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The map label for this gene is guaB [H]

Identifier: 17546148

GI number: 17546148

Start: 1528044

End: 1529507

Strand: Direct

Name: guaB [H]

Synonym: RSc1429

Alternate gene names: 17546148

Gene position: 1528044-1529507 (Clockwise)

Preceding gene: 17546145

Following gene: 17546149

Centisome position: 41.12

GC content: 66.94

Gene sequence:

>1464_bases
ATGCGTCTTGTCCAGAAAGCACTCACGTTCGATGATGTGCTGCTCGTCCCGGCCTACTCGGCCGTTCTTCCCCGCGATAC
GTCGCTTCGCACCAAACTCACCCGCACGATCGAGCTCGCCATTCCGCTGGTGTCCGCCGCCATGGACACCGTCACGGAAG
CGCGCCTGGCCATCGCCATGGCGCAGCAGGGCGGCATCGGCATCGTTCACAAGAACCTGAAGCCGGAAGAGCAGGCGCGC
GAAGTCGCCAAGGTCAAGCGCTTCGAGTCGGGCGTGCTGCGCGACCCGATCACCATCGGCCCGGACATGAAGGTCCGTGA
CGTGATGGCGCTGTCGGCGCAGCATGGCATCTCGGGCTTCCCGGTGCTGGAAGGCAACAAGGTGGTGGGCATCATCACCA
ACCGCGACCTGCGCTTCGAAGAAGAGCTGGACGCGCCGGTGCGCGCCAAGATGACGCCGGGCGAGAAGCTCGTCACCGTC
AGGGAAGGCGCCTCGCTGGAAGAGGCCAAGCGCCTGATGAACAAGCACCGCCTGGAGCGCGTGCTGGTGGTCGACGGCAA
TTTCGAGCTGCGCGGCCTCATCACCGTCAAGGACATCCAGAAGGCCACCGAGCATCCGCTGGCCTCCAAGGACGAGCGCG
GCTCGCTGCGCGTCGGCGCGGCGGTGGGCGTGGGCCCGGACAATGACCTGCGCGTCGACCTGCTGGTCAAGGCCGGCGTG
GACGTGATCGTGGTCGATACCGCGCACGGCCACAGCCAGGGCGTGCTGAGCCGCGTGCGCTGGATCAAGGACAAATACCC
GCAGGTGCAGGTGATCGGCGGCAACATCGCCACGGCCGAAGCCGCGAAGGCGCTGGTCGACCACGGCGCGGACGGCGTCA
AGGTCGGCATCGGCCCGGGCTCGATCTGCACGACGCGGATTGTAGCCGGCGTGGGCGTGCCGCAGATCAGCGCGGTGTCC
AACGTGGCCGAGGCGCTCAAGAACACCGGCGTGCCCCTGGTGGCCGACGGCGGCGTGCGCTACTCGGGCGACATCGCCAA
GGCACTGGCGGCTGGCGCGCACACCGTGATGATGGGCGGCATGTTCGCCGGCACCGAAGAGGCGCCGGGCGAGGTGTTCC
TGTACCAGGGACGCTCGTACAAGAGCTACCGCGGTATGGGTTCGGTGGGCGCCATGAAGGACGGCGCGGCCGACCGCTAC
TTCCAGGAAGACAACACCGCCAACGTCGATAAGCTGGTGCCGGAAGGCATCGAGGGCCGCGTCCCATACAAGGGCTCGGT
GCTGCCGATCGTCCATCAGCTCACCGGCGGCATCCGCTCGTCGATGGGCTACTGCGGCTGCGCGTCGATCGCCGAATGGC
ACGAGAAGAGCCAGTTCGTCCAGATCACCGCCGCCGGCATGCGCGAATCGCACGTGCACGACGTGCAGATCACGAAGGAA
GCGCCGAACTATCACCTCGACTGA

Upstream 100 bases:

>100_bases
TGCGCCGGTGTGCGAAGAAAAATTTATCAAGCATAGCATGGTCATAACCAAACGTGGCGAGATTCCCGTATAATCCGATT
TTGCGCCTAGAGGATTCGCT

Downstream 100 bases:

>100_bases
CCGGCGCTCCGGTCATCGCACCCGCGATAGAAGGCACGCAGTATTGGCGCCGGGGCGCGGACGCTCCGGCGGCGTTCAAT
CCGGTGGCCGGCGCGCGGGG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRTIELAIPLVSAAMDTVTEARLAIAMAQQGGIGIVHKNLKPEEQAR
EVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGFPVLEGNKVVGIITNRDLRFEEELDAPVRAKMTPGEKLVTV
REGASLEEAKRLMNKHRLERVLVVDGNFELRGLITVKDIQKATEHPLASKDERGSLRVGAAVGVGPDNDLRVDLLVKAGV
DVIVVDTAHGHSQGVLSRVRWIKDKYPQVQVIGGNIATAEAAKALVDHGADGVKVGIGPGSICTTRIVAGVGVPQISAVS
NVAEALKNTGVPLVADGGVRYSGDIAKALAAGAHTVMMGGMFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVLPIVHQLTGGIRSSMGYCGCASIAEWHEKSQFVQITAAGMRESHVHDVQITKE
APNYHLD

Sequences:

>Translated_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRTIELAIPLVSAAMDTVTEARLAIAMAQQGGIGIVHKNLKPEEQAR
EVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGFPVLEGNKVVGIITNRDLRFEEELDAPVRAKMTPGEKLVTV
REGASLEEAKRLMNKHRLERVLVVDGNFELRGLITVKDIQKATEHPLASKDERGSLRVGAAVGVGPDNDLRVDLLVKAGV
DVIVVDTAHGHSQGVLSRVRWIKDKYPQVQVIGGNIATAEAAKALVDHGADGVKVGIGPGSICTTRIVAGVGVPQISAVS
NVAEALKNTGVPLVADGGVRYSGDIAKALAAGAHTVMMGGMFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVLPIVHQLTGGIRSSMGYCGCASIAEWHEKSQFVQITAAGMRESHVHDVQITKE
APNYHLD
>Mature_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRTIELAIPLVSAAMDTVTEARLAIAMAQQGGIGIVHKNLKPEEQAR
EVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGFPVLEGNKVVGIITNRDLRFEEELDAPVRAKMTPGEKLVTV
REGASLEEAKRLMNKHRLERVLVVDGNFELRGLITVKDIQKATEHPLASKDERGSLRVGAAVGVGPDNDLRVDLLVKAGV
DVIVVDTAHGHSQGVLSRVRWIKDKYPQVQVIGGNIATAEAAKALVDHGADGVKVGIGPGSICTTRIVAGVGVPQISAVS
NVAEALKNTGVPLVADGGVRYSGDIAKALAAGAHTVMMGGMFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSVLPIVHQLTGGIRSSMGYCGCASIAEWHEKSQFVQITAAGMRESHVHDVQITKE
APNYHLD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=43.064182194617, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI217035146, Length=451, Percent_Identity=44.3458980044346, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=451, Percent_Identity=44.3458980044346, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=451, Percent_Identity=44.3458980044346, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=451, Percent_Identity=44.3458980044346, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=44.2953020134228, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=43.4589800443459, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=41.019955654102, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI156104880, Length=264, Percent_Identity=35.9848484848485, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=37.0967741935484, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=37.0967741935484, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=37.0967741935484, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=37.0967741935484, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.0123203285421, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1786293, Length=225, Percent_Identity=36, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=39.1578947368421, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=41.0501193317422, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17560440, Length=280, Percent_Identity=34.6428571428571, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=41.0309278350515, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=40.2862985685072, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=40.4123711340206, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.3508771929825, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=41.6666666666667, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=40.5797101449275, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=40.5797101449275, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.2698412698413, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52066; Mature: 52066

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRTIELAIPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
AQQGGIGIVHKNLKPEEQAREVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGF
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCCC
PVLEGNKVVGIITNRDLRFEEELDAPVRAKMTPGEKLVTVREGASLEEAKRLMNKHRLER
EEECCCEEEEEEECCCCCCHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCE
VLVVDGNFELRGLITVKDIQKATEHPLASKDERGSLRVGAAVGVGPDNDLRVDLLVKAGV
EEEEECCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCC
DVIVVDTAHGHSQGVLSRVRWIKDKYPQVQVIGGNIATAEAAKALVDHGADGVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQISAVSNVAEALKNTGVPLVADGGVRYSGDIAKALAAGAHTVMMGG
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEECC
MFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
EECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSVLPIVHQLTGGIRSSMGYCGCASIAEWHEKSQFVQITAAGMRESHVHDVQITKE
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEC
APNYHLD
CCCCCCC
>Mature Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRTIELAIPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
AQQGGIGIVHKNLKPEEQAREVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGF
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCCC
PVLEGNKVVGIITNRDLRFEEELDAPVRAKMTPGEKLVTVREGASLEEAKRLMNKHRLER
EEECCCEEEEEEECCCCCCHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCE
VLVVDGNFELRGLITVKDIQKATEHPLASKDERGSLRVGAAVGVGPDNDLRVDLLVKAGV
EEEEECCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCC
DVIVVDTAHGHSQGVLSRVRWIKDKYPQVQVIGGNIATAEAAKALVDHGADGVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQISAVSNVAEALKNTGVPLVADGGVRYSGDIAKALAAGAHTVMMGG
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCEEEECC
MFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
EECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSVLPIVHQLTGGIRSSMGYCGCASIAEWHEKSQFVQITAAGMRESHVHDVQITKE
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEC
APNYHLD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA