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The map label for this gene is dctA [H]

Identifier: 17546676

GI number: 17546676

Start: 2135754

End: 2137040

Strand: Reverse

Name: dctA [H]

Synonym: RSc1957

Alternate gene names: 17546676

Gene position: 2137040-2135754 (Counterclockwise)

Preceding gene: 17546678

Following gene: 17546671

Centisome position: 57.5

GC content: 64.88

Gene sequence:

>1287_bases
ATGAACACCAAACGCCTGACCACCCATATCGGCGTAGCGATGCTGCTTGGCATCGCGGTCGGCTGGGGATGCCACGAGTA
CGCGAAGGACGCCCAGGCGGCTAAGGAGCTCGCCTCGTACTTCAGTATCGTGACCGACATCTTCCTGCGCATGATCAAGA
TGATCATTGCGCCGCTGGTCTTCTCGACCCTGGTGACGGGGCTGGCGAGCATGAGCGGCGGCCGCTCGGTCGGCCGCATT
GGCCTGCGCGCGATGCTGTGGTTCGTCACCGCGTCCGTGATCTCGCTGGCGCTGGGCATGGTGCTGGTCAACTTCTTCCA
GCCCGGTATGCAGCTGAACATGCCGCTGCCGGATACGGCGGCGGCGGTGGGGCTCAAGACGGGCGACTTCACGCTCAAGG
GCTTCTTCACCCACGTCTTCCCGCGCAGCATCGTGGAATCGATGGCGAACAACGAGATCCTGCAGATCCTGGTGTTCTCG
CTGTTCTTCGGTGCGGCGCTGGCCAGCGTCGAGAAGCCGATGGAGACCGTCGTCGGGCGCGGGCTGGAGGAACTGACCAA
GCTGATGTTCCGCATCACCGACTACGTGATGCGCTTTGCGCCGCTGGGCGTGTTTGCCGCCATGGCCGCCGCCATCACCG
TGGAAGGCGTGGGCGTGCTGTGGACGTACGGCAAGCTGATCGGCGAGTTCTACCTCGGCCTGGCGCTGCTGTGGATGATC
CTGTTCCTGGTGGGCTACCTGCTGCTGGGCCGCTCCATCGGGCGCCTGGCCTCGTTGATCCGTGAGCCGATCCTGCTGGC
CTTCGCGACCGCCAGCAGCGAGTCGGCCTATCCGAAGACCATCGAGGCGCTGGATCGCTTTGGCGTGCCCAAGCGCATCT
CCAGCTTCGTGCTGCCGCTGGGCTACTCGTTCAACCTCGACGGCTCGATGATGTACCAGGCCTTTGCCGTGCTGTTCATC
GCACAGGCCTACAACATCGAAATGGGCTTCACGCAACAGCTGACCCTGCTGCTGGTGCTGATGCTGACCAGCAAGGGCAT
GGCCGGCGTGGCGCGCGCGTCGCTGGTGGTGGTGGCCGCGACGCTGCCGATGTTCCATCTGCCCGAGGCGGGCCTGCTGC
TGATCCTGGGCATCGACCAGTTCTTCGACATGGGCCGCACGGCCACCAACGTGATCGGCAACAGCATTGCCACCGCCGTG
GTGGCGAAGTATGAGCGTGAGGACGAGGTCGAGGCGGAAGCGGTCCAGCCCGCCGCGGCGCAGGCGGATATCGCGAGCGC
CGGCTAA

Upstream 100 bases:

>100_bases
GCTCGCGCTTTCGGGCGCAGCGGCAGGCCAGACGCCATCCGCAGCGACACCATCAAAGCCAAGGGTCGAAGTCATGGCCC
GAGCACCCGTAGGAGGGGGA

Downstream 100 bases:

>100_bases
GGCGCGTCCTTGCCCTCGGACCGGCGGCGCAGTCCGCTGGTCCAGGGAGCCGCGCTCCCACCGAGGCCATGACATGACGG
GCCCGCAGGTTTCTGCGGGC

Product: glutamate symport transmembrane protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNTKRLTTHIGVAMLLGIAVGWGCHEYAKDAQAAKELASYFSIVTDIFLRMIKMIIAPLVFSTLVTGLASMSGGRSVGRI
GLRAMLWFVTASVISLALGMVLVNFFQPGMQLNMPLPDTAAAVGLKTGDFTLKGFFTHVFPRSIVESMANNEILQILVFS
LFFGAALASVEKPMETVVGRGLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWMI
LFLVGYLLLGRSIGRLASLIREPILLAFATASSESAYPKTIEALDRFGVPKRISSFVLPLGYSFNLDGSMMYQAFAVLFI
AQAYNIEMGFTQQLTLLLVLMLTSKGMAGVARASLVVVAATLPMFHLPEAGLLLILGIDQFFDMGRTATNVIGNSIATAV
VAKYEREDEVEAEAVQPAAAQADIASAG

Sequences:

>Translated_428_residues
MNTKRLTTHIGVAMLLGIAVGWGCHEYAKDAQAAKELASYFSIVTDIFLRMIKMIIAPLVFSTLVTGLASMSGGRSVGRI
GLRAMLWFVTASVISLALGMVLVNFFQPGMQLNMPLPDTAAAVGLKTGDFTLKGFFTHVFPRSIVESMANNEILQILVFS
LFFGAALASVEKPMETVVGRGLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWMI
LFLVGYLLLGRSIGRLASLIREPILLAFATASSESAYPKTIEALDRFGVPKRISSFVLPLGYSFNLDGSMMYQAFAVLFI
AQAYNIEMGFTQQLTLLLVLMLTSKGMAGVARASLVVVAATLPMFHLPEAGLLLILGIDQFFDMGRTATNVIGNSIATAV
VAKYEREDEVEAEAVQPAAAQADIASAG
>Mature_428_residues
MNTKRLTTHIGVAMLLGIAVGWGCHEYAKDAQAAKELASYFSIVTDIFLRMIKMIIAPLVFSTLVTGLASMSGGRSVGRI
GLRAMLWFVTASVISLALGMVLVNFFQPGMQLNMPLPDTAAAVGLKTGDFTLKGFFTHVFPRSIVESMANNEILQILVFS
LFFGAALASVEKPMETVVGRGLEELTKLMFRITDYVMRFAPLGVFAAMAAAITVEGVGVLWTYGKLIGEFYLGLALLWMI
LFLVGYLLLGRSIGRLASLIREPILLAFATASSESAYPKTIEALDRFGVPKRISSFVLPLGYSFNLDGSMMYQAFAVLFI
AQAYNIEMGFTQQLTLLLVLMLTSKGMAGVARASLVVVAATLPMFHLPEAGLLLILGIDQFFDMGRTATNVIGNSIATAV
VAKYEREDEVEAEAVQPAAAQADIASAG

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=459, Percent_Identity=27.2331154684096, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI66773030, Length=471, Percent_Identity=26.963906581741, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI21314632, Length=447, Percent_Identity=26.6219239373602, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI40254478, Length=422, Percent_Identity=25.1184834123223, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4827012, Length=275, Percent_Identity=32.3636363636364, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI5032093, Length=402, Percent_Identity=27.6119402985075, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=30.0724637681159, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI223468566, Length=283, Percent_Identity=30.3886925795053, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI262359914, Length=396, Percent_Identity=26.010101010101, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI194239697, Length=150, Percent_Identity=36.6666666666667, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI301601644, Length=154, Percent_Identity=34.4155844155844, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1790514, Length=418, Percent_Identity=38.755980861244, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=40.2409638554217, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1788024, Length=411, Percent_Identity=24.5742092457421, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789473, Length=405, Percent_Identity=23.9506172839506, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=25.7075471698113, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71996953, Length=459, Percent_Identity=26.797385620915, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=408, Percent_Identity=24.7549019607843, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=450, Percent_Identity=25.7777777777778, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=446, Percent_Identity=24.4394618834081, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983099, Length=446, Percent_Identity=24.4394618834081, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=149, Percent_Identity=34.8993288590604, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583025, Length=455, Percent_Identity=27.2527472527473, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17137668, Length=455, Percent_Identity=27.2527472527473, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24583023, Length=455, Percent_Identity=27.2527472527473, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281360483, Length=429, Percent_Identity=26.5734265734266, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137666, Length=429, Percent_Identity=26.5734265734266, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360481, Length=423, Percent_Identity=26.7139479905437, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46137; Mature: 46137

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCC
>Mature Secondary Structure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HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA