVFGGFSAKSLQERIVDVGAVAVITADEQMRGGKALPLKAIADEALAMEGSEAVRHVIVYRRTGAGVNWVEGRD
RAMDEVEAGQPDTCEVTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWALLTMQWTFDLKPDDVFWCTADIGWVTGHT
YIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIQKHRVNTFYTAPTAIRSLIKAAEADETSHPKRYDLSSLRLLGTVGEPI
NPEAWMWYHTNIGGGRCPIVDTFWQTETGGHMISPLPGATPLVPGSCTLPLPGIMAAIVDETGQDLPDGQGGILVVKRPW
PAMIRTIWGDPERFRKSYFPAELGGKLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPLVAEAAV
VGRPDDMTGEAICAFVVLKRTRPNGDEARQIATDLRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEDI
TQDTSTLENPAILEQLKEAR
>Mature_659_residues
AGIESVLQETRVFEPPASFVKQANIAGMDAYRTLCAEAERDYEGFWARLAHEHLLWHKPFSKVLDESRAPFYTWFEDGEL
NASYNCLERNLENGNADKVAVIFEADDGSVARITYRELHARVCRFANGLKALGIRKGDRVVIYMPMSIEGVVAMQACARI
GATHSVVFGGFSAKSLQERIVDVGAVAVITADEQMRGGKALPLKAIADEALAMEGSEAVRHVIVYRRTGAGVNWVEGRDR
AMDEVEAGQPDTCEVTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWALLTMQWTFDLKPDDVFWCTADIGWVTGHTY
IAYGPLAAGATQVVFEGVPTYPNAGRFWDMIQKHRVNTFYTAPTAIRSLIKAAEADETSHPKRYDLSSLRLLGTVGEPIN
PEAWMWYHTNIGGGRCPIVDTFWQTETGGHMISPLPGATPLVPGSCTLPLPGIMAAIVDETGQDLPDGQGGILVVKRPWP
AMIRTIWGDPERFRKSYFPAELGGKLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRMGTMEIESALVANPLVAEAAVV
GRPDDMTGEAICAFVVLKRTRPNGDEARQIATDLRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEDIT
QDTSTLENPAILEQLKEAR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=681, Percent_Identity=46.5491923641703, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI253970489, Length=694, Percent_Identity=45.6772334293948, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI28416953, Length=635, Percent_Identity=46.4566929133858, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=37.6377952755906, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=29.4896030245747, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI42544132, Length=530, Percent_Identity=29.622641509434, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI38505220, Length=535, Percent_Identity=30.4672897196262, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI31982927, Length=652, Percent_Identity=24.5398773006135, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI115511026, Length=536, Percent_Identity=27.7985074626866, Blast_Score=164, Evalue=4e-40,
Organism=Homo sapiens, GI58082049, Length=522, Percent_Identity=27.9693486590038, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI157311624, Length=536, Percent_Identity=26.1194029850746, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI157311622, Length=536, Percent_Identity=26.1194029850746, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI187761345, Length=574, Percent_Identity=25.0871080139373, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI187761343, Length=574, Percent_Identity=25.0871080139373, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI195947378, Length=455, Percent_Identity=25.7142857142857, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI42544134, Length=322, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1790505, Length=635, Percent_Identity=52.1259842519685, Blast_Score=638, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=626, Percent_Identity=39.1373801916933, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=611, Percent_Identity=26.3502454991817, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI221142682, Length=542, Percent_Identity=25.4612546125461, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1786810, Length=544, Percent_Identity=23.7132352941176, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI145693145, Length=371, Percent_Identity=26.6846361185984, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71983001, Length=677, Percent_Identity=43.7223042836041, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71982997, Length=676, Percent_Identity=43.7869822485207, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569507, Length=651, Percent_Identity=24.4239631336406, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71985884, Length=604, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=569, Percent_Identity=25.6590509666081, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=571, Percent_Identity=24.3432574430823, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17538037, Length=141, Percent_Identity=30.4964539007092, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319264, Length=664, Percent_Identity=47.5903614457831, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6323182, Length=670, Percent_Identity=45.0746268656716, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319699, Length=549, Percent_Identity=22.4043715846995, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24667955, Length=675, Percent_Identity=46.5185185185185, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=50.5338078291815, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24667959, Length=531, Percent_Identity=49.3408662900188, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21355225, Length=649, Percent_Identity=33.4360554699538, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI21355181, Length=528, Percent_Identity=26.3257575757576, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24656500, Length=373, Percent_Identity=27.0777479892761, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24581924, Length=572, Percent_Identity=23.4265734265734, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72439; Mature: 72308

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIESVLQETRVFEPPASFVKQANIAGMDAYRTLCAEAERDYEGFWARLAHEHLLWHKP
CCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
FSKVLDESRAPFYTWFEDGELNASYNCLERNLENGNADKVAVIFEADDGSVARITYRELH
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVCRFANGLKALGIRKGDRVVIYMPMSIEGVVAMQACARIGATHSVVFGGFSAKSLQER
HHHHHHHCCHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
IVDVGAVAVITADEQMRGGKALPLKAIADEALAMEGSEAVRHVIVYRRTGAGVNWVEGRD
HHHCCEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCHHHHEEEEEEEECCCCCCCCCCCH
RAMDEVEAGQPDTCEVTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWALLTMQWTFD
HHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEEEE
LKPDDVFWCTADIGWVTGHTYIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIQKHRVNTF
CCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCEE
YTAPTAIRSLIKAAEADETSHPKRYDLSSLRLLGTVGEPINPEAWMWYHTNIGGGRCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEECCCCCCCCCEEEEEEECCCCCCCCEE
DTFWQTETGGHMISPLPGATPLVPGSCTLPLPGIMAAIVDETGQDLPDGQGGILVVKRPW
ECCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFRKSYFPAELGGKLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRM
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVANPLVAEAAVVGRPDDMTGEAICAFVVLKRTRPNGDEARQIATDLRNWVG
EHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEDITQDTSTLENPAILEQLKEAR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
AGIESVLQETRVFEPPASFVKQANIAGMDAYRTLCAEAERDYEGFWARLAHEHLLWHKP
CCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
FSKVLDESRAPFYTWFEDGELNASYNCLERNLENGNADKVAVIFEADDGSVARITYRELH
HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVCRFANGLKALGIRKGDRVVIYMPMSIEGVVAMQACARIGATHSVVFGGFSAKSLQER
HHHHHHHCCHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
IVDVGAVAVITADEQMRGGKALPLKAIADEALAMEGSEAVRHVIVYRRTGAGVNWVEGRD
HHHCCEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCHHHHEEEEEEEECCCCCCCCCCCH
RAMDEVEAGQPDTCEVTPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWALLTMQWTFD
HHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEEEE
LKPDDVFWCTADIGWVTGHTYIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIQKHRVNTF
CCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCEE
YTAPTAIRSLIKAAEADETSHPKRYDLSSLRLLGTVGEPINPEAWMWYHTNIGGGRCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEECCCCCCCCCEEEEEEECCCCCCCCEE
DTFWQTETGGHMISPLPGATPLVPGSCTLPLPGIMAAIVDETGQDLPDGQGGILVVKRPW
ECCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFRKSYFPAELGGKLYLAGDGSVRDKETGYFTIMGRIDDVLNVSGHRM
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVANPLVAEAAVVGRPDDMTGEAICAFVVLKRTRPNGDEARQIATDLRNWVG
EHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEDITQDTSTLENPAILEQLKEAR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA