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The map label for this gene is argE [H]

Identifier: 17546360

GI number: 17546360

Start: 1763076

End: 1764269

Strand: Reverse

Name: argE [H]

Synonym: RSc1641

Alternate gene names: 17546360

Gene position: 1764269-1763076 (Counterclockwise)

Preceding gene: 17546361

Following gene: 17546359

Centisome position: 47.47

GC content: 70.6

Gene sequence:

>1194_bases
ATGAGCACCACCGCCACCGCACTTTCCACGCTCGACTGGACGCGCAAGCTGGTCAGCTTCGACACCACCAGCCGCGGCTC
CAACCTGGCGCTGATCGAAACCGTGCGCGACCACCTGCACGGCCTGGGCCTGCAGACGCATCTGTCGTACAGCGACGGGC
GCGACAAGGCCAACCTGTTCGCCACGGTCCCGGCGGCGGACGGCGGCGTGCAGGGCGGTATCGTGCTGTCGGGCCACACC
GATGTGGTGCCGGTCGACGGGCAGCGCTGGAGCAGCGATCCGTTCGCGCCCGAAGTGCGCGACGGCAGGCTGTACGGGCG
CGGCACGTGCGACATGAAGGGCTTCATCGCCGCGTCGCTGGCGCTGGTGCCGTCGGTGCTGCGGGCGCGCCTGCGCGAGC
CGATCCACCTGGCGCTGTCATACGACGAAGAAGTCGGCTGCATGGGCGCGCCGCGCATGATCGAAGACCTGATCGCGCGA
GGCATCCGCCCCGCCGGCTGCATCGTCGGTGAGCCGACCGGCATGCGCCCGATCGTCGCCCACAAGGGCATCAACGCCTA
CCGCTGCCGCGTGCACGGCCGCGCCGCGCATTCGTCGCTGACGCCGCGGGGCGTCAACGCCATAGAATACGCCGCCCGCA
TCATCTGCTTCGTGCGCGACCTGGCCGACGAATTCCGGGCCCGGGGGCCGTTCGACGCGGCGTTCGATGTGCCGTTCACC
ACCGCCTCCACCGGGCTCATCGACGGCGGCATCGCGCTCAATACCATTCCCGCGCTGTGCGAATTCGTCTTCGAGTTCCG
CAGCCTGCCGGGCATCGATGCGCCGGCGATCCGCGCGCGCGTGGAGCACTACGTGCGCGAGACCATCGAGCCGGCCATGC
GGCGCGAGCATCCGGAGGCCCGCATCGAACTGGACGAGATCGCCGCCGCCCCGTCGCTGGACGCCTCCGAACAGGCCGCC
ATCACGCAGCTCGTGCGCGCGCTGACCGCGGACAACGCCCCGCGCAAGGTCGCCTACGCCACCGAGGCGGGCCTGTTCCA
GCGCGCCGGCATCCCGGCTGTTCTATGCGGCCCGGGCCACATCGAGCAGGCGCACAAGGCCGACGAATACGTCGAACTGG
CCCAGCTCGATGCCTGCGACCGCTTCCTGGCCAACGTGGCGCGCAGCCTGATGCTGGAGCCCGCCTCGGCCTGA

Upstream 100 bases:

>100_bases
AACATCCCCGCCGAGACCGCCGCGCTGGCGCAGGCCATCCGCCAGACCATGCGGCAGCTGACCTGACCGGACCGCCCGCC
CTCACCCGCAGGACACCACC

Downstream 100 bases:

>100_bases
GCATCGCCTTCTGGCGGCGGCCCGCCTGTCGGTGGGGCGCCATCCCGGCGGAGGCGTTCGCTACAATAGCGGGCTTCCTC
GGCGCTTCATTTCCCGTTTT

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSTTATALSTLDWTRKLVSFDTTSRGSNLALIETVRDHLHGLGLQTHLSYSDGRDKANLFATVPAADGGVQGGIVLSGHT
DVVPVDGQRWSSDPFAPEVRDGRLYGRGTCDMKGFIAASLALVPSVLRARLREPIHLALSYDEEVGCMGAPRMIEDLIAR
GIRPAGCIVGEPTGMRPIVAHKGINAYRCRVHGRAAHSSLTPRGVNAIEYAARIICFVRDLADEFRARGPFDAAFDVPFT
TASTGLIDGGIALNTIPALCEFVFEFRSLPGIDAPAIRARVEHYVRETIEPAMRREHPEARIELDEIAAAPSLDASEQAA
ITQLVRALTADNAPRKVAYATEAGLFQRAGIPAVLCGPGHIEQAHKADEYVELAQLDACDRFLANVARSLMLEPASA

Sequences:

>Translated_397_residues
MSTTATALSTLDWTRKLVSFDTTSRGSNLALIETVRDHLHGLGLQTHLSYSDGRDKANLFATVPAADGGVQGGIVLSGHT
DVVPVDGQRWSSDPFAPEVRDGRLYGRGTCDMKGFIAASLALVPSVLRARLREPIHLALSYDEEVGCMGAPRMIEDLIAR
GIRPAGCIVGEPTGMRPIVAHKGINAYRCRVHGRAAHSSLTPRGVNAIEYAARIICFVRDLADEFRARGPFDAAFDVPFT
TASTGLIDGGIALNTIPALCEFVFEFRSLPGIDAPAIRARVEHYVRETIEPAMRREHPEARIELDEIAAAPSLDASEQAA
ITQLVRALTADNAPRKVAYATEAGLFQRAGIPAVLCGPGHIEQAHKADEYVELAQLDACDRFLANVARSLMLEPASA
>Mature_396_residues
STTATALSTLDWTRKLVSFDTTSRGSNLALIETVRDHLHGLGLQTHLSYSDGRDKANLFATVPAADGGVQGGIVLSGHTD
VVPVDGQRWSSDPFAPEVRDGRLYGRGTCDMKGFIAASLALVPSVLRARLREPIHLALSYDEEVGCMGAPRMIEDLIARG
IRPAGCIVGEPTGMRPIVAHKGINAYRCRVHGRAAHSSLTPRGVNAIEYAARIICFVRDLADEFRARGPFDAAFDVPFTT
ASTGLIDGGIALNTIPALCEFVFEFRSLPGIDAPAIRARVEHYVRETIEPAMRREHPEARIELDEIAAAPSLDASEQAAI
TQLVRALTADNAPRKVAYATEAGLFQRAGIPAVLCGPGHIEQAHKADEYVELAQLDACDRFLANVARSLMLEPASA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=269, Percent_Identity=27.1375464684015, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1790395, Length=348, Percent_Identity=35.632183908046, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788816, Length=239, Percent_Identity=29.7071129707113, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551016, Length=401, Percent_Identity=24.9376558603491, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24649202, Length=348, Percent_Identity=25.5747126436782, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24649204, Length=348, Percent_Identity=25.5747126436782, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24649210, Length=341, Percent_Identity=24.9266862170088, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 42712; Mature: 42581

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00759 ARGE_DAPE_CPG2_2 ; PS00196 COPPER_BLUE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTATALSTLDWTRKLVSFDTTSRGSNLALIETVRDHLHGLGLQTHLSYSDGRDKANLF
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEE
ATVPAADGGVQGGIVLSGHTDVVPVDGQRWSSDPFAPEVRDGRLYGRGTCDMKGFIAASL
EECCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
ALVPSVLRARLREPIHLALSYDEEVGCMGAPRMIEDLIARGIRPAGCIVGEPTGMRPIVA
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCHHH
HKGINAYRCRVHGRAAHSSLTPRGVNAIEYAARIICFVRDLADEFRARGPFDAAFDVPFT
HCCCCEEEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TASTGLIDGGIALNTIPALCEFVFEFRSLPGIDAPAIRARVEHYVRETIEPAMRREHPEA
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
RIELDEIAAAPSLDASEQAAITQLVRALTADNAPRKVAYATEAGLFQRAGIPAVLCGPGH
HEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCEEEECCCC
IEQAHKADEYVELAQLDACDRFLANVARSLMLEPASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STTATALSTLDWTRKLVSFDTTSRGSNLALIETVRDHLHGLGLQTHLSYSDGRDKANLF
CCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEE
ATVPAADGGVQGGIVLSGHTDVVPVDGQRWSSDPFAPEVRDGRLYGRGTCDMKGFIAASL
EECCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHH
ALVPSVLRARLREPIHLALSYDEEVGCMGAPRMIEDLIARGIRPAGCIVGEPTGMRPIVA
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCHHH
HKGINAYRCRVHGRAAHSSLTPRGVNAIEYAARIICFVRDLADEFRARGPFDAAFDVPFT
HCCCCEEEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
TASTGLIDGGIALNTIPALCEFVFEFRSLPGIDAPAIRARVEHYVRETIEPAMRREHPEA
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
RIELDEIAAAPSLDASEQAAITQLVRALTADNAPRKVAYATEAGLFQRAGIPAVLCGPGH
HEEHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCEEEECCCC
IEQAHKADEYVELAQLDACDRFLANVARSLMLEPASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]