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The map label for this gene is mel [H]

Identifier: 17546220

GI number: 17546220

Start: 1606005

End: 1607243

Strand: Direct

Name: mel [H]

Synonym: RSc1501

Alternate gene names: 17546220

Gene position: 1606005-1607243 (Clockwise)

Preceding gene: 17546219

Following gene: 17546221

Centisome position: 43.21

GC content: 68.6

Gene sequence:

>1239_bases
ATGCGAATCGACTTCACGATCAACAACGGTGGTGACGCAGCCGCGCGCTACCTCACCTGGGCGCCGTCGCCATTGCGGCT
TCGCCTGCTCGATGCCACGCCGGGGCCGGATGTGGTCGCAACCCTGTCGGAAGATCGCCAGCCCAATGGCGGCTCCATCC
GGTTCTGTGCGACGCCCGATGGCAACTTCACCCCGACGCTCAAAGTGCCGCTGCCGGCGAGCGGCGCCTCCGTGACGGTC
TACGTTCGCGGAAAATTCGGCACGCCCAGCCAGGCCGATGGCGACGTCAGTATCGTGGTCGGCGGGCCGGCGTCGGAACT
CGGCCGCTTGCCCGTCATGGTGCGGGTGCGCAAGAACGCGAATCAGCTGACCCCGGCCGAGCGGGACCGCTTCATCTCGG
CCATGGCGCAGATCAACAACCGGGGGACGGGGCGGTTCACCGATTTCCGCAACATGCACGTCGCGGGCCGTGCCGATCAG
CAGGCCCATGGCGGCCCCGGCTTCCTGCCGTGGCACCGGGCCTATCTGCTCGACCTGGAGCGCGAGCTGCAGGCCATCGA
CCCCGCGGTGACGATCCCGTATTGGCGCTTCGATCGGCCGGCGCCGAATCTGTTCACCACCGACTTCATCGGCGTGCCGG
ATGCGCTCGGCACGGTGAGTTTCAGCCCGGCCAACCCGCTGCAGTTCTGGGCCACCGACGGCGTGCAAGGGATCCTGAGG
CGCCAGCTGGGCGCGAGCCCCGGCGCGCAGGCCGCCCCGAACATCCTGACCGAGGCGCAGACGCTGGCGCTCGGCAGTGC
GTACCGGAATTTCCGGGGCATGCAGGGCAATCCGCACGGCTCCGCGCATGTCAGCTATTTCTCGGGCAGCATCTCGTCGA
TCCCGACCGCCGCCAAGGATCCGCTGTTCTTCCTGCTGCACTGCAATGTCGACAGGCTGTGGGCCAAATGGCAGTCGCAG
GTGGGGCGGTACGATGCGAACGTGGCGGCCGCCTATGACGCCGGTCCGACGCCGACGAGCCTGCTCGCGGGCCACAATCT
GCACGACACGCTGTGGCCGTGGAACGGCATCGTGACGCCGCCTCGGCCGTCGACCGCCCCCGGCGGAGCCATGGCCGGAT
CGTCGTGCGTCTCGGCGCCGGGGAACGCGCCCCGCGTCAGCGACATGCTGGACTTCCAGGGGGTGGTGAGCAGTTCGGCC
AAGCTCGGCTTTGCCTACGACGATGTGCCCTTGCCCTGA

Upstream 100 bases:

>100_bases
ATGCCCGATACACCGCCATCCTCCGGTTTGCTGAAGATGTACCCCAGGGCGCGCCCTCTACGGTCGAGGGCGTTCAAGCA
CTCACGAGGAGGTACCGGGC

Downstream 100 bases:

>100_bases
TCCGACCTTCATTGGGAGCGCACCACCATGACTGCAAACAAGACCAAGGGCAAGGCTTCCGGCTCCGCCGCCCGGAAGGC
CGCCACGAAGCGCCCGGCCG

Product: tyrosinase oxidoreductase

Products: NA

Alternate protein names: Monophenol monooxygenase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRIDFTINNGGDAAARYLTWAPSPLRLRLLDATPGPDVVATLSEDRQPNGGSIRFCATPDGNFTPTLKVPLPASGASVTV
YVRGKFGTPSQADGDVSIVVGGPASELGRLPVMVRVRKNANQLTPAERDRFISAMAQINNRGTGRFTDFRNMHVAGRADQ
QAHGGPGFLPWHRAYLLDLERELQAIDPAVTIPYWRFDRPAPNLFTTDFIGVPDALGTVSFSPANPLQFWATDGVQGILR
RQLGASPGAQAAPNILTEAQTLALGSAYRNFRGMQGNPHGSAHVSYFSGSISSIPTAAKDPLFFLLHCNVDRLWAKWQSQ
VGRYDANVAAAYDAGPTPTSLLAGHNLHDTLWPWNGIVTPPRPSTAPGGAMAGSSCVSAPGNAPRVSDMLDFQGVVSSSA
KLGFAYDDVPLP

Sequences:

>Translated_412_residues
MRIDFTINNGGDAAARYLTWAPSPLRLRLLDATPGPDVVATLSEDRQPNGGSIRFCATPDGNFTPTLKVPLPASGASVTV
YVRGKFGTPSQADGDVSIVVGGPASELGRLPVMVRVRKNANQLTPAERDRFISAMAQINNRGTGRFTDFRNMHVAGRADQ
QAHGGPGFLPWHRAYLLDLERELQAIDPAVTIPYWRFDRPAPNLFTTDFIGVPDALGTVSFSPANPLQFWATDGVQGILR
RQLGASPGAQAAPNILTEAQTLALGSAYRNFRGMQGNPHGSAHVSYFSGSISSIPTAAKDPLFFLLHCNVDRLWAKWQSQ
VGRYDANVAAAYDAGPTPTSLLAGHNLHDTLWPWNGIVTPPRPSTAPGGAMAGSSCVSAPGNAPRVSDMLDFQGVVSSSA
KLGFAYDDVPLP
>Mature_412_residues
MRIDFTINNGGDAAARYLTWAPSPLRLRLLDATPGPDVVATLSEDRQPNGGSIRFCATPDGNFTPTLKVPLPASGASVTV
YVRGKFGTPSQADGDVSIVVGGPASELGRLPVMVRVRKNANQLTPAERDRFISAMAQINNRGTGRFTDFRNMHVAGRADQ
QAHGGPGFLPWHRAYLLDLERELQAIDPAVTIPYWRFDRPAPNLFTTDFIGVPDALGTVSFSPANPLQFWATDGVQGILR
RQLGASPGAQAAPNILTEAQTLALGSAYRNFRGMQGNPHGSAHVSYFSGSISSIPTAAKDPLFFLLHCNVDRLWAKWQSQ
VGRYDANVAAAYDAGPTPTSLLAGHNLHDTLWPWNGIVTPPRPSTAPGGAMAGSSCVSAPGNAPRVSDMLDFQGVVSSSA
KLGFAYDDVPLP

Specific function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tyrosinase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17505853, Length=238, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551924, Length=232, Percent_Identity=28.8793103448276, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17554098, Length=221, Percent_Identity=31.6742081447964, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI193202602, Length=277, Percent_Identity=29.2418772563177, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71999521, Length=232, Percent_Identity=27.1551724137931, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008922
- InterPro:   IPR002227 [H]

Pfam domain/function: PF00264 Tyrosinase [H]

EC number: =1.14.18.1 [H]

Molecular weight: Translated: 43955; Mature: 43955

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00497 TYROSINASE_1 ; PS00498 TYROSINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDFTINNGGDAAARYLTWAPSPLRLRLLDATPGPDVVATLSEDRQPNGGSIRFCATPD
CEEEEEECCCCCHHEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCC
GNFTPTLKVPLPASGASVTVYVRGKFGTPSQADGDVSIVVGGPASELGRLPVMVRVRKNA
CCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCHHHHCCCCEEEEEECCC
NQLTPAERDRFISAMAQINNRGTGRFTDFRNMHVAGRADQQAHGGPGFLPWHRAYLLDLE
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
RELQAIDPAVTIPYWRFDRPAPNLFTTDFIGVPDALGTVSFSPANPLQFWATDGVQGILR
HHHHHCCCEEECCEEECCCCCCCCEEECCCCCCCHHCEEEECCCCCCEEEECCCHHHHHH
RQLGASPGAQAAPNILTEAQTLALGSAYRNFRGMQGNPHGSAHVSYFSGSISSIPTAAKD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHCCCCCCCC
PLFFLLHCNVDRLWAKWQSQVGRYDANVAAAYDAGPTPTSLLAGHNLHDTLWPWNGIVTP
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCEECC
PRPSTAPGGAMAGSSCVSAPGNAPRVSDMLDFQGVVSSSAKLGFAYDDVPLP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure
MRIDFTINNGGDAAARYLTWAPSPLRLRLLDATPGPDVVATLSEDRQPNGGSIRFCATPD
CEEEEEECCCCCHHEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCC
GNFTPTLKVPLPASGASVTVYVRGKFGTPSQADGDVSIVVGGPASELGRLPVMVRVRKNA
CCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCHHHHCCCCEEEEEECCC
NQLTPAERDRFISAMAQINNRGTGRFTDFRNMHVAGRADQQAHGGPGFLPWHRAYLLDLE
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
RELQAIDPAVTIPYWRFDRPAPNLFTTDFIGVPDALGTVSFSPANPLQFWATDGVQGILR
HHHHHCCCEEECCEEECCCCCCCCEEECCCCCCCHHCEEEECCCCCCEEEECCCHHHHHH
RQLGASPGAQAAPNILTEAQTLALGSAYRNFRGMQGNPHGSAHVSYFSGSISSIPTAAKD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHCCCCCCCC
PLFFLLHCNVDRLWAKWQSQVGRYDANVAAAYDAGPTPTSLLAGHNLHDTLWPWNGIVTP
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCEECC
PRPSTAPGGAMAGSSCVSAPGNAPRVSDMLDFQGVVSSSAKLGFAYDDVPLP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3002431; 2846043; 1901488 [H]