Click here to switch to the map view.

The map label for this gene is ahpC2 [C]

Identifier: 17546365

GI number: 17546365

Start: 1769837

End: 1770529

Strand: Reverse

Name: ahpC2 [C]

Synonym: RSc1646

Alternate gene names: 17546365

Gene position: 1770529-1769837 (Counterclockwise)

Preceding gene: 17546366

Following gene: 17546364

Centisome position: 47.64

GC content: 64.94

Gene sequence:

>693_bases
ATGCGGCCGGGCACGACGGATGCTTGGCCGATTGCAGCACATTCACCCATCGTTGCCGGCCGCGTCCGCCCGCCGCTTGC
CTGCCTGGCCGGCGCGCTTCTTGTTTGCAGGACGCCGTCCGCTGCGCCCCCTCAGGAGAAGCCCATGAAGACCATTGGTG
ACAAGCTCGAGCCGTTCAAGGTGATCGGTGTCAAGCCGGGGTTCAACCGCCATGAGGAAAACGGCCAGTCGGCGTTCGAA
GACATCACTGAGGCATCGTTCCCGGGCAAGTGGAAGGTCATCTATTTCTACCCGAAGGACTTCACCTTCGTGTGCCCGAC
CGAGATCGTCGCCTTCGCCAGGCTGAATCAGGACTTCGAAGACCGCGACACCGTCGTGCTGGGCGGCTCGACCGACAACG
AATTCGTCAAGCTGGCCTGGCGCCGCGAGCACAAGGACCTCGACCGGCTGAAGCAATGGTCGTTCGCCGACACCACCGGC
GCGCTGATCGACCAGCTGGGCGTGCGCGAGCACGAAGCCGGCGTCGCGCTGCGGGCCACGTTCATCGTCGATCCGGACAA
CGTGATCCAGCACGTCTCGGTGAACAACCTGAACGTGGGCCGCAACCCGGATGAAGTCCTGCGCATCCTCGACGCCCTGC
AGACCGACGAGCTGTGCCCGTGCAACCGCGCCGTCGGCGGCGCCACGCTCTGA

Upstream 100 bases:

>100_bases
CGGCGGCCGCCTCACGCTGGAGAACCGCACGCCGCCCGAGACCGGGCTGGTCGTCAGCGCCTGCTACGCACGCGGCTGAT
CCGCCCCGCCTGCGTCGTCC

Downstream 100 bases:

>100_bases
GCGCGGGCACCTGCCACCCCGCGCAGCCACCTTCGGCCGCCGCTCATGGGAGAACCGGATGGACTTCCTTCAAGCGATCA
AGGCGCGCATTCCCGACTAC

Product: alkyl hydroperoxide reductase (subunit C) oxidoreductase

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MRPGTTDAWPIAAHSPIVAGRVRPPLACLAGALLVCRTPSAAPPQEKPMKTIGDKLEPFKVIGVKPGFNRHEENGQSAFE
DITEASFPGKWKVIYFYPKDFTFVCPTEIVAFARLNQDFEDRDTVVLGGSTDNEFVKLAWRREHKDLDRLKQWSFADTTG
ALIDQLGVREHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLRILDALQTDELCPCNRAVGGATL

Sequences:

>Translated_230_residues
MRPGTTDAWPIAAHSPIVAGRVRPPLACLAGALLVCRTPSAAPPQEKPMKTIGDKLEPFKVIGVKPGFNRHEENGQSAFE
DITEASFPGKWKVIYFYPKDFTFVCPTEIVAFARLNQDFEDRDTVVLGGSTDNEFVKLAWRREHKDLDRLKQWSFADTTG
ALIDQLGVREHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLRILDALQTDELCPCNRAVGGATL
>Mature_230_residues
MRPGTTDAWPIAAHSPIVAGRVRPPLACLAGALLVCRTPSAAPPQEKPMKTIGDKLEPFKVIGVKPGFNRHEENGQSAFE
DITEASFPGKWKVIYFYPKDFTFVCPTEIVAFARLNQDFEDRDTVVLGGSTDNEFVKLAWRREHKDLDRLKQWSFADTTG
ALIDQLGVREHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLRILDALQTDELCPCNRAVGGATL

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=156, Percent_Identity=42.3076923076923, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=42.3076923076923, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI32189392, Length=160, Percent_Identity=41.25, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI4505591, Length=186, Percent_Identity=36.0215053763441, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI32455266, Length=186, Percent_Identity=36.0215053763441, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI32455264, Length=186, Percent_Identity=36.0215053763441, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=36.4779874213836, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI33188454, Length=66, Percent_Identity=46.969696969697, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=35.8288770053476, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=39.622641509434, Blast_Score=123, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=39.622641509434, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17554494, Length=151, Percent_Identity=37.7483443708609, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6323613, Length=159, Percent_Identity=43.3962264150943, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320661, Length=159, Percent_Identity=42.1383647798742, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319407, Length=160, Percent_Identity=31.25, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=40.5228758169935, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17157991, Length=159, Percent_Identity=38.9937106918239, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24641739, Length=159, Percent_Identity=38.9937106918239, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656348, Length=156, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17864676, Length=156, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357347, Length=162, Percent_Identity=34.5679012345679, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17975518, Length=165, Percent_Identity=32.1212121212121, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652436, Length=165, Percent_Identity=32.1212121212121, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652434, Length=165, Percent_Identity=32.1212121212121, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 25404; Mature: 25404

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGTTDAWPIAAHSPIVAGRVRPPLACLAGALLVCRTPSAAPPQEKPMKTIGDKLEPFK
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHEEECCCCCCCCCCCCHHHHCCCCCCEE
VIGVKPGFNRHEENGQSAFEDITEASFPGKWKVIYFYPKDFTFVCPTEIVAFARLNQDFE
EEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHHHHHHHHHCCCCC
DRDTVVLGGSTDNEFVKLAWRREHKDLDRLKQWSFADTTGALIDQLGVREHEAGVALRAT
CCCEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEE
FIVDPDNVIQHVSVNNLNVGRNPDEVLRILDALQTDELCPCNRAVGGATL
EEECCHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPGTTDAWPIAAHSPIVAGRVRPPLACLAGALLVCRTPSAAPPQEKPMKTIGDKLEPFK
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHEEECCCCCCCCCCCCHHHHCCCCCCEE
VIGVKPGFNRHEENGQSAFEDITEASFPGKWKVIYFYPKDFTFVCPTEIVAFARLNQDFE
EEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHHHHHHHHHCCCCC
DRDTVVLGGSTDNEFVKLAWRREHKDLDRLKQWSFADTTGALIDQLGVREHEAGVALRAT
CCCEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEEE
FIVDPDNVIQHVSVNNLNVGRNPDEVLRILDALQTDELCPCNRAVGGATL
EEECCHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA