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The map label for this gene is risS [H]

Identifier: 17546366

GI number: 17546366

Start: 1770551

End: 1771912

Strand: Reverse

Name: risS [H]

Synonym: RSc1647

Alternate gene names: 17546366

Gene position: 1771912-1770551 (Counterclockwise)

Preceding gene: 17546367

Following gene: 17546365

Centisome position: 47.68

GC content: 68.36

Gene sequence:

>1362_bases
TTGCGCATTCCGCGTCCGGCCGCGCTGCGGCGCCTGCTGATCAGCGTATTCGGTTCGCTGTTCTGGCGAACCTTCATGCT
GATCGCGTTGCTGATCGCGATCTCGCTCGGGGCATGGTTCCAGAGCTTCCGCATTTTCGAGCGCGAGCCGCGCGCGCAGC
AGATCGCCATGCAGATCGTCAGCGTGGTCAAGCTGACGCGGGCGGCGCTGCTCTACTCCGATCCGGCGCGGCGGCGCTTC
CTGCTGCTCGACCTGGTGCAGAACGAGGGCATCAAGGTCTATCCGCGCGAAAAGGAAGACGAATACCGCACGCCGCAGGC
CAATCCCTACCTCACGCAGCTGGTCCAGCGGGAGATCCGCAACCGCCTGGGCCAGGACACCGTGATCGCCACCGCGGTCA
ACGACATCCCCGGCGTGTGGGTCAGCTTCCAGATCGAGGGCGACGACTACTGGGTCGCCATCAGCCCGGACCGCTTCGAG
CACGTGCCGGGGCTGCAATGGCTGTGGTGGTCGATCGCGGCGCTGGTGCTGTCGGTGCTGGGCGCGGCCTTCATCACCTC
GCGCGTCAACCAGCCGCTCAAGCGGCTGGCCGATACCGCGCGCGCCATCAGCGCGGGCGATGATCCGAAGTCGCTGCCCG
AGGGCGGCGGCACGGAAGTGGCCCAGGCGAATCACAGCTTCAACCAGATGGTGCGGGACCTCAAGCAGCTGGAAGCCGAC
CGCGCCGTGATGCTCGCCGGCATCTCGCACGATCTGCGCACGCCGCTCACGCGCCTGCGCCTGGAAACCGAGATGAGCCC
GGTCGACGACCAGACCCGCGAGCTGATGGTGGCCGACATCGAACAGATGGACGCCATCATCGGCCAGTTCCTGGACTATG
CGCGCCCCTCCGGCGAGATGCTGGAAGCCGTCGACCTGACCGAACTGGTGCGCGATACCGCACCGGTCTATTCCGCCCAC
GACGACATCGACCTCACGCTCAAGCTGGCGCCCGAGGCCATCGCCCGCTGCAACCGGATGGAAACCCAGCGCATCCTCGA
CAACCTGATCGAGAACGCGCGCCGCTACGGCAAGACGCACGACACCGGCCGCGCCGAGATCACGGTCAGCACCGCGCTGC
AGGGCAACGAGGTGGTGCTGTGCGTGGCCGACCGCGGCGCCGGCGTGCCGGCCGACCAGCTGGCGCTGTTGACGCGGCCG
TTCTACCGGCTGGAATCCGCGCGCAGCGAGGCCAAGGGCGCGGGCCTCGGCATGTCGATCGTGAGCCGGATCCTGCAGCG
CAGCGGCGGCCGCCTCACGCTGGAGAACCGCACGCCGCCCGAGACCGGGCTGGTCGTCAGCGCCTGCTACGCACGCGGCT
GA

Upstream 100 bases:

>100_bases
CCGCGCTTCATCCAGACGGTCTGGGGCCTGGGCTACGTGTTCATCCCGGACGGCGCCAAGTAACGCGCGGCACGCCTCCA
ACCCTTCTTCCGCCCACGAC

Downstream 100 bases:

>100_bases
TCCGCCCCGCCTGCGTCGTCCATGCGGCCGGGCACGACGGATGCTTGGCCGATTGCAGCACATTCACCCATCGTTGCCGG
CCGCGTCCGCCCGCCGCTTG

Product: oxidative stress resistance two-component transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRIPRPAALRRLLISVFGSLFWRTFMLIALLIAISLGAWFQSFRIFEREPRAQQIAMQIVSVVKLTRAALLYSDPARRRF
LLLDLVQNEGIKVYPREKEDEYRTPQANPYLTQLVQREIRNRLGQDTVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFE
HVPGLQWLWWSIAALVLSVLGAAFITSRVNQPLKRLADTARAISAGDDPKSLPEGGGTEVAQANHSFNQMVRDLKQLEAD
RAVMLAGISHDLRTPLTRLRLETEMSPVDDQTRELMVADIEQMDAIIGQFLDYARPSGEMLEAVDLTELVRDTAPVYSAH
DDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTHDTGRAEITVSTALQGNEVVLCVADRGAGVPADQLALLTRP
FYRLESARSEAKGAGLGMSIVSRILQRSGGRLTLENRTPPETGLVVSACYARG

Sequences:

>Translated_453_residues
MRIPRPAALRRLLISVFGSLFWRTFMLIALLIAISLGAWFQSFRIFEREPRAQQIAMQIVSVVKLTRAALLYSDPARRRF
LLLDLVQNEGIKVYPREKEDEYRTPQANPYLTQLVQREIRNRLGQDTVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFE
HVPGLQWLWWSIAALVLSVLGAAFITSRVNQPLKRLADTARAISAGDDPKSLPEGGGTEVAQANHSFNQMVRDLKQLEAD
RAVMLAGISHDLRTPLTRLRLETEMSPVDDQTRELMVADIEQMDAIIGQFLDYARPSGEMLEAVDLTELVRDTAPVYSAH
DDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTHDTGRAEITVSTALQGNEVVLCVADRGAGVPADQLALLTRP
FYRLESARSEAKGAGLGMSIVSRILQRSGGRLTLENRTPPETGLVVSACYARG
>Mature_453_residues
MRIPRPAALRRLLISVFGSLFWRTFMLIALLIAISLGAWFQSFRIFEREPRAQQIAMQIVSVVKLTRAALLYSDPARRRF
LLLDLVQNEGIKVYPREKEDEYRTPQANPYLTQLVQREIRNRLGQDTVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFE
HVPGLQWLWWSIAALVLSVLGAAFITSRVNQPLKRLADTARAISAGDDPKSLPEGGGTEVAQANHSFNQMVRDLKQLEAD
RAVMLAGISHDLRTPLTRLRLETEMSPVDDQTRELMVADIEQMDAIIGQFLDYARPSGEMLEAVDLTELVRDTAPVYSAH
DDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTHDTGRAEITVSTALQGNEVVLCVADRGAGVPADQLALLTRP
FYRLESARSEAKGAGLGMSIVSRILQRSGGRLTLENRTPPETGLVVSACYARG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=439, Percent_Identity=32.8018223234624, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=31.1355311355311, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790346, Length=280, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082128, Length=287, Percent_Identity=26.8292682926829, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=257, Percent_Identity=28.4046692607004, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=207, Percent_Identity=25.1207729468599, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=265, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=31.2775330396476, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=23.4323432343234, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790861, Length=280, Percent_Identity=25.3571428571429, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=28.310502283105, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50602; Mature: 50602

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPRPAALRRLLISVFGSLFWRTFMLIALLIAISLGAWFQSFRIFEREPRAQQIAMQIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SVVKLTRAALLYSDPARRRFLLLDLVQNEGIKVYPREKEDEYRTPQANPYLTQLVQREIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
NRLGQDTVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFEHVPGLQWLWWSIAALVLSVL
HHCCCCCEEEEECCCCCCEEEEEEEECCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHH
GAAFITSRVNQPLKRLADTARAISAGDDPKSLPEGGGTEVAQANHSFNQMVRDLKQLEAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHC
RAVMLAGISHDLRTPLTRLRLETEMSPVDDQTRELMVADIEQMDAIIGQFLDYARPSGEM
CEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LEAVDLTELVRDTAPVYSAHDDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTH
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DTGRAEITVSTALQGNEVVLCVADRGAGVPADQLALLTRPFYRLESARSEAKGAGLGMSI
CCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VSRILQRSGGRLTLENRTPPETGLVVSACYARG
HHHHHHCCCCEEEECCCCCCCCCCEEHHHHHCC
>Mature Secondary Structure
MRIPRPAALRRLLISVFGSLFWRTFMLIALLIAISLGAWFQSFRIFEREPRAQQIAMQIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SVVKLTRAALLYSDPARRRFLLLDLVQNEGIKVYPREKEDEYRTPQANPYLTQLVQREIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
NRLGQDTVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFEHVPGLQWLWWSIAALVLSVL
HHCCCCCEEEEECCCCCCEEEEEEEECCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHH
GAAFITSRVNQPLKRLADTARAISAGDDPKSLPEGGGTEVAQANHSFNQMVRDLKQLEAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHC
RAVMLAGISHDLRTPLTRLRLETEMSPVDDQTRELMVADIEQMDAIIGQFLDYARPSGEM
CEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LEAVDLTELVRDTAPVYSAHDDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTH
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DTGRAEITVSTALQGNEVVLCVADRGAGVPADQLALLTRPFYRLESARSEAKGAGLGMSI
CCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VSRILQRSGGRLTLENRTPPETGLVVSACYARG
HHHHHHCCCCEEEECCCCCCCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]