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The map label for this gene is lgrE [H]

Identifier: 17546523

GI number: 17546523

Start: 1941939

End: 1944437

Strand: Reverse

Name: lgrE [H]

Synonym: RSc1804

Alternate gene names: 17546523

Gene position: 1944437-1941939 (Counterclockwise)

Preceding gene: 17546524

Following gene: 17546522

Centisome position: 52.32

GC content: 73.79

Gene sequence:

>2499_bases
ATGATGACCATCACGACGGATCGGACACCCCCGGCGGCCGGCGCCGCCCTAGACCGCAACCGCAGCGCCTATGCCGGCCT
GGCCGACGTGCTGGAGCGCGCCGGCCTGGCCGAGCATGCGCTGTACCTGAACTGGGGCTACCGGCCGGTCGACGGCCAGC
CGGACTGGGCCGCCCGCGAACTGCCGCCGGGCGAACTCGGCCGGATGCAGGCACGCCTGGTCCTCGAGGTGCTGGGCGAC
ACGCCGCTGGACGGCCGGCGCGTGCTCGACGTCGGCTGCGGGCGCGGCGGCGCGCTCGCGCTGATGGGCCGCCTGCATGC
GCCCGCCGCCCTCGCCGGCGCCGACATCAGCGCCGCGAACATCGCCTACTGCCGCAAGCGCCACACGCATCCGCGCCTGC
GCTTCCAGATCGCGGACGCGTGCCGGCTGCCCTATCCCGACAGCAGCATGGATGTGGTCTTCAACCTGGAATCGTCCGGC
GCCTATCCCGACATCGGGGCGTTCTTCCATCACGTGCACCGCATCCTCAGGGTGGGCGGGCGCTTCTGCCTTGCCGACGT
GTTCGATGCCGACAGCGTGGCGTGGGTCCGCGCCGCGCTGGAGCAGGCCGGATTCACGCTTGAGCGGGAGCGCTCGATCC
CTGCGCAGGTGCGCGCGGCGCGCGAGCGCGCTTCGCCCGGCATCTGGCGCCGGCTGGACACCGCGCTGACCGCGCTCGAC
GCGCCCGGCCTGCGGCGGGAGCTGGAGCGCTACCTGGCCGCGCCATCGTCCGGGCTGTTCCAGGCACTGGAAGACGGCCG
CGTCGACTATCGGCTCTTTCACTGGCGCAAGACGTGCCCCGCAGCCGGCCGGATCGATGCCGACGTGATCGCCCGGCTGG
CCACGCGCTCCGCCCGGCTCGATGCCGCGCTGCAGGATCGCGCGCCATCGGCCGCCGCACCGCAGTCCCCCGCACCGGGG
CCGGCCAATGCCTCGGCGTCGGCCTGGTTCCCGTTCACTGCGCCCGACGCGCAGGCGGGCTTCAACGTCTTCGCGCTGCC
CTATGCCGGCGGCGGGGCCTCGGTCTACCGGGCGTGGACCCTGCCGCGGCGCCCCGGCGCCGCCCCGTGGCAGCTCTGCC
CGGTGCAGTTGCCGGGCCGCGAGAGCCGCTTCGGCGAGCCGCTGATCGATGACATGGCCACGCTGGCCGATCGCCTTGCC
GATGCCATCGGCCCCTATGCGCACCGGCCGTGGGCGCTGCTGGGCTGCAGCCTCGGCTGCAAGATCGCCTTTGAAGTGGC
GCGCCGCTTCGCGCGGCAGGGCCGCCCGCCCGCGCTGCTGTTCCTGATGGCCTGCCCCGCGCCCGGCCTGCCGCTGGGCC
GACGGATCTCGACCCGCGCCGAAGCCGATTTCGCGCGCGAGGTATGCCATCTCGGCGGCACGCCCCCGGAAGTGCTGGCC
GACGCCGAGATGATGCGCACCCTCATGCCGATCCTGCGCAACGACAGCGCGCTGGCCGAGCACTACGTCGCTGCCGAGGA
CGCCACCGTCAACGTGCCGATCGTCATGGTGGCCGCCGGCGACGACCACCTCGTCACGGTGGAGGAAGCGCGGCGCTGGC
AGCGCCATGCCGGCGCCGGCTTCGACTGGCGCCTGGTGGACGGCGGCCACTTTTTCCTGCGGCAGCGGCGCCGGGAACTG
ACGGACTGGCTGCTGGACGCCCTGCGCCGCGGCGAGCGGACCCTACCAGTGCAGACCACCACCACCGACGTTCCCGATGT
TCCATGCAGCACCCCCGAGCAGCCGCGCGACCCGAGCCGGATGCCCGCCCCCGGCGCGAGCGCCAACCTCGTGCTGGCAC
CGGGCGAGATCCTGGTGGTCACGGCGCCCCGCAGCCTCGCCGCCCGCCTCACCCCGGCTGTGCTGAGCGACGACGAGCAG
CGGCAACTGGCGCGCTTCGCGTTCGACGCCGACCGGGAGCGCTACCTGGCCGCGCACTGGGCCAAGCGCCGCGTGCTGGG
CGCGCTGCTGGCGGCCGCACCGCGATCGCTGCGCTTCGGGGCACAGGCGGGCGGCAAGCCCTACCTGATTGGCGAGGCGC
TGCATTTCAGCCTGTCGCACAGTGGCGACCGGGTTGCCGTGGCGGTCTGCCGGCACGCGCCCGTGGGCGTCGACATCGAG
CAGGCACGCGGCATCGCATGCCATGCGTCGGCCGCGCGGATCATGCATCCGCTCGACCGGATCGCCCCGCAGTGCGAGAC
CCCCGAAGACCGCTTCCTCGCGGCCTGGAGCCTGAAGGAAGCCGTCGCGAAATGCACGGGCGCAGGCCTGGCCCTGCCCT
TCGACTCGCTGCGCCTCGCGTTCGCCGGCAACGGGCGGTACGGCTGCCTCCTGGGCACGCATGCGGCCTGGGAGGCACAT
CACCAGCATGAGGACGGCGTGCATCTCGCGGTCGCGAGCGCGACGCCGTGGGCGGCCCTGCGCATCCTCCCGCTGGACGC
GGCGCTCGCCGAGGGTTGA

Upstream 100 bases:

>100_bases
GGCTGGGCATCATGCGCGCCGCCGGCCAGCCGGTGATGGTGAAGCAGCCCGCGCCGCCACCGCCCCACCCCGACCCCGAA
ACCTACCTGCGGGAGCACGC

Downstream 100 bases:

>100_bases
ACGCGCGCACGGGTGTTGCGGCACCGCGGGCGTTCGGGCACAATCGCCGGCCTGCGGAGATGGCATGCCTCCCTTAACCG
CCGATCCCATCGGCTGATGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 832; Mature: 832

Protein sequence:

>832_residues
MMTITTDRTPPAAGAALDRNRSAYAGLADVLERAGLAEHALYLNWGYRPVDGQPDWAARELPPGELGRMQARLVLEVLGD
TPLDGRRVLDVGCGRGGALALMGRLHAPAALAGADISAANIAYCRKRHTHPRLRFQIADACRLPYPDSSMDVVFNLESSG
AYPDIGAFFHHVHRILRVGGRFCLADVFDADSVAWVRAALEQAGFTLERERSIPAQVRAARERASPGIWRRLDTALTALD
APGLRRELERYLAAPSSGLFQALEDGRVDYRLFHWRKTCPAAGRIDADVIARLATRSARLDAALQDRAPSAAAPQSPAPG
PANASASAWFPFTAPDAQAGFNVFALPYAGGGASVYRAWTLPRRPGAAPWQLCPVQLPGRESRFGEPLIDDMATLADRLA
DAIGPYAHRPWALLGCSLGCKIAFEVARRFARQGRPPALLFLMACPAPGLPLGRRISTRAEADFAREVCHLGGTPPEVLA
DAEMMRTLMPILRNDSALAEHYVAAEDATVNVPIVMVAAGDDHLVTVEEARRWQRHAGAGFDWRLVDGGHFFLRQRRREL
TDWLLDALRRGERTLPVQTTTTDVPDVPCSTPEQPRDPSRMPAPGASANLVLAPGEILVVTAPRSLAARLTPAVLSDDEQ
RQLARFAFDADRERYLAAHWAKRRVLGALLAAAPRSLRFGAQAGGKPYLIGEALHFSLSHSGDRVAVAVCRHAPVGVDIE
QARGIACHASAARIMHPLDRIAPQCETPEDRFLAAWSLKEAVAKCTGAGLALPFDSLRLAFAGNGRYGCLLGTHAAWEAH
HQHEDGVHLAVASATPWAALRILPLDAALAEG

Sequences:

>Translated_832_residues
MMTITTDRTPPAAGAALDRNRSAYAGLADVLERAGLAEHALYLNWGYRPVDGQPDWAARELPPGELGRMQARLVLEVLGD
TPLDGRRVLDVGCGRGGALALMGRLHAPAALAGADISAANIAYCRKRHTHPRLRFQIADACRLPYPDSSMDVVFNLESSG
AYPDIGAFFHHVHRILRVGGRFCLADVFDADSVAWVRAALEQAGFTLERERSIPAQVRAARERASPGIWRRLDTALTALD
APGLRRELERYLAAPSSGLFQALEDGRVDYRLFHWRKTCPAAGRIDADVIARLATRSARLDAALQDRAPSAAAPQSPAPG
PANASASAWFPFTAPDAQAGFNVFALPYAGGGASVYRAWTLPRRPGAAPWQLCPVQLPGRESRFGEPLIDDMATLADRLA
DAIGPYAHRPWALLGCSLGCKIAFEVARRFARQGRPPALLFLMACPAPGLPLGRRISTRAEADFAREVCHLGGTPPEVLA
DAEMMRTLMPILRNDSALAEHYVAAEDATVNVPIVMVAAGDDHLVTVEEARRWQRHAGAGFDWRLVDGGHFFLRQRRREL
TDWLLDALRRGERTLPVQTTTTDVPDVPCSTPEQPRDPSRMPAPGASANLVLAPGEILVVTAPRSLAARLTPAVLSDDEQ
RQLARFAFDADRERYLAAHWAKRRVLGALLAAAPRSLRFGAQAGGKPYLIGEALHFSLSHSGDRVAVAVCRHAPVGVDIE
QARGIACHASAARIMHPLDRIAPQCETPEDRFLAAWSLKEAVAKCTGAGLALPFDSLRLAFAGNGRYGCLLGTHAAWEAH
HQHEDGVHLAVASATPWAALRILPLDAALAEG
>Mature_832_residues
MMTITTDRTPPAAGAALDRNRSAYAGLADVLERAGLAEHALYLNWGYRPVDGQPDWAARELPPGELGRMQARLVLEVLGD
TPLDGRRVLDVGCGRGGALALMGRLHAPAALAGADISAANIAYCRKRHTHPRLRFQIADACRLPYPDSSMDVVFNLESSG
AYPDIGAFFHHVHRILRVGGRFCLADVFDADSVAWVRAALEQAGFTLERERSIPAQVRAARERASPGIWRRLDTALTALD
APGLRRELERYLAAPSSGLFQALEDGRVDYRLFHWRKTCPAAGRIDADVIARLATRSARLDAALQDRAPSAAAPQSPAPG
PANASASAWFPFTAPDAQAGFNVFALPYAGGGASVYRAWTLPRRPGAAPWQLCPVQLPGRESRFGEPLIDDMATLADRLA
DAIGPYAHRPWALLGCSLGCKIAFEVARRFARQGRPPALLFLMACPAPGLPLGRRISTRAEADFAREVCHLGGTPPEVLA
DAEMMRTLMPILRNDSALAEHYVAAEDATVNVPIVMVAAGDDHLVTVEEARRWQRHAGAGFDWRLVDGGHFFLRQRRREL
TDWLLDALRRGERTLPVQTTTTDVPDVPCSTPEQPRDPSRMPAPGASANLVLAPGEILVVTAPRSLAARLTPAVLSDDEQ
RQLARFAFDADRERYLAAHWAKRRVLGALLAAAPRSLRFGAQAGGKPYLIGEALHFSLSHSGDRVAVAVCRHAPVGVDIE
QARGIACHASAARIMHPLDRIAPQCETPEDRFLAAWSLKEAVAKCTGAGLALPFDSLRLAFAGNGRYGCLLGTHAAWEAH
HQHEDGVHLAVASATPWAALRILPLDAALAEG

Specific function: In the final step of gramicidin biosynthesis, reduces the pentadecapeptide-aldehyde intermediate, that is released from the terminal module of the non-ribosomal peptide synthetase LgrD, to the final product ethanolamine-containing gramicidin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioesterase family [H]

Homologues:

Organism=Homo sapiens, GI89257335, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012223
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00975 Thioesterase [H]

EC number: NA

Molecular weight: Translated: 89948; Mature: 89948

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTITTDRTPPAAGAALDRNRSAYAGLADVLERAGLAEHALYLNWGYRPVDGQPDWAARE
CEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCHHCEEEEECCEEECCCCCCCCCCC
LPPGELGRMQARLVLEVLGDTPLDGRRVLDVGCGRGGALALMGRLHAPAALAGADISAAN
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHCCCCCCHHH
IAYCRKRHTHPRLRFQIADACRLPYPDSSMDVVFNLESSGAYPDIGAFFHHVHRILRVGG
HHHHHHCCCCCCEEEEEHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCC
RFCLADVFDADSVAWVRAALEQAGFTLERERSIPAQVRAARERASPGIWRRLDTALTALD
CEEEEECCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHC
APGLRRELERYLAAPSSGLFQALEDGRVDYRLFHWRKTCPAAGRIDADVIARLATRSARL
CCHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHH
DAALQDRAPSAAAPQSPAPGPANASASAWFPFTAPDAQAGFNVFALPYAGGGASVYRAWT
HHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEE
LPRRPGAAPWQLCPVQLPGRESRFGEPLIDDMATLADRLADAIGPYAHRPWALLGCSLGC
CCCCCCCCCCEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCH
KIAFEVARRFARQGRPPALLFLMACPAPGLPLGRRISTRAEADFAREVCHLGGTPPEVLA
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
DAEMMRTLMPILRNDSALAEHYVAAEDATVNVPIVMVAAGDDHLVTVEEARRWQRHAGAG
HHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCEEEEECCCCCEEEHHHHHHHHHHCCCC
FDWRLVDGGHFFLRQRRRELTDWLLDALRRGERTLPVQTTTTDVPDVPCSTPEQPRDPSR
CEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCC
MPAPGASANLVLAPGEILVVTAPRSLAARLTPAVLSDDEQRQLARFAFDADRERYLAAHW
CCCCCCCCEEEECCCCEEEEECCHHHHHHCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
AKRRVLGALLAAAPRSLRFGAQAGGKPYLIGEALHFSLSHSGDRVAVAVCRHAPVGVDIE
HHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEHEEEEEECCCCCEEEEEEECCCCCCCCHH
QARGIACHASAARIMHPLDRIAPQCETPEDRFLAAWSLKEAVAKCTGAGLALPFDSLRLA
HHCCEEEEHHHHHHHHHHHHHCCCCCCCHHHEEEHHHHHHHHHHHCCCCEECCHHHEEEE
FAGNGRYGCLLGTHAAWEAHHQHEDGVHLAVASATPWAALRILPLDAALAEG
EECCCCEEEEEECCHHHHHHCCCCCCEEEEEECCCCCEEEEEEECHHHHCCC
>Mature Secondary Structure
MMTITTDRTPPAAGAALDRNRSAYAGLADVLERAGLAEHALYLNWGYRPVDGQPDWAARE
CEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCHHCEEEEECCEEECCCCCCCCCCC
LPPGELGRMQARLVLEVLGDTPLDGRRVLDVGCGRGGALALMGRLHAPAALAGADISAAN
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHCCCCCCHHH
IAYCRKRHTHPRLRFQIADACRLPYPDSSMDVVFNLESSGAYPDIGAFFHHVHRILRVGG
HHHHHHCCCCCCEEEEEHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCC
RFCLADVFDADSVAWVRAALEQAGFTLERERSIPAQVRAARERASPGIWRRLDTALTALD
CEEEEECCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHC
APGLRRELERYLAAPSSGLFQALEDGRVDYRLFHWRKTCPAAGRIDADVIARLATRSARL
CCHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHH
DAALQDRAPSAAAPQSPAPGPANASASAWFPFTAPDAQAGFNVFALPYAGGGASVYRAWT
HHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEE
LPRRPGAAPWQLCPVQLPGRESRFGEPLIDDMATLADRLADAIGPYAHRPWALLGCSLGC
CCCCCCCCCCEECCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCH
KIAFEVARRFARQGRPPALLFLMACPAPGLPLGRRISTRAEADFAREVCHLGGTPPEVLA
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
DAEMMRTLMPILRNDSALAEHYVAAEDATVNVPIVMVAAGDDHLVTVEEARRWQRHAGAG
HHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCEEEEECCCCCEEEHHHHHHHHHHCCCC
FDWRLVDGGHFFLRQRRRELTDWLLDALRRGERTLPVQTTTTDVPDVPCSTPEQPRDPSR
CEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCC
MPAPGASANLVLAPGEILVVTAPRSLAARLTPAVLSDDEQRQLARFAFDADRERYLAAHW
CCCCCCCCEEEECCCCEEEEECCHHHHHHCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
AKRRVLGALLAAAPRSLRFGAQAGGKPYLIGEALHFSLSHSGDRVAVAVCRHAPVGVDIE
HHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEHEEEEEECCCCCEEEEEEECCCCCCCCHH
QARGIACHASAARIMHPLDRIAPQCETPEDRFLAAWSLKEAVAKCTGAGLALPFDSLRLA
HHCCEEEEHHHHHHHHHHHHHCCCCCCCHHHEEEHHHHHHHHHHHCCCCEECCHHHEEEE
FAGNGRYGCLLGTHAAWEAHHQHEDGVHLAVASATPWAALRILPLDAALAEG
EECCCCEEEEEECCHHHHHHCCCCCCEEEEEECCCCCEEEEEEECHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA