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The map label for this gene is emrY [H]

Identifier: 17546192

GI number: 17546192

Start: 1575853

End: 1577406

Strand: Direct

Name: emrY [H]

Synonym: RSc1473

Alternate gene names: 17546192

Gene position: 1575853-1577406 (Clockwise)

Preceding gene: 17546179

Following gene: 17546193

Centisome position: 42.4

GC content: 68.98

Gene sequence:

>1554_bases
ATGAACACGCCAAGCACGGACCACACGCCTTCCGCCCAGTCGGCGCCGCGCCGCCAGCCGGCCGGATCGACGGTCGCCAG
CCGGCTGGAGCTGCGCATGGTCGGCATGGTGATCGGCCTGGCGACCGGCGTGGATTACATGGCCAACCTGATGTTCTCGA
TCGCCGGGCCGCATATCGAGGGCGGGGTGCTGGCCTCGCAGGACGTCTACCTGTGGGCGGTGACGTCCTATGCGGCGGCG
GCCAGCCTGGCGATCCTGGTGATGGGACGGCTGGCCGACCGGATGACCTATCGCCGGCACACGCTGCTGTCGCTGCTGAT
CTTCATTGCCGGCACGCTGATGTGCGCGGCGGCCGAGGGCGGCACCATGCTGATCTTCGGGCGGGCCGTACAGGGCTTCG
GTGGCGGGCCGATGCTGTCCACGTCGCGCATCTTCGTGCAGCACAGCCCGGCACACGAGCGCCGCACCATGATGAAGGGG
ATGATCTACGGCATCTTCGGGCTGACCTGCGTCTCGCCGGTGCTCTCCGCCGCGCTGACGGAGCAGTTCGGCTGGCGCGC
CATCTTCGTGGCCCAGTTGCTGGTGGCGGTGATGGTGTGCGGCCTGGTGGCGGCGTTCTACCCGCATCCCCACCAGCATG
AACGCACGGGCGACTTCGCCTCGCTGGACTGGCCCTCCGCCATCGCTTTCGGCCTCGCCGCGCTGATCGCGCTGCACGGC
TTCCAGCAGGCGCGCTTCGTGCACCCCGACGGCTCGCCGGCGCAGGTGCTGCCCATCCTGGCCGTGGTCGCGCTGGTCGC
CTGGATCGGCATCCGCCAGACCGGGCACCCGCTGCCGTGGGTGGACCTGCGCGCCACGTTGCAGCGCCGCTTCATAGTGG
GCATGGTGTTCTATGCCATCTACTACGGCTTTGCCAGCGCGTGGAGCTTCCTGTCCTCCAGCCTGCTGCAGAACGGCCTG
GGCTTCCGCTACGAGACCACCGCGCAGTTCATGAGCCTGTCGGGGCTGGTGACGCTGCTGCTGGGCATCGCCAACTTCCA
GTTGACCGATTACCTGCCGCGCAAGCACGTGCTGATCGCCATCGGTTTCGTGTTGATGGCGGGCGCGATGCTGTGGCTGT
CGCGCACGGCCATGCCCGGCGCATCGGCCGGCGTGCTGGCGCCGGGGTTCGTGATGGAGGGCATGGTCGGCATGCTGGTG
GTGATCCAGGTGGCGGGGCTGACCTATGTCGACCTGCCCGCCGAGGACTTCGGCCATGCCTACCAGTTCAAGGGCATCAT
GCGCGCCTGGGCCCAGGCCTTCGGCACGCTGCTGGCGACGCTGATGCTGCAGCGCGGACAGGCGCAGCACCGCACCGACC
TGGTCGGCCATGTCTCGGCGCTGACGCCGTCGTGGCTGTGGCCGCATCCGCTGCAGGGTGCGGAATTGGTGCGGCTGTCA
GCGGAGATCGACCGGCAGGCGACGCTGCTGGCGTGCGGTGACCTGTTCGTCTGGAGCGCGGCGATTGCGCTGGCGTGCGC
GGTGGCGATTCTCGCGCAGCGGACGTTGCGCTGA

Upstream 100 bases:

>100_bases
GAAGGTGTCCCAGTCGTTCCAGTCCGTCGTTCGCATGGTTGAACAATGAATTTGTGATACGGCGATTTCCACGGGTTTCC
AAGCAAATTACCATCCCGAC

Downstream 100 bases:

>100_bases
TGCCCGGCGCCGTCCTCGGCGAGGACCGGGGTGGCGCGGCGCGCGGGTGTCAGCAGGACGGGCACGGCCGATACGCCGAT
GGGGTGGCACGGGGTGCGGC

Product: multidrug resistance-like transmembrane protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MNTPSTDHTPSAQSAPRRQPAGSTVASRLELRMVGMVIGLATGVDYMANLMFSIAGPHIEGGVLASQDVYLWAVTSYAAA
ASLAILVMGRLADRMTYRRHTLLSLLIFIAGTLMCAAAEGGTMLIFGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKG
MIYGIFGLTCVSPVLSAALTEQFGWRAIFVAQLLVAVMVCGLVAAFYPHPHQHERTGDFASLDWPSAIAFGLAALIALHG
FQQARFVHPDGSPAQVLPILAVVALVAWIGIRQTGHPLPWVDLRATLQRRFIVGMVFYAIYYGFASAWSFLSSSLLQNGL
GFRYETTAQFMSLSGLVTLLLGIANFQLTDYLPRKHVLIAIGFVLMAGAMLWLSRTAMPGASAGVLAPGFVMEGMVGMLV
VIQVAGLTYVDLPAEDFGHAYQFKGIMRAWAQAFGTLLATLMLQRGQAQHRTDLVGHVSALTPSWLWPHPLQGAELVRLS
AEIDRQATLLACGDLFVWSAAIALACAVAILAQRTLR

Sequences:

>Translated_517_residues
MNTPSTDHTPSAQSAPRRQPAGSTVASRLELRMVGMVIGLATGVDYMANLMFSIAGPHIEGGVLASQDVYLWAVTSYAAA
ASLAILVMGRLADRMTYRRHTLLSLLIFIAGTLMCAAAEGGTMLIFGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKG
MIYGIFGLTCVSPVLSAALTEQFGWRAIFVAQLLVAVMVCGLVAAFYPHPHQHERTGDFASLDWPSAIAFGLAALIALHG
FQQARFVHPDGSPAQVLPILAVVALVAWIGIRQTGHPLPWVDLRATLQRRFIVGMVFYAIYYGFASAWSFLSSSLLQNGL
GFRYETTAQFMSLSGLVTLLLGIANFQLTDYLPRKHVLIAIGFVLMAGAMLWLSRTAMPGASAGVLAPGFVMEGMVGMLV
VIQVAGLTYVDLPAEDFGHAYQFKGIMRAWAQAFGTLLATLMLQRGQAQHRTDLVGHVSALTPSWLWPHPLQGAELVRLS
AEIDRQATLLACGDLFVWSAAIALACAVAILAQRTLR
>Mature_517_residues
MNTPSTDHTPSAQSAPRRQPAGSTVASRLELRMVGMVIGLATGVDYMANLMFSIAGPHIEGGVLASQDVYLWAVTSYAAA
ASLAILVMGRLADRMTYRRHTLLSLLIFIAGTLMCAAAEGGTMLIFGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKG
MIYGIFGLTCVSPVLSAALTEQFGWRAIFVAQLLVAVMVCGLVAAFYPHPHQHERTGDFASLDWPSAIAFGLAALIALHG
FQQARFVHPDGSPAQVLPILAVVALVAWIGIRQTGHPLPWVDLRATLQRRFIVGMVFYAIYYGFASAWSFLSSSLLQNGL
GFRYETTAQFMSLSGLVTLLLGIANFQLTDYLPRKHVLIAIGFVLMAGAMLWLSRTAMPGASAGVLAPGFVMEGMVGMLV
VIQVAGLTYVDLPAEDFGHAYQFKGIMRAWAQAFGTLLATLMLQRGQAQHRTDLVGHVSALTPSWLWPHPLQGAELVRLS
AEIDRQATLLACGDLFVWSAAIALACAVAILAQRTLR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=485, Percent_Identity=24.3298969072165, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789042, Length=496, Percent_Identity=24.5967741935484, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87081983, Length=237, Percent_Identity=26.1603375527426, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790195, Length=307, Percent_Identity=25.0814332247557, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55689; Mature: 55689

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPSTDHTPSAQSAPRRQPAGSTVASRLELRMVGMVIGLATGVDYMANLMFSIAGPHIE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGVLASQDVYLWAVTSYAAAASLAILVMGRLADRMTYRRHTLLSLLIFIAGTLMCAAAEG
CCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTMLIFGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKGMIYGIFGLTCVSPVLSAALT
CEEEEEECHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQFGWRAIFVAQLLVAVMVCGLVAAFYPHPHQHERTGDFASLDWPSAIAFGLAALIALHG
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FQQARFVHPDGSPAQVLPILAVVALVAWIGIRQTGHPLPWVDLRATLQRRFIVGMVFYAI
HHHCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YYGFASAWSFLSSSLLQNGLGFRYETTAQFMSLSGLVTLLLGIANFQLTDYLPRKHVLIA
HHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHH
IGFVLMAGAMLWLSRTAMPGASAGVLAPGFVMEGMVGMLVVIQVAGLTYVDLPAEDFGHA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHCCH
YQFKGIMRAWAQAFGTLLATLMLQRGQAQHRTDLVGHVSALTPSWLWPHPLQGAELVRLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AEIDRQATLLACGDLFVWSAAIALACAVAILAQRTLR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTPSTDHTPSAQSAPRRQPAGSTVASRLELRMVGMVIGLATGVDYMANLMFSIAGPHIE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGVLASQDVYLWAVTSYAAAASLAILVMGRLADRMTYRRHTLLSLLIFIAGTLMCAAAEG
CCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTMLIFGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKGMIYGIFGLTCVSPVLSAALT
CEEEEEECHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQFGWRAIFVAQLLVAVMVCGLVAAFYPHPHQHERTGDFASLDWPSAIAFGLAALIALHG
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FQQARFVHPDGSPAQVLPILAVVALVAWIGIRQTGHPLPWVDLRATLQRRFIVGMVFYAI
HHHCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YYGFASAWSFLSSSLLQNGLGFRYETTAQFMSLSGLVTLLLGIANFQLTDYLPRKHVLIA
HHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHH
IGFVLMAGAMLWLSRTAMPGASAGVLAPGFVMEGMVGMLVVIQVAGLTYVDLPAEDFGHA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCHHHHCCH
YQFKGIMRAWAQAFGTLLATLMLQRGQAQHRTDLVGHVSALTPSWLWPHPLQGAELVRLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AEIDRQATLLACGDLFVWSAAIALACAVAILAQRTLR
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]